Genomes and Genes
Experts and Doctors on base sequence in Chapel Hill, North Carolina, United States
Locale: Chapel Hill, North Carolina, United States
Topic: base sequence
Publications204 found, 100 shown here
- Gowen L, Johnson B, Latour A, Sulik K, Koller B. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet. 1996;12:191-4 pubmed..In addition, the neuroepithelium in Brca1-deficient embryos appeared disorganized, with signs of both rapid proliferation and excessive cell death. ..
- Schultz T, Quatrano R. Characterization and expression of a rice RAD23 gene. Plant Mol Biol. 1997;34:557-62 pubmed..A single transcript (1.5 kb) of osRAD23 was detected in total RNA from rice embryonic tissue, while three transcripts (1.8, 1.5 and 1.0 kb) were observed in total RNA from vegetative tissues of rice. ..
- Yang N, Eckhart A, Xin X, Faber J. CRE-like response element regulates expression of rat alpha 2D-adrenergic receptor gene in vascular smooth muscle. Am J Physiol. 1997;273:H85-95 pubmed..In addition, promoter activity was increased 300% by forskolin or 8-bromoadenosine 3',5'-cyclic monophosphate, indicating that the CRE-like element may regulate alpha 2D-AR expression in vascular tissue...
- Zhang Y, Sun V, Spremulli L. Role of domains in Escherichia coli and mammalian mitochondrial elongation factor Ts in the interaction with elongation factor Tu. J Biol Chem. 1997;272:21956-63 pubmed..coli EF-Tu approximately 25-fold more tightly than E. coli EF-Ts. Thus, the higher strength of the interaction between EF-Tsmt and EF-Tu can be localized primarily to a single subdomain. ..
- Dominski Z, Erkmann J, Yang X, Sanchez R, Marzluff W. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. Genes Dev. 2002;16:58-71 pubmed..Antibodies to hZFP100 precipitate U7 snRNA, and expression of hZFP100 in Xenopus oocytes stimulates processing of histone pre-mRNA, showing that hZFP100 is a component of the processing machinery. ..
- Mager J, Montgomery N, de Villena F, Magnuson T. Genome imprinting regulated by the mouse Polycomb group protein Eed. Nat Genet. 2003;33:502-7 pubmed..These data identify Eed as a member of a new class of trans-acting factors that regulate parent-of-origin expression at imprinted loci. ..
- Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, et al. BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol Cell Biol. 2003;23:5664-79 pubmed
- Wang J, He X, Luo Y, Yarbrough W. A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. Biochem J. 2006;393:489-501 pubmed..Taken together, our data suggest that LZAP can regulate ARF biochemical and biological activity. Additionally, LZAP has p53-dependent cell-cycle effects that are independent of ARF. ..
- Reinhardt J, Baltrus D, Nishimura M, Jeck W, Jones C, Dangl J. De novo assembly using low-coverage short read sequence data from the rice pathogen Pseudomonas syringae pv. oryzae. Genome Res. 2009;19:294-305 pubmed publisher..syringae pan-genome, a corresponding contraction of the core genome, and a further diversification of the type III effector complement for this important plant pathogen species. ..
- Erickson L, Kim H, Maeda N. Junctions between genes in the haptoglobin gene cluster of primates. Genomics. 1992;14:948-58 pubmed..The observation that Alu sequences define the junctions between genes in the haptoglobin gene cluster emphasizes the importance of Alu sequences in the evolution of multigene families. ..
- Piedrahita J, Zhang S, Hagaman J, Oliver P, Maeda N. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A. 1992;89:4471-5 pubmed..Mice homozygous for the disrupted gene were produced from the heterozygotes; they appear healthy, even though they have no apolipoprotein E in their plasma. ..
- Brown E, Day S, Jansen R, Lemon S. The 5' nontranslated region of hepatitis A virus RNA: secondary structure and elements required for translation in vitro. J Virol. 1991;65:5828-38 pubmed..Significantly, this region shares several conserved structural features with the internal ribosome entry site element of murine encephalomyocarditis virus. ..
