Experts and Doctors on cell cycle proteins in Durham, North Carolina, United States

Summary

Locale: Durham, North Carolina, United States
Topic: cell cycle proteins

Top Publications

  1. Yamada A, Duffy B, Perry J, Kornbluth S. DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7. J Cell Biol. 2004;167:841-9 pubmed
    ..These data establish Hsl7 as a component of the replication checkpoint and reveal that similar cell cycle control modules can be co-opted for use by distinct checkpoints in different organisms. ..
  2. Schmalzigaug R, Rodriguiz R, Bonner P, Davidson C, Wetsel W, Premont R. Impaired fear response in mice lacking GIT1. Neurosci Lett. 2009;458:79-83 pubmed publisher
    ..However, GIT1-KO mice show impaired responses to fear conditioning and fear-potentiated startle. Overall, these findings suggest that GIT1 is involved in the regulation of amygdala-mediated experience-based emotional behaviors. ..
  3. Cui B, Johnson S, Bullock N, Ali Osman F, Bigner D, Friedman H. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Mol Pharmacol. 2009;75:1356-63 pubmed publisher
    ..This MMR-independent activation seems to be the result of DNA interstrand cross-link formation. ..
  4. Hickman M, Rusche L. The Sir2-Sum1 complex represses transcription using both promoter-specific and long-range mechanisms to regulate cell identity and sexual cycle in the yeast Kluyveromyces lactis. PLoS Genet. 2009;5:e1000710 pubmed publisher
    ..This study reveals that a single repressive complex can act through two distinct mechanisms to regulate gene expression and illustrates how mechanisms by which regulatory proteins act can change over evolutionary time...
  5. Ding Q, MacAlpine D. Preferential re-replication of Drosophila heterochromatin in the absence of geminin. PLoS Genet. 2010;6:e1001112 pubmed publisher
    ..These results suggest that there are chromatin and cell cycle specific controls that regulate the re-assembly of the pre-RC outside of G1. ..
  6. Giangrande P, Zhu W, Rempel R, Laakso N, Nevins J. Combinatorial gene control involving E2F and E Box family members. EMBO J. 2004;23:1336-47 pubmed
    ..We propose that these examples of combinatorial interactions involving E2F proteins provide a basis for the specificity of transcription control in the Rb/E2F pathway. ..
  7. DeGregori J, Leone G, Miron A, Jakoi L, Nevins J. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci U S A. 1997;94:7245-50 pubmed
    ..We conclude that E2F family members play distinct roles in cell cycle control and that E2F1 may function as a specific signal for the initiation of an apoptosis pathway that must normally be blocked for a productive proliferation event. ..
  8. Premont R, Perry S, Schmalzigaug R, Roseman J, Xing Y, Claing A. The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors. Cell Signal. 2004;16:1001-11 pubmed
    ..Thus, GIT and PIX proteins are tightly associated as a multimeric nexus capable of linking together important signaling molecules, including PAKs. ..
  9. Fang Y, Tsao C, Goodman B, Furumai R, Tirado C, Abraham R, et al. ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J. 2004;23:3164-74 pubmed
    ..These results demonstrate that MMR proteins and ATR functionally interact during the cellular response to genotoxic stress, and that ATR serves as a haploinsufficient tumor suppressor in MMR-deficient cells. ..

More Information

Publications90

  1. Fujimoto M, Fujimoto Y, Poe J, Jansen P, Lowell C, DeFranco A, et al. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity. 2000;13:47-57 pubmed
    ..Thus, CD19 functions as a specialized adapter protein for the amplification of Src family kinases that is crucial for intrinsic and antigen receptor-induced signal transduction. ..
  2. Yu L, Kelly U, Ebright J, Malek G, Saloupis P, Rickman D, et al. Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina. Biochim Biophys Acta. 2007;1773:1473-82 pubmed
    ..These findings suggest that PRL-1 is a molecular component of the photoreceptor's response to oxidative stress acting upstream of the glutathione system. ..
