Genomes and Genes
Experts and Doctors on molecular sequence data in Durham, North Carolina, United States
Locale: Durham, North Carolina, United States
Topic: molecular sequence data
Publications225 found, 100 shown here
- Sterner J, Dew Knight S, Musahl C, Kornbluth S, Horowitz J. Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. Mol Cell Biol. 1998;18:2748-57 pubmed..These data provide the first evidence that Rb and Rb-related proteins can directly regulate DNA replication and that components of licensing factor are targets of the products of tumor suppressor genes. ..
- O briant K, Ali S, Weier H, Bepler G. An 84-kilobase physical map and repeat polymorphisms of the gastrin/cholecystokinin brain receptor region at the junction of chromosome segments 11p15.4 and 15.5. Chromosome Res. 1998;6:415-8 pubmed
- Otto J, Kim E, Young S, Casey P. Cloning and characterization of a mammalian prenyl protein-specific protease. J Biol Chem. 1999;274:8379-82 pubmed..These data indicate that both the yeast and the human RCE1 gene products are bona fide prenyl protein proteases and suggest that they play a major role in the processing of CAAX-type prenylated proteins. ..
- Premont R, Macrae A, Aparicio S, Kendall H, Welch J, Lefkowitz R. The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. J Biol Chem. 1999;274:29381-9 pubmed..The divergence of individual GRKs at vastly different rates reveals that strikingly different evolutionary pressures apply to the function of the individual GRKs. ..
- Kwak E, Gerald N, Larochelle D, Vithalani K, Niswonger M, Maready M, et al. LvsA, a protein related to the mouse beige protein, is required for cytokinesis in Dictyostelium. Mol Biol Cell. 1999;10:4429-39 pubmed..Thus, on the basis of the sequence analysis of the LvsA protein and the phenotype of the lvsA mutants, we postulate that LvsA plays an important role in a membrane-processing pathway that is essential for cytokinesis. ..
- Pi M, Garner S, Flannery P, Spurney R, Quarles L. Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. J Biol Chem. 2000;275:3256-63 pubmed..The presence of a cation-sensing response in osteoblasts from CasR(-/-) mice indicates the existence of a novel osteoblastic extracellular cation-sensing mechanism. ..
- Sahoo T, Goenaga Diaz E, Serebriiskii I, Thomas J, Kotova E, Cuellar J, et al. Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene. Genomics. 2001;71:123-6 pubmed..In addition, these results provide another example of the utility of rigorous computational and comparative sequence analysis for refining gene structure. ..
- Kishnani P, Faulkner E, VanCamp S, Jackson M, Brown T, Boney A, et al. Canine model and genomic structural organization of glycogen storage disease type Ia (GSD Ia). Vet Pathol. 2001;38:83-91 pubmed
- McVie Wylie A, Lamson D, Chen Y. Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. Genomics. 2001;72:113-7 pubmed..From these data, we believe that the chromosomal localization, tissue distribution, and predicted function make GLUT10 an excellent candidate for a susceptibility gene involved in NIDDM. ..
- Fox D, Cruz M, Sia R, Ke H, Cox G, Cardenas M, et al. Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. Mol Microbiol. 2001;39:835-49 pubmed..In summary, our studies reveal a central role for calcineurin B in virulence and antifungal drug action in the human fungal pathogen C. neoformans. ..
- Chao A, Dierick H, Addy T, Bejsovec A. Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila. Genetics. 2003;165:601-12 pubmed..Our findings have important implications for assigning null mutant phenotypes and for selecting appropriate alleles to use in suppressor screens. ..
- Tebbit C, Bentley R, Olson J, Marks J. Estrogen receptor alpha (ESR1) mutant A908G is not a common feature in benign and malignant proliferations of the breast. Genes Chromosomes Cancer. 2004;40:51-4 pubmed..These results indicate that ESR1 mutant A908G does not occur with significant frequency in either benign or malignant proliferations of breast epithelia. ..
