Experts and Doctors on flame retardants in Durham, North Carolina, United States
Locale: Durham, North Carolina, United States
Topic: flame retardants
- Stapleton H, Klosterhaus S, Keller A, Ferguson P, Van Bergen S, Cooper E, et al. Identification of flame retardants in polyurethane foam collected from baby products. Environ Sci Technol. 2011;45:5323-31 pubmed publisher..Future studies are therefore warranted to specifically measure infants exposure to these flame retardants from intimate contact with these products and to determine if there are any associated health concerns...
- Cooper E, Covaci A, van Nuijs A, Webster T, Stapleton H. Analysis of the flame retardant metabolites bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP) in urine using liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2011;401:2123-32 pubmed publisher..The presented method is simple and sufficiently sensitive to detect these FR metabolites in humans and may be applied to future studies to increase our understanding of exposure to and potential health effects from FRs. ..
- Brown D, Van Overmeire I, Goeyens L, Denison M, De Vito M, Clark G. Analysis of Ah receptor pathway activation by brominated flame retardants. Chemosphere. 2004;55:1509-18 pubmed..When tested in the CALUX assay these compounds were found to be equivalent to, or more active than their chlorinated analogues. Relative effective potency values were determined from dose response curves for these brominated HAHs...
- Dishaw L, Powers C, Ryde I, Roberts S, Seidler F, Slotkin T, et al. Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. Toxicol Appl Pharmacol. 2011;256:281-9 pubmed publisher..Additionally, these data suggest that OPFRs may affect neurodevelopment with similar or greater potency compared to known and suspected neurotoxicants. ..
- Stapleton H, Klosterhaus S, Eagle S, Fuh J, Meeker J, Blum A, et al. Detection of organophosphate flame retardants in furniture foam and U.S. house dust. Environ Sci Technol. 2009;43:7490-5 pubmed..The high prevalence of these chemicals in foam and the high concentrations measured in dust (as high as 1.8 mg/g) warrant further studies to evaluate potential health effects from dust exposure, particularly for children. ..
- Stapleton H, Allen J, Kelly S, Konstantinov A, Klosterhaus S, Watkins D, et al. Alternate and new brominated flame retardants detected in U.S. house dust. Environ Sci Technol. 2008;42:6910-6 pubmed..This study highlights the fact that numerous types of brominated flame retardants are present in indoor environments, raising questions about exposure to mixtures of these contaminants. ..
- Stapleton H, Kelly S, Allen J, McClean M, Webster T. Measurement of polybrominated diphenyl ethers on hand wipes: estimating exposure from hand-to-mouth contact. Environ Sci Technol. 2008;42:3329-34 pubmed..These estimates are greater than dietary intake rates and suggest hand-to-mouth contact may be a key exposure route for PBDEs. ..
- Hoppe A, Carey G. Polybrominated diphenyl ethers as endocrine disruptors of adipocyte metabolism. Obesity (Silver Spring). 2007;15:2942-50 pubmed publisher..These alterations, hallmark features of metabolic obesity, suggest the need for further research on the contribution of lipid-soluble, endocrine-disrupting environmental chemicals to the obesity epidemic. ..