Experts and Doctors on larva in Durham, North Carolina, United States

Summary

Locale: Durham, North Carolina, United States
Topic: larva

Top Publications

  1. Dasgupta S, DiGiulio R, Drollette B, L Plata D, Brownawell B, McElroy A. Hypoxia depresses CYP1A induction and enhances DNA damage, but has minimal effects on antioxidant responses in sheepshead minnow (Cyprinodon variegatus) larvae exposed to dispersed crude oil. Aquat Toxicol. 2016;177:250-60 pubmed publisher
    ..This study demonstrates the importance of considering hypoxia as an enhanced risk factor in assessing the effects of contaminants in areas where seasonal hypoxia may be prevalent. ..
  2. Eddins D, Cerutti D, Williams P, Linney E, Levin E. Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. Neurotoxicol Teratol. 2010;32:99-108 pubmed publisher
    ..This may be helpful in screening for persisting neurobehavioral defects from a variety of toxicants. ..
  3. Morris W, Bronstein J, Wilson W. Three-way coexistence in obligate mutualist-exploiter interactions: the potential role of competition. Am Nat. 2003;161:860-75 pubmed
    ..Our results suggest that mutualist/exploiter coexistence may be more easily achieved than previously thought, thus highlighting the need for a better understanding of competition among and between mutualists and exploiters. ..
  4. Walters F, deFontes C, Hart H, Warren G, Chen J. Lepidopteran-active variable-region sequence imparts coleopteran activity in eCry3.1Ab, an engineered Bacillus thuringiensis hybrid insecticidal protein. Appl Environ Microbiol. 2010;76:3082-8 pubmed publisher
    ..1Ab can interact with different binding sites than the activated form of mCry3A in the WCR brush border and may provide a different mode of action from the standpoint of resistance management. ..
  5. Bailey J, Oliveri A, Karbhari N, Brooks R, De La Rocha A, Janardhan S, et al. Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish. Neurotoxicology. 2016;52:23-33 pubmed publisher
    ..Social behavior and some aspects of motor function were altered in exposed fish; the importance of examining emotional or psychological consequences of early life exposure to retinoid acting chemicals is discussed. ..
  6. Brown D, Bailey J, Oliveri A, Levin E, Di Giulio R. Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish. Neurotoxicol Teratol. 2016;53:55-63 pubmed publisher
    ..Furthermore, this is the first longitudinal behavioral study to use killifish, an environmentally important estuarine teleost fish, and this testing framework can be used for future contaminant assessment. ..
  7. Nijhout H, Grunert L. The cellular and physiological mechanism of wing-body scaling in Manduca sexta. Science. 2010;330:1693-5 pubmed publisher
    ..Thus, proportional growth is under hormonal control and indirectly regulated by the central nervous system. ..
  8. Stewart A, Tsubouchi A, Rolls M, Tracey W, Sherwood N. Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. J Neurosci. 2012;32:11631-42 pubmed publisher
  9. Tsubouchi A, Caldwell J, Tracey W. Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae. Curr Biol. 2012;22:2124-34 pubmed publisher
    ..These cells show physiological responses to force. Ion channels in several force-sensing gene families are required for behavioral sensitivity to touch and for the formation of the actin-rich sensory filopodia. ..