- Sweet C, Ribeiro A, Raetz C. Oxidation and transamination of the 3"-position of UDP-N-acetylglucosamine by enzymes from Acidithiobacillus ferrooxidans. Role in the formation of lipid a molecules with four amide-linked acyl chains. J Biol Chem. 2004;279:25400-10 pubmed..As shown in the accompanying papers, UDP-GlcNAc3N is selectively acylated by LpxAs of A. ferrooxidans, L. interrogans, and M. loti. UDP-GlcNAc3N may be useful as a substrate analog for diverse enzymes that utilize UDP-GlcNAc...
- Barnes A, Smith F, VanDongen H, VanDongen A, Milgram S. The identification of a second actin-binding region in spinophilin/neurabin II. Brain Res Mol Brain Res. 2004;124:105-13 pubmed..The second ABD targets to spines inefficiently and thus may interact with and affect actin filaments in a different manner than the first ABD. ..
- Hu B, Zhang C, Baawo K, Qin R, Cole G, Lee J, et al. Zebrafish K5 promoter driven GFP expression as a transgenic system for oral research. Oral Oncol. 2010;46:31-7 pubmed publisher..This study indicated a high fidelity of GFP reporter gene expression in the tongue under the control of zebrafish keratin 5 promoter. This zebrafish transgenic model system may be used for future studies on oral development and cancer. ..
- Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villen J, et al. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A. 2010;107:15299-304 pubmed publisher..This study provides a system-based view of beta-arrestin-mediated phosphorylation events downstream of a 7TMR and opens avenues for research in a rapidly evolving area of 7TMR signaling. ..
- Xie T, Liang J, Liu N, Wang Q, Li Y, Noble P, et al. MicroRNA-127 inhibits lung inflammation by targeting IgG Fc? receptor I. J Immunol. 2012;188:2437-44 pubmed publisher..Understanding how miRNAs regulate lung inflammation may represent an attractive way to control inflammation induced by infectious or noninfectious lung injury. ..
- Stiles G. Adenosine receptors. J Biol Chem. 1992;267:6451-4 pubmed..We are likely to begin to see evidence for a whole group of adenosine receptors undetected by previous technology. One era of adenosine receptor research has just ended, and we now enter the new with anxious anticipation. ..
- Samson F, Lee J, Hung W, Potter T, Herbstreith M, Roses A, et al. Isolation and localization of a slow troponin (TnT) gene on chromosome 19 by subtraction hybridization of a cDNA muscle library using myotonic dystrophy muscle cDNA. J Neurosci Res. 1990;27:441-51 pubmed..2. Sequence analysis confirmed that MSL 366 is the cDNA for human slow skeletal muscle troponin T. A genomic clone has been isolated and linkage studies with DM are in progress. ..
- Query C, Bentley R, Keene J. A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Cell. 1989;57:89-101 pubmed
- Kobilka B, Matsui H, Kobilka T, Yang Feng T, Francke U, Caron M, et al. Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science. 1987;238:650-6 pubmed..Two related genes have been identified by low stringency Southern blot analysis. These genes may represent additional alpha 2-adrenergic receptor subtypes. ..
- Denis C, Draper M, Liu H, Malvar T, Vallari R, Cook W. The yeast CCR4 protein is neither regulated by nor associated with the SPT6 and SPT10 proteins and forms a functionally distinct complex from that of the SNF/SWI transcription factors. Genetics. 1994;138:1005-13 pubmed..These data suggest that CCR4 acts by a separate mechanism from that used by the SNF/SWI general transcription factors in affecting gene expression. ..
- Bao Y, Kishnani P, Wu J, Chen Y. Hepatic and neuromuscular forms of glycogen storage disease type IV caused by mutations in the same glycogen-branching enzyme gene. J Clin Invest. 1996;97:941-8 pubmed..Further study of genotype/phenotype correlations may yield useful information in predicting the clinical outcomes. ..
- Kadlec L, Pendergast A. The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation. Proc Natl Acad Sci U S A. 1997;94:12390-5 pubmed..Additionally, these results provide further evidence for the importance of the cABL carboxyl terminus and its binding proteins in the regulation of cABL function. ..
- Redick S, Settles D, Briscoe G, Erickson H. Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. J Cell Biol. 2000;149:521-7 pubmed..The integrin-binding synergy site is a much more extensive surface than the small linear peptide sequence. ..
