Experts and Doctors on biological clocks in Chapel Hill, North Carolina, United States
Locale: Chapel Hill, North Carolina, United States
Topic: biological clocks
Thompson C, Selby C, Van Gelder R, Blaner W, Lee J, Quadro L, et al
. Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice. J Biol Rhythms. 2004;19:504-17 pubmed
..These data demonstrate that both cryptochromes and opsins regulate nonvisual photoresponses. ..
Kang T, Lindsey Boltz L, Reardon J, Sancar A. Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase. Proc Natl Acad Sci U S A. 2010;107:4890-5 pubmed publisher
..These findings may be used as a guide for timing of cisplatin chemotherapy. ..
Li G, Henriquez C, Frohlich F. Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation. PLoS Comput Biol. 2017;13:e1005797 pubmed publisher
..Our model proposes a broader and more central role of the thalamus in the genesis of multiple distinct thalamo-cortical rhythms than previously assumed...
Thrower D, Stemple J, Yeh E, Bloom K. Nuclear oscillations and nuclear filament formation accompany single-strand annealing repair of a dicentric chromosome in Saccharomyces cerevisiae. J Cell Sci. 2003;116:561-9 pubmed
..Our findings indicate that microtubule-dependent processes facilitate recombination...
Ozgur S, Sancar A. Purification and properties of human blue-light photoreceptor cryptochrome 2. Biochemistry. 2003;42:2926-32 pubmed
..These findings reveal new properties of this protein already known to function as a circadian photoreceptor and a light-independent negative transcriptional regulator of the clock genes. ..
Thompson C, Selby C, Partch C, Plante D, Thresher R, Araujo F, et al
. Further evidence for the role of cryptochromes in retinohypothalamic photoreception/phototransduction. Brain Res Mol Brain Res. 2004;122:158-66 pubmed
Miyamoto Y, Sancar A. Circadian regulation of cryptochrome genes in the mouse. Brain Res Mol Brain Res. 1999;71:238-43 pubmed
..Third, mutation in Cry2 causes a phase delay in Cry1 and mPer1 expression both in the SCN and internal organs relative to wild-type animals. Finally, no obvious periodicity in mCry2 expression was seen in all tissues tested. ..
Sancar A. Regulation of the mammalian circadian clock by cryptochrome. J Biol Chem. 2004;279:34079-82 pubmed
Partch C, Shields K, Thompson C, Selby C, Sancar A. Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5. Proc Natl Acad Sci U S A. 2006;103:10467-10472 pubmed publisher
..Collectively, these findings indicate that PP5, CKIepsilon, and cryptochrome dynamically regulate the mammalian circadian clock. ..