Experts and Doctors on intracellular signaling peptides and proteins in Chapel Hill, North Carolina, United States

Summary

Locale: Chapel Hill, North Carolina, United States
Topic: intracellular signaling peptides and proteins

Top Publications

  1. Worthylake R, Lemoine S, Watson J, Burridge K. RhoA is required for monocyte tail retraction during transendothelial migration. J Cell Biol. 2001;154:147-60 pubmed
    ..Finally, we find that p160ROCK signaling negatively regulates integrin adhesions and that inhibition of RhoA results in an accumulation of beta2 integrin in the unretracted tails. ..
  2. Harris T, Peifer M. Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila. J Cell Biol. 2004;167:135-47 pubmed
    ..Thus, although epithelial polarity develops in the absence of AJs, AJs play specific roles in maintaining epithelial architecture and segregating basolateral cues. ..
  3. Arthur J, Lich J, Ye Z, Allen I, Gris D, Wilson J, et al. Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. J Immunol. 2010;185:4515-9 pubmed publisher
    ..Both DCs and neutrophils fail to respond to chemokines in vitro. These findings indicate that NLRP12 is important in maintaining neutrophils and peripheral DCs in a migration-competent state. ..
  4. McCudden C, Willard F, Kimple R, Johnston C, Hains M, Jones M, et al. G alpha selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN. Biochim Biophys Acta. 2005;1745:254-64 pubmed
    ..Consistent with our binding studies, the GDI activity of GPSM2 GoLoco motifs on Galpha(o) was significantly lower than that toward Galpha(i1), suggesting that the in vivo targets of GPSM2 are most likely to be Galpha(i)-subunits. ..
  5. Maddox A, Burridge K. RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J Cell Biol. 2003;160:255-65 pubmed
    ..Cumulatively, these results suggest that the mitotic increase in RhoA activity leads to rearrangements of the cortical actin cytoskeleton that promote cortical rigidity, resulting in mitotic cell rounding. ..
  6. Kang T, Sancar A. Circadian regulation of DNA excision repair: implications for chrono-chemotherapy. Cell Cycle. 2009;8:1665-7 pubmed
    ..Here we review the significance of the connection linking the circadian clock with nucleotide excision repair and discuss potential implications for chemotherapy. ..
  7. Thompson W, Rubin C, Rubin J. Mechanical regulation of signaling pathways in bone. Gene. 2012;503:179-93 pubmed publisher
  8. Vernon M, Lobachev K, Petes T. High rates of "unselected" aneuploidy and chromosome rearrangements in tel1 mec1 haploid yeast strains. Genetics. 2008;179:237-47 pubmed publisher
    ..This property of the mec1-21 strains is suppressed by a plasmid containing the DNA2 gene (located on chromosome VIII) that encodes an essential nuclease/helicase involved in DNA replication and DNA repair. ..
  9. Ritchie K, Petes T. The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics. 2000;155:475-9 pubmed
    ..TEL1 is primarily involved in telomere length regulation. By an epistasis analysis, we conclude that Tel1p and the Mre11p/Rad50p/Xrs2p complex function in a single pathway of telomere length regulation. ..

More Information

Publications81

  1. Craven R, Petes T. Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae. Mol Cell Biol. 2000;20:2378-84 pubmed
    ..In addition, the loss of telomeric silencing in mec1 strains was not a consequence of the slightly shortened telomeres observed in these strains. ..
  2. Girdler G, Applewhite D, Perry W, Rogers S, Röper K. The Gas2 family protein Pigs is a microtubule +TIP that affects cytoskeleton organisation. J Cell Sci. 2016;129:121-34 pubmed publisher
  3. Guilluy C, Osborne L, Van Landeghem L, Sharek L, Superfine R, Garcia Mata R, et al. Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. Nat Cell Biol. 2014;16:376-81 pubmed publisher
    ..Our results demonstrate that mechanotransduction is not restricted to cell surface receptors and adhesions but can occur in the nucleus. ..