- Nozik Grayck E, Dieterle C, Piantadosi C, Enghild J, Oury T. Secretion of extracellular superoxide dismutase in neonatal lungs. Am J Physiol Lung Cell Mol Physiol. 2000;279:L977-84 pubmed..The changes in EC-SOD localization and activity have implications for the neonatal pulmonary response to oxidative stress and the biological activity of NO at birth...
- Oliver C, Terry Lorenzo R, Elliott E, Bloomer W, Li S, Brautigan D, et al. Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. Mol Cell Biol. 2002;22:4690-701 pubmed..These studies provided new insights into the assembly and regulation of a neurabin I/PP1 complex that controls actin rearrangement to promote spine development in mammalian neurons. ..
- Zelko I, Folz R. Myeloid zinc finger (MZF)-like, Kruppel-like and Ets families of transcription factors determine the cell-specific expression of mouse extracellular superoxide dismutase. Biochem J. 2003;369:375-86 pubmed..We propose a model that highlights competition between Ets activators and Kruppel-like repressors within the proximal promoter region that determines the level of EC-SOD expression in a particular cell type. ..
- Yamada A, Duffy B, Perry J, Kornbluth S. DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7. J Cell Biol. 2004;167:841-9 pubmed..These data establish Hsl7 as a component of the replication checkpoint and reveal that similar cell cycle control modules can be co-opted for use by distinct checkpoints in different organisms. ..
- Gao F, Weaver E, Lu Z, Li Y, Liao H, Ma B, et al. Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein. J Virol. 2005;79:1154-63 pubmed..Thus, the computer-generated "consensus" env genes are capable of expressing envelope glycoproteins that retain the structural, functional, and immunogenic properties of wild-type HIV-1 envelopes. ..
- Wang X, McGrath S, Cotter R, Raetz C. Expression cloning and periplasmic orientation of the Francisella novicida lipid A 4'-phosphatase LpxF. J Biol Chem. 2006;281:9321-30 pubmed publisher..The availability of the lpxF gene will facilitate re-engineering lipid A structures in diverse bacteria...
- Hong L, Simon J. Binding of Cu(II) to human alpha-synucleins: comparison of wild type and the point mutations associated with the familial Parkinson's disease. J Phys Chem B. 2009;113:9551-61 pubmed publisher..g., small oligomeric species, such as dimers and trimers) relative to WT and A53T. Thus, we propose that the high affinity site is attributed to the binding of Cu(II) to those small oligomeric species. ..
- Bonsignori M, Moody M, Parks R, Holl T, Kelsoe G, Hicks C, et al. HIV-1 envelope induces memory B cell responses that correlate with plasma antibody levels after envelope gp120 protein vaccination or HIV-1 infection. J Immunol. 2009;183:2708-17 pubmed publisher..The inability to generate high titers of long-lived anti-envelope Abs is a major hurdle to overcome for the development of a successful HIV-1 vaccine. ..
- Howarth D, Hagey L, Law S, Ai N, Krasowski M, Ekins S, et al. Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro. Aquat Toxicol. 2010;98:245-255 pubmed publisher..These data demonstrate that both mammalian and teleost FXR (Fxralpha2 isoform) are activated by primary and secondary bile acids. ..
- Bennett S, Mercer J, Noor M. Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2. PLoS ONE. 2010;5:e11006 pubmed publisher..We conclude that the evolutionary history of dmbrca2 in D. yakuba and perhaps in other Drosophila species may be more complicated than can be inferred from examination of the published single genome sequences per species. ..
- Hoopes C, Taketo M, Ozato K, Liu Q, Howard T, Linney E, et al. Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma. Genomics. 1992;14:611-7 pubmed..Rxra mapped to Chr 2 near the centromere, Rxrb mapped to the H-2 region of Chr 17, and Rxrg was tightly linked to the Pbx gene on distal Chr 1. These results underscore that RXR genes are dispersed in the genome. ..
- Zehring W, Greenleaf A. The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro. J Biol Chem. 1990;265:8351-3 pubmed..We conclude that in this system Sp1 interacts with a component of the transcription machinery, other than the carboxyl-terminal domain, which is preserved between mammals and insects. ..
