Experts and Doctors on ige receptors in Durham, North Carolina, United States
Locale: Durham, North Carolina, United States
Topic: ige receptors
Liang Y, Tedder T. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics. 2001;72:119-27 pubmed
..1 along with CD20, FcepsilonRIbeta, and HTm4. Thus, like CD20 and FcepsilonRIbeta, the other MS4A family members are likely to be components of oligomeric cell surface complexes that serve diverse signal transduction functions. ..
Liang Y, Buckley T, Tu L, Langdon S, Tedder T. Structural organization of the human MS4A gene cluster on Chromosome 11q12. Immunogenetics. 2001;53:357-68 pubmed
..Like CD20 and FcepsilonRIbeta, the 10 other human MS4A family members are likely to be components of oligomeric cell surface complexes involved in signal transduction in diverse cell lineages. ..
Zhu M, Liu Y, Koonpaew S, Granillo O, Zhang W. Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med. 2004;200:991-1000 pubmed
Zhu M, Rhee I, Liu Y, Zhang W. Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX. J Biol Chem. 2006;281:18408-13 pubmed
..In addition, Fc epsilonRI-mediated cytokine production and cell survival were also enhanced. These data suggested that LAX negatively regulates mast cell function. ..
Liu Y, Zhu M, Nishida K, Hirano T, Zhang W. An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med. 2007;204:93-103 pubmed
..We further demonstrated that RasGRP1-/- mast cells were defective in granule translocation, microtubule formation, and RhoA activation. Our results identified RasGRP1 as an essential regulator of mast cell function. ..