- Steinhauer W, Walsh R, Kalfayan L. Sequence and structure of the Drosophila melanogaster ovarian tumor gene and generation of an antibody specific for the ovarian tumor protein. Mol Cell Biol. 1989;9:5726-32 pubmed..5 kilobases. The proline-rich, hydrophilic otu protein is novel. An antibody prepared to a beta-gal-otu fusion protein recognized a 110-kilodalton ovarian protein which was altered in the ovaries of otu gene mutants. ..
- Lubahn D, Joseph D, Sullivan P, Willard H, French F, Wilson E. Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science. 1988;240:327-30 pubmed..The deduced amino acid sequence of AR within the DNA-binding domain has highest sequence identity with the progesterone receptor. ..
- Detloff P, Lewis J, John S, Shehee W, Langenbach R, Maeda N, et al. Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy. Mol Cell Biol. 1994;14:6936-43 pubmed..One plug deleted 20 kb of DNA containing the two adult beta-globin genes. The other replaced the same region with the human beta-globin gene containing the mutation responsible for sickle cell anemia. ..
- Hara Y, Ioannou P, Drousiotou A, Stylianidou G, Anastasiadou V, Suzuki K. Mutation analysis of a Sandhoff disease patient in the Maronite community in Cyprus. Hum Genet. 1994;94:136-40 pubmed..An extensive evaluation of the prevalence of this mutant allele in this community is being initiated. ..
- Ho K, Marschke K, Tan J, Power S, Wilson E, French F. A complex response element in intron 1 of the androgen-regulated 20-kDa protein gene displays cell type-dependent androgen receptor specificity. J Biol Chem. 1993;268:27226-35 pubmed..Interestingly, a 131-base pair subfragment of In-1c retained ARE specificity in all three cell lines. ..
- Hanson R, Sun J, Willis D, Marzluff W. Efficient extraction and partial purification of the polyribosome-associated stem-loop binding protein bound to the 3' end of histone mRNA. Biochemistry. 1996;35:2146-56 pubmed..Treatment of the polyribosomes with micrococcal nuclease prior to salt extraction solubilized 5-10 times more SLBP as an RNA-protein complex. The SLBP could be subsequently partially purified from this complex. ..
- Waldo G, Paterson A, Boyer J, Nicholas R, Harden T. Molecular cloning, expression and regulatory activity of G alpha 11- and beta gamma-subunit-stimulated phospholipase C-beta from avian erythrocytes. Biochem J. 1996;316 ( Pt 2):559-68 pubmed..The turkey PLC-beta was more sensitive to activation by G alpha 11 than was PLC-beta 2, and was more sensitive to activation by beta gamma-subunits than either PLC-beta 2 or PLC-beta 1. ..
- Nantel A, Quatrano R. Characterization of three rice basic/leucine zipper factors, including two inhibitors of EmBP-1 DNA binding activity. J Biol Chem. 1996;271:31296-305 pubmed..Thus, osZIP-2 factors may be involved in sequestering a particular group of G-box-binding factors into inactive heterodimers. ..
- Aitsebaomo J, Kingsley Kallesen M, Wu Y, Quertermous T, Patterson C. Vezf1/DB1 is an endothelial cell-specific transcription factor that regulates expression of the endothelin-1 promoter. J Biol Chem. 2001;276:39197-205 pubmed
- Duarte W, Shibata T, Takenaga K, Takahashi E, Kubota K, Ohya K, et al. S100A4: a novel negative regulator of mineralization and osteoblast differentiation. J Bone Miner Res. 2003;18:493-501 pubmed..These findings indicate that S100A4 is a novel negative regulator of matrix mineralization likely by modulating the process of osteoblast differentiation. ..
- Li J, Waters S, Drobna Z, Devesa V, Styblo M, Thomas D. Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype. Toxicol Appl Pharmacol. 2005;204:164-9 pubmed..This lineage-specific loss of function caused by the deletion event must have occurred in the Pan lineage after Homo-Pan divergence about 5 million years ago. ..
- Choi V, Samulski R, McCarty D. Effects of adeno-associated virus DNA hairpin structure on recombination. J Virol. 2005;79:6801-7 pubmed
- Bhattacharyya D, Ramachandran S, Sharma S, Pathmasiri W, King C, Baskerville Abraham I, et al. Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links. PLoS ONE. 2011;6:e23582 pubmed publisher..OX) play an important role in the conformation and the conformational dynamics of Pt-DNA adducts, possibly explaining their influence on the ability of many damage-recognition proteins to bind to Pt-DNA adducts. ..
