Experts and Doctors on animals in Durham, United States

Summary

Locale: Durham, United States
Topic: animals

Top Publications

  1. Chen Z, Stamler J. Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase. Trends Cardiovasc Med. 2006;16:259-65 pubmed
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  2. Perz Edwards A, Hardison N, Linney E. Retinoic acid-mediated gene expression in transgenic reporter zebrafish. Dev Biol. 2001;229:89-101 pubmed
    ..Together these data suggest that the reporter expression we see in zebrafish is dependent upon conserved vertebrate pathways of RA synthesis. ..
  3. Kuraoka M, Liao D, Yang K, Allgood S, Levesque M, Kelsoe G, et al. Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. J Immunol. 2009;183:3237-48 pubmed publisher
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  4. Gao F, Li Y, Decker J, Peyerl F, Bibollet Ruche F, Rodenburg C, et al. Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice. AIDS Res Hum Retroviruses. 2003;19:817-23 pubmed
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  5. Bennett S, Mercer J, Noor M. Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2. PLoS ONE. 2010;5:e11006 pubmed publisher
    ..We conclude that the evolutionary history of dmbrca2 in D. yakuba and perhaps in other Drosophila species may be more complicated than can be inferred from examination of the published single genome sequences per species. ..
  6. Katz A, Gentile M, Craig D, Quick G, Cheifetz I. Heliox does not affect gas exchange during high-frequency oscillatory ventilation if tidal volume is held constant. Crit Care Med. 2003;31:2006-9 pubmed
    ..We hypothesized that when tidal volume delivery is held constant, heliox does not alter gas exchange...
  7. Hatch A, York J. SnapShot: Inositol phosphates. Cell. 2010;143:1030-1030.e1 pubmed publisher
  8. Li X, McDonnell D. The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Mol Cell Biol. 2002;22:3663-73 pubmed
    ..Cumulatively, these findings suggest that the nuclear corepressors N-CoR and SMRT serve a previously unappreciated role as regulators of B-Myb transcriptional activity. ..
  9. Carré J, McCormick C, Hariri A. The social neuroendocrinology of human aggression. Psychoneuroendocrinology. 2011;36:935-44 pubmed publisher
    ..We also speculate on one putative neural mechanism through which testosterone may bias human aggressive behavior. Finally, we conclude by highlighting important questions that should be addressed in future research...
  10. Halsell S, Chu B, Kiehart D. Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis. Genetics. 2000;155:1253-65 pubmed
    ..Our studies provide direct genetic proof of the biological relevance of regulation of myosin by Rho signal transduction in an intact metazoan. ..

Locale

Detail Information

Publications62

  1. Chen Z, Stamler J. Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase. Trends Cardiovasc Med. 2006;16:259-65 pubmed
    ....
  2. Perz Edwards A, Hardison N, Linney E. Retinoic acid-mediated gene expression in transgenic reporter zebrafish. Dev Biol. 2001;229:89-101 pubmed
    ..Together these data suggest that the reporter expression we see in zebrafish is dependent upon conserved vertebrate pathways of RA synthesis. ..
  3. Kuraoka M, Liao D, Yang K, Allgood S, Levesque M, Kelsoe G, et al. Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. J Immunol. 2009;183:3237-48 pubmed publisher
    ....
  4. Gao F, Li Y, Decker J, Peyerl F, Bibollet Ruche F, Rodenburg C, et al. Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice. AIDS Res Hum Retroviruses. 2003;19:817-23 pubmed
    ....
  5. Bennett S, Mercer J, Noor M. Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2. PLoS ONE. 2010;5:e11006 pubmed publisher
    ..We conclude that the evolutionary history of dmbrca2 in D. yakuba and perhaps in other Drosophila species may be more complicated than can be inferred from examination of the published single genome sequences per species. ..
  6. Katz A, Gentile M, Craig D, Quick G, Cheifetz I. Heliox does not affect gas exchange during high-frequency oscillatory ventilation if tidal volume is held constant. Crit Care Med. 2003;31:2006-9 pubmed
    ..We hypothesized that when tidal volume delivery is held constant, heliox does not alter gas exchange...
