Experts and Doctors on cell division in Durham, North Carolina, United States


Locale: Durham, North Carolina, United States
Topic: cell division

Top Publications

  1. Markert M, Boeck A, Hale L, Kloster A, McLaughlin T, Batchvarova M, et al. Transplantation of thymus tissue in complete DiGeorge syndrome. N Engl J Med. 1999;341:1180-9 pubmed
    ..Early thymus transplantation - before the development of infectious complications - may promote successful immune reconstitution. ..
  2. Chang C, Walther P, McDonnell D. Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer. Cancer Res. 2001;61:8712-7 pubmed
  3. Yao H, Whoriskey W, Capel B. Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Genes Dev. 2002;16:1433-40 pubmed
  4. Barki Harrington L, Bookout A, Wang G, Lamb M, Leeb Lundberg L, Daaka Y. Requirement for direct cross-talk between B1 and B2 kinin receptors for the proliferation of androgen-insensitive prostate cancer PC3 cells. Biochem J. 2003;371:581-7 pubmed
    ..Selective inhibition of B1R, which is up-regulated in injured and cancerous tissue, may be beneficial for the treatment of advanced prostate cancer. ..
  5. Borel C, McKee A, Parra A, Haglund M, Solan A, Prabhakar V, et al. Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage. Stroke. 2003;34:427-33 pubmed
    ..Proliferation of cells in the vascular wall is associated with perivascular thrombus. Cellular proliferation and subsequent vessel wall thickening may contribute to the syndrome of delayed cerebral vasospasm. ..
  6. Fields R, Schoenecker J, Hart J, Hoffman M, Pizzo S, Lawson J. Protease-activated receptor-2 signaling triggers dendritic cell development. Am J Pathol. 2003;162:1817-22 pubmed
    ..These results suggest that endogenous serine proteases stimulate DC development in vitro. Thus, serine proteases may help trigger adaptive immune responses in vivo. ..
  7. Shan S, Robson N, Cao Y, Qiao T, Li C, Kontos C, et al. Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival. FASEB J. 2004;18:326-8 pubmed
    ..These subsequent signals from endothelial cells promote early survival and proliferation of disseminated tumor cells before onset of angiogenesis. ..
  8. Sempowski G, Cross S, Heinly C, Scearce R, Haynes B. CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis. J Immunol. 2004;172:787-94 pubmed
  9. Learn C, Hartzell T, Wikstrand C, Archer G, Rich J, Friedman A, et al. Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme. Clin Cancer Res. 2004;10:3216-24 pubmed
    ..However, this decrease does not effectively inhibit the biologically relevant processes of DNA synthesis, cellular growth, and invasion in cells expressing EGFRvIII. ..

More Information

Publications113 found, 100 shown here

  1. Brennan J, Capel B. One tissue, two fates: molecular genetic events that underlie testis versus ovary development. Nat Rev Genet. 2004;5:509-21 pubmed
  2. Paliulis L, Nicklas R. Micromanipulation of chromosomes reveals that cohesion release during cell division is gradual and does not require tension. Curr Biol. 2004;14:2124-9 pubmed
    ..This implied that tension from spindle forces was required, but we showed directly that no tension was necessary to pull chromatids apart. ..
  3. Goudar R, Shi Q, Hjelmeland M, Keir S, McLendon R, Wikstrand C, et al. Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther. 2005;4:101-12 pubmed
    ..These studies suggest that simultaneous inhibition of growth factor receptor and mTOR pathways offer increased benefit in glioma therapy. ..
  4. Okubo T, Knoepfler P, Eisenman R, Hogan B. Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. Development. 2005;132:1363-74 pubmed
    ..We propose a model in which Nmyc is essential in the developing lung for maintaining a distal population of undifferentiated, proliferating progenitor cells. ..
  5. Gao C, Mi Z, Guo H, Kuo P. Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. Neoplasia. 2007;9:699-706 pubmed
    ..This relationship between OPN and Stat1 in the context of tumor biology has not been previously examined. ..
