Experts and Doctors on glutamate decarboxylase in Winston Salem, North Carolina, United States
Locale: Winston Salem, North Carolina, United States
Topic: glutamate decarboxylase
Shi L, Argenta A, Winseck A, Brunso Bechtold J. Stereological quantification of GAD-67-immunoreactive neurons and boutons in the hippocampus of middle-aged and old Fischer 344 x Brown Norway rats. J Comp Neurol. 2004;478:282-91 pubmed
..It is possible that loss of CA1 inhibitory interneurons in the dorsal hippocampus contributes to the learning and memory impairments reported in old rats. ..
Garcia Espinosa M, Wallin R, Hutson S, Sweatt A. Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids. J Neurochem. 2007;100:1458-68 pubmed
..BCATc may also provide neurons with sensitivity to nutrient-derived BCAAs, which may be important in regions that control feeding behavior, such as the arcuate nucleus of the hypothalamus, where neurons express high levels of BCATc. ..
Turner C, Debenedetto D, Ware E, Walburg C, Lee A, Stowe R, et al
. MK801-induced activated caspase-3 exhibits selective co-localization with GAD67. Neurosci Lett. 2009;462:152-6 pubmed publisher
..These data suggest that whereas somatic expression of AC3 and GAD67 may be non-overlapping, areas that exhibit punctate GAD67 (and are high in synaptic turnover) may be more vulnerable to MK801 exposure. ..
Turner C, Ware E, Stowe R, Debenedetto D, Walburg C, Lee A, et al
. Postnatal expression of GAD67. Neurochem Res. 2010;35:254-61 pubmed publisher
..In contrast, at P14 and especially P21, both puncta and cell bodies were robustly labeled. Our data indicate that adult-like expression of GAD67 emerges quite late in the postnatal period. ..
Turner C, Debenedetto D, Ware E, Stowe R, Lee A, Swanson J, et al
. Postnatal exposure to MK801 induces selective changes in GAD67 or parvalbumin. Exp Brain Res. 2010;201:479-88 pubmed publisher
..More importantly, such differential effects may be of great clinical importance, given that cognitive deficits are seen in children exposed to anesthetics that act by blocking the NMDAR. ..