  4. McCormick M, Goel R, Fulton D, Oess S, Newman D, Tzima E. Platelet-endothelial cell adhesion molecule-1 regulates endothelial NO synthase activity and localization through signal transducers and activators of transcription 3-dependent NOSTRIN expression. Arterioscler Thromb Vasc Biol. 2011;31:643-9 pubmed publisher
    ..Our results reveal an elegant mechanism of eNOS regulation by PECAM-1 through signal transducers and activators of transcription 3-mediated transcriptional control of NOSTRIN. ..
  5. Loomis R, Holmes D, Elms A, Solski P, Der C, Su L. Citron kinase, a RhoA effector, enhances HIV-1 virion production by modulating exocytosis. Traffic. 2006;7:1643-53 pubmed
    ..Finally, citron-K promotes exocytosis of microvesicles or exosomes that co-purify with HIV-1 virions. We conclude that citron-K enhances HIV-1 virion production by stimulating the endosomal compartments and exocytosis. ..
  6. Mohan K, Nosbisch J, Elston T, Bear J, Haugh J. A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis. Biophys J. 2017;113:185-194 pubmed publisher
    ..This model offers a framework for a mechanistic understanding of phospholipase C/PKC signaling in chemotactic gradient sensing and can guide the design of experiments to assess the roles of putative feedback loops. ..
  7. Ye P, Li L, Lund P, D Ercole A. Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination. Brain Res Dev Brain Res. 2002;136:111-21 pubmed
    ..Nonetheless, the finding that IGF-I stimulates brain growth less well in the absence of IRS-1 suggests that IRS-1-mediated signaling may be more central to IGF-I action in cells other than glia and oligodendrocytes. ..
  8. Ostapkowicz A, Inai K, Smith L, Kreda S, Spychala J. Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor. Mol Cancer Ther. 2006;5:238-45 pubmed
    ..Thus, our results suggest that during transition to invasive breast cancer there is a significant structural reorganization of lipid rafts and underlying cytoskeleton that is reversed upon histone deacetylase inhibition. ..
  9. Guntas G, Lewis S, Mulvaney K, Cloer E, Tripathy A, Lane T, et al. Engineering a genetically encoded competitive inhibitor of the KEAP1-NRF2 interaction via structure-based design and phage display. Protein Eng Des Sel. 2016;29:1-9 pubmed publisher
    ..The structure-based phage display strategy employed here is a general approach for engineering high-affinity binders that compete with naturally occurring interactions. ..
  10. Huai Q, Sun Y, Wang H, Chin L, Li L, Robinson H, et al. Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. FEBS Lett. 2003;549:171-5 pubmed
    ..As a result, the conformational changes may diminish the DJ-1 binding with its partner, leading to the familial Parkinson's disease caused by the single L166P mutation. ..
  11. Alahari S, Reddig P, Juliano R. The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK. EMBO J. 2004;23:2777-88 pubmed
    ..In addition, PAK1 and Nischarin colocalize in membrane ruffles, structures known to be involved in cell motility. Thus, Nischarin may regulate cell migration by forming inhibitory complexes with PAK family kinases. ..
  12. Unsal Kaçmaz K, Chastain P, Qu P, Minoo P, Cordeiro Stone M, Sancar A, et al. The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol Cell Biol. 2007;27:3131-42 pubmed
  13. Smith Roe S, Patel S, Simpson D, Zhou Y, Rao S, Ibrahim J, et al. Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts. Cell Cycle. 2011;10:1618-24 pubmed
    ..A better understanding of how Timeless, Tipin and Claspin promote SCC will elucidate non-checkpoint functions of these proteins at DNA replication forks and inform models of the establishment of SCC. ..
  14. Aitsebaomo J, Portbury A, Schisler J, Patterson C. Brothers and sisters: molecular insights into arterial-venous heterogeneity. Circ Res. 2008;103:929-39 pubmed publisher
    ..We explore arterial-venous differences in selected organs, as well as their respective endothelial cell architectural organization that results in their inter- and intraorgan heterogeneity. ..