- Rice G, Leonard C, Weeks K. RNA secondary structure modeling at consistent high accuracy using differential SHAPE. RNA. 2014;20:846-54 pubmed publisher..Three-reagent SHAPE-directed modeling scales concisely to structurally complex RNAs to resolve the in-solution secondary structure analysis problem for many classes of RNA. ..
- Nanba E, Suzuki K. Organization of the mouse acid beta-galactosidase gene. Biochem Biophys Res Commun. 1991;178:158-64 pubmed..Compared to the cDNA sequence from C57BL/6J mouse, there were five nucleotide polymorphisms in the protein-coding region, two of which resulted in altered amino acids. ..
- Bova C, Olsen J, Swanstrom R. The avian retrovirus env gene family: molecular analysis of host range and antigenic variants. J Virol. 1988;62:75-83 pubmed..Using a molecular recombinant, we demonstrated that type-specific neutralization of two subgroup A viruses was associated with the gp85-coding domain of the virus...
- Matsunaga T, Mu D, Park C, Reardon J, Sancar A. Human DNA repair excision nuclease. Analysis of the roles of the subunits involved in dual incisions by using anti-XPG and anti-ERCC1 antibodies. J Biol Chem. 1995;270:20862-9 pubmed..Using a defined system for excision repair we also demonstrate that the 3' incision can occur without the 5' incision, leading us to conclude that under certain conditions the two incisions can occur independently. ..
- Kim H, Lyons K, Saitoh E, Azen E, Smithies O, Maeda N. The structure and evolution of the human salivary proline-rich protein gene family. Mamm Genome. 1993;4:3-14 pubmed..During this evolutionary process, multiple rearrangements and gene conversion occurred mainly in the region from the 3' end of IVS2 and the 3' end of exon 3. ..
- Zhou Z, Gartner A, Cade R, Ammerer G, Errede B. Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases. Mol Cell Biol. 1993;13:2069-80 pubmed..Therefore, STE7 activation must precede modification of FUS3 (and KSS1). These findings suggest that STE7 hyperphosphorylation is a consequence of its activation but not the determining event. ..
- Stamm L, Young N, Frye J, Hardham J. Identification and sequences of the Treponema pallidum mglA and mglC genes. DNA Seq. 1996;6:293-8 pubmed..The putative T. pallidum mgl operon encodes the first high-affinity ABC transport system identified in this spirochete. ..
- Wang C, Guttridge D, Mayo M, Baldwin A. NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol. 1999;19:5923-9 pubmed..Our findings demonstrate that A1 is an important antiapoptotic gene controlled by NF-kappaB and establish that the prosurvival function of NF-kappaB can be manifested at multiple levels. ..
- Li T, Yang C, Jin D, Stafford D. Identification of a Drosophila vitamin K-dependent gamma-glutamyl carboxylase. J Biol Chem. 2000;275:18291-6 pubmed..We found the mRNA for Drosophila gamma-glutamyl carboxylase in virtually every embryonic and adult stage that we investigated, with the highest concentration evident in the adult head. ..
- Liu Q, Hamil K, Sivashanmugam P, Grossman G, Soundararajan R, Rao A, et al. Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and human. Endocrinology. 2001;142:4529-39 pubmed..The ESC42 gene, located on chromosome 20q11, contains two exons encoding two nearly identical predicted signal peptides and a third exon encoding the rest of the protein. ..
- Bassi G, de Oliveira D, White M, Weeks K. Recruitment of intron-encoded and co-opted proteins in splicing of the bI3 group I intron RNA. Proc Natl Acad Sci U S A. 2002;99:128-33 pubmed..Thus, the bI3 ribonucleoprotein is the product of a process in which a once-catalytically active RNA now obligatorily requires two facilitating protein cofactors, both of which are compromised in their original functions. ..
- Wong A, Ghosh N, McKinnon K, Reed W, Piskurich J, Wright K, et al. Regulation and specificity of MHC2TA promoter usage in human primary T lymphocytes and cell line. J Immunol. 2002;169:3112-9 pubmed..These results show that MHC2TA PIII is induced in activated T lymphocytes, and that the induced binding of ARE-2 is a crucial step in this process. ..
