Experts and Doctors on gene expression regulation in Chapel Hill, North Carolina, United States

Summary

Locale: Chapel Hill, North Carolina, United States
Topic: gene expression regulation

Top Publications

  1. Feng S, Muraoka Cook R, Hunter D, Sandahl M, Caskey L, Miyazawa K, et al. The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation. Mol Cell Biol. 2009;29:892-906 pubmed publisher
  2. Cliffe A, Arbuckle J, Vogel J, Geden M, Rothbart S, Cusack C, et al. Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation. Cell Host Microbe. 2015;18:649-58 pubmed publisher
    ..JNK is present on viral promoters during reactivation, thereby linking a neuronal-specific stress pathway and HSV reactivation from latency. ..
  3. Hemphill D, McIlwraith C, Slayden R, Samulski R, Goodrich L. Adeno-associated virus gene therapy vector scAAVIGF-I for transduction of equine articular chondrocytes and RNA-seq analysis. Osteoarthritis Cartilage. 2016;24:902-11 pubmed publisher
  4. Sun X, Casbas Hernandez P, Bigelow C, Makowski L, Joseph Jerry D, Smith Schneider S, et al. Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression. Breast Cancer Res Treat. 2012;131:1003-12 pubmed publisher
    ..Given the role of macrophages in carcinogenesis, these findings have important implications for breast cancer etiology and progression. ..
  5. Kashatus D, Cogswell P, Baldwin A. Expression of the Bcl-3 proto-oncogene suppresses p53 activation. Genes Dev. 2006;20:225-35 pubmed
  6. Philpot B, Cho K, Bear M. Obligatory role of NR2A for metaplasticity in visual cortex. Neuron. 2007;53:495-502 pubmed
    ..These data support the hypothesis that experience-dependent changes in NR2A/B are functionally significant and yield a mechanism for an adjustable synaptic modification threshold in visual cortex. ..
  7. Ciencewicki J, Gowdy K, Krantz Q, Linak W, Brighton L, Gilmour M, et al. Diesel exhaust enhanced susceptibility to influenza infection is associated with decreased surfactant protein expression. Inhal Toxicol. 2007;19:1121-33 pubmed
    ..Taken together, the results demonstrate that exposure to DE enhances the susceptibility to respiratory viral infections by reducing the expression and production of antimicrobial surfactant proteins. ..
  8. Wang Z, Burge C. Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. RNA. 2008;14:802-13 pubmed publisher
    ..Here, we summarize the current state of knowledge of splicing cis-regulatory elements and their context-dependent effects on splicing, emphasizing recent global/genome-wide studies and open questions. ..
  9. Gardner K, Allis C, Strahl B. Operating on chromatin, a colorful language where context matters. J Mol Biol. 2011;409:36-46 pubmed publisher

More Information

Publications277 found, 100 shown here

  1. Samuelson L, Gerber D. Improved function and growth of pancreatic cells in a three-dimensional bioreactor environment. Tissue Eng Part C Methods. 2013;19:39-47 pubmed publisher
    ..These findings suggest that a 3D microgravity bioreactor environment mimics the niche of the pancreas yielding a cell source with potential for cell-based therapy in the treatment of diabetes. ..
  2. Cogswell P, Kashatus D, Keifer J, Guttridge D, Reuther J, Bristow C, et al. NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B. J Biol Chem. 2003;278:2963-8 pubmed
    ..These data indicate that the NF-kappa B regulatory pathway exists in mitochondria and that NF-kappa B can negatively regulate mitochondrial mRNA expression. ..
  3. Hatada S, Grant D, Maeda N. An intronic endogenous retrovirus-like sequence attenuates human haptoglobin-related gene expression in an orientation-dependent manner. Gene. 2003;319:55-63 pubmed
    ..Our data suggest that a combination of multiple small effects of RTVL-Ia including aberrant splicing accounts for the low (6%) expression of the present-day HPR relative to HP. ..
  4. Kim J, Narula A, Jobin C. Salvia miltiorrhiza water-soluble extract, but not its constituent salvianolic acid B, abrogates LPS-induced NF-kappaB signalling in intestinal epithelial cells. Clin Exp Immunol. 2005;141:288-97 pubmed
    ..Modulation of bacterial product-mediated NF-kappaB signalling by natural plant extracts may represent an attractive strategy towards the prevention and treatment of intestinal inflammation. ..