  15. Sarkar S. Tyrosine phosphorylation and translocation of LAT in platelets. FEBS Lett. 1998;441:357-60 pubmed
    ..Moreover, LAT, like syk and beta3, translocates to the cytoskeleton during the late stage of thrombin-stimulated irreversible aggregation and not during ADP-stimulated reversible aggregation. ..
  16. Garcia Mata R, Dubash A, Sharek L, Carr H, Frost J, Burridge K. The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity. Mol Cell Biol. 2007;27:8683-97 pubmed
    ..Together, our results suggest that the interaction between Net1 and Dlg1 may contribute to the mechanism of Net1-mediated transformation. ..
  17. Robbins G, Truax A, Davis B, Zhang L, Brickey W, Ting J. Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins. J Biol Chem. 2012;287:24294-303 pubmed publisher
    ..In summary, we conclude that Nlrc5 is important in the regulation of MHC-I expression by reducing H3K27me3 on MHC-I promoter and joins CIITA as an NLR subfamily that controls MHC gene transcription. ..
  18. Ling Y, Maile L, Badley Clarke J, Clemmons D. DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells. J Biol Chem. 2005;280:3151-8 pubmed
    ..These results demonstrate that DOK1 mediates SHP-2/beta3 association in response to IGF-I thereby mediating the effect of integrin ligand occupancy on IGF-IR-linked signaling in smooth muscle cells. ..
  19. Zhang L, Pagano J. Interferon regulatory factor 7 mediates activation of Tap-2 by Epstein-Barr virus latent membrane protein 1. J Virol. 2001;75:341-50 pubmed
    ..The induction of Tap-2 by IRF-7 and LMP-1 may have an important implication for the immune response to EBV and its persistence in vivo...
  20. Serçin O, Kemp M. Characterization of functional domains in human Claspin. Cell Cycle. 2011;10:1599-606 pubmed
    ..We conclude that multiple protein-DNA and protein-protein interactions may be important for Claspin function during DNA replication and DNA replication checkpoint signaling. ..
  21. Harris T, Peifer M. The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila. J Cell Biol. 2005;170:813-23 pubmed
    ..These results reveal key steps in the assembly of the apical domain in Drosophila. ..
  22. McDonough H, Charles P, Hilliard E, Qian S, Min J, Portbury A, et al. Stress-dependent Daxx-CHIP interaction suppresses the p53 apoptotic program. J Biol Chem. 2009;284:20649-59 pubmed publisher
    ..By abrogating p53-dependent apoptotic pathways and by ubiquitination competitive with Daxx sumoylation, CHIP integrates the proteotoxic stress response of the cell with cell cycle pathways that influence cell survival. ..
  23. McNally R, Davis B, Clements C, Accavitti Loper M, Mak T, Ting J. DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J Biol Chem. 2011;286:4098-106 pubmed publisher
  24. Haddock B, Zhu Y, Doyle S, Abdullah L, Davis C. Role of MARCKS in regulated secretion from mast cells and airway goblet cells. Am J Physiol Lung Cell Mol Physiol. 2014;306:L925-36 pubmed publisher
    ..Results from studies using peptide inhibitors with human bronchial epithelial cells and with binding assays using purified mucins suggested that MANS inhibited the mucin binding assay, rather than the secretory response. ..
  25. Maile L, Clemmons D. The alphaVbeta3 integrin regulates insulin-like growth factor I (IGF-I) receptor phosphorylation by altering the rate of recruitment of the Src-homology 2-containing phosphotyrosine phosphatase-2 to the activated IGF-I receptor. Endocrinology. 2002;143:4259-64 pubmed
  26. Potts M, Vaughn A, McDonough H, Patterson C, Deshmukh M. Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP. J Cell Biol. 2005;171:925-30 pubmed
    ..These data identify an important function of XIAP in cardiomyocytes and point to a striking similarity in the regulation of apoptosis in postmitotic cells. ..