  6. Burnetti A, Aydin M, Buchler N. Cell cycle Start is coupled to entry into the yeast metabolic cycle across diverse strains and growth rates. Mol Biol Cell. 2016;27:64-74 pubmed publisher
    ..More generally, our approach shows how studies in genetically diverse strains efficiently identify robust phenotypes and steer the experimentalist away from strain-specific idiosyncrasies. ..
  7. Mudryj M, Hiebert S, Nevins J. A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 1990;9:2179-84 pubmed
    ..We also believe that the E2F transcription factor is the first example of a regulator of the class of immediate early genes that is slowly activated by stimulation of cell proliferation. ..
  8. Ikeda M, Jakoi L, Nevins J. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc Natl Acad Sci U S A. 1996;93:3215-20 pubmed
    ..These results suggest that the specific ability of Rb protein to interact with each E2F species, dependent on concentration of active Rb relative to accumulation of E2F, may be critical in cell-growth decisions. ..
  9. Ohtani K, DeGregori J, Leone G, Herendeen D, Kelly T, Nevins J. Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol Cell Biol. 1996;16:6977-84 pubmed
    ..These results thus provide a direct link between the initiation of DNA replication and the cell growth regulatory pathway involving G1 cyclin-dependent kinases, the Rb tumor suppressor, and E2F. ..
  10. Pan X, Heitman J. Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. Mol Cell Biol. 2002;22:3981-93 pubmed
    ..Our studies illustrate in molecular detail how protein kinase A combinatorially effects a key developmental switch. Similar mechanisms may operate in pathogenic fungi and more complex multicellular eukaryotic organisms. ..
  11. Marchuk D, Srinivasan S, Squire T, Zawistowski J. Vascular morphogenesis: tales of two syndromes. Hum Mol Genet. 2003;12 Spec No 1:R97-112 pubmed
    ..Emerging but intriguing tales are being told by the genes (and their protein products) mutated in these disorders. ..
  12. Hart J, Gunn M, Pizzo S. A CD91-positive subset of CD11c+ blood dendritic cells: characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens. J Immunol. 2004;172:70-8 pubmed
    ..Therefore, CD11c(+) lin(-) DC use CD91/LRP to facilitate the uptake and subsequent presentation of an array of Ags complexed within the CD91/LRP ligand, the activated form of alpha2-macroglobulin (alpha2M*). ..
  13. Gardner K, Moore D, Erickson H. The C-terminal linker of Escherichia coli FtsZ functions as an intrinsically disordered peptide. Mol Microbiol. 2013;89:264-75 pubmed publisher
    ..Modelling the Ct-linker as a worm-like chain, we predict that it functions as a stiff entropic spring linking the bending protofilaments to the membrane. ..
  14. Quarles L, Hartle J, Siddhanti S, Guo R, Hinson T. A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor. J Bone Miner Res. 1997;12:393-402 pubmed
    ..These findings suggest that an extra-cellular cation-sensing mechanism is present in murine-derived osteoblasts that is functionally similar to but molecularly distinct from CaR. ..
  15. McCartney B, Kulikauskas R, LaJeunesse D, Fehon R. The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. Development. 2000;127:1315-24 pubmed
    ..These results indicate that Merlin and Expanded function together to regulate proliferation and differentiation, and have implications for understanding the functions of other Protein 4.1 superfamily members. ..
  16. Bao S, Wu Q, Li Z, Sathornsumetee S, Wang H, McLendon R, et al. Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res. 2008;68:6043-8 pubmed publisher
  17. Poulson N, Lechler T. Robust control of mitotic spindle orientation in the developing epidermis. J Cell Biol. 2010;191:915-22 pubmed publisher
    ..These data have uncovered two important regulatory points controlling ACD in the epidermis and allow a framework for analysis of how external cues control this important choice. ..