- Gaskins E, Gilk S, DeVore N, Mann T, Ward G, Beckers C. Identification of the membrane receptor of a class XIV myosin in Toxoplasma gondii. J Cell Biol. 2004;165:383-93 pubmed
- Stalheim L, Ding Y, Gullapalli A, Paing M, Wolfe B, Morris D, et al. Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. Mol Pharmacol. 2005;67:78-87 pubmed..These findings further suggest that the diverse functions of arrestins in regulating PAR2 signaling and trafficking are controlled by multiple independent interactions involving both the intracellular loops and the C-tail. ..
- Legassie J, Jarstfer M. Telomerase as a DNA-dependent DNA polymerase. Biochemistry. 2005;44:14191-201 pubmed..The splint ligation approach that we outline will allow the generation of tTR mutants containing a variety of nucleotide analogues, facilitating more elaborate studies of the interactions between the telomerase template and active site. ..
- Love D, Sobsey M. Simple and rapid F+ coliphage culture, latex agglutination, and typing assay to detect and source track fecal contamination. Appl Environ Microbiol. 2007;73:4110-8 pubmed
- Jones C, Wilkinson K, Hung K, Weeks K, Spremulli L. Lack of secondary structure characterizes the 5' ends of mammalian mitochondrial mRNAs. RNA. 2008;14:862-71 pubmed publisher..These data are consistent with a model in which the specialized mitochondrial ribosome preferentially allows passage of unstructured 5' sequences into the mRNA entrance site to participate in translation initiation. ..
- Heenan E, Vanhooke J, Temple B, Betts L, SONDEK J, Dohlman H. Structure and function of Vps15 in the endosomal G protein signaling pathway. Biochemistry. 2009;48:6390-401 pubmed publisher..These findings reveal that the Vps15 Gbeta-like domain serves as a scaffold to assemble Gpa1 and Atg14, whereas the kinase and intermediate domains are required for proper signaling at the endosome. ..
- Deisenroth C, Thorner A, Enomoto T, Perou C, Zhang Y. Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. Mol Cell Biol. 2010;30:3981-93 pubmed publisher..Our data demonstrate a unique c-Myb-Hep27-Mdm2-p53 mitochondria-to-nucleus signaling pathway that may have functional significance for ER-positive breast cancers. ..
- LaFave M, Sekelsky J. Transcription initiation from within P elements generates hypomorphic mutations in Drosophila melanogaster. Genetics. 2011;188:749-52 pubmed publisher..We detected evidence of this transcription in four different types of P constructs, regardless of whether the insertion was in a coding exon, intron, 5' untranslated region, or upstream of the gene span. ..
- Lickwar C, Mueller F, Hanlon S, McNally J, Lieb J. Genome-wide protein-DNA binding dynamics suggest a molecular clutch for transcription factor function. Nature. 2012;484:251-5 pubmed publisher..Our model predicts a clutch-like mechanism that rapidly engages a treadmilling transcription factor into a stable binding state, or vice versa, to modulate transcription factor function. ..
- Ehre C, Worthington E, Liesman R, Grubb B, Barbier D, O Neal W, et al. Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs. Proc Natl Acad Sci U S A. 2012;109:16528-33 pubmed publisher..In contrast, increased Muc5ac secretion appears to exhibit a protective role against influenza infection. ..
- Flannick J, Thorleifsson G, Beer N, Jacobs S, Grarup N, Burtt N, et al. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet. 2014;46:357-63 pubmed publisher..In contrast, loss-of-function mutations in humans provide strong evidence that SLC30A8 haploinsufficiency protects against T2D, suggesting ZnT8 inhibition as a therapeutic strategy in T2D prevention. ..
- Yang C, Carlow D, Wolfenden R, Short S. Cloning and nucleotide sequence of the Escherichia coli cytidine deaminase (ccd) gene. Biochemistry. 1992;31:4168-74 pubmed..Nevertheless, cytidine deaminase and mammalian plus bacterial adenosine deaminases share a single region (TVHA) of sequence identity that is tentatively identified as part of the cytidine deaminase active site. ..