  27. Ling Y, Maile L, Lieskovska J, Badley Clarke J, Clemmons D. Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells. Mol Biol Cell. 2005;16:3353-64 pubmed
    ..We conclude that SHPS-1 functions as an anchor protein that recruits both Shc and SHP-2 and that their recruitment is necessary for IGF-I-dependent Shc phosphorylation, which is required for an optimal mitogenic response in SMCs. ..
  28. Lockman K, Hinson J, Medlin M, Morris D, Taylor J, Mack C. Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. J Biol Chem. 2004;279:42422-30 pubmed
    ..Taken together these results demonstrate that S1P activates multiple signaling pathways in SMC and regulates proliferation by ERK-dependent activation of Elk-1 and differentiation by RhoA-dependent activation of MRTF-A. ..
  29. Williams K, Lich J, Duncan J, Reed W, Rallabhandi P, Moore C, et al. The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem. 2005;280:39914-24 pubmed
    ..Mutants containing the NBD-LRR or PyD-NBD also blocked IRAK-1 activation. This is the first example of a CLR protein that antagonizes inflammatory responses initiated by TLR agonists via interference with IRAK-1 activation. ..
  30. Reddig P, Xu D, Juliano R. Regulation of p21-activated kinase-independent Rac1 signal transduction by nischarin. J Biol Chem. 2005;280:30994-1002 pubmed
    ..Thus, Nischarin, in addition to regulating the PAK strand of Rac1 signaling, can also regulate other links in the web of Rac1 signaling pathways. ..
  31. Zhang J, Petit C, King D, Lee A. Phosphorylation of a PDZ domain extension modulates binding affinity and interdomain interactions in postsynaptic density-95 (PSD-95) protein, a membrane-associated guanylate kinase (MAGUK). J Biol Chem. 2011;286:41776-85 pubmed publisher
    ..These experiments revealed a novel mode of regulation by a detachable PDZ element and offer a first glimpse at the dynamic interaction of PDZ and SH3-guanylate kinase domains in membrane-associated guanylate kinases. ..
  32. PURCELL S, Moran J, Fromer M, Ruderfer D, Solovieff N, Roussos P, et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014;506:185-90 pubmed publisher
    ..5 to 1 per cent) and moderately large effect. Taken together, these data suggest that population-based exome sequencing can discover risk alleles and complements established gene-mapping paradigms in neuropsychiatric disease. ..
  33. Unsal Kaçmaz K, Mullen T, Kaufmann W, Sancar A. Coupling of human circadian and cell cycles by the timeless protein. Mol Cell Biol. 2005;25:3109-16 pubmed
  34. Fritz Six K, Dunworth W, Li M, Caron K. Adrenomedullin signaling is necessary for murine lymphatic vascular development. J Clin Invest. 2008;118:40-50 pubmed
    ..Collectively, our studies identify a class of genes involved in lymphangiogenesis that represent a pharmacologically tractable system for the treatment of lymphedema or inhibition of tumor metastasis. ..
  35. Weimer J, Yokota Y, Stanco A, Stumpo D, Blackshear P, Anton E. MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex. Development. 2009;136:2965-75 pubmed publisher
  36. Watanabe S, Ishikawa K, Fish K, Oh J, Motloch L, Kohlbrenner E, et al. Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure. J Am Coll Cardiol. 2017;70:1744-1756 pubmed publisher
    ..I-1c gene therapy in pigs. Intracoronary delivery of BNP116.I-1c was safe and improved contractility of the left ventricle and atrium in a large animal model of nonischemic HF. ..
  37. Conti B, Davis B, Zhang J, O Connor W, Williams K, Ting J. CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. J Biol Chem. 2005;280:18375-85 pubmed
    ..We propose that CLR16.2 serves to attenuate T cell activation via TCR and co-stimulatory molecules, and its reduction during T cell stimulation allows the ensuing cellular activation. ..
