Genomes and Genes
Experts and Doctors on animals in Durham, North Carolina, United States
Locale: Durham, North Carolina, United States
Publications834 found, 100 shown here
- Steele M, Brown K. Genetic predisposition to respiratory diseases: infiltrative lung diseases. Respiration. 2007;74:601-8 pubmed..Further insight into these areas may lead to new therapeutic interventions. ..
- Zhang Y, Su S, Hecox D, Brady G, Mackin K, Clark A, et al. Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. J Immunol. 2008;181:6092-100 pubmed..The central tolerance phenotype implies that tolerizing self-Ag is expressed in bone marrow...
- Chichlowski M, Hale L. Effects of Helicobacter infection on research: the case for eradication of Helicobacter from rodent research colonies. Comp Med. 2009;59:10-7 pubmed..Therefore, frequent screening of rodent research colonies for Helicobacter spp. and the eradication of these pathogens should be key goals of the research community. ..
- Bolaños D, Litvaitis M. Embryonic muscle development in direct and indirect developing marine flatworms (Platyhelminthes, Polycladida). Evol Dev. 2009;11:290-301 pubmed publisher..Furthermore, they provide additional support that the orthogonal muscle pattern of circular and longitudinal muscles is a symplesiomorphy of Spiralia. ..
- Chen H, Liao D, Holl T, Snowden P, Ueda Y, Kelsoe G. Genetic regulation of pristane-induced oil granuloma responses. Int J Exp Pathol. 2010;91:472-83 pubmed publisher..Interestingly, IL-6(-/-) mice had intact MG formation; however, SG organization was impaired. These studies provide insight into granulomateous pathology induced by non-infectious substances for example, biomedical sutures. ..
- Wong J, Yao G, Nevins J, You L. Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC. Mol Cell. 2011;41:275-85 pubmed publisher..In addition to demonstrating how noise can be exploited to probe signaling dynamics, our results reveal how coordination of the MYC/RB/E2F pathway enables dynamic discrimination of aberrant and normal levels of growth stimulation. ..
- Rangwala F, Guy C, Lu J, Suzuki A, Burchette J, Abdelmalek M, et al. Increased production of sonic hedgehog by ballooned hepatocytes. J Pathol. 2011;224:401-10 pubmed publisher..These results help to explain why fibrosis stage correlates with hepatocyte ballooning in NASH. ..
- Mito J, Ferrer J, Brigman B, Lee C, Dodd R, Eward W, et al. Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging. Cancer. 2012;118:5320-30 pubmed publisher..The authors concluded that their technique has the potential to be used for intraoperative image-guided surgery to identify microscopic residual disease in patients with cancer. ..
- Chavez J, Summers S. A ceramide-centric view of insulin resistance. Cell Metab. 2012;15:585-94 pubmed publisher..Moreover, we describe how a ceramide-centric view of insulin resistance might be reconciled in the context of other prominent models of nutrient-induced insulin resistance. ..
- Haglund M. Optical imaging of visual cortex epileptic foci and propagation pathways. Epilepsia. 2012;53 Suppl 1:87-97 pubmed publisher..This experimental study demonstrates that optical imaging can precisely localize an epileptic focus, and provides excellent spatial resolution of the changes that occur in and around the site of the epileptic focus. ..
- Kim K, Abraham D, Williams B, Violin J, Mao L, Rockman H. ?-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury. Am J Physiol Heart Circ Physiol. 2012;303:H1001-10 pubmed publisher..Our data suggest that this novel class of drugs may provide an advantage over conventional ARBs by supporting cardiac function and reducing cellular injury during acute cardiac injury. ..
- Sparks M, Makhanova N, Griffiths R, Snouwaert J, Koller B, Coffman T. Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension. 2013;61:166-73 pubmed publisher..Thus, TP receptors in vascular smooth muscle cells play a major role in mediating the actions of thromboxane A(2) in TP agonist-induced shock, hypertension, and vascular remodeling of the aorta. ..
- Michelotti G, Xie G, Swiderska M, Choi S, Karaca G, Krüger L, et al. Smoothened is a master regulator of adult liver repair. J Clin Invest. 2013;123:2380-94 pubmed..The results identify SMO as a master regulator of hepatic epithelial regeneration based on its ability to promote mesenchymal-to-epithelial transitions in a subpopulation of HSC-derived MFs with features of multipotent progenitors. ..