  7. Hatch A, York J. SnapShot: Inositol phosphates. Cell. 2010;143:1030-1030.e1 pubmed publisher
  8. Li X, McDonnell D. The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Mol Cell Biol. 2002;22:3663-73 pubmed
    ..Cumulatively, these findings suggest that the nuclear corepressors N-CoR and SMRT serve a previously unappreciated role as regulators of B-Myb transcriptional activity. ..
  9. Carré J, McCormick C, Hariri A. The social neuroendocrinology of human aggression. Psychoneuroendocrinology. 2011;36:935-44 pubmed publisher
    ..We also speculate on one putative neural mechanism through which testosterone may bias human aggressive behavior. Finally, we conclude by highlighting important questions that should be addressed in future research...
  10. Halsell S, Chu B, Kiehart D. Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis. Genetics. 2000;155:1253-65 pubmed
    ..Our studies provide direct genetic proof of the biological relevance of regulation of myosin by Rho signal transduction in an intact metazoan. ..
  11. Cho K, Cai Y, Yi H, Yeh A, Aslanukov A, Ferreira P. Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. Traffic. 2007;8:1722-35 pubmed
    ..The data also strengthen a model whereby the selection of a large array of cargoes for transport by a restricted number of motor proteins is mediated by adaptor proteins such as RanBP2. ..
  12. Pattabiraman P, Pecen P, Rao P. MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure. Invest Ophthalmol Vis Sci. 2013;54:1636-49 pubmed publisher
    ..This study examined the expression and distribution of MRP4 in the trabecular meshwork (TM) cells and its role in homeostasis of IOP...
  13. Gerardo C, Quackenbush E, Lewis B, Rose S, Greene S, Toschlog E, et al. The Efficacy of Crotalidae Polyvalent Immune Fab (Ovine) Antivenom Versus Placebo Plus Optional Rescue Therapy on Recovery From Copperhead Snake Envenomation: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial. Ann Emerg Med. 2017;70:233-244.e3 pubmed publisher
    ..Treatment with FabAV reduces limb disability measured by the Patient-Specific Functional Scale 14 days after copperhead envenomation. ..
  14. Runcie D, Garfield D, Babbitt C, Wygoda J, Mukherjee S, Wray G. Genetics of gene expression responses to temperature stress in a sea urchin gene network. Mol Ecol. 2012;21:4547-62 pubmed publisher
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  15. Kay R, Campbell V, Rossie J, Colbert M, Rowe T. Olfactory fossa of Tremacebus harringtoni (platyrrhini, early Miocene, Sacanana, Argentina): implications for activity pattern. Anat Rec A Discov Mol Cell Evol Biol. 2004;281:1157-72 pubmed
    ..This finding accords well with previous observations that the orbits of Tremacebus are not as large as nocturnal Aotus...
  16. Barkauskas C, Cronce M, Rackley C, Bowie E, Keene D, Stripp B, et al. Type 2 alveolar cells are stem cells in adult lung. J Clin Invest. 2013;123:3025-36 pubmed publisher
    ..Results suggest that a similar dynamic exists between AEC2s and mesenchymal cells in the human lung. ..
  17. Salinas R, Pearring J, Ding J, Spencer W, Hao Y, Arshavsky V. Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release. J Cell Biol. 2017;216:1489-1499 pubmed publisher
    ..Our findings explain how the outer segment structure evolved from the primary cilium to provide photoreceptor cells with vast membrane surfaces for efficient light capture. ..
  18. Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi S, et al. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest. 2008;118:3331-42 pubmed publisher
    ..Together, these data suggest that activation of Hh signaling promotes EMT and contributes to the evolution of biliary fibrosis during chronic cholestasis. ..
  19. Guthrie O. Aminoglycoside induced ototoxicity. Toxicology. 2008;249:91-6 pubmed publisher
    ..Animal experiments have provided encouraging evidence for the protection of cochlear hair cells and neurons from aminoglycoside toxicity. However, the extent to which such protection, generalize to human ototoxicity remains unresolved...
  20. Werner Allen J, Lee C, Liu P, Nicely N, Wang S, Greenleaf A, et al. cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72. J Biol Chem. 2011;286:5717-26 pubmed publisher
    ..This work presents the first structural evidence of a cis-proline-specific enzyme and an unexpected mechanism of isomer-based regulation of phosphorylation, with broad implications for CTD biology. ..