- Khatri G, MacAllister T, Sista P, Bastia D. The replication terminator protein of E. coli is a DNA sequence-specific contra-helicase. Cell. 1989;59:667-74 pubmed..This contra-helicase activity is polar, i.e., the impedance to unwinding takes place in only one orientation of the tau sequence. The results illuminate the mechanism of replication termination specifically at tau. ..
- El Mestikawy S, Giros B, Pohl M, Hamon M, Kingsmore S, Seldin M, et al. Characterization of an atypical member of the Na+/Cl(-)-dependent transporter family: chromosomal localization and distribution in GABAergic and glutamatergic neurons in the rat brain. J Neurochem. 1994;62:445-55 pubmed..The gene encoding for XT1 is localized to the mouse chromosome 3 in the vicinity of the locus for the mouse neurological disorder spastic (spa). ..
- Chen J, Chiang Y, Denis C. CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase. EMBO J. 2002;21:1414-26 pubmed..The various regulatory effects of the CCR4-NOT complex on gene expression may be executed in part through these CCR4 exonuclease activities. ..
- Palmer S, Burch L, Davis R, Herczyk W, Howell D, Reinsmoen N, et al. The role of innate immunity in acute allograft rejection after lung transplantation. Am J Respir Crit Care Med. 2003;168:628-32 pubmed..Therapies directed at inhibition of innate immune responses mediated by TLR4 may represent a novel and effective means to prevent acute rejection after lung transplantation. ..
- Dagenbach E, Endow S. A new kinesin tree. J Cell Sci. 2004;117:3-7 pubmed
- Davis L, Bennett V. Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. J Biol Chem. 1990;265:10589-96 pubmed..The finding that the 33-amino acid repeating sequence is involved in interaction with the anion exchanger implies that this motif may perform a role in molecular recognition in diverse proteins. ..
- Jakoi E, Brown A, Ho Y, Snyderman R. Molecular cloning of the cDNA for ligatin. J Cell Sci. 1989;93 ( Pt 2):227-32 pubmed..In addition, one of these antibodies produced a punctate immunofluorescence pattern within the cytosol of U937 cells in a similar fashion to anti-ligatin serum. ..
- Lee M, Sander M, Hsieh T. Single strand DNA cleavage reaction of duplex DNA by Drosophila topoisomerase II. J Biol Chem. 1989;264:13510-8 pubmed..The implication of this observation on the sequential cleavage of the two strands of the DNA duplex during the normal DNA double strand passage process catalyzed by type II DNA topoisomerases is discussed. ..
- Benovic J, DeBlasi A, Stone W, Caron M, Lefkowitz R. Beta-adrenergic receptor kinase: primary structure delineates a multigene family. Science. 1989;246:235-40 pubmed..RNA blot analysis revealed a messenger RNA of four kilobases with highest amounts in brain and spleen. Genomic DNA blot analysis also suggests that beta-ARK may be the first sequenced member of a multigene family of receptor kinases. ..
- Sharma S, King L, Corley R, Maki R. Comparative sequence analysis of cDNA clones encoding I-A molecules of the CH12 B cell lymphoma: nucleotide differences do not account for their "defective" function in B cell stimulation. Immunol Invest. 1987;16:425-36 pubmed..The results provide no evidence for structural alterations in either A alpha or A beta which could account for these observations. The implications of these findings on the role of class II molecules in B cell activation is discussed. ..
- Kumar A, Wolpert C, Kandt R, Segal J, Pufky J, Roses A, et al. A de novo frame-shift mutation in the tuberin gene. Hum Mol Genet. 1995;4:1471-2 pubmed
- Drummond J, Li G, Longley M, Modrich P. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science. 1995;268:1909-12 pubmed
- Ward M, Gimeno C, Fink G, Garrett S. SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription. Mol Cell Biol. 1995;15:6854-63 pubmed..Thus, the product of SOK2 may act downstream of PKA to regulate the expression of genes important in growth and development. ..