  18. Giangrande P, Zhu W, Schlisio S, Sun X, Mori S, Gaubatz S, et al. A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. Genes Dev. 2004;18:2941-51 pubmed
  19. Yoshizaki A, Miyagaki T, DiLillo D, Matsushita T, Horikawa M, Kountikov E, et al. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature. 2012;491:264-8 pubmed publisher
    ..The ex vivo expansion and reinfusion of autologous B10 cells may provide a novel and effective in vivo treatment for severe autoimmune diseases that are resistant to current therapies. ..
  20. Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, et al. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Nat Genet. 2014;46:245-52 pubmed publisher
    ..These data identify a key role for Lis1 in hematopoietic stem cells and mark its directed control of asymmetric division as a critical regulator of normal and malignant hematopoietic development. ..
  21. Rohde J, Heitman J, Cardenas M. The TOR kinases link nutrient sensing to cell growth. J Biol Chem. 2001;276:9583-6 pubmed
    ..Ongoing clinical studies address new clinical applications for rapamycin as an antiproliferative drug for chemotherapy and invasive cardiology. ..
  22. Levery S, Momany M, Lindsey R, Toledo M, Shayman J, Fuller M, et al. Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth. FEBS Lett. 2002;525:59-64 pubmed
    ..fumigatus cultured in the presence of these inhibitors displayed a significantly reduced GlcCer/GalCer ratio. These results suggest that synthesis of GlcCer is essential for normal development of A. fumigatus and A. nidulans. ..
  23. Brennan J, Tilmann C, Capel B. Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. Genes Dev. 2003;17:800-10 pubmed
    ..This work identifies PDGF signaling through the alpha receptor as an important event downstream of Sry in testis organogenesis and Leydig cell differentiation. ..
  24. Plattner R, Pendergast A. Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling. Cell Cycle. 2003;2:273-4 pubmed
  25. Yarmolenko P, Zhao Y, Landon C, Spasojevic I, Yuan F, Needham D, et al. Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours. Int J Hyperthermia. 2010;26:485-98 pubmed publisher
    ..In the clinic, the rate of tumour progression must be considered in design of treatment regimens involving HT-LTSL-DOX. ..
  26. Wheeler B, Ruderman B, Willard H, Scott K. Uncoupling of genomic and epigenetic signals in the maintenance and inheritance of heterochromatin domains in fission yeast. Genetics. 2012;190:549-57 pubmed publisher
    ..Together, these studies provide evidence for chromatin-dependent, epigenetic control of gene silencing that is heritable, stable, and self-sustaining, even in the absence of the originating genomic signals...
  27. Pan L, Bradney C, Zheng B, Zhuang Y. Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. Immunology. 2004;111:147-54 pubmed
    ..At older ages, these mice frequently develop antinuclear antibodies and proteinuria. Our studies suggest that E2A regulates T-cell function and the loss of E2A may promote age-dependent autoimmune diseases. ..
  28. King F, Szakmary A, Cox D, Lin H. Yb modulates the divisions of both germline and somatic stem cells through piwi- and hh-mediated mechanisms in the Drosophila ovary. Mol Cell. 2001;7:497-508 pubmed
    ..We also show that Yb acts via the piwi- and hh-mediated signaling pathways that emanate from the same signaling cells to control GSC and SSC division, respectively. hh signaling also has a minor effect in GSC division. ..
  29. Harashima T, Heitman J. The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell. 2002;10:163-73 pubmed
    ..Our studies demonstrate that Gpa2 signals in conjunction with Gbeta structural mimics and that homologous G protein subunits or effectors may be conserved in multicellular eukaryotes. ..
  30. Misra U, Payne S, Pizzo S. Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen. J Biol Chem. 2011;286:1248-59 pubmed publisher
    ..The present studies suggest that PSA may be involved in a signal transduction-dependent feedback loop, whereby it promotes a more aggressive behavior by human prostate cancer cells. ..