  21. Iyer R, Pluciennik A, Genschel J, Tsai M, Beese L, Modrich P. MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. J Biol Chem. 2010;285:11730-9 pubmed publisher
    ..These findings also indicate that MutSbeta- and MutSalpha-initiated repair events differ in fundamental ways. ..
  22. Krangel M. Mechanics of T cell receptor gene rearrangement. Curr Opin Immunol. 2009;21:133-9 pubmed publisher
    ..Together these influences may explain the ordered activation and inactivation of T cell receptor locus recombination events and the phenomenon of Tcrb allelic exclusion. ..
  23. Zhang P, Sun B, Osada T, Rodriguiz R, Yang X, Luo X, et al. Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease. Hum Gene Ther. 2012;23:460-72 pubmed publisher
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  24. Shivapooja P, Wang Q, Orihuela B, Rittschof D, Lopez G, Zhao X. Bioinspired surfaces with dynamic topography for active control of biofouling. Adv Mater. 2013;25:1430-4 pubmed publisher
    ..The bio-inspired dynamic surfaces can be fabricated over large areas through simple and practical processes. This new mechanism is complementary with existing materials and methods for biofouling control...
  25. McCarthy M, Kontoyiannis D, Cornely O, Perfect J, Walsh T. Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi. J Infect Dis. 2017;216:S474-S483 pubmed publisher
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  26. Murata Y, Wharton R. Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos. Cell. 1995;80:747-56 pubmed
    ..These and other observations suggest that pum acts by recognizing the NRE and then recruiting nos. Presumably, the resulting complex inhibits some component of the translation machinery. ..
  27. Markiewicz E, Ledran M, Hutchison C. Remodelling of the nuclear lamina and nucleoskeleton is required for skeletal muscle differentiation in vitro. J Cell Sci. 2005;118:409-20 pubmed
    ..In myoblasts transfected with the mutant lamins, this complex was disrupted. These data suggest that remodelling of the nucleoskeleton is necessary for skeletal-muscle differentiation and for correct regulation of Rb pathways. ..
  28. Briggs M, Schachat F. Physiologically regulated alternative splicing patterns of fast troponin T RNA are conserved in mammals. Am J Physiol. 1996;270:C298-305 pubmed
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  29. Kurokawa M, Zhao C, Reya T, Kornbluth S. Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias. Mol Cell Biol. 2008;28:5494-506 pubmed publisher
    ..These data provide an explanation for apoptosome inhibition by activated leukemogenic tyrosine kinases and suggest that alterations in Hsp90beta-apoptosome interactions may contribute to chemoresistance in leukemias. ..
  30. Arcasoy M, Amin K, Vollmer R, Jiang X, Demark Wahnefried W, Haroon Z. Erythropoietin and erythropoietin receptor expression in human prostate cancer. Mod Pathol. 2005;18:421-30 pubmed
    ..The coexpression of erythropoietin receptor and its ligand erythropoietin in human prostate cancer cells suggests the potential for growth regulation by erythropoietin-erythropoietin receptor in an autocrine or paracrine manner. ..
  31. Settles D, Cihak R, Erickson H. Tenascin-C expression in dystrophin-related muscular dystrophy. Muscle Nerve. 1996;19:147-54 pubmed
    ..Therefore, in dystrophic muscle, TN-C expression may be stimulated by the degenerative process and remain upregulated unless the tissue undergoes successful regeneration. ..
  32. Maciver N, Michalek R, Rathmell J. Metabolic regulation of T lymphocytes. Annu Rev Immunol. 2013;31:259-83 pubmed publisher
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  33. Fleming C, Billiard S, Di Giulio R. Hypoxia inhibits induction of aryl hydrocarbon receptor activity in topminnow hepatocarcinoma cells in an ARNT-dependent manner. Comp Biochem Physiol C Toxicol Pharmacol. 2009;150:383-9 pubmed publisher
    ..This study supports the hypothesis that HIF-1alpha is able to sequester ARNT from AhR and limit the activity of the AhR pathway, but suggests that the converse is not true. ..