- Park H, Boduluri S, Moomaw J, Casey P, Beese L. Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution. Science. 1997;275:1800-4 pubmed..One cleft contains a nine-residue peptide that may mimic the binding of the Ras substrate; the other cleft is lined with highly conserved aromatic residues appropriate for binding the farnesyl isoprenoid with required specificity. ..
- Kanipes M, Hill J, Henry S. The Schizosaccharomyces pombe cho1+ gene encodes a phospholipid methyltransferase. Genetics. 1998;150:553-62 pubmed..pombe cho1 mutants. These results suggest that both the structure and function of the phospholipid N-methyltransferases are broadly conserved among eukaryotic organisms. ..
- Kumar J, Erickson H, Sheetz M. Ultrastructural and biochemical properties of the 120-kDa form of chick kinectin. J Biol Chem. 1998;273:31738-43 pubmed..Immunoprecipitation with a 160-kDa kinectin-specific antibody brought down the 120-kDa kinectin. Thus, we suggest that kinectin is an extended parallel coiled-coil dimer, often a heterodimer. ..
- Calvert J, Riney T, Kontos C, Cha E, Prieto V, Shea C, et al. Allelic and locus heterogeneity in inherited venous malformations. Hum Mol Genet. 1999;8:1279-89 pubmed..Of the two remaining families, one excludes linkage to the TIE2 locus, establishing the existence of at least one additional locus for dominantly inherited venous malformations. ..
- McHeyzer Williams L, Cool M, McHeyzer Williams M. Antigen-specific B cell memory: expression and replenishment of a novel b220(-) memory b cell compartment. J Exp Med. 2000;191:1149-66 pubmed..Thus, we identify new cellular components of B cell memory and propose a model for long-term protective immunity that is regulated by a complex balance of committed memory B cells with subspecialized immune function. ..
- Wuebbens M, Liu M, Rajagopalan K, Schindelin H. Insights into molybdenum cofactor deficiency provided by the crystal structure of the molybdenum cofactor biosynthesis protein MoaC. Structure. 2000;8:709-18 pubmed..This residue is located near the N-terminal end of helix alpha4 at an interface between two monomers. The MoaC structure provides a framework for the analysis of additional dysfunctional mutations in the corresponding human gene. ..
- Liu S, Guo R, Quarles L. Cloning and characterization of the proximal murine Phex promoter. Endocrinology. 2001;142:3987-95 pubmed..Our findings are consistent with the predominant expression of Phex in bone and cartilage. Additional studies will be needed to confirm the regulatory regions in the Phex promoter that function in a cell-restricted manner. ..
- Freeman J, Gonzalo P, Pitcher J, Claing A, Lavergne J, Reboud J, et al. Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. Biochemistry. 2002;41:12850-7 pubmed
- Borron P, Mostaghel E, Doyle C, Walsh E, McHeyzer Williams M, Wright J. Pulmonary surfactant proteins A and D directly suppress CD3+/CD4+ cell function: evidence for two shared mechanisms. J Immunol. 2002;169:5844-50 pubmed
- Crump J, van Ingen J, Morrissey A, Boeree M, Mavura D, Swai B, et al. Invasive disease caused by nontuberculous mycobacteria, Tanzania. Emerg Infect Dis. 2009;15:53-5 pubmed publisher..avium complex sequevar MAC-D. Invasive NTM disease is present in HIV-infected patients in sub-Saharan Africa. ..
- Drendall C, Pham Q, Dietze E. Purification and characterization of recombinant CH3 domain fragment of the CREB-binding protein. Protein Expr Purif. 2010;70:196-205 pubmed publisher..Our results suggest that Akt signaling may have important implications on the in vivo molecular interaction of CBP with various transcription factors and modulation of cellular responses. ..
- Gonzalez Gronow M, Cuchacovich M, Francos R, Cuchacovich S, Fernandez M, Blanco A, et al. Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism. J Neuroimmunol. 2010;227:153-61 pubmed publisher..Because VDAC and hexokinase-I are essential for brain protection from ischemic damage, the presence of these autoantibodies suggests a possible causal role in the neurologic pathogenesis of autism. ..