  5. Glantz L, Gilmore J, Overstreet D, Salimi K, Lieberman J, Jarskog L. Pro-apoptotic Par-4 and dopamine D2 receptor in temporal cortex in schizophrenia, bipolar disorder and major depression. Schizophr Res. 2010;118:292-9 pubmed publisher
    ..Changes in the Par-4/D2DR signaling pathway represent a novel mechanism that may link apoptotic and dopamine signaling pathways in major depression and schizophrenia. ..
  6. Alves Bezerra M, Klett E, De Paula I, Ramos I, Coleman R, Gondim K. Long-chain acyl-CoA synthetase 2 knockdown leads to decreased fatty acid oxidation in fat body and reduced reproductive capacity in the insect Rhodnius prolixus. Biochim Biophys Acta. 2016;1861:650-62 pubmed publisher
  7. Fridell Y, Searles L. Vermilion as a small selectable marker gene for Drosophila transformation. Nucleic Acids Res. 1991;19:5082 pubmed
  8. Santulli Marotto S, Qian Y, Ferguson S, Clarke S. Anti-Sm B cell differentiation in Ig transgenic MRL/Mp-lpr/lpr mice: altered differentiation and an accelerated response. J Immunol. 2001;166:5292-9 pubmed
    ..These data suggest that a defect in B-1 differentiation may be a factor in the loss of tolerance to Sm and provide insight into the low prevalence of the anti-Sm response in lupus. ..
  9. McHugh E, Zhu W, Milgram S, Mager S. The GABA transporter GAT1 and the MAGUK protein Pals1: interaction, uptake modulation, and coexpression in the brain. Mol Cell Neurosci. 2004;26:406-17 pubmed
    ..We hypothesize that Pals1 contributes to the stability of the GAT1, thus promoting the expression level of the transporter protein. In the CNS, Pals1 may stabilize GAT1 at appropriate levels in specific GABAergic neurons. ..
  10. Ning S, Huye L, Pagano J. Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling. J Biol Chem. 2005;280:12262-70 pubmed
    ..A regulatory network between type I IFNs and IRF7 is proposed. The distinct pathways may reflect special roles for an efficient antiviral response at different stages of virus infection. ..
  11. Dai Q, Qian S, Li H, McDonough H, Borchers C, Huang D, et al. Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. J Biol Chem. 2005;280:38673-81 pubmed
    ..The association of BAG2 with CHIP provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP. ..
  12. Hansen J, Holt L, Sartor R. Gene expression patterns in experimental colitis in IL-10-deficient mice. Inflamm Bowel Dis. 2009;15:890-9 pubmed publisher
    ..Although most upregulated genes in experimental colitis are immune-related, aquaporin-4 and mitochondrial ribosomal protein-L33, which have not been previously associated with inflammation, were most highly upregulated. ..
  13. Quintero O, DiVito M, Adikes R, Kortan M, Case L, Lier A, et al. Human Myo19 is a novel myosin that associates with mitochondria. Curr Biol. 2009;19:2008-13 pubmed publisher
    ..Expressing the GFP-Myo19 tail in CAD cells resulted in decreased mitochondrial run lengths in neurites. These results suggest that this novel myosin functions as an actin-based motor for mitochondrial movement in vertebrate cells. ..
  14. Karlsson E, Sheridan P, Beck M. Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cells. J Nutr. 2010;140:1691-7 pubmed publisher
    ..It is imperative to understand how the obese state alters memory T cells, because impairment in maintenance of functional memory responses has important implications for vaccine efficacy in an obese population. ..
  15. Muraoka Cook R, Sandahl M, Strunk K, Miraglia L, Husted C, Hunter D, et al. ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo. Mol Cell Biol. 2009;29:4935-48 pubmed publisher
    ..These results demonstrate that the Cyt1 and Cyt2 ErbB4 isoforms, differing by only 16 amino acids, exhibit markedly opposing effects on mammary epithelium growth and differentiation. ..