More Information

Publications42

  1. King F, Lin H. Somatic signaling mediated by fs(1)Yb is essential for germline stem cell maintenance during Drosophila oogenesis. Development. 1999;126:1833-44 pubmed
  2. Callier V, Nijhout H. Control of body size by oxygen supply reveals size-dependent and size-independent mechanisms of molting and metamorphosis. Proc Natl Acad Sci U S A. 2011;108:14664-9 pubmed publisher
    ..We show that under these conditions, larvae do not use the critical weight mechanism, but instead use a size-independent mechanism that is independent of the brain...
  3. Bastidas R, Shertz C, Lee S, Heitman J, Cardenas M. Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor. Eukaryot Cell. 2012;11:270-81 pubmed publisher
  4. Hwang R, Zhong L, Xu Y, Johnson T, Zhang F, Deisseroth K, et al. Nociceptive neurons protect Drosophila larvae from parasitoid wasps. Curr Biol. 2007;17:2105-2116 pubmed publisher
    ..The nociception behavior of Drosophila melanagaster larvae includes an innately encoded directional preference. Nociception behavior is elicited by the ecologically relevant sensory stimulus of parasitoid wasp attack. ..
  5. Wray G, Kitazawa C, Miner B. Culture of echinoderm larvae through metamorphosis. Methods Cell Biol. 2004;74:75-86 pubmed
  6. Lickwar C, Camp J, Weiser M, Cocchiaro J, Kingsley D, Furey T, et al. Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells. PLoS Biol. 2017;15:e2002054 pubmed publisher
  7. Garfield D, Runcie D, Babbitt C, Haygood R, Nielsen W, Wray G. The impact of gene expression variation on the robustness and evolvability of a developmental gene regulatory network. PLoS Biol. 2013;11:e1001696 pubmed publisher
    ..These results indicate that the position and properties of gene interactions within a network can have important evolutionary consequences independent of their immediate regulatory role. ..
  8. Robertson J, Tsubouchi A, Tracey W. Larval defense against attack from parasitoid wasps requires nociceptive neurons. PLoS ONE. 2013;8:e78704 pubmed publisher
    ..Thus, the class IV neurons allow for a nociceptive behavioral response to a naturally occurring predator of Drosophila. ..
  9. Israel J, Martik M, Byrne M, Raff E, Raff R, McClay D, et al. Comparative Developmental Transcriptomics Reveals Rewiring of a Highly Conserved Gene Regulatory Network during a Major Life History Switch in the Sea Urchin Genus Heliocidaris. PLoS Biol. 2016;14:e1002391 pubmed publisher
  10. Stankiewicz P, Khan T, Szafranski P, Slattery L, Streff H, Vetrini F, et al. Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features. Am J Hum Genet. 2017;101:503-515 pubmed publisher
    ..Taken together, our data demonstrate the pathogenic role of BPTF haploinsufficiency in syndromic neurodevelopmental anomalies and extend the clinical spectrum of human disorders caused by ablation of chromatin remodeling complexes. ..
  11. Clayton J, Glander K. Dietary choices by four captive slender lorises (Loris tardigradus) when presented with various insect life stages. Zoo Biol. 2011;30:189-98 pubmed publisher
    ..They preferred the larvae stage to the adult stage in all three insect species, and males and females had different insect species and life stage preferences...
  12. Hu B, Chen H, Liu X, Zhang C, Cole G, Lee J, et al. Transgenic overexpression of cdx1b induces metaplastic changes of gene expression in zebrafish esophageal squamous epithelium. Zebrafish. 2013;10:218-27 pubmed publisher
    ..However, cdx1b failed to induce histological IM, or to modulate cell proliferation and apoptosis in the squamous epithelium of adult transgenic zebrafish. ..
  13. Asano M, Nevins J, Wharton R. Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev. 1996;10:1422-32 pubmed
    ..Furthermore, they suggest that the downregulation of E2F upon entry into S phase may be essential to prevent the induction of apoptosis. ..
  14. Zhang C, Chen A, Gettel N, Hsieh T. Essential functions of DNA topoisomerase I in Drosophila melanogaster. Dev Biol. 2000;222:27-40 pubmed
    ..The cytological and genetic analysis of the top1 mutant demonstrates that in Drosophila, topo I plays critical roles in many developmental stages active in cell proliferation. ..
  15. Hu C, Petersen M, Hoyer N, Spitzweck B, Tenedini F, Wang D, et al. Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior. Nat Neurosci. 2017;20:1085-1095 pubmed publisher
    ..Our findings unveil how integration of somatosensory input and neuropeptide-mediated modulation can produce robust modality-specific escape behavior. ..
  16. Buznikov G, Nikitina L, Seidler F, Slotkin T, Bezuglov V, Milosević I, et al. Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids. Neurotoxicol Teratol. 2008;30:503-9 pubmed publisher
    ..Our findings reinforce a role for APP in development and point to specific interactions with neurotransmitter systems that act as morphogens in developing sea urchins as well as in the mammalian brain. ..
  17. Dong W, Macaulay L, Kwok K, Hinton D, Stapleton H. Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages. Aquat Toxicol. 2013;132-133:190-9 pubmed publisher
    ..Our results demonstrate effects of OH-BDEs on thyroid regulating gene expression and provide more insight into potential sites of injury during early life stages. ..