  3. Keaton M, Bardes E, Marquitz A, Freel C, Zyla T, Rudolph J, et al. Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation. Curr Biol. 2007;17:1181-9 pubmed
    ..In yeast cells, the combination of CKI binding and preferential phosphorylation/dephosphorylation of different B cyclin/CDK complexes renders S phase progression immune from checkpoints acting via CDK tyrosine phosphorylation. ..
  4. Zhang F, Diehl R, Kohl N, Gibbs J, Giros B, Casey P, et al. cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I. J Biol Chem. 1994;269:3175-80 pubmed
  5. Wu Q, Guo Y, Yamada A, Perry J, Wang M, Araki M, et al. A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. Curr Biol. 2007;17:213-24 pubmed
    ..This balance allows proper maintenance of Cyclin B levels and Cdc2 kinase activity during CSF arrest. ..
  6. Johnson D, Cress W, Jakoi L, Nevins J. Oncogenic capacity of the E2F1 gene. Proc Natl Acad Sci U S A. 1994;91:12823-7 pubmed
    ..Cells transfected with E2F1 and DP1 or the E2F1-VP16 chimera form colonies in soft agar and induce tumor formation in nude mice. We conclude that deregulated E2F1 expression and function can have oncogenic consequences. ..
  7. Schmalzigaug R, Phee H, Davidson C, Weiss A, Premont R. Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. J Histochem Cytochem. 2007;55:1039-48 pubmed
  8. Pi M, Quarles L. A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium. J Bone Miner Res. 2004;19:862-9 pubmed
    ..These findings are consistent with strontium activation of a novel Galphaq-coupled extracellular cation-sensing receptor in osteoblasts with distinct cation specificity. ..
  9. Smith J, Evans E, Murakami M, Moyer M, Moseley M, Vande Woude G, et al. Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. J Cell Biol. 2000;151:1391-400 pubmed
  10. Mason E, Zhao Y, Goraksha Hicks P, Coloff J, Gannon H, Jones S, et al. Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer Res. 2010;70:8066-76 pubmed publisher
    ..These data show that distinct pathways regulate p53 after DNA damage and metabolic stress and that inhibiting glucose metabolism may enhance the efficacy of and overcome resistance to targeted molecular cancer therapies. ..
  11. Ito A, Kawaguchi Y, Lai C, Kovacs J, Higashimoto Y, Appella E, et al. MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J. 2002;21:6236-45 pubmed
  12. Walsh S, Margolis S, Kornbluth S. Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx. Mol Cancer Res. 2003;1:280-9 pubmed
    ..Collectively, these data demonstrate a new role for Erk in mitotic regulation, identify the Ser 101-directed kinase, and provide a picture of cyclin B1/Cdc2 regulation by the combinatorial action of distinct kinases. ..
  13. Paschen W, Proud C, Mies G. Shut-down of translation, a global neuronal stress response: mechanisms and pathological relevance. Curr Pharm Des. 2007;13:1887-902 pubmed
  14. Wang W, Huper G, Guo Y, Murphy S, Olson J, Marks J. Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer. Oncogene. 2005;24:2705-14 pubmed
    ..Therefore, this simple method of dynamic transcriptional profiling yielded a series of novel methylation-sensitive genes in breast cancer including the BRCA1 and p53 responsive gene, GADD45a. ..
  15. Zurita Martinez S, Puria R, Pan X, Boeke J, Cardenas M. Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. Genetics. 2007;176:2139-50 pubmed
  16. Nikitin P, Yan C, Forte E, Bocedi A, Tourigny J, White R, et al. An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. Cell Host Microbe. 2010;8:510-22 pubmed publisher
    ..We propose that heightened oncogenic activity in early cell divisions activates a growth-suppressive DDR that is attenuated by viral latency products to induce cell immortalization. ..