  16. Boyd K, Kumar S, O Buckley T, Porcu P, Morrow A. Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis. J Neurochem. 2010;112:784-96 pubmed publisher
    ..As GABAergic steroids contribute to ethanol actions and ethanol sensitivity, the mechanisms of this effect of ethanol may be important factors that contribute to the behavioral actions of ethanol and risk for alcohol abuse disorders. ..
  17. Lei Y, Wen H, Yu Y, Taxman D, Zhang L, Widman D, et al. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity. 2012;36:933-46 pubmed publisher
    ..This study establishes a link between an NLR protein and the viral-induced autophagic machinery via an intermediary partner, TUFM. ..
  18. Pandya K, Cowhig J, Brackhan J, Kim H, Hagaman J, Rojas M, et al. Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2008;105:13063-8 pubmed publisher
  19. Fedoriw A, Starmer J, Yee D, Magnuson T. Nucleolar association and transcriptional inhibition through 5S rDNA in mammals. PLoS Genet. 2012;8:e1002468 pubmed publisher
    ..These results demonstrate that 5S rDNA sequence can significantly contribute to the positioning of a locus and suggest a novel, endogenous mechanism for nuclear organization in mammals. ..
  20. Barrigan L, Tuladhar S, Brunton J, Woolard M, Chen C, Saini D, et al. Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response. Infect Immun. 2013;81:2028-42 pubmed publisher
    ..These results also indicate that disruption of a nonessential gene(s) that is involved in bacterial immune evasion, like F. tularensis clpB, can serve as a model for the rational design of attenuated vaccines. ..
  21. Matsushima G, Itoh Lindstrom Y, Ting J. Activation of the HLA-DRA gene in primary human T lymphocytes: novel usage of TATA and the X and Y promoter elements. Mol Cell Biol. 1992;12:5610-9 pubmed
    ..This study of nontransformed lymphocytes reveals several novel features of DRA gene regulation and underscores the value and necessity of such studies. ..
  22. Shutes A, Berzat A, Cox A, Der C. Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase. Curr Biol. 2004;14:2052-6 pubmed
    ..We propose that Grb2 overcomes N-terminal negative regulation to promote Wrch-1 effector interaction. Thus, Wrch-1 exhibits an atypical model of regulation not seen in other Rho family GTPases. ..
  23. Everly D, Mainou B, Raab Traub N. Induction of Id1 and Id3 by latent membrane protein 1 of Epstein-Barr virus and regulation of p27/Kip and cyclin-dependent kinase 2 in rodent fibroblast transformation. J Virol. 2004;78:13470-8 pubmed
    ..Decreased p27 was correlated with increased levels of Cdk2 and increased levels of phosphorylated retinoblastoma protein. This study describes new properties of LMP1 that likely contribute to transformation and oncogenesis. ..
  24. Dan H, Cooper M, Cogswell P, Duncan J, Ting J, Baldwin A. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev. 2008;22:1490-500 pubmed publisher
    ..The results provide insight into the effects of Akt/mTOR-dependent signaling on gene expression and into the therapeutic action of rapamycin. ..
  25. Schisler J, Charles P, Parker J, Hilliard E, Mapara S, Meredith D, et al. Stable patterns of gene expression regulating carbohydrate metabolism determined by geographic ancestry. PLoS ONE. 2009;4:e8183 pubmed publisher
  26. Bosch D, Kimple A, Muller R, Giguère P, Machius M, Willard F, et al. Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica. PLoS Pathog. 2012;8:e1003040 pubmed publisher
    ..Collectively, our studies suggest that E. histolytica possesses a divergent heterotrimeric G-protein signaling axis that modulates key aspects of cellular processes related to the pathogenesis of this infectious organism...
  27. Worthmann K, Leitges M, Teng B, Sestu M, Tossidou I, Samson T, et al. Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) ?/?. Am J Pathol. 2013;183:1945-1959 pubmed publisher
  28. Wu C, Xu Z, Huang K. Effects of Dietary Selenium on Inflammation and Hydrogen Sulfide in the Gastrointestinal Tract in Chickens. Biol Trace Elem Res. 2016;174:428-435 pubmed
    ..The downregulation exacerbates the inflammation and impacts H2S-mediated intestinal functions. ..