  38. Wang H, Huang Z, Xia L, Feng Q, Erdjument Bromage H, Strahl B, et al. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science. 2001;293:853-7 pubmed
    ..Our finding reveals Arg 3 of H4 as a novel methylation site by PRMT1 and indicates that Arg 3 methylation plays an important role in transcriptional regulation. ..
  39. Franceschini N, North K, Kopp J, McKenzie L, Winkler C. NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE review. Genet Med. 2006;8:63-75 pubmed
    ..Nevertheless, the available data suggest that large epidemiological case-control studies to examine the association between NPHS2 variants and nephrotic syndrome are warranted. ..
  40. Lieskovska J, Ling Y, Badley Clarke J, Clemmons D. The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells. J Biol Chem. 2006;281:25041-53 pubmed
    ..Upon IGF-I stimulation, a complex assembles on SHPS-1 that contains SHP-2, c-Src, and Shc wherein Src phosphorylates Shc, a signaling step that is necessary for an optimal mitogenic response. ..
  41. Allen I, Wilson J, Schneider M, Lich J, Roberts R, Arthur J, et al. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-?B signaling. Immunity. 2012;36:742-54 pubmed publisher
    ..NLRP12 interacted with both NIK and TRAF3, and Nlrp12(-/-) cells have constitutively elevated NIK, p100 processing to p52 and reduced TRAF3. Thus, NLRP12 is a checkpoint of noncanonical NF-?B, inflammation, and tumorigenesis. ..
  42. Choi W, Harris N, Sumigray K, Peifer M. Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo. Mol Biol Cell. 2013;24:945-63 pubmed publisher
    ..Further, Rap1, Bazooka, and aPKC, but not Canoe, regulate columnar cell shape. These data reshape our view, suggesting that polarity establishment is regulated by a protein network rather than a linear pathway. ..
  43. Williams K, Taxman D, Linhoff M, Reed W, Ting J. Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes. J Immunol. 2003;170:5354-8 pubmed
    ..These analyses show that Monarch-1 enhances nonclassical and classical MHC class I expression at the level of the promoter, RNA, and protein expression. ..
  44. Craven R, Petes T. The Saccharomyces cerevisiae suppressor of choline sensitivity (SCS2) gene is a multicopy Suppressor of mec1 telomeric silencing defects. Genetics. 2001;158:145-54 pubmed
    ..Genetic analysis revealed that Scs2p probably acts through a different telomeric silencing pathway from that affected by Mec1p. ..
  45. Mallory J, Bashkirov V, Trujillo K, Solinger J, Dominska M, Sung P, et al. Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. DNA Repair (Amst). 2003;2:1041-64 pubmed
    ..As observed with Xrs2p, however, strains with mutations of DUN1 or RFA2 that eliminate SQ motifs have no effect on telomere length or DNA damage sensitivity. ..
  46. Bi E, Chiavetta J, Chen H, Chen G, Chan C, Pringle J. Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast. Mol Biol Cell. 2000;11:773-93 pubmed
    ..The former pathway appears to be more important in diploids and at low temperatures, whereas the latter pathway appears to be more important in haploids and at high temperatures. ..
  47. Fotheringham J, Coalson N, Raab Traub N. Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through ?v-integrin membrane translocation. J Virol. 2012;86:10308-20 pubmed publisher
    ..The specific effects of LMP2A on an integrin with a diverse repertoire of ligand specificities could promote migration of different cell types and be initiated by multiple chemoattractants. ..
  48. Allen I, Lich J, Arthur J, Jania C, Roberts R, Callaway J, et al. Characterization of NLRP12 during the development of allergic airway disease in mice. PLoS ONE. 2012;7:e30612 pubmed publisher
    ..Thus, the allergic airway inflammation models described here should be appropriate for subsequent studies that seek to decipher the contribution of NLRP12 in mediating the host response to agents associated with asthma exacerbation. ..