- Goldstein J, Austin S, Boyette K, Kanaly A, Veerapandiyan A, Rehder C, et al. Molecular analysis of the AGL gene: identification of 25 novel mutations and evidence of genetic heterogeneity in patients with Glycogen Storage Disease Type III. Genet Med. 2010;12:424-30 pubmed publisher..The finding of at least one of the two exon 3 mutations in all of the Glycogen Storage Disease Type IIIb patients tested allows for diagnosis of this subtype without the need for a muscle biopsy. ..
- Foster M, Thompson J, Forrester M, Sha Y, McMahon T, Bowles D, et al. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. Nitric Oxide. 2013;34:37-46 pubmed publisher..Collectively, these findings demonstrate the general utility of interaction proteomics for defining new aspects of NOS2 physiology. ..
- Kohler M, Berchuck A, Davidoff A, Humphrey P, Dodge R, Iglehart J, et al. Overexpression and mutation of p53 in endometrial carcinoma. Cancer Res. 1992;52:1622-7 pubmed
- Tiberi M, Jarvie K, Silvia C, Falardeau P, Gingrich J, Godinot N, et al. Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. Proc Natl Acad Sci U S A. 1991;88:7491-5 pubmed..On the basis of its properties we propose that this dopamine receptor subtype be called D1B. ..
- Mudryj M, Hiebert S, Nevins J. A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 1990;9:2179-84 pubmed..We also believe that the E2F transcription factor is the first example of a regulator of the class of immediate early genes that is slowly activated by stimulation of cell proliferation. ..
- King K, Dohlman H, Thorner J, Caron M, Lefkowitz R. Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit. Science. 1990;250:121-3 pubmed..This in vivo reconstitution system provides a new approach for examining ligand binding and G protein coupling to cell surface receptors...
- Enghild J, Salvesen G, Brew K, Nagase H. Interaction of human rheumatoid synovial collagenase (matrix metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human alpha 2-macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cle. J Biol Chem. 1989;264:8779-85 pubmed..These results suggest that alpha 2M may play an important role in regulating the activities of matrix metalloproteinases in the extracellular space. ..
- Enghild J, Thøgersen I, Pizzo S, Salvesen G. Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. J Biol Chem. 1989;264:15975-81 pubmed..Our data allow identification of several recently reported cDNA clones and clarify the confusion surrounding the composition of plasma proteins referred to as inter-alpha-trypsin inhibitor. ..
- Stumpo D, Graff J, Albert K, Greengard P, Blackshear P. Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C. Proc Natl Acad Sci U S A. 1989;86:4012-6 pubmed..Genomic blot analysis indicated the likelihood of a single gene coding for this mRNA. We propose the name myristoylated alanine-rich C kinase substrate (MARCKS) for this protein. ..
- Miller D, Niemeyer C, Chitkara P. Dominant unc-37 mutations suppress the movement defect of a homeodomain mutation in unc-4, a neural specificity gene in Caenorhabditis elegans. Genetics. 1993;135:741-53 pubmed..We propose that unc-37 may be regulated by unc-4. Alternatively, unc-37 may encode a gene product that interacts with the unc-4 homeodomain. ..
- Belanger K, Kenna M, Wei S, Davis L. Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p. J Cell Biol. 1994;126:619-30 pubmed
- Lee M, Hsieh T. Linker insertion mutagenesis of Drosophila topoisomerase II. Probing the structure of eukaryotic topoisomerase II. J Mol Biol. 1994;235:436-47 pubmed..We discuss the possible structural and functional implications of these results. ..
- Velaz Faircloth M, McGraw T, alandro M, Fremeau R, Kilberg M, Anderson K. Characterization and distribution of the neuronal glutamate transporter EAAC1 in rat brain. Am J Physiol. 1996;270:C67-75 pubmed..Sections that were emulsion-dipped and counterstained with cresyl violet revealed EAAC1 labeling localized exclusively over neuronal cell bodies, including some nonglutamatergic neurons such as spinal cord ventral horn cells...
- Wyckoff T, Lin S, Cotter R, Dotson G, Raetz C. Hydrocarbon rulers in UDP-N-acetylglucosamine acyltransferases. J Biol Chem. 1998;273:32369-72 pubmed..E. coli G173M LpxA and the reciprocal P. aeruginosa M169G LpxA show reversed substrate selectivity in vitro and in vivo, demonstrating the existence of precise hydrocarbon rulers in LpxAs. ..