  29. Hamil K, Hall S. Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: regulation of TSC-22 gene expression. Endocrinology. 1994;134:1205-12 pubmed
    ..A 5-kb transcript became detectable by 30 days and decreased after 50 days of age. Ovarian 1.8-kb TSC-22 transcript levels increased about 2-fold during the same maturation period. ..
  30. Sorscher D, Barrett J, Cordeiro Stone M. Timing of replication of differentially transcribed genes in Syrian hamster embryo fibroblasts. Mol Carcinog. 1993;8:28-33 pubmed
    ..These results suggest that downregulation of transcription is not always accompanied by a concomitant change in time of gene replication from early to late S phase. ..
  31. Kakoki M, Tsai Y, Kim H, Hatada S, Ciavatta D, Takahashi N, et al. Altering the expression in mice of genes by modifying their 3' regions. Dev Cell. 2004;6:597-606 pubmed
    ..In mice having two functionally different native genes with modified 3'UTRs, the desired expression was obtained. ..
  32. Woods K, Thomson J, Hammond S. Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem. 2007;282:2130-4 pubmed
    ..We propose a model whereby miR-17-92 promotes cell proliferation by shifting the E2F transcriptional balance away from the pro-apoptotic E2F1 and toward the proliferative E2F3 transcriptional network. ..
  33. Karrasch T, Kim J, Jang B, Jobin C. The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules. PLoS ONE. 2007;2:e596 pubmed
    ..We conclude that while luteolin shows beneficial effects on spontaneous colitis, it aggravates DSS-induced experimental colitis by blocking NF-kappaB-dependent protective molecules in enterocytes. ..
  34. McNally R, Davis B, Clements C, Accavitti Loper M, Mak T, Ting J. DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J Biol Chem. 2011;286:4098-106 pubmed publisher
  35. Kanther M, Sun X, Muhlbauer M, Mackey L, Flynn E, Bagnat M, et al. Microbial colonization induces dynamic temporal and spatial patterns of NF-?B activation in the zebrafish digestive tract. Gastroenterology. 2011;141:197-207 pubmed publisher
    ..The observed patterns of NF-?B-dependent responses to microbial colonization indicate that cells in the gastrointestinal tract respond robustly to the microbial environment. ..
  36. Zhang S, Barros S, Moretti A, Yu N, Zhou J, Preisser J, et al. Epigenetic regulation of TNFA expression in periodontal disease. J Periodontol. 2013;84:1606-16 pubmed publisher
  37. Duronio R, Xiong Y. Signaling pathways that control cell proliferation. Cold Spring Harb Perspect Biol. 2013;5:a008904 pubmed publisher
    ..Consequently, both mitogenic and antiproliferative signals exert their effects on cell proliferation through the transcriptional regulation and ubiquitin-dependent degradation of cyclins and CDK inhibitors. ..
  38. Waterfield M, Khan I, Cortez J, Fan U, Metzger T, Greer A, et al. The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol. 2014;15:258-65 pubmed publisher
  39. Chen P, Smith T, Wu J, Siesser P, Bisnett B, Khan F, et al. Glycosylation of KEAP1 links nutrient sensing to redox stress signaling. EMBO J. 2017;36:2233-2250 pubmed publisher
  40. Magness S, Jijon H, Van Houten Fisher N, Sharpless N, Brenner D, Jobin C. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol. 2004;173:1561-70 pubmed
    ..In summary, the cis-NF-kappa B(EGFP) mouse will serve as a valuable tool to address multiple questions regarding the cell-specific and real-time activation of NF-kappa B during normal and diseased states. ..
  41. Sockman K, Ball G. Independent effects of song quality and experience with photostimulation on expression of the immediate, early gene ZENK (EGR-1) in the auditory telencephalon of female European starlings. Dev Neurobiol. 2009;69:339-49 pubmed publisher
    ..Thus, photoexperience affects activity in an area of the forebrain that processes social signals, an effect that we hypothesize mediates, in part, the effects of age on reproductive decisions in photoperiodic songbirds...