  49. Allen I, McElvania TeKippe E, Wilson J, Lich J, Arthur J, Sullivan J, et al. Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis. PLoS ONE. 2013;8:e60842 pubmed publisher
    ..tuberculosis infection. Together, these data suggest that NLRP12 does not significantly contribute to the in vivo host innate immune response to LPS stimulation, Klebsiella pneumonia infection or Mycobacterium tuberculosis...
  50. Ehre C, Rossi A, Abdullah L, De Pestel K, Hill S, Olsen J, et al. Barrier role of actin filaments in regulated mucin secretion from airway goblet cells. Am J Physiol Cell Physiol. 2005;288:C46-56 pubmed
    ..We conclude that actin filaments negatively regulate mucin secretion basally in airway goblet cells and are dynamically remodeled in agonist-stimulated cells to promote exocytosis. ..
  51. Furukawa M, Xiong Y. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol. 2005;25:162-71 pubmed
    ..These results may reconcile previously observed cytoplasmic sequestration of NRF2 by KEAP1 and suggest a possible regulatory step between KEAP1-NRF2 binding and NRF2 degradation. ..
  52. Petit C, Zhang J, Sapienza P, Fuentes E, Lee A. Hidden dynamic allostery in a PDZ domain. Proc Natl Acad Sci U S A. 2009;106:18249-54 pubmed publisher
    ..This hidden dynamic allostery raises the possibility of as-yet unidentified or untapped allosteric regulation in this PDZ domain and is a very clear example of function arising from dynamics rather than from structure. ..
  53. Davis B, Roberts R, Huang M, Willingham S, Conti B, Brickey W, et al. Cutting edge: NLRC5-dependent activation of the inflammasome. J Immunol. 2011;186:1333-7 pubmed publisher
    ..These results invoke a model in which NLRC5 interacts with NLRP3 to cooperatively activate the inflammasome. ..
  54. Alahari S, Lee J, Juliano R. Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration. J Cell Biol. 2000;151:1141-54 pubmed
    ..Thus, Nischarin may play a negative role in cell migration by antagonizing the actions of Rac on cytoskeletal organization and cell movement. ..
  55. Ye Z, Lich J, Moore C, Duncan J, Williams K, Ting J. ATP binding by monarch-1/NLRP12 is critical for its inhibitory function. Mol Cell Biol. 2008;28:1841-50 pubmed
    ..The results of this study are consistent with a model wherein ATP binding regulates the anti-inflammatory activity of Monarch-1. ..
  56. Fries K, Miller W, Raab Traub N. The A20 protein interacts with the Epstein-Barr virus latent membrane protein 1 (LMP1) and alters the LMP1/TRAF1/TRADD complex. Virology. 1999;264:159-66 pubmed publisher
    ..These data indicate that A20 alters the interactions between LMP1 and the TRAF molecules and TRADD, affecting the activation of NF-kB, JNK, and perhaps other TRAF-mediated signaling events...
  57. Maile L, Aday A, Busby W, Sanghani R, Veluvolu U, Clemmons D. Modulation of integrin antagonist signaling by ligand binding of the heparin-binding domain of vitronectin to the alphaVbeta3 integrin. J Cell Biochem. 2008;105:437-46 pubmed publisher
  58. Craven R, Greenwell P, Dominska M, Petes T. Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics. 2002;161:493-507 pubmed
    ..Similar chromosome rearrangements have been detected in mammalian cells with mutations in ATM (related to TEL1) and ATR (related to MEC1) and in mammalian cells that approach cell crisis. ..
  59. Mallory J, Petes T. Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. Proc Natl Acad Sci U S A. 2000;97:13749-54 pubmed
    ..Tel1p phosphorylates serine in an SQ motif in PHAS-I. Mutations in the kinase domains of Tel1p and Mec1p result in loss of in vitro kinase activity and the in vivo phenotypes associated with the null tel1 and mec1 mutations. ..