  17. Liu H, Toyn J, Chiang Y, Draper M, Johnston L, Denis C. DBF2, a cell cycle-regulated protein kinase, is physically and functionally associated with the CCR4 transcriptional regulatory complex. EMBO J. 1997;16:5289-98 pubmed
    ..These data indicate that DBF2 is involved in the control of gene expression and suggest that the CCR4 complex regulates transcription during the late mitotic part of the cell cycle. ..
  18. Cardenas M, Heitman J. FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. EMBO J. 1995;14:5892-907 pubmed
    ..These studies demonstrate that TOR2 is an essential, highly conserved component of a signal transduction pathway regulating cell cycle progression conserved from yeast to man. ..
  19. McMillan J, Sia R, Lew D. A morphogenesis checkpoint monitors the actin cytoskeleton in yeast. J Cell Biol. 1998;142:1487-99 pubmed
    ..However, the ability to respond to such perturbations by delaying cell cycle progression was restricted to a narrow window of the cell cycle, delimited by the periodic accumulation of the checkpoint effector, Swe1p. ..
  20. Fehon R, Oren T, LaJeunesse D, Melby T, McCartney B. Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method. Genetics. 1997;146:245-52 pubmed
  21. Barrott J, Haystead T. Hsp90, an unlikely ally in the war on cancer. FEBS J. 2013;280:1381-96 pubmed publisher
    ..We propose that in contrast to the majority of chemotherapeutics our growing armamentarium of investigational Hsp90 drugs represents an elegant choice that offers real hope in the long-term treatment of certain cancers. ..
  22. Yan S, Wang W, Marques J, Mohan R, Saleh A, Durrant W, et al. Salicylic acid activates DNA damage responses to potentiate plant immunity. Mol Cell. 2013;52:602-10 pubmed publisher
    ..Our study suggests that activation of DNA damage responses is an intrinsic component of the plant immune responses. ..
  23. McNulty J, Lew D. Swe1p responds to cytoskeletal perturbation, not bud size, in S. cerevisiae. Curr Biol. 2005;15:2190-8 pubmed
    ..Swe1p does not respond to insufficient bud size. Instead, actin stress empowers Swe1p to promote arrest. The effectiveness of Swe1p in promoting that arrest declines as cells progress through the cell cycle. ..
  24. Ohtani K, DeGregori J, Nevins J. Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci U S A. 1995;92:12146-50 pubmed
    ..These results suggest the involvement of E2F1 and cyclin E in an autoregulatory loop that governs the accumulation of critical activities affecting the progression of cells through G1. ..
  25. Rogers K, Higgins P, Milla M, Phillips R, Horowitz J. DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. Proc Natl Acad Sci U S A. 1996;93:7594-9 pubmed
    ..Thus, we conclude that DP-2 encodes a set of structurally, and perhaps functionally, distinct proteins in vivo. ..
  26. Kadyrov F, Dzantiev L, Constantin N, Modrich P. Endonucleolytic function of MutLalpha in human mismatch repair. Cell. 2006;126:297-308 pubmed
    ..Therefore, the mode of excision initiation may differ in these organisms. ..
  27. Komarnitsky S, Chiang Y, Luca F, Chen J, Toyn J, Winey M, et al. DBF2 protein kinase binds to and acts through the cell cycle-regulated MOB1 protein. Mol Cell Biol. 1998;18:2100-7 pubmed
    ..We discuss models concerning the role of DBF2 and MOB1 in controlling the telophase/G1 transition. ..
  28. Slifer M, Martin E, Bronson P, Browning Large C, Doraiswamy P, Welsh Bohmer K, et al. Lack of association between UBQLN1 and Alzheimer disease. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:208-13 pubmed
    ..Our results suggest that UBQLN1 variants do not increase risk for AD in these data. ..
  29. Westmoreland T, Marks J, Olson J, Thompson E, Resnick M, Bennett C. Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. Eukaryot Cell. 2004;3:430-46 pubmed
    ..These results indicate that cell cycle transition through G1 and S phases is CCR4 dependent following radiation or replication stress. ..