  42. Bortone D, Polleux F. KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner. Neuron. 2009;62:53-71 pubmed publisher
  43. Ribeiro C, Hurd H, Wu Y, Martino M, Jones L, Brighton B, et al. Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia. PLoS ONE. 2009;4:e5806 pubmed publisher
  44. Mo J, Xia Y, Ning Z, Wade T, Mumford J. Elevated ERCC1 gene expression in blood cells associated with exposure to arsenic from drinking water in Inner Mongolia. Anticancer Res. 2009;29:3253-9 pubmed
    ..275, p<0.0001). The results showed that mRNA levels of ERCC1 expression were significantly associated with arsenic concentrations in drinking water, implicating the DNA repair response was induced by arsenic exposure. ..
  45. Leichty A, Pfennig D, Jones C, Pfennig K. Relaxed genetic constraint is ancestral to the evolution of phenotypic plasticity. Integr Comp Biol. 2012;52:16-30 pubmed publisher
    ..Thus, relaxed genetic constraint may be a cause--not a consequence--of the evolution of phenotypic plasticity, and thereby contribute to the evolution of novel traits. ..
  46. Itoh Lindstrom Y, Piskurich J, Felix N, Wang Y, Brickey W, Platt J, et al. Reduced IL-4-, lipopolysaccharide-, and IFN-gamma-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain. J Immunol. 1999;163:2425-31 pubmed
    ..These findings demonstrate a requirement for CIITA in IFN-gamma-, IL-4-, and endotoxin-induced MHC class II expression as well as the possibility of rare CIITA-independent MHC class II expression. ..
  47. Alahari S, Reddig P, Juliano R. The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK. EMBO J. 2004;23:2777-88 pubmed
    ..In addition, PAK1 and Nischarin colocalize in membrane ruffles, structures known to be involved in cell motility. Thus, Nischarin may regulate cell migration by forming inhibitory complexes with PAK family kinases. ..
  48. Szczytkowski J, Lysle D. Dopamine D1 receptors within the basolateral amygdala mediate heroin-induced conditioned immunomodulation. J Neuroimmunol. 2010;226:38-47 pubmed publisher
    ..This study is the first to demonstrate that the expression of heroin's conditioned effects on proinflammatory mediators require dopamine D(1) receptors within the BLA. ..
  49. Porcu P, O Buckley T, Song S, Harenza J, Lu L, Wang X, et al. Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation. PLoS ONE. 2011;6:e18405 pubmed publisher
    ..DOC levels were also strongly correlated with networks of genes associated with neuronal function, innate immune pathways, and steroid metabolism, likely linked to behavioral phenotypes. ..
  50. Vincent H, Ziehr B, Moorman N. Human Cytomegalovirus Strategies to Maintain and Promote mRNA Translation. Viruses. 2016;8:97 pubmed publisher
    ..Here we review key regulatory steps in mRNA translation, and the strategies used by HCMV to maintain protein synthesis in infected cells. ..
  51. Ho K, Wilson E, French F. Androgen regulated prostate genes: structural analysis and regulation. Prog Clin Biol Res. 1987;239:125-53 pubmed
  52. Balmer C, LaMantia A. Loss of Gli3 and Shh function disrupts olfactory axon trajectories. J Comp Neurol. 2004;472:292-307 pubmed
    ..Thus, two genes that influence induction and subsequent differentiation of craniofacial structures and the forebrain have distinct consequences for ORN axon growth during the initial genesis of the olfactory pathway. ..
  53. Juliano R, Dixit V, Kang H, Kim T, Miyamoto Y, Xu D. Epigenetic manipulation of gene expression: a toolkit for cell biologists. J Cell Biol. 2005;169:847-57 pubmed
    ..However, we will restrict our comments primarily to the cell culture situation, only briefly alluding to fundamental differences between utilization in animals versus cells. ..
  54. Shibutani S, de la Cruz A, Tran V, Turbyfill W, Reis T, Edgar B, et al. Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev Cell. 2008;15:890-900 pubmed publisher
    ..We propose that pRb-independent inhibition of E2F during S phase is an evolutionarily conserved feature of the metazoan cell cycle that is necessary for development. ..
  55. Steinbach E, Kobayashi T, Russo S, Sheikh S, Gipson G, Kennedy S, et al. Innate PI3K p110? regulates Th1/Th17 development and microbiota-dependent colitis. J Immunol. 2014;192:3958-68 pubmed publisher
    ..Defects in p110? expression and/or function may underlie the pathogenesis of human inflammatory bowel disease and lead to new therapeutic strategies. ..