  60. Ni H, Wang X, Diener K, Yao Z. MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase. Biochem Biophys Res Commun. 1998;243:492-6 pubmed
    ..Phosphorylation of MAPKAPK5 by ERK and p38 kinase increased its activity by 9 and 15 fold respectively. Taken together, these data suggest that MAPKAPK5 is a novel in vitro substrate for ERK and p38 kinase. ..
  61. Mudgil Y, Uhrig J, Zhou J, Temple B, Jiang K, Jones A. Arabidopsis N-MYC DOWNREGULATED-LIKE1, a positive regulator of auxin transport in a G protein-mediated pathway. Plant Cell. 2009;21:3591-609 pubmed publisher
    ..AGB1, auxin, and sugars are required for NDL1 protein stability in regions of the root where auxin gradients are established; thus, the signaling mechanism contains feedback loops. ..
  62. Li M, Wu Y, Caron K. Haploinsufficiency for adrenomedullin reduces pinopodes and diminishes uterine receptivity in mice. Biol Reprod. 2008;79:1169-75 pubmed publisher
    ..Taken together, our studies identify a new class of pharmacologically tractable proteins that are involved in establishing uterine receptivity through the regulation of pinopode formation. ..
  63. Glantz L, Gilmore J, Hamer R, Lieberman J, Jarskog L. Synaptophysin and postsynaptic density protein 95 in the human prefrontal cortex from mid-gestation into early adulthood. Neuroscience. 2007;149:582-91 pubmed
  64. Scott R, Thelin W, Milgram S. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. J Biol Chem. 2002;277:22934-41 pubmed
    ..Our findings are the first to identify a regulatory protein that associates with GCC to modulate the catalytic activity of the enzyme and provides new insights in mechanisms that regulate GCC activity in response to bacterial toxin. ..
  65. Mei S, Gu H, Ward A, Yang X, Guo H, He K, et al. p38 mitogen-activated protein kinase (MAPK) promotes cholesterol ester accumulation in macrophages through inhibition of macroautophagy. J Biol Chem. 2012;287:11761-8 pubmed publisher
    ..Together, our results provide brand new insight about cholesterol ester accumulation in macrophages and foam cell formation. ..
  66. Kim S, Ishida H, Yamane D, Yi M, Swinney D, Foung S, et al. Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry. J Virol. 2013;87:4214-24 pubmed publisher
    ..We propose a model by which MKNK1 acts to facilitate viral entry downstream of the epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK), both of which have been implicated in the entry process. ..
  67. Bang D, Wilson W, Ryan M, Yeh J, Baldwin A. GSK-3? promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-?B. Cancer Discov. 2013;3:690-703 pubmed publisher
    ..These data identify GSK-3? as a key downstream effector of oncogenic KRAS via its ability to coordinately regulate distinct NF-?B signaling pathways. ..
  68. Arthur J, Lich J, Aziz R, Kotb M, Ting J. Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase. J Immunol. 2007;179:6291-6 pubmed
    ..This demonstrates that Hsp90 is a critical regulator of Monarch-1 anti-inflammatory activity. ..
  69. Wang J, He X, Luo Y, Yarbrough W. A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. Biochem J. 2006;393:489-501 pubmed
    ..Taken together, our data suggest that LZAP can regulate ARF biochemical and biological activity. Additionally, LZAP has p53-dependent cell-cycle effects that are independent of ARF. ..
  70. Lich J, Williams K, Moore C, Arthur J, Davis B, Taxman D, et al. Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes. J Immunol. 2007;178:1256-60 pubmed
    ..Congruently, silencing Monarch-1 with shRNA enhances the expression of p52-dependent chemokines. ..
  71. Dackor R, Fritz Six K, Smithies O, Caron K. Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age. J Biol Chem. 2007;282:18094-9 pubmed
  72. Ritchie K, Mallory J, Petes T. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:6065-75 pubmed
    ..This result argues that the role of Tel1p in telomere maintenance is not solely a direct activation of telomerase. ..