- Alarcon C, Heitman J, Cardenas M. Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. Mol Biol Cell. 1999;10:2531-46 pubmed
- Skipsey M, Andrews C, Townson J, Jepson I, Edwards R. Cloning and characterization of glyoxalase I from soybean. Arch Biochem Biophys. 2000;374:261-8 pubmed publisher..Both enzymes are associated with cell division in soybean cultures, but GmGST 3 (0.4% total protein) was 40 times more abundant than GmGlyox I (0.01%)...
- Gilbert J, Kumar A, Newey S, Rao N, Ioannou P, Qiu H, et al. Physical and cDNA mapping in the DBH region of human chromosome 9q34. Hum Hered. 2000;50:151-7 pubmed..The genomic clones of the contig, cDNAs and new STSs will be useful reagents for the further study and mapping of this region. ..
- Bogerd H, Wiegand H, Yang J, Cullen B. Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K. J Virol. 2000;74:9353-61 pubmed
- Schmidt S, Barcellos L, DeSombre K, Rimmler J, Lincoln R, Bucher P, et al. Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis. Am J Hum Genet. 2002;70:708-17 pubmed..03), whereas a higher proportion of APOE-2 carriers exhibit a mild disease course (P=.02). ..
- Lu Y. Molecular evolution at the self-incompatibility locus of Physalis longifolia (Solanaceae). J Mol Evol. 2002;54:784-93 pubmed..The two modes of selection can significantly modify the branch lengths of an S genealogy and may be ubiquitous to recognition systems. ..
- Smiley R, Collins T, Hammes G, Hsieh T. Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase II. Proc Natl Acad Sci U S A. 2007;104:4840-5 pubmed..In the presence of AMPPNP, a reduction in FRET occurs, suggesting an opening or partial opening of the DNA gate. However, the single-molecule experiments indicate that the open and closed states do not interconvert at a measurable rate. ..
- HORNE H, Lee P, Murphy S, Alonso M, Olson J, Marks J. Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. Mol Cancer Res. 2009;7:199-209 pubmed publisher..These data implicate MAL as a commonly altered gene in breast cancer with implications for response to chemotherapy. ..
- Kim N, Huang S, Williams J, Li Y, Clark A, Cho J, et al. Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I. Science. 2011;332:1561-4 pubmed publisher..The reported studies extend the role of Top1 to include the processing of rNMPs in genomic DNA into irreversible single-strand breaks, an activity that can have distinct mutagenic consequences and may be relevant to human disease. ..
- Kim N, Mudrak S, Jinks Robertson S. The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites. DNA Repair (Amst). 2011;10:1262-71 pubmed publisher..These results demonstrate that the catalytic activity of Rev1 is biologically relevant and is required specifically for dCMP insertion during the bypass of endogenous AP sites. ..
- Gaya E, Högnabba F, Holguin A, Molnar K, Fernández Brime S, Stenroos S, et al. Implementing a cumulative supermatrix approach for a comprehensive phylogenetic study of the Teloschistales (Pezizomycotina, Ascomycota). Mol Phylogenet Evol. 2012;63:374-87 pubmed publisher..Our results confirm the use of a cumulative supermatrix approach as a viable method to generate comprehensive phylogenies summarizing relationships of taxa with multi-locus to single locus data...
- Modliszewski J, Willis J. Allotetraploid Mimulus sookensis are highly interfertile despite independent origins. Mol Ecol. 2012;21:5280-98 pubmed publisher..Together, the data suggest that although recurrent origins may be common, they can contribute to genetic diversity without contributing to reproductive isolation among independently arisen polyploid lineages...
- Lloyd R, Foster P, Guille M, Littlewood D. Next generation sequencing and comparative analyses of Xenopus mitogenomes. BMC Genomics. 2012;13:496 pubmed publisher..These could help us better understand how processes such mitochondrial replication and gene expression influence xenopus growth and development, as well as how they evolved and are regulated. ..