- Nishimoto J, Nanba E, Inui K, Okada S, Suzuki K. GM1-gangliosidosis (genetic beta-galactosidase deficiency): identification of four mutations in different clinical phenotypes among Japanese patients. Am J Hum Genet. 1991;49:566-74 pubmed..The prediction that these mutations are responsible for the clinical disease was confirmed by no expression of the catalytic activity of the mutant proteins in the COS-I cell expression system.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Nanba E, Suzuki K. Molecular cloning of mouse acid beta-galactosidase cDNA: sequence, expression of catalytic activity and comparison with the human enzyme. Biochem Biophys Res Commun. 1990;173:141-8 pubmed..All seven cysteine residues in the mouse enzyme are conserved in the human enzyme. Although the nucleotide sequence could be aligned to 60% identity with the E. coli beta-galactosidase, similarity in the amino acid sequence was minimal. ..
- Errede B, Ammerer G. STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes. Genes Dev. 1989;3:1349-61 pubmed..We propose that the STE12 product interacts with different transcription factors in different sequence contexts and that PRTF/GRM is one of these factors. ..
- Inamine J, Loechel S, Collier A, Barile M, Hu P. Nucleotide sequence of the MgPa (mgp) operon of Mycoplasma genitalium and comparison to the P1 (mpp) operon of Mycoplasma pneumoniae. Gene. 1989;82:259-67 pubmed..The RBS sequence is followed by sequences of dyad symmetry that have the potential to form two alternative stem-and-loop structures, which could be involved in controlling initiation of translation. ..
- Koller B, Smithies O. Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci U S A. 1989;86:8932-5 pubmed..Breeding of offspring from such animals will allow investigation of the effects of homozygous loss of beta 2-microglobulin. ..
- Shehee W, Loeb D, Adey N, Burton F, Casavant N, Cole P, et al. Nucleotide sequence of the BALB/c mouse beta-globin complex. J Mol Biol. 1989;205:41-62 pubmed..The significance of these homologies is unclear, but these regions are candidates for further study in functional assays in erythroid cell lines or transgenic animals. ..
- Ware J, Davis L, Frazier D, Bajaj S, Stafford D. Genetic defect responsible for the dysfunctional protein: factor IXLong Beach. Blood. 1988;72:820-2 pubmed..Moreover, our data identify a residue in the catalytic domain of FIXa essential for normal function. ..
- Matthysse A, White S, Lightfoot R. Genes required for cellulose synthesis in Agrobacterium tumefaciens. J Bacteriol. 1995;177:1069-75 pubmed..Transposon insertions showed that at least the last gene of each of these operons (celC and celE) was required for cellulose synthesis in A. tumefaciens...
- Kim S, Malhotra K, Smith C, Taylor J, Sancar A. Characterization of (6-4) photoproduct DNA photolyase. J Biol Chem. 1994;269:8535-40 pubmed..Furthermore, we provide evidence that the (6-4) photoproduct photolyase converts the photoproduct to unmodified bases probably through an oxetane intermediate. ..
- Becker S, Quay J, Koren H, Haskill J. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994;266:L278-86 pubmed..MCP-1 mRNA expression, on the other hand, was not increased by LPS in AM. GRO protein was present in supernatants of stimulated epithelial cells and AM.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Vinik B, Kay E, Fiedorek F. Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5. Mamm Genome. 1995;6:782-3 pubmed
- Hsu D, Zhao X, Zhao S, Kazantsev A, Wang R, Todo T, et al. Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. Biochemistry. 1996;35:13871-7 pubmed..We conclude that these newly discovered members of the photolyase/photoreceptor family are not photolyases and instead may function as blue-light photoreceptors in humans. ..
- Baur M, Esch R, Errede B. Cooperative binding interactions required for function of the Ty1 sterile responsive element. Mol Cell Biol. 1997;17:4330-7 pubmed..These results establish a direct role for Tec1p in the Ty1 SRE and yet another set of combinatorial interactions that achieve a qualitatively distinct mode of transcriptional regulation with Ste12p. ..
- Bahler J, Pringle J. Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis. Genes Dev. 1998;12:1356-70 pubmed..Thus, Pom1p may position the growth and cytokinesis machineries by interaction with both the actin and microtubule cytoskeletons. ..