  31. Smulders Srinivasan T, Lin H. Screens for piwi suppressors in Drosophila identify dosage-dependent regulators of germline stem cell division. Genetics. 2003;165:1971-91 pubmed
    ..The other two types are deficiencies that cause lethality and female-specific lethality in a piwi2 mutant background, revealing the zygotic function of piwi in somatic development. ..
  32. Vollmer R. Use of Bayes rule and MIB-1 proliferation index to discriminate Spitz nevus from malignant melanoma. Am J Clin Pathol. 2004;122:499-505 pubmed
    ..The algorithm tabulates guidelines for the predictive probabilities of Spitz nevus given an observed PI. ..
  33. Taylor R, Ewert D, England J, Halpern M. Major histocompatibility (B) complex control of the growth pattern of v-src DNA-induced primary tumors. Virology. 1992;191:477-9 pubmed
  34. Heinly C, Sempowski G, Lee D, Patel D, McDermott P, Scearce R, et al. Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice. Int Immunol. 2001;13:157-66 pubmed
    ..05). Thus, CD7 and CD28 deficiencies combined to produce abnormalities in the absolute number of B7-1/B7-2-expressing cells in the thymus, thymocyte IL-2 receptor expression and CD3-triggered cytokine production. ..
  35. Ferguson E, Rathmell J. New roles for pyruvate kinase M2: working out the Warburg effect. Trends Biochem Sci. 2008;33:359-62 pubmed publisher
    ..PKM2 enhances the use of glycolytic intermediates for macromolecular biosynthesis and tumor growth. These findings illustrate the distinct advantages of this metabolic phenotype in cancer cell growth. ..
  36. Allen L, Lefkowitz R, Caron M, Cotecchia S. G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc Natl Acad Sci U S A. 1991;88:11354-8 pubmed
    ..These findings suggest that analogous spontaneously occurring mutations in this class of receptor proteins could play a key role in the induction or progression of neoplastic transformation and atherosclerosis. ..
  37. Kwak E, Gerald N, Larochelle D, Vithalani K, Niswonger M, Maready M, et al. LvsA, a protein related to the mouse beige protein, is required for cytokinesis in Dictyostelium. Mol Biol Cell. 1999;10:4429-39 pubmed
    ..Thus, on the basis of the sequence analysis of the LvsA protein and the phenotype of the lvsA mutants, we postulate that LvsA plays an important role in a membrane-processing pathway that is essential for cytokinesis. ..
  38. Dietze E, Caldwell L, Grupin S, Mancini M, Seewaldt V. Tamoxifen but not 4-hydroxytamoxifen initiates apoptosis in p53(-) normal human mammary epithelial cells by inducing mitochondrial depolarization. J Biol Chem. 2001;276:5384-94 pubmed
    ..We hypothesize that an early event in the induction of apoptosis by tamoxifen involves mitochondrial depolarization and caspase activation, and this may be important for effective chemoprevention. ..
  39. Pendergast A. The Abl family kinases: mechanisms of regulation and signaling. Adv Cancer Res. 2002;85:51-100 pubmed
  40. Erickson H. The FtsZ protofilament and attachment of ZipA--structural constraints on the FtsZ power stroke. Curr Opin Cell Biol. 2001;13:55-60 pubmed
    ..A model is proposed here for how membrane-bound ZipA can reach around the FtsZ protofilament to bind the carboxy-terminal peptide, which faces away from the membrane. ..
  41. Ueda Y, Liao D, Yang K, Patel A, Kelsoe G. T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. J Immunol. 2007;178:3593-601 pubmed
    ..We propose that inflammation-induced extramedullary lymphopoiesis represents a specialized mechanism for innate Ab responses to microbial pathogens. ..
  42. Dhar S, Bitting R, Rylova S, Jansen P, Lockhart E, Koeberl D, et al. Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. Ann Neurol. 2002;51:448-66 pubmed
    ..Flupirtine may be useful as a drug capable of halting the progression of neurodegenerative diseases caused by dysregulated apoptosis. ..