  34. Urs N, Snyder J, Jacobsen J, Peterson S, Caron M. Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action. Proc Natl Acad Sci U S A. 2012;109:20732-7 pubmed publisher
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  35. Prasad V, Kurtzberg J. Umbilical cord blood transplantation for non-malignant diseases. Bone Marrow Transplant. 2009;44:643-51 pubmed publisher
    ..Every effort should be made to perform transplantation early in the course of disease before extensive damage to various tissues and organs ensues. ..
  36. Spiegelberg B, Xiong J, Smith J, Gu R, York J. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. J Biol Chem. 1999;274:13619-28 pubmed
    ..We propose that inhibition of human BPntase may account for lithium-induced nephrotoxicity, which may be overcome by supplementation of current therapeutic regimes with inhibitors of nucleotide biosynthesis, such as methionine. ..
  37. Damodaran T, Bilska M, Rahman A, Abou Doni M. Sarin causes early differential alteration and persistent overexpression in mRNAs coding for glial fibrillary acidic protein (GFAP) and vimentin genes in the central nervous system of rats. Neurochem Res. 2002;27:407-15 pubmed
    ..These changes could affect the neuronal cell types, thus altering the neuron-glia homeostasis. ..
  38. Kondilis Mangum H, Cobb R, Osipovich O, Srivatsan S, Oltz E, Krangel M. Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo. J Immunol. 2010;184:6970-7 pubmed publisher
    ..We suggest that enhancer- and promoter-dependent transcription generates optimal recombinase substrates in which some nucleosomes are missing and others are covalently modified. ..
  39. Watson M, Kingsmore S, Johnston G, Siegelman M, Le Beau M, Lemons R, et al. Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. J Exp Med. 1990;172:263-72 pubmed
    ..These data characterize the organization of a genomic region that may be critical for intercellular communication within the immune system. ..
  40. Rho H, McClay D. The control of foxN2/3 expression in sea urchin embryos and its function in the skeletogenic gene regulatory network. Development. 2011;138:937-45 pubmed publisher
    ..Thus, FoxN2/3 is necessary for normal ingression, for expression of several skeletal matrix genes, for preventing transfating and for fusion of the PMC syncytium. ..
  41. Rapacciuolo A, Esposito G, Caron K, Mao L, Thomas S, Rockman H. Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy. J Am Coll Cardiol. 2001;38:876-82 pubmed
    ..These data demonstrate a nearly complete requirement of endogenous norepinephrine and epinephrine for the induction of in vivo pressure-overload cardiac hypertrophy and for the activation of hypertrophic signaling pathways. ..
  42. Kingsmore S, Giros B, Suh D, Bieniarz M, Caron M, Seldin M. Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion. Nat Genet. 1994;7:136-41 pubmed
    ..These results provide evidence that Glrb is necessary for postsynaptic expression of glycine receptor complexes, and suggest Glrb as a candidate gene for inherited myoclonus in other species. ..
  43. Hemenway C, Heitman J. Proline isomerases in microorganisms and small eukaryotes. Ann N Y Acad Sci. 1993;696:38-46 pubmed
  44. Shea S, Katz L, Mooney R. Noradrenergic induction of odor-specific neural habituation and olfactory memories. J Neurosci. 2008;28:10711-9 pubmed publisher
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  45. Lapadula E, Lapadula D, Abou Donia M. Persistent alterations of calmodulin kinase II activity in chickens after an oral dose of tri-o-cresyl phosphate. Biochem Pharmacol. 1991;42:171-80 pubmed
    ..This finding supports the significance of altered calmodulin kinase II in the pathogenesis of OPIDN. ..
  46. Griffin T, Huebner J, Kraus V, Guilak F. Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum. 2009;60:2935-44 pubmed publisher
    ..These results imply a pleiotropic role of leptin in the development of OA by regulating both the skeletal and immune systems. ..
  47. Shukla A, Xiao K, Lefkowitz R. Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci. 2011;36:457-69 pubmed publisher
    ..Biophysical studies aimed at understanding multiple active conformations of the 7TMRs and the β-arrestins have begun to unravel the mechanistic basis for the diverse functional capabilities of β-arrestins in cellular signaling. ..
  48. Folz R, Nepluev I. Poly(A) cDNA-specific (PACS) RT-PCR: a quantitative method for the measurement of any poly(A)-containing mRNA not affected by contaminating genomic DNA. Biotechniques. 2000;29:762, 764-5, 766-8 pubmed
    ..A second cDNA-specific sense primer can be used that does not need to be separated by intronic DNA sequence. ..