- Tillotson L. RIN ZF, a novel zinc finger gene, encodes proteins that bind to the CACC element of the gastrin promoter. J Biol Chem. 1999;274:8123-8 pubmed..These findings suggest that a novel set of zinc finger proteins may help regulate gastrin gene expression by interfering with Sp1 transactivation. ..
- Mallory J, Petes T. Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. Proc Natl Acad Sci U S A. 2000;97:13749-54 pubmed..Tel1p phosphorylates serine in an SQ motif in PHAS-I. Mutations in the kinase domains of Tel1p and Mec1p result in loss of in vitro kinase activity and the in vivo phenotypes associated with the null tel1 and mec1 mutations. ..
- Brinson A, Harden T. Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. J Biol Chem. 2001;276:11939-48 pubmed
- Erie D. The many conformational states of RNA polymerase elongation complexes and their roles in the regulation of transcription. Biochim Biophys Acta. 2002;1577:224-39 pubmed..The role of each of the conformational states in elongation is then discussed in detail. Finally, an integrated mechanism of elongation is presented, bringing together the panoply of experiments. ..
- Pettit S, Gulnik S, Everitt L, Kaplan A. The dimer interfaces of protease and extra-protease domains influence the activation of protease and the specificity of GagPol cleavage. J Virol. 2003;77:366-74 pubmed..Assembly domains within GagPol outside the protease domain also influence enzyme activation. ..
- Hatada S, Grant D, Maeda N. An intronic endogenous retrovirus-like sequence attenuates human haptoglobin-related gene expression in an orientation-dependent manner. Gene. 2003;319:55-63 pubmed..Our data suggest that a combination of multiple small effects of RTVL-Ia including aberrant splicing accounts for the low (6%) expression of the present-day HPR relative to HP. ..
- Tian Q, Nagpal P, Reed J. Regulation of Arabidopsis SHY2/IAA3 protein turnover. Plant J. 2003;36:643-51 pubmed..The chemical juglone (5-hydroxy-1,4-naphthoquinone) inhibited the interaction, suggesting that peptidyl-prolyl isomerization may mediate auxin-induced SHY2/IAA3 protein turnover. ..
- Gherghe C, Weeks K. The SL1-SL2 (stem-loop) domain is the primary determinant for stability of the gamma retroviral genomic RNA dimer. J Biol Chem. 2006;281:37952-61 pubmed..Second, intermolecular duplex formation plays a biological role distinct from simply stabilizing the structure of the retroviral genomic RNA dimer. ..
- Nackley A, Shabalina S, Tchivileva I, Satterfield K, Korchynskyi O, Makarov S, et al. Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science. 2006;314:1930-3 pubmed..These data highlight the functional significance of synonymous variations and suggest the importance of haplotypes over single-nucleotide polymorphisms for analysis of genetic variations. ..
- Mortimer S, Weeks K. C2'-endo nucleotides as molecular timers suggested by the folding of an RNA domain. Proc Natl Acad Sci U S A. 2009;106:15622-7 pubmed publisher..Because the motif is both simple and ubiquitous, C2'-endo nucleotides may function as molecular timers in many RNA folding and ligand recognition reactions. ..
- Bermek O, Weller S, Griffith J. The UL8 subunit of the helicase-primase complex of herpes simplex virus promotes DNA annealing and has a high affinity for replication forks. J Biol Chem. 2017;292:15611-15621 pubmed publisher..The properties of UL8 uncovered here suggest that UL8 may be involved in the generation of the X- and Y-branched structures that are the hallmarks of HSV replication. ..
- Yamabhai M, Kay B. Examining the specificity of Src homology 3 domain--ligand interactions with alkaline phosphatase fusion proteins. Anal Biochem. 1997;247:143-51 pubmed
- Orren D, Selby C, Hearst J, Sancar A. Post-incision steps of nucleotide excision repair in Escherichia coli. Disassembly of the UvrBC-DNA complex by helicase II and DNA polymerase I. J Biol Chem. 1992;267:780-8 pubmed..The discovery of psoralen-UvrB photocross-linking offers the potential of active-site labeling. ..