  56. Wang H, Han X, Wittchen E, Hartnett M. TNF-α mediates choroidal neovascularization by upregulating VEGF expression in RPE through ROS-dependent β-catenin activation. Mol Vis. 2016;22:116-28 pubmed
    ..These results provide mechanisms of crosstalk between inflammatory mediator, TNF-α, and ROS in RPE cells. ..
  57. Phanstiel D, Van Bortle K, Spacek D, Hess G, Shamim M, Machol I, et al. Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Macrophage Development. Mol Cell. 2017;67:1037-1048.e6 pubmed publisher
  58. Katafuchi M, Matsuura T, Atsawasuwan P, Sato H, Yamauchi M. Biochemical characterization of collagen in alveolar mucosa and attached gingiva of pig. Connect Tissue Res. 2007;48:85-92 pubmed
    ..These results indicate that alveolar mucosa is a fibrillar collagen-rich tissue and, in comparison to gingival tissue, re-models slowly. ..
  59. Mangiamele L, Thomson C, Lebonville C, Burmeister S. Characterization of the plasticity-related gene, Arc, in the frog brain. Dev Neurobiol. 2010;70:813-25 pubmed publisher
  60. Palmer M, Mergner V, Richman R, Manning J, Kuroda M, Lucchesi J. The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males. Genetics. 1993;134:545-57 pubmed
    ..Our findings support the hypothesis that msl-1 plays a direct role in increasing the level of X-linked gene transcription in male nuclei. ..
  61. Sass G, Mohler J, Walsh R, Kalfayan L, Searles L. Structure and expression of hybrid dysgenesis-induced alleles of the ovarian tumor (otu) gene in Drosophila melanogaster. Genetics. 1993;133:253-63 pubmed
    ..The results of this study demonstrate that the diverse mutant phenotypes of otu are the consequence of different levels of otu function. ..
  62. Fenton S, Groce N, Lee D. Characterization of the mouse epidermal growth factor promoter and 5'-flanking region. Role for an atypical TATA sequence. J Biol Chem. 1996;271:30870-8 pubmed
    ..These data suggest that the TTTAAA sequence functions as an atypical TATA box. ..
  63. Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, et al. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. J Biol Chem. 2003;278:14146-52 pubmed
    ..These results show that a novel xenobiotic-responsive enhancer module in the distal region of the CYP2B6 promoter (CYP2B6-XREM) together with the PBREM mediates optimal drug-induced expression of CYP2B6. ..
  64. Askew E, Minges J, Hnat A, Wilson E. Structural features discriminate androgen receptor N/C terminal and coactivator interactions. Mol Cell Endocrinol. 2012;348:403-10 pubmed publisher
    ..We conclude that helix 12 residues outside the AF2 binding cleft modulate AR transcriptional activity by providing flexibility to accommodate FXXLF or LXXLL motif binding. ..
  65. Plante B, Lessey B, Taylor R, Wang W, Bagchi M, Yuan L, et al. G protein-coupled estrogen receptor (GPER) expression in normal and abnormal endometrium. Reprod Sci. 2012;19:684-93 pubmed publisher
    ..Together, these data suggest that normal endometrial GPER expression is cyclic and regulated by nuclear estrogen and progesterone receptors, while expression is dysregulated in endometriosis. ..
  66. Toews A, Roe E, Goodrum J, Bouldin T, Weaver J, Goines N, et al. Tellurium causes dose-dependent coordinate down-regulation of myelin gene expression. Brain Res Mol Brain Res. 1997;49:113-9 pubmed
    ..This suggests the down-regulation is related to the tellurium-induced cholesterol deficit, and not to the loss of axonal contact associated with early stages of demyelination or to the entry of activated macrophages...
  67. Thresher R, Vitaterna M, Miyamoto Y, Kazantsev A, Hsu D, Petit C, et al. Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. Science. 1998;282:1490-4 pubmed
    ..These data are consistent with the hypothesis that CRY2 protein modulates circadian responses in mice and suggest that cryptochromes have a role in circadian photoreception in mammals. ..