  43. Yingling J, Das P, Savage C, Zhang M, Padgett R, Wang X. Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. Proc Natl Acad Sci U S A. 1996;93:8940-4 pubmed
  44. Reya T, Duncan A, Ailles L, Domen J, Scherer D, Willert K, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003;423:409-14 pubmed
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development. ..
  45. Bowers E, Horvath J, Bond J, Cianciolo G, Pizzo S. Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response. J Leukoc Biol. 2009;86:1259-68 pubmed publisher
    ..These results support alpha(2)M* as an effective antigen-delivery system that may be particularly useful for vaccines based on weakly immunogenic subunits or requiring dose sparing...
  46. Chen K, Koe C, Xing Z, Tian X, Rossi F, Wang C, et al. Arl2- and Msps-dependent microtubule growth governs asymmetric division. J Cell Biol. 2016;212:661-76 pubmed publisher
    ..Therefore, Arl2- and Msps-dependent microtubule growth is a new paradigm regulating asymmetric division of neural stem cells. ..
  47. Abu Issa R, Smyth G, Smoak I, Yamamura K, Meyers E. Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Development. 2002;129:4613-25 pubmed
    ..This study defines the cardiovascular defects present in Fgf8 mutants and supports a role for Fgf8 in development of all the pharyngeal arches and in NCC survival. ..
  48. Liu Y, Jiang H, Crawford H, Hogan B. Role for ETS domain transcription factors Pea3/Erm in mouse lung development. Dev Biol. 2003;261:10-24 pubmed
    ..Our results provide the first functional evidence that Pea3 subfamily members play a role in epithelial-mesenchymal interactions during lung organogenesis. ..
  49. Pedrotty D, Koh J, Davis B, Taylor D, Wolf P, Niklason L. Engineering skeletal myoblasts: roles of three-dimensional culture and electrical stimulation. Am J Physiol Heart Circ Physiol. 2005;288:H1620-6 pubmed
    ..Hence, cardiac milieu appears to stimulate proliferation but does not affect differentiation of skeletal myoblasts...
  50. Baba T, Convery P, Matsumura N, Whitaker R, Kondoh E, Perry T, et al. Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. Oncogene. 2009;28:209-18 pubmed publisher
    ..The activity of these cells may be epigenetically detected and such cells might serve as pertinent chemotherapeutic targets for reducing disease recurrence...
  51. Buchakjian M, Kornbluth S. The engine driving the ship: metabolic steering of cell proliferation and death. Nat Rev Mol Cell Biol. 2010;11:715-27 pubmed publisher
    ..Elucidating these pathways is of great importance, as metabolic aberrations and their downstream effects are known to contribute to the aetiology of cancer and degenerative disorders. ..
  52. Lin H, Schagat T. Neuroblasts: a model for the asymmetric division of stem cells. Trends Genet. 1997;13:33-9 pubmed
    ..These findings are illuminating in understanding the general mechanism of stem cell division. ..
  53. Qumsiyeh M. Structure and function of the nucleus: anatomy and physiology of chromatin. Cell Mol Life Sci. 1999;55:1129-40 pubmed
    ..5) Chromosomal autoconstruction and reconstruction into a functional nucleus are altered during cell cycle and during differentiation (much more work needed on this area). ..
  54. Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, et al. Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol Cell Biol. 2000;20:3626-32 pubmed
    ..Thus, the previously described specificity of Rb function as a transcriptional repressor in quiescent cells coincides with the association of Rb with this novel E2F product. ..
  55. Ward R, Schweizer L, Lamb R, Fehon R. The protein 4.1, ezrin, radixin, moesin (FERM) domain of Drosophila Coracle, a cytoplasmic component of the septate junction, provides functions essential for embryonic development and imaginal cell proliferation. Genetics. 2001;159:219-28 pubmed
    ..This result suggests the presence of a second functional domain within Coracle, a notion supported by molecular characterization of a series of coracle alleles. ..