  30. Deeks M, Rodrigues C, Dimmock S, Ketelaar T, Maciver S, Malhó R, et al. Arabidopsis CAP1 - a key regulator of actin organisation and development. J Cell Sci. 2007;120:2609-18 pubmed
    ..Surprisingly, cap1 plants show disruption in plant signalling pathways required for co-ordinated organ expansion suggesting that plant CAP has evolved to attain plant-specific signalling functions. ..
  31. Li X, McDonnell D. The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Mol Cell Biol. 2002;22:3663-73 pubmed
    ..Cumulatively, these findings suggest that the nuclear corepressors N-CoR and SMRT serve a previously unappreciated role as regulators of B-Myb transcriptional activity. ..
  32. Ohtani K, Nevins J. Functional properties of a Drosophila homolog of the E2F1 gene. Mol Cell Biol. 1994;14:1603-12 pubmed
    ..We conclude that the drosE2F1 cDNA encodes an activity with extensive structural and functional similarity to the human E2F1 protein. ..
  33. Yan Z, Choi S, Liu X, Zhang M, Schageman J, Lee S, et al. Highly coordinated gene regulation in mouse skeletal muscle regeneration. J Biol Chem. 2003;278:8826-36 pubmed
    ..This study identifies novel genes potentially important for muscle regeneration and reveals highly coordinated myogenic cell proliferation and differentiation programs in adult skeletal muscle regeneration in vivo. ..
  34. Smith D, Leone G, DeGregori J, Ahmed M, Qumsiyeh M, Nevins J. Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. Cell Growth Differ. 2000;11:625-33 pubmed
    ..This suggests the existence of cell type-specific inhibitory pathways induced by these signals. ..
  35. Bose I, Irazoqui J, Moskow J, Bardes E, Zyla T, Lew D. Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. J Biol Chem. 2001;276:7176-86 pubmed
    ..We suggest that Bem1p acts to concentrate polarity establishment proteins at a discrete site, facilitating polarization and promoting Cdc24p phosphorylation at specific times during the cell cycle. ..
  36. Premont R, Claing A, Vitale N, Freeman J, Pitcher J, Patton W, et al. beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proc Natl Acad Sci U S A. 1998;95:14082-7 pubmed
    ..Moreover, they provide a mechanism for integration of receptor activation and endocytosis through regulation of ARF protein activation by GRK-mediated recruitment of the GIT1 ARF GAP to the plasma membrane. ..
  37. Lorenz M, Heitman J. TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. J Biol Chem. 1995;270:27531-7 pubmed
    ..These studies confirm that the TOR proteins are direct targets of FKBP12-rapamycin, reveal that drug-resistant mutations prevent this association, and define structural features of these complexes. ..
  38. McMillan J, Longtine M, Sia R, Theesfeld C, Bardes E, Pringle J, et al. The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. Mol Cell Biol. 1999;19:6929-39 pubmed
    ..These findings suggest that Hsl1p and Hsl7p interact directly with Swe1p to promote its recognition by the ubiquitination complex, leading ultimately to its destruction. ..
  39. Chellappan S, Hiebert S, Mudryj M, Horowitz J, Nevins J. The E2F transcription factor is a cellular target for the RB protein. Cell. 1991;65:1053-61 pubmed
  40. Fujimoto M, Poe J, Jansen P, Sato S, Tedder T. CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. J Immunol. 1999;162:7088-94 pubmed
    ..The absence of this CD19/Src-family kinase amplification loop may account for the hyporesponsive phenotype of CD19-deficient B cells. ..
  41. Shaheen R, Shamseldin H, Loucks C, Seidahmed M, Ansari S, Ibrahim Khalil M, et al. Mutations in CSPP1, encoding a core centrosomal protein, cause a range of ciliopathy phenotypes in humans. Am J Hum Genet. 2014;94:73-9 pubmed publisher
    ..Our results expand the list of centrosomal proteins implicated in human ciliopathies. ..
