Experts and Doctors on gtp binding proteins in Chapel Hill, North Carolina, United States


Locale: Chapel Hill, North Carolina, United States
Topic: gtp binding proteins

Top Publications

  1. Chenette E, Abo A, Der C. Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase. J Biol Chem. 2005;280:13784-92 pubmed
    ..In summary, Chp is implicated in cell transformation, and the unique amino and carboxyl termini of Chp represent atypical mechanisms of regulation of Rho GTPase function. ..
  2. Shih H, Hales K, Pringle J, Peifer M. Identification of septin-interacting proteins and characterization of the Smt3/SUMO-conjugation system in Drosophila. J Cell Sci. 2002;115:1259-71 pubmed
  3. Mudgil Y, Uhrig J, Zhou J, Temple B, Jiang K, Jones A. Arabidopsis N-MYC DOWNREGULATED-LIKE1, a positive regulator of auxin transport in a G protein-mediated pathway. Plant Cell. 2009;21:3591-609 pubmed publisher
    ..AGB1, auxin, and sugars are required for NDL1 protein stability in regions of the root where auxin gradients are established; thus, the signaling mechanism contains feedback loops. ..
  4. Heenan E, Vanhooke J, Temple B, Betts L, SONDEK J, Dohlman H. Structure and function of Vps15 in the endosomal G protein signaling pathway. Biochemistry. 2009;48:6390-401 pubmed publisher
    ..These findings reveal that the Vps15 Gbeta-like domain serves as a scaffold to assemble Gpa1 and Atg14, whereas the kinase and intermediate domains are required for proper signaling at the endosome. ..
  5. Clark G, Kinch M, Rogers Graham K, Sebti S, Hamilton A, Der C. The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. J Biol Chem. 1997;272:10608-15 pubmed
    ..Thus, it is possible that Rheb function may be inhibited by farnesyltransferase inhibitors treatment and, consequently, may contribute to the ability of these inhibitors to impair Ras transformation. ..
  6. Lee M, Dohlman H. Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol. 2008;18:211-5 pubmed publisher
    ..Our data suggest that intracellular proteins function in cooperation with mating pheromones to amplify G protein signaling, thereby leading to full pathway activation. ..
  7. Lundblad R, White G. The interaction of thrombin with blood platelets. Platelets. 2005;16:373-85 pubmed
    ..Thus, the maximal hemostatic response requires both PAR receptors and the GpIb receptors. ..
  8. Itoh Lindstrom Y, Piskurich J, Felix N, Wang Y, Brickey W, Platt J, et al. Reduced IL-4-, lipopolysaccharide-, and IFN-gamma-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain. J Immunol. 1999;163:2425-31 pubmed
    ..These findings demonstrate a requirement for CIITA in IFN-gamma-, IL-4-, and endotoxin-induced MHC class II expression as well as the possibility of rare CIITA-independent MHC class II expression. ..
  9. Cappell S, Baker R, Skowyra D, Dohlman H. Systematic analysis of essential genes reveals important regulators of G protein signaling. Mol Cell. 2010;38:746-57 pubmed publisher
    ..These insights to the G protein signaling network reveal the essential genome as an untapped resource for identifying new components and regulators of signal transduction pathways. ..

More Information


  1. Zeller C, Parnell S, Dohlman H. The RACK1 ortholog Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast. J Biol Chem. 2007;282:25168-76 pubmed
    ..Our findings reveal the existence of an unusual Gbeta subunit, one having multiple functions within the cell in addition to serving as a signal transducer for cell surface receptors and intracellular effectors. ..
  2. Zhang Y, Xiong Y. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol Cell. 1999;3:579-91 pubmed
    ..Our results suggest an ARF-regulated MDM2-dependent p53 stabilization and link the human tumor-associated mutations in ARF with a functional alteration. ..
  3. Zohn I, Symons M, Chrzanowska Wodnicka M, Westwick J, Der C. Mas oncogene signaling and transformation require the small GTP-binding protein Rac. Mol Cell Biol. 1998;18:1225-35 pubmed
    ..Thus, Rho family proteins are common mediators of transformation by a diverse variety of oncogene proteins that include Ras, Dbl family, and G-protein-coupled oncogene proteins. ..
  4. Boyer J, Waldo G, Harden T. Molecular cloning and expression of an avian G protein-coupled P2Y receptor. Mol Pharmacol. 1997;52:928-34 pubmed
    ..Taken together, these results describe the identification of an avian phospholipase C-coupled P2Y receptor that, like the mammalian P2Y2 receptor, is activated by both adenine and uridine nucleotides...
  5. Bi E, Pringle J. ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:5264-75 pubmed
    ..As ZDS1 and ZDS2 have recently been identified also by numerous other groups studying a wide range of biological phenomena, the roles of Cdc42p in intracellular signaling may be more diverse than has previously been appreciated. ..
  6. Waldo G, Paterson A, Boyer J, Nicholas R, Harden T. Molecular cloning, expression and regulatory activity of G alpha 11- and beta gamma-subunit-stimulated phospholipase C-beta from avian erythrocytes. Biochem J. 1996;316 ( Pt 2):559-68 pubmed
    ..The turkey PLC-beta was more sensitive to activation by G alpha 11 than was PLC-beta 2, and was more sensitive to activation by beta gamma-subunits than either PLC-beta 2 or PLC-beta 1. ..
  7. Boyer J, Delaney S, Villanueva D, Harden T. A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates. Mol Pharmacol. 2000;57:805-10 pubmed
    ..This is the first cloned P2Y receptor that is clearly Gi/adenylyl cyclase-linked. ..
  8. Harton J, Cressman D, Chin K, Der C, Ting J. GTP binding by class II transactivator: role in nuclear import. Science. 1999;285:1402-5 pubmed
    ..GTP binding by CIITA correlates with nuclear import. Thus, unlike other GTP-binding proteins, CIITA is involved in transcriptional activation that uses GTP binding to facilitate its own nuclear import. ..
  9. Ricks T, Trejo J. Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization. J Biol Chem. 2009;284:34444-57 pubmed publisher
    ..Thus, our studies reveal a novel function for phosphorylation that differentially regulates PAR2 desensitization and endocytic trafficking. ..
  10. Gris P, Gauthier J, Cheng P, Gibson D, Gris D, Laur O, et al. A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. Mol Pain. 2010;6:33 pubmed publisher
  11. Maurice D, Waldo G, Morris A, Nicholas R, Harden T. Identification of G alpha 11 as the phospholipase C-activating G-protein of turkey erythrocytes. Biochem J. 1993;290 ( Pt 3):765-70 pubmed
    ..Taken together, these results unambiguously identify the protein purified from turkey erythrocytes, on the basis of its capacity to activate avian phospholipase C, as G alpha 11. ..