  56. Kiehart D. Myosins motor Miranda. Mol Cell. 2003;12:1346-7 pubmed
    ..New evidence shows that myosin motors drive the spatial segregation of cell fate determinants during asymmetric cell division. How they do so remains a mystery. ..
  57. Wang Z, Lin H. Nanos maintains germline stem cell self-renewal by preventing differentiation. Science. 2004;303:2016-9 pubmed
    ..Thus, Nanos is essential for both establishing and maintaining GSCs by preventing their precocious entry into oogenesis. These functions are likely achieved by repressing the translation of differentiation factors in PGCs and GSCs. ..
  58. Huang J, Niu X, Pippen A, Annex B, Kontos C. Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia. Arterioscler Thromb Vasc Biol. 2005;25:354-8 pubmed
    ..Thus, PTEN provides a new target for the treatment of neointimal hyperplasia. ..
  59. Cui H, Benfey P. Interplay between SCARECROW, GA and LIKE HETEROCHROMATIN PROTEIN 1 in ground tissue patterning in the Arabidopsis root. Plant J. 2009;58:1016-27 pubmed publisher
    ..Together, these results suggest that epigenetic regulation is probably the common basis for SCR and GA activity in cortex cell proliferation. ..
  60. Szakmary A, Reedy M, Qi H, Lin H. The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster. J Cell Biol. 2009;185:613-27 pubmed publisher
    ..The entire Yb protein is necessary for piwi expression in niche cells. A double mutant of Yb and a novel locus show male germline loss, revealing a function for Yb in male germline stem cell maintenance. ..
  61. Mork L, Tang H, Batchvarov I, Capel B. Mouse germ cell clusters form by aggregation as well as clonal divisions. Mech Dev. 2012;128:591-6 pubmed publisher
    ..We show that germ cell clusters in the fetal gonad arise through aggregation as well as cell division. Intercellular bridges, however, are likely restricted to cells of the same genotype. ..
  62. Alarcon C, Heitman J, Cardenas M. Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. Mol Biol Cell. 1999;10:2531-46 pubmed
  63. Rich J, Zhang M, Datto M, Bigner D, Wang X. Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. J Biol Chem. 1999;274:35053-8 pubmed
    ..This suggests that the loss of p15(INK4B) may explain, in part, the selective loss of growth inhibition by TGF-beta in gliomas to form a more aggressive tumor phenotype. ..
  64. Gerald N, Damer C, O Halloran T, De Lozanne A. Cytokinesis failure in clathrin-minus cells is caused by cleavage furrow instability. Cell Motil Cytoskeleton. 2001;48:213-23 pubmed
    ..We postulate that this morphology is the result of contraction at the rear of the presumptive daughter cells in concert with incomplete furrow ingression. ..
  65. Ohtani K, DeGregori J, Nevins J. Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci U S A. 1995;92:12146-50 pubmed
    ..These results suggest the involvement of E2F1 and cyclin E in an autoregulatory loop that governs the accumulation of critical activities affecting the progression of cells through G1. ..
  66. Cox D, Chao A, Baker J, Chang L, Qiao D, Lin H. A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Genes Dev. 1998;12:3715-27 pubmed
    ..Decreasing C. elegans piwi expression reduces the proliferation of GSC-equivalent cells. Thus, piwi represents a novel class of genes required for GSC division in diverse organisms. ..
  67. Flores K, McAllister K, Greer P, Wiseman R, Hale L. Thymic model for examining BRCA2 expression and function. Mol Carcinog. 2002;35:103-9 pubmed
    ..These studies suggest that BRCA2 mRNA levels are modulated during DNA damage and may be important during apoptosis. ..
  68. Suliman H, Carraway M, Welty Wolf K, Whorton A, Piantadosi C. Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. J Biol Chem. 2003;278:41510-8 pubmed
    ..NRF-1 expression and growth were restored by exogenous oxidant exposure indicating that oxidative stress stimulates biogenesis in part via NRF-1 activation and corresponding to recovery events after LPS-induced liver damage. ..