- Moser M, Knoth R, Bode C, Patterson C. LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in limbic tissues and transactivates the CNS midline enhancer element. Brain Res Mol Brain Res. 2004;128:141-9 pubmed
- Sun W. A statistical framework for eQTL mapping using RNA-seq data. Biometrics. 2012;68:1-11 pubmed publisher..However, our method establishes a statistical framework for future developments of eQTL mapping methods using RNA-seq data (e.g., linkage-based eQTL mapping), and the joint study of multiple genetic markers and/or multiple genes. ..
- Comer A, Searles L, Kalfayan L. Identification of a genomic DNA fragment containing the Drosophila melanogaster ovarian tumor gene (otu) and localization of regions governing its expression. Gene. 1992;118:171-9 pubmed
- McDowell J, An Y, Huang S, McKinney E, Meagher R. The arabidopsis ACT7 actin gene is expressed in rapidly developing tissues and responds to several external stimuli. Plant Physiol. 1996;111:699-711 pubmed..The ACT7 promoter sequence contains a remarkable number of motifs with sequence similarity to putative phytohormone response elements. ..
- Shaffer J, Kier W. Muscular tissues of the squid Doryteuthis pealeii express identical myosin heavy chain isoforms: an alternative mechanism for tuning contractile speed. J Exp Biol. 2012;215:239-46 pubmed publisher..pealeii express identical myosin isoforms, and it is likely that differences in muscle ultrastructure, not myosin ATPase activity, represent the most important mechanism for tuning contractile speeds. ..
- Connell T, Black W, Kawula T, Barritt D, Dempsey J, Kverneland K, et al. Recombination among protein II genes of Neisseria gonorrhoeae generates new coding sequences and increases structural variability in the protein II family. Mol Microbiol. 1988;2:227-36 pubmed..Moreover, we found that reassortment of the two HV regions among P.II genes occurs, generating increased structural and antigenic variability in the P.II protein family. ..
- Nicholas R, Lamson D, Schultz D. Penicillin-binding protein 1B from Escherichia coli contains a membrane association site in addition to its transmembrane anchor. J Biol Chem. 1993;268:5632-41 pubmed..These results strongly suggest that the periplasmic domain of PBP 1B associates with membranes independent of its amino terminal transmembrane region. ..
- Schwab K, De Leon R, Sobsey M. Immunoaffinity concentration and purification of waterborne enteric viruses for detection by reverse transcriptase PCR. Appl Environ Microbiol. 1996;62:2086-94 pubmed..The results of enteric viruses were compared with those for standard bacterial and coliphage indicators of fecal contamination. ..
- Lemon S, Binn L, Marchwicki R, Murphy P, Ping L, Jansen R, et al. In vivo replication and reversion to wild type of a neutralization-resistant antigenic variant of hepatitis A virus. J Infect Dis. 1990;161:7-13 pubmed..Virus was not recovered from liver 96 days after challenge. These studies further define virologic events in hepatitis A and show that in vivo replication of an antigenic variant was restricted compared with that of wild-type virus...
- Sass G, Mohler J, Walsh R, Kalfayan L, Searles L. Structure and expression of hybrid dysgenesis-induced alleles of the ovarian tumor (otu) gene in Drosophila melanogaster. Genetics. 1993;133:253-63 pubmed..The results of this study demonstrate that the diverse mutant phenotypes of otu are the consequence of different levels of otu function. ..
- Tan J, Hall S, Hamil K, Grossman G, Petrusz P, Liao J, et al. Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis. Mol Endocrinol. 2000;14:14-26 pubmed..In addition, PIAS1 was expressed in spermatogenic cells. The results suggest that PIAS1 functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. ..
- Badorrek C, Weeks K. Architecture of a gamma retroviral genomic RNA dimer. Biochemistry. 2006;45:12664-72 pubmed..Instead, the retroviral dimerization domain adopts a compact architecture characterized by close packing of its constituent helices. ..
- Mandel E, Kaltenbrun E, Callis T, Zeng X, Marques S, Yelon D, et al. The BMP pathway acts to directly regulate Tbx20 in the developing heart. Development. 2010;137:1919-29 pubmed publisher..Collectively, our findings define Tbx20 as a direct transcriptional target of the BMP/SMAD1 signaling pathway during cardiac maturation. ..