Experts and Doctors on archaeal proteins in Durham, North Carolina, United States


Locale: Durham, North Carolina, United States
Topic: archaeal proteins

Top Publications

  1. Wuebbens M, Liu M, Rajagopalan K, Schindelin H. Insights into molybdenum cofactor deficiency provided by the crystal structure of the molybdenum cofactor biosynthesis protein MoaC. Structure. 2000;8:709-18 pubmed
    ..This residue is located near the N-terminal end of helix alpha4 at an interface between two monomers. The MoaC structure provides a framework for the analysis of additional dysfunctional mutations in the corresponding human gene. ..
  2. Schmid A, Pan M, Sharma K, Baliga N. Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon. Nucleic Acids Res. 2011;39:2519-33 pubmed publisher
    ..We discuss conserved and unique features of the Idr1-Idr2 system in the context of similar systems in organisms from other domains of life...
  3. Sharma K, Gillum N, Boyd J, SCHMID A. The RosR transcription factor is required for gene expression dynamics in response to extreme oxidative stress in a hypersaline-adapted archaeon. BMC Genomics. 2012;13:351 pubmed publisher
    ..salinarum. We have therefore renamed VNG0258H as RosR, for reactive oxygen species regulator...
  4. Hsieh T, Plank J. Reverse gyrase functions as a DNA renaturase: annealing of complementary single-stranded circles and positive supercoiling of a bubble substrate. J Biol Chem. 2006;281:5640-7 pubmed
    ..These biochemical activities also suggest that reverse gyrase can have an important biological function in sensing and eliminating unpaired regions in the genome of a hyperthermophilic organism. ..
  5. Capp C, Qian Y, Sage H, Huber H, Hsieh T. Separate and combined biochemical activities of the subunits of a naturally split reverse gyrase. J Biol Chem. 2010;285:39637-45 pubmed publisher
    ..These results provide new insight into the mechanism of positive supercoil induction by reverse gyrase...
  6. Guan Z, Naparstek S, Calo D, Eichler J. Protein glycosylation as an adaptive response in Archaea: growth at different salt concentrations leads to alterations in Haloferax volcanii S-layer glycoprotein N-glycosylation. Environ Microbiol. 2012;14:743-53 pubmed publisher
    ..Thus, in response to changes in environmental salinity, Hfx. volcanii not only modulates the N-linked glycans decorating the S-layer glycoprotein but also the sites of such post-translational modification...
  7. Elharar Y, Podilapu A, Guan Z, Kulkarni S, Eichler J. Assembling Glycan-Charged Dolichol Phosphates: Chemoenzymatic Synthesis of a Haloferax volcanii N-Glycosylation Pathway Intermediate. Bioconjug Chem. 2017;28:2461-2470 pubmed publisher
    ..The in vitro system for the study of AglG activity developed here represents the first such tool for studying halophilic glycosyltransferases and will allow for a detailed understanding of archaeal N-glycosylation...
  8. Martínez Pastor M, Lancaster W, Tonner P, Adams M, Schmid A. A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea. Nucleic Acids Res. 2017;45:9990-10001 pubmed publisher
    ..These results suggest that archaea use bacterial-type TFs in a eukaryotic regulatory network topology to adapt to harsh environments...