  42. Asano M, Nevins J, Wharton R. Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev. 1996;10:1422-32 pubmed
    ..Furthermore, they suggest that the downregulation of E2F upon entry into S phase may be essential to prevent the induction of apoptosis. ..
  43. Wang W, Nahta R, Huper G, Marks J. TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein. Mol Cancer Res. 2004;2:442-52 pubmed
    ..GADD45a null cells are not subject to TAFII70 inhibition, further supporting the relevance of this interaction. ..
  44. Cook J, Chasse D, Nevins J. The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. J Biol Chem. 2004;279:9625-33 pubmed
  45. Hemenway C, Heitman J. Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae. Mol Gen Genet. 1999;261:388-401 pubmed
    ..Taken together, our findings support a model in which calcineurin and Lic4 are components of signalling cascades that regulate cation stress responses in yeast. ..
  46. Winkler K, Swenson K, Kornbluth S, Means A. Requirement of the prolyl isomerase Pin1 for the replication checkpoint. Science. 2000;287:1644-7 pubmed
    ..Therefore, Pin1 appears to be required for the checkpoint delaying the onset of mitosis in response to incomplete replication. ..
  47. Kozmin S, Jinks Robertson S. The mechanism of nucleotide excision repair-mediated UV-induced mutagenesis in nonproliferating cells. Genetics. 2013;193:803-17 pubmed publisher
    ..The requirement for specific DNA-damage checkpoint proteins suggests roles in recruiting and/or activating factors required to fill such gaps. ..
  48. Silverstone A, Ciampaglio C, Sun T. The Arabidopsis RGA gene encodes a transcriptional regulator repressing the gibberellin signal transduction pathway. Plant Cell. 1998;10:155-69 pubmed
    ..Because the rga mutation abolished the high level of expression of the GA biosynthetic gene GA4 in the ga1-3 mutant background, we conclude that RGA may also play a role in controlling GA biosynthesis. ..
  49. Schmalzigaug R, Rodriguiz R, Phillips L, Davidson C, Wetsel W, Premont R. Anxiety-like behaviors in mice lacking GIT2. Neurosci Lett. 2009;451:156-61 pubmed publisher
    ..Immobility times in tail suspension were reduced in GIT2-KO males, but were normal in GIT2-KO females. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses. ..
  50. McMillan J, Theesfeld C, Harrison J, Bardes E, Lew D. Determinants of Swe1p degradation in Saccharomyces cerevisiae. Mol Biol Cell. 2002;13:3560-75 pubmed
    ..The other region did not appear to affect interactions with known Swe1p regulators, suggesting that other as-yet-unknown regulators exist. ..
  51. Schlisio S, Halperin T, Vidal M, Nevins J. Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. EMBO J. 2002;21:5775-86 pubmed
    ..We suggest that the ability of RYBP to mediate an interaction between E2F2 or E2F3 and YY1 is an important component of Cdc6 activation and provides a basis for specificity of E2F function. ..
  52. Crenshaw D, Yang J, Means A, Kornbluth S. The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. EMBO J. 1998;17:1315-27 pubmed
    ..Taken together, these data suggest that Pin1 may modulate cell cycle control through interaction with Cdc25 and its activator, Plx1. ..
  53. Swenson K, Winkler K, Means A. A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. Mol Biol Cell. 2003;14:156-72 pubmed
    ..Our studies suggest a new role for MLK3, separable from its function in the JNK pathway, that may contribute to promoting microtubule instability, a hallmark of M phase entry. ..
  54. Tu Q, Pi M, Quarles L. Calcyclin mediates serum response element (SRE) activation by an osteoblastic extracellular cation-sensing mechanism. J Bone Miner Res. 2003;18:1825-33 pubmed
    ..These results implicate calcyclin in the activation of SRE and establish a role for calcyclin as an accessory protein involved in the cation-sensing pathway in osteoblasts. ..