  18. Sloan R, Swanson C, Gavilano L, Smith K, Malek P, Snow Smith M, et al. Characterization of null and hypomorphic alleles of the Drosophila l(2)dtl/cdt2 gene: Larval lethality and male fertility. Fly (Austin). 2012;6:173-83 pubmed publisher
    ..We conclude that "denticleless" is a misnomer, but that l(2)dtl/cdt2 is an essential gene for Drosophila development. ..
  19. Powers C, Yen J, Linney E, Seidler F, Slotkin T. Silver exposure in developing zebrafish (Danio rerio): persistent effects on larval behavior and survival. Neurotoxicol Teratol. 2010;32:391-7 pubmed publisher
    ..Ag(+) is a developmental toxicant at concentrations only slightly above allowable levels. At low concentrations, Ag(+) acts as a neurobehavioral toxicant even in the absence of dysmorphology. ..
  20. Zhong L, Hwang R, Tracey W. Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae. Curr Biol. 2010;20:429-34 pubmed publisher
    ..Our results suggest that neurons that detect harsh touch in Drosophila utilize similar mechanosensory molecules. ..
  21. Tobler A, Nijhout H. A switch in the control of growth of the wing imaginal disks of Manduca sexta. PLoS ONE. 2010;5:e10723 pubmed publisher
    ..At the end of larval life feeding stops but the disks continue to grow, so at that time disk growth has become uncoupled from nutrition. We sought to determine at exactly what point in development this uncoupling occurs...
  22. Yen J, Donerly S, Levin E, Linney E. Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicol Teratol. 2011;33:735-41 pubmed publisher
    ..Because of its availability outside the mother at the time of fertilization, zebrafish provides a complementary model for studying the neurotoxicity of very early developmental exposures. ..
  23. Powers C, Slotkin T, Seidler F, Badireddy A, Padilla S. Silver nanoparticles alter zebrafish development and larval behavior: distinct roles for particle size, coating and composition. Neurotoxicol Teratol. 2011;33:708-14 pubmed publisher
    ..Different AgNP formulations are thus likely to produce distinct patterns of developmental neurotoxicity. ..
  24. Maynard J, Pham T, Zheng T, Jockheck Clark A, Rankin H, Newgard C, et al. Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Dev Biol. 2010;339:295-306 pubmed publisher
  25. Jung D, Cho Y, Collins L, Swenberg J, Di Giulio R. Effects of benzo[a]pyrene on mitochondrial and nuclear DNA damage in Atlantic killifish (Fundulus heteroclitus) from a creosote-contaminated and reference site. Aquat Toxicol. 2009;95:44-51 pubmed publisher
    ..Results also suggest that multi-generational exposures in the wild may lead to adaptations that dampen DNA damage arising from BaP exposure. ..
  26. Suzuki Y, Nijhout H. Genetic basis of adaptive evolution of a polyphenism by genetic accommodation. J Evol Biol. 2008;21:57-66 pubmed publisher
    ..The finding shows that the mechanism of genetic accommodation relies on genetic changes that are consistent with the current view of the genetic basis of adaptive evolution. ..
  27. Burns A, Stephens W, Stagaman K, Wong S, Rawls J, Guillemin K, et al. Contribution of neutral processes to the assembly of gut microbial communities in the zebrafish over host development. ISME J. 2016;10:655-64 pubmed publisher
  28. Philip J, Fitches E, Harrison R, Bonning B, Gatehouse J. Characterisation of functional and insecticidal properties of a recombinant cathepsin L-like proteinase from flesh fly (Sarcophaga peregrina), which plays a role in differentiation of imaginal discs. Insect Biochem Mol Biol. 2007;37:589-600 pubmed
    ..Production of a inactive mutant form of ScathL showed that enzyme activity was necessary for the complete proprotein processing observed during production as a recombinant protein, and for insecticidal activity. ..
  29. Suzuki Y, Nijhout H. Evolution of a polyphenism by genetic accommodation. Science. 2006;311:650-2 pubmed
    ..Evidently, mechanisms that regulate developmental hormones can mask genetic variation and act as evolutionary capacitors, facilitating the origin of novel adaptive phenotypes. ..
  30. Chen Y, Lehman V, Lewit Y, Averette A, Heitman J. Calcineurin governs thermotolerance and virulence of Cryptococcus gattii. G3 (Bethesda). 2013;3:527-39 pubmed publisher
    ..gattii VGI and C. neoformans H99. Importantly, we demonstrate that C. gattii calcineurin is essential for virulence in a murine inhalation model, supporting C. gattii calcineurin as an attractive antifungal drug target. ..
  31. Baugh L. To grow or not to grow: nutritional control of development during Caenorhabditis elegans L1 arrest. Genetics. 2013;194:539-55 pubmed publisher
    ..The phenomenology of L1 arrest will be reviewed, as well as regulation of developmental arrest and starvation survival by various signaling pathways and gene regulatory mechanisms. ..
  32. Wang Z, Lin H. The division of Drosophila germline stem cells and their precursors requires a specific cyclin. Curr Biol. 2005;15:328-33 pubmed
    ..Our results indicate that stem cells may use specific cell cycle regulators for their division. ..
  33. Wang Z, Lin H. Nanos maintains germline stem cell self-renewal by preventing differentiation. Science. 2004;303:2016-9 pubmed
    ..Thus, Nanos is essential for both establishing and maintaining GSCs by preventing their precocious entry into oogenesis. These functions are likely achieved by repressing the translation of differentiation factors in PGCs and GSCs. ..