  49. Jones Mason M, Zhao X, Kappes D, Lasorella A, Iavarone A, Zhuang Y. E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity. 2012;36:348-61 pubmed publisher
    ..These studies identify an important role for E proteins in the activation of CD4(+) lineage differentiation as thymocytes undergo the DP to SP transition. ..
  50. Carroll E, Gerrelli D, Gasca S, Berg E, Beier D, Copp A, et al. Cordon-bleu is a conserved gene involved in neural tube formation. Dev Biol. 2003;262:16-31 pubmed
    ..Finally, we show that cobl interacts with the neurulation gene Vangl2 to facilitate midbrain neural tube closure, demonstrating roles for both cobl and Vangl2 in midbrain neurulation. ..
  51. Lee B, Hulata G, Kocher T. Two unlinked loci controlling the sex of blue tilapia (Oreochromis aureus). Heredity (Edinb). 2004;92:543-9 pubmed
    ..These markers have immediate utility for studying the strength of different sex chromosome alleles, and for identifying broodstock carrying copies of the W haplotype. ..
  52. Wang Z, Wang R, Sheng H, Sheng S, Paschen W, Yang W. Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons. Spinal Cord. 2013;51:139-43 pubmed publisher
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  53. Gurley S, Mach C, Stegbauer J, Yang J, Snow K, Hu A, et al. Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice. Am J Physiol Renal Physiol. 2010;298:F788-95 pubmed publisher
    ..Identification of these naturally occurring strain differences should prove useful for nephropathy modeling and may be exploited to allow identification of novel susceptibility alleles for albuminuria in diabetes...
  54. Teng B, Hacker K, Chen S, Means A, Rathmell W. Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma. Mol Oncol. 2011;5:465-74 pubmed publisher
    ..These observations suggest Pin1 may have a mild tumor suppressive role in ccRCC. ..
  55. Chen W, Huang F, de Renshaw T, Andrews N. Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis. Blood. 2011;117:6319-25 pubmed publisher
    ..We conclude that, in spite of its expression pattern, hemojuvelin is primarily important in the liver. ..
  56. Chen Z, Koralov S, Kelsoe G. Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. J Exp Med. 2000;192:1339-52 pubmed
    ..Clearance of circulating ICs is impaired in preautoimmune C4(-)(/)-, but not Cr2(-)(/)-, mice. C4 deficiency causes spontaneous, lupus-like autoimmunity through a mechanism that is independent of CR1/CR2. ..
  57. Povsic T, Kohout T, Lefkowitz R. Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. J Biol Chem. 2003;278:51334-9 pubmed
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  58. Friedman M, Krams R, Chandran K. Flow interactions with cells and tissues: cardiovascular flows and fluid-structure interactions. Sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008, Pasadena, California. Ann Biomed Eng. 2010;38:1178-87 pubmed
    ..The second part describes recent advances in the application of fluid-structure interaction analysis to arterial flows and the dynamics of heart valves. ..
  59. Monserrate J, York J. Inositol phosphate synthesis and the nuclear processes they affect. Curr Opin Cell Biol. 2010;22:365-73 pubmed publisher
    ..The purpose of this review is to cover the latest data gathered regarding only the nuclear roles of the various inositol phosphates while simultaneously providing a step-by-step tour of IP synthesis in eukaryotes...
  60. Pfenning A, Kim T, Spotts J, Hemberg M, Su D, West A. Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. PLoS ONE. 2010;5:e10870 pubmed publisher
    ..Together these data strongly support the characterization of CaRF as a unique transcription factor and provide the first insight into the program of CaRF-regulated transcription in neurons. ..
  61. Zhang X, Lee T, Davidson C, Lazarus C, Wetsel W, Ellinwood E. Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors. Neuropsychopharmacology. 2007;32:377-87 pubmed
    ..To the extent that sensitization plays a role in chronic cocaine abuse, a combination of these clinically available drugs may be useful in treatment of the disorder. ..
  62. Zhang S, Truskey G, Kraus W. Effect of cyclic stretch on beta1D-integrin expression and activation of FAK and RhoA. Am J Physiol Cell Physiol. 2007;292:C2057-69 pubmed
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