  55. Culligan K, Britt A. Both ATM and ATR promote the efficient and accurate processing of programmed meiotic double-strand breaks. Plant J. 2008;55:629-38 pubmed publisher
    ..They also indicate that ATM and ATR act redundantly to inhibit sustained interactions between non-homologous chromatids, and that these ectopic interactions require SPO11 activity. ..
  56. Guo J, Yamada A, Kajino T, Wu J, Tang W, Freel C, et al. Aven-dependent activation of ATM following DNA damage. Curr Biol. 2008;18:933-42 pubmed publisher
    ..In aggregate, these findings place Aven, a known apoptotic inhibitor, as a critical transducer of the DNA-damage signal. ..
  57. Brush M, Shenolikar S. Control of cellular GADD34 levels by the 26S proteasome. Mol Cell Biol. 2008;28:6989-7000 pubmed publisher
  58. Chen H, Kuo C, Kang H, Howell A, Zyla T, Jin M, et al. Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p. Mol Biol Cell. 2012;23:3814-26 pubmed publisher
    ..We suggest that an indirect mechanism linking Rho GTPases and formins via Rho effectors may provide finer spatiotemporal control for the formin-nucleated actin cytoskeleton. ..
  59. Park S, Asano M. The origin recognition complex is dispensable for endoreplication in Drosophila. Proc Natl Acad Sci U S A. 2008;105:12343-8 pubmed publisher
    ..This study provides insight into the physiologic roles of ORC during metazoan development and proposes that DNA replication initiation is governed differently in mitotic and endocycles. ..
  60. Mudryj M, Devoto S, Hiebert S, Hunter T, Pines J, Nevins J. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell. 1991;65:1243-53 pubmed
    ..We suggest that these interactions control the activity of E2F and that disruption of the complexes by E1A contributes to a loss of cellular proliferation control. ..
  61. Jackson L, Reed S, Haase S. Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6. Mol Cell Biol. 2006;26:2456-66 pubmed
    ..Taken together, these findings suggest that the SCF(Cdc4) ubiquitin ligase complex regulates Clb6 turnover and that the functional differences exhibited by Clb5 and Clb6 arise from the distinct mechanisms controlling their stability. ..
  62. Johnson D, Ohtani K, Nevins J. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev. 1994;8:1514-25 pubmed
  63. Ikeda M, Jakoi L, Nevins J. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc Natl Acad Sci U S A. 1996;93:3215-20 pubmed
    ..These results suggest that the specific ability of Rb protein to interact with each E2F species, dependent on concentration of active Rb relative to accumulation of E2F, may be critical in cell-growth decisions. ..
  64. Paidhungat M, Garrett S. Cdc1 is required for growth and Mn2+ regulation in Saccharomyces cerevisiae. Genetics. 1998;148:1777-86 pubmed
    ..These findings are compatible with a model in which Cdc1 regulates intracellular, and in particular cytosolic, Mn2+ levels which, in turn, are necessary for cell growth. ..
  65. Theesfeld C, Zyla T, Bardes E, Lew D. A monitor for bud emergence in the yeast morphogenesis checkpoint. Mol Biol Cell. 2003;14:3280-91 pubmed
    ..We discuss models for translating cellular geometry (in this case, the emergence of a bud) into biochemical signals regulating cell proliferation. ..
  66. Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams R, et al. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev. 1998;12:2120-30 pubmed
  67. Smith J, Richardson D, Kopf J, Yoshida M, Hollingsworth R, Kornbluth S. Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin. Mol Cell Biol. 2002;22:1412-23 pubmed
    ..Collectively, these data suggest that a nuclear population of Crk bound to Wee1 promotes apoptotic death of mammalian cells. ..
  68. Rich J, Zhang M, Datto M, Bigner D, Wang X. Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. J Biol Chem. 1999;274:35053-8 pubmed
    ..This suggests that the loss of p15(INK4B) may explain, in part, the selective loss of growth inhibition by TGF-beta in gliomas to form a more aggressive tumor phenotype. ..