  69. Chen Y, Bjornson K, Redick S, Erickson H. A rapid fluorescence assay for FtsZ assembly indicates cooperative assembly with a dimer nucleus. Biophys J. 2005;88:505-14 pubmed
    ..Fragmentation was absent in the model, another characteristic of cooperative assembly. We are left with an enigma: how can the FtsZ protofilament, which appears to be one-subunit thick, assemble with apparent cooperativity? ..
  70. Kozmin S, Jinks Robertson S. The mechanism of nucleotide excision repair-mediated UV-induced mutagenesis in nonproliferating cells. Genetics. 2013;193:803-17 pubmed publisher
    ..The requirement for specific DNA-damage checkpoint proteins suggests roles in recruiting and/or activating factors required to fill such gaps. ..
  71. Seldin L, Muroyama A, Lechler T. NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures. elife. 2016;5: pubmed publisher
    ..Our results reveal an additional and direct function of NuMA during mitotic spindle positioning, as well as a reiterative use of spindle orientation in the skin to build diverse structures. ..
  72. Paidhungat M, Garrett S. Cdc1 is required for growth and Mn2+ regulation in Saccharomyces cerevisiae. Genetics. 1998;148:1777-86 pubmed
    ..These findings are compatible with a model in which Cdc1 regulates intracellular, and in particular cytosolic, Mn2+ levels which, in turn, are necessary for cell growth. ..
  73. Benov L, Fridovich I. Superoxide dependence of the toxicity of short chain sugars. J Biol Chem. 1998;273:25741-4 pubmed
    ..The toxicity of the short chain sugars appears to be because of an O-2-dependent oxidation to alpha, beta-dicarbonyl compounds. In keeping with this view was the O-2-independent toxicity of methylglyoxal. ..
  74. Udvadia A, Koster R, Skene J. GAP-43 promoter elements in transgenic zebrafish reveal a difference in signals for axon growth during CNS development and regeneration. Development. 2001;128:1175-82 pubmed
  75. Misra U, Akabani G, Pizzo S. The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation. J Biol Chem. 2002;277:36509-20 pubmed
    ..We conclude that cAMP-dependent signal transduction as well as other signaling cascades are essential for alpha(2)M*-induced cell proliferation. ..
  76. Atchison F, Capel B, Means A. Pin1 regulates the timing of mammalian primordial germ cell proliferation. Development. 2003;130:3579-86 pubmed
    ..These results indicate that Pin1 regulates the timing of PGC proliferation during mouse embryonic development. ..
  77. Poe J, Haas K, Uchida J, Lee Y, Fujimoto M, Tedder T. Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background. J Immunol. 2004;172:2100-10 pubmed
    ..Moreover, this study defines CD22 and CD40 as the first examples of lymphocyte coreceptors that influence induction of the c-Myc:CUL1 ubiquitin ligase pathway. ..
  78. Dzhagalov I, Giguere V, He Y. Lymphocyte development and function in the absence of retinoic acid-related orphan receptor alpha. J Immunol. 2004;173:2952-9 pubmed
  79. Nijhout H, Grunert L. The cellular and physiological mechanism of wing-body scaling in Manduca sexta. Science. 2010;330:1693-5 pubmed publisher
    ..Thus, proportional growth is under hormonal control and indirectly regulated by the central nervous system. ..
  80. Engel P, Gribben J, Freeman G, Zhou L, Nozawa Y, Abe M, et al. The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. Blood. 1994;84:1402-7 pubmed
    ..The FUN-1 monoclonal antibody also completely blocked the costimulatory activity of B7-2/B70 in functional assays. Therefore, the serologically defined CD86 differentiation antigen is the B7-2/B70 molecule. ..
  81. Pan X, Heitman J. Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:4874-87 pubmed
  82. Lopes N, Gregg D, Vasudevan S, Hassanain H, Goldschmidt Clermont P, Kovacic H. Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling. Mol Cell Biol. 2003;23:5401-8 pubmed
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