  68. Sen B, Styner M, Xie Z, Case N, Rubin C, Rubin J. Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node. J Biol Chem. 2009;284:34607-17 pubmed publisher
    ..Our novel findings suggest that mechanical loading regulates mesenchymal stem cell differentiation through inhibition of GSK3beta, which in turn regulates multiple downstream effectors. ..
  69. Sampey B, Freemerman A, Zhang J, Kuan P, Galanko J, O Connell T, et al. Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. PLoS ONE. 2012;7:e38812 pubmed publisher
    ..These data also suggest that modifying the availability or metabolism of saturated fatty acids may limit the inflammation associated with obesity leading to Metabolic Syndrome. ..
  70. Thompson C, Selby C, Van Gelder R, Blaner W, Lee J, Quadro L, et al. Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice. J Biol Rhythms. 2004;19:504-17 pubmed
    ..These data demonstrate that both cryptochromes and opsins regulate nonvisual photoresponses. ..
  71. Vendrov A, Madamanchi N, Niu X, Molnar K, Runge M, Szyndralewiez C, et al. NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis. J Biol Chem. 2010;285:26545-57 pubmed publisher
    ..Together, these data suggest that increased CD44 and HA expression and CD44-HA-dependent gene regulation may play a role in atherosclerosis stimulated by NADPH oxidase activation. ..
  72. Mackey Cushman S, Gao J, Holmes D, Nunoya J, Wang R, Unutmaz D, et al. FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity. Genes Immun. 2011;12:559-67 pubmed publisher
    ..5 expression in human Treg cells impaired the Treg function to suppress target T cells. We conclude that FoxP3 interacts with H1.5 to alter its binding to target genes to modulate their expression and to program Treg function. ..
  73. Tan J, Joseph D, Quarmby V, Lubahn D, Sar M, French F, et al. The rat androgen receptor: primary structure, autoregulation of its messenger ribonucleic acid, and immunocytochemical localization of the receptor protein. Mol Endocrinol. 1988;2:1276-85 pubmed
    ..Immunocytochemical staining localized the androgen receptor to epithelial cell nuclei in rat ventral prostate. ..
  74. Chang J, Monroe D, Oliver J, Roberts H. TFPIbeta, a second product from the mouse tissue factor pathway inhibitor (TFPI) gene. Thromb Haemost. 1999;81:45-9 pubmed
    ..In addition, heparin does not enhance the inhibition of factor Xa by mouse TFPIbeta although it does accelerate factor Xa inhibition by TFPI. ..
  75. Miyamoto Y, Sancar A. Circadian regulation of cryptochrome genes in the mouse. Brain Res Mol Brain Res. 1999;71:238-43 pubmed
    ..Third, mutation in Cry2 causes a phase delay in Cry1 and mPer1 expression both in the SCN and internal organs relative to wild-type animals. Finally, no obvious periodicity in mCry2 expression was seen in all tissues tested. ..
  76. McFall A, Ulku A, Lambert Q, Kusa A, Rogers Graham K, Der C. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol. 2001;21:5488-99 pubmed
    ..We conclude that a PI3K- and RalGEF-independent Ras effector(s) likely cooperates with Raf to confer anoikis resistance upon RIE-1 cells, thus underscoring the complex nature by which Ras transforms cells. ..
  77. Thompson C, Selby C, Partch C, Plante D, Thresher R, Araujo F, et al. Further evidence for the role of cryptochromes in retinohypothalamic photoreception/phototransduction. Brain Res Mol Brain Res. 2004;122:158-66 pubmed
  78. Quigley C, Tan J, He B, Zhou Z, Mebarki F, Morel Y, et al. Partial androgen insensitivity with phenotypic variation caused by androgen receptor mutations that disrupt activation function 2 and the NH(2)- and carboxyl-terminal interaction. Mech Ageing Dev. 2004;125:683-95 pubmed
    ..These studies indicate that the function of an AR AF2 mutant in male development can vary greatly depending on the genetic background. ..
  79. Callis T, Cao D, Wang D. Bone morphogenetic protein signaling modulates myocardin transactivation of cardiac genes. Circ Res. 2005;97:992-1000 pubmed
    ..Furthermore, myocardin protein levels were dramatically increased by BMP-2 treatment in cardiomyocytes. These findings suggest myocardin participates in a BMP signaling-dependent cardiac gene transcriptional program. ..