  69. Wang Q, Goldstein M, Alexander P, Wakeman T, Sun T, Feng J, et al. Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks. EMBO J. 2014;33:862-77 pubmed publisher
    ..These findings suggest that Rad17 plays a critical role in the cellular response to DNA damage via regulation of the MRN/ATM pathway. ..
  70. Paidhungat M, Garrett S. A homolog of mammalian, voltage-gated calcium channels mediates yeast pheromone-stimulated Ca2+ uptake and exacerbates the cdc1(Ts) growth defect. Mol Cell Biol. 1997;17:6339-47 pubmed
    ..These and other results suggest Mid1 and Cch1 are components of a yeast Ca2+ channel that may mediate Ca2+ uptake in response to mating pheromone, salt stress, and Mn2+ depletion. ..
  71. Wojtaszek J, Liu J, D Souza S, Wang S, Xue Y, Walker G, et al. Multifaceted recognition of vertebrate Rev1 by translesion polymerases ? and ?. J Biol Chem. 2012;287:26400-8 pubmed publisher
  72. Tibbetts R, Brumbaugh K, Williams J, Sarkaria J, Cliby W, Shieh S, et al. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 1999;13:152-7 pubmed
    ..ATR phosphorylated p53 at Ser-15 and Ser-37 in vitro, suggesting that p53 is a target for phosphorylation by ATR in DNA-damaged cells. ..
  73. Liang Y, Tedder T. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics. 2001;72:119-27 pubmed
    ..1 along with CD20, FcepsilonRIbeta, and HTm4. Thus, like CD20 and FcepsilonRIbeta, the other MS4A family members are likely to be components of oligomeric cell surface complexes that serve diverse signal transduction functions. ..
  74. Cao Y, Janssen E, Duncan A, Altman A, Billadeau D, Abraham R. Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J. 2002;21:4809-19 pubmed
    ..Vav1 cells. Finally, evidence is presented to suggest that the alternative Vav family members, Vav-2 and Vav-3, are activated during TCR ligation, and partially compensate for the loss of Vav-1 in Jurkat T cells. ..
  75. Poe J, Haas K, Uchida J, Lee Y, Fujimoto M, Tedder T. Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background. J Immunol. 2004;172:2100-10 pubmed
    ..Moreover, this study defines CD22 and CD40 as the first examples of lymphocyte coreceptors that influence induction of the c-Myc:CUL1 ubiquitin ligase pathway. ..
  76. Dang T, Bao S, Wang X. Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability. Genes Cells. 2005;10:287-95 pubmed
    ..Taken together, these results suggest a critical and specific role of Rad9 in the activation of S-phase checkpoint and the maintenance of chromosome stability. ..
  77. Ficklin M, Zhao S, Feng G. Ubiquilin-1 regulates nicotine-induced up-regulation of neuronal nicotinic acetylcholine receptors. J Biol Chem. 2005;280:34088-95 pubmed
    ..These data suggest that ubiquilin-1 limits the availability of unassembled nicotinic acetylcholine receptor subunits in neurons by drawing them to the proteosome, thus regulating nicotine-induced up-regulation. ..
  78. Lin W, Lin F, Nevins J. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001;15:1833-44 pubmed
    ..Finally, we also show that E2F1 is required for DNA damaged induced apoptosis in mouse thymocytes. We conclude that the cellular response to DNA damage makes use of signals from the Rb/E2F cell cycle pathway. ..
  79. Chen J, Rappsilber J, Chiang Y, Russell P, Mann M, Denis C. Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. J Mol Biol. 2001;314:683-94 pubmed
    ..The distinct location of CAF40 and CAF130 and the evolutionary conservation of CAF40 implicate them in novel roles in the function of the CCR4-NOT complex. ..
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    ..The origin of the angiogenic cells in this physiological exercise model remains to be determined...
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    ..Given previous work implicating E2F in the control of telomerase gene expression, these results thus point to complementary roles for the Rb/E2F pathway in the control of telomere length. ..