  80. Yadav P, Abbas A, Farrell M, Setola V, Sciaky N, Huang X, et al. The presynaptic component of the serotonergic system is required for clozapine's efficacy. Neuropsychopharmacology. 2011;36:638-51 pubmed publisher
    ..These results show that clozapine's ability to normalize NMDA-receptor hypofunction, which is characteristic of schizophrenia, depends on an intact presynaptic serotonergic neuronal system. ..
  81. Pandya K, Pulli B, Bultman S, Smithies O. Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression. Gene Expr. 2010;15:51-9 pubmed
    ..These data indicate that during reciprocal and inducible gene expression H3ac parallels bMHC isoform expression while H3K4me3 parallels expression of the tightly linked aMHC isoform. ..
  82. Stefanini L, Ye F, Snider A, Sarabakhsh K, Piatt R, Paul D, et al. A talin mutant that impairs talin-integrin binding in platelets decelerates ?IIb?3 activation without pathological bleeding. Blood. 2014;123:2722-31 pubmed publisher
    ..Together our data indicate that reduction of talin-?3 integrin binding affinity results in decelerated ?IIb?3 integrin activation and protection from arterial thrombosis without pathological bleeding. ..
  83. Cheshire J, Baldwin A. Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation. Mol Cell Biol. 1997;17:6746-54 pubmed
  84. Chen C, Paing M, Trejo J. Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation. J Biol Chem. 2004;279:10020-31 pubmed
    ..These findings reveal a new level of complexity in the regulation of protease-activated GPCR signaling. ..
  85. Wu Y, Ferguson J, Wang H, Kelley R, Ren R, McDonough H, et al. PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation. J Mol Cell Cardiol. 2008;44:47-58 pubmed
  86. Doherty H, Kim H, Hiller S, Sulik K, Maeda N. A mouse strain where basal connective tissue growth factor gene expression can be switched from low to high. PLoS ONE. 2010;5:e12909 pubmed publisher
  87. Parsons C, Stefanovic B, Seki E, Aoyama T, Latour A, Marzluff W, et al. Mutation of the 5'-untranslated region stem-loop structure inhibits ?1(I) collagen expression in vivo. J Biol Chem. 2011;286:8609-19 pubmed publisher
    ..These results confirm an important role of the 5' stem-loop in regulating type I collagen mRNA and protein expression and provide a mouse model for further study of collagen-associated diseases. ..
  88. Jeffries C, Fried H, Perkins D. Additional layers of gene regulatory complexity from recently discovered microRNA mechanisms. Int J Biochem Cell Biol. 2010;42:1236-42 pubmed publisher
  89. Lawrimore J, Barry T, Barry R, York A, Friedman B, Cook D, et al. Microtubule dynamics drive enhanced chromatin motion and mobilize telomeres in response to DNA damage. Mol Biol Cell. 2017;28:1701-1711 pubmed publisher
    ..These findings reveal how relaxation of external tethers to the nuclear envelope and internal chromatin-chromatin tethers, together with microtubule dynamics, can mobilize the genome in response to DNA damage. ..
  90. Vetreno R, Qin L, Crews F. Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking. Neurobiol Dis. 2013;59:52-62 pubmed publisher
  91. Holt B, Boyes D, Ellerström M, Siefers N, Wiig A, Kauffman S, et al. An evolutionarily conserved mediator of plant disease resistance gene function is required for normal Arabidopsis development. Dev Cell. 2002;2:807-17 pubmed
    ..Further, AtTIP49a is essential for both sporophyte and female gametophyte viability. Thus, regulators of R function overlap with essential modulators of plant development. ..
  92. McEachron T, Pawlinski R, Richards K, Church F, Mackman N. Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis. Blood. 2010;116:5037-44 pubmed publisher
    ..Cells lacking PAR-2 failed to express PAI-1 in response to thrombin and factor Xa did not activate the PAR-1/PAR-2 complex. Our results reveal how PAR-1 and PAR-2 on tumor cells mediate crosstalk between coagulation and fibrinolysis. ..