- Harrison A, DuBois L, St John Williams L, Moseley M, Hardison R, Heimlich D, et al. Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment. Mol Cell Proteomics. 2016;15:1117-38 pubmed publisher..Identification of novel protein targets and metabolic biomarkers will advance development of therapeutic and diagnostic options for treatment of disease. ..
- Cieślar Pobuda A, Knoflach V, Ringh M, Stark J, Likus W, Siemianowicz K, et al. Transdifferentiation and reprogramming: Overview of the processes, their similarities and differences. Biochim Biophys Acta Mol Cell Res. 2017;1864:1359-1369 pubmed publisher..This process involves an ectopic expression of transcription factors and/or other stimuli. Unlike in the case of reprogramming, tissues obtained by this method do not carry the risk of subsequent teratomagenesis. ..
- Frielle T, Collins S, Daniel K, Caron M, Lefkowitz R, Kobilka B. Cloning of the cDNA for the human beta 1-adrenergic receptor. Proc Natl Acad Sci U S A. 1987;84:7920-4 pubmed..Mammalian beta 1AR and beta 2AR are thus products of distinct genes, both of which are apparently related to the putative G-21 receptor. ..
- Zhang F, Moomaw J, Casey P. Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I. J Biol Chem. 1994;269:23465-70 pubmed..The use of these inhibitors, coupled with a steady-state kinetic analysis of the enzyme, reveals that the reaction catalyzed by GGTase I proceeds through a random ordered sequential mechanism. ..
- Audoly L, Ruan X, Wagner V, Goulet J, Tilley S, Koller B, et al. Role of EP(2) and EP(3) PGE(2) receptors in control of murine renal hemodynamics. Am J Physiol Heart Circ Physiol. 2001;280:H327-33 pubmed..We conclude that EP(3 )receptors mediate vasoconstriction in the kidney of male mice and its actions are tonically active in the basal state. Furthermore, EP(3) receptors are capable of buffering PGE(2)-mediated renal vasodilation...
- Lee P, Schmidt M, Hall W. Excitatory and inhibitory circuitry in the superficial gray layer of the superior colliculus. J Neurosci. 2001;21:8145-53 pubmed..2001), our results support the hypothesis that ACh reduces CTN activity by nicotinic receptor-mediated excitation of local GABAergic interneurons. These interneurons in turn use GABA(B) receptors to inhibit the CTNs. ..
- Morehouse E, James T, Ganley A, Vilgalys R, Berger L, Murphy P, et al. Multilocus sequence typing suggests the chytrid pathogen of amphibians is a recently emerged clone. Mol Ecol. 2003;12:395-403 pubmed..dendrobatidis is diploid and primarily reproduces clonally. In contrast to the lack of nucleotide polymorphism, electrophoretic karyotyping of multiple strains demonstrated a number of chromosome length polymorphisms. ..
- Hollingsworth J, Cook D, Brass D, Walker J, Morgan D, Foster W, et al. The role of Toll-like receptor 4 in environmental airway injury in mice. Am J Respir Crit Care Med. 2004;170:126-32 pubmed..These data demonstrate in the mouse that the requirement of TLR4 for pulmonary inflammation depends on the nature of the toxin and appears specific to toxin and exposure conditions. ..
- Chatterjee P, Mukherjee S, Shakes L, Wilson W, Coren J, Harewood K, et al. Selecting transpositions using phage P1 headful packaging: new markerless transposons for functionally mapping long-range regulatory sequences in bacterial artificial chromosomes and P1-derived artificial chromosomes. Anal Biochem. 2004;335:305-15 pubmed..The procedure nevertheless offers a potential approach to map recombinogenic sequences in BACs and PACs...
- Nathan J, Romac J, Peng R, Peyton M, Macdonald R, Liddle R. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology. 2005;128:717-27 pubmed..We propose that PSTI-I prevents pancreatitis by inhibiting the activity of trypsin, rather than by reducing trypsinogen activation. ..
- Shetty A, Hattiangady B, Shetty G. Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes. Glia. 2005;51:173-86 pubmed..Additionally, the results demonstrate that decreased FGF-2 concentration during aging is a consequence of age-related impairment in FGF-2 synthesis by astrocytes. ..
- Jia J, Kondo M, Zhuang Y. Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion. EMBO J. 2007;26:2387-99 pubmed..Results presented here suggest that germline transcription, although necessary for V(D)J recombination, is not sufficient to instruct allelic exclusion. ..
- Nelson C, Kovacs J, Nobles K, Whalen E, Lefkowitz R. Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. J Biol Chem. 2008;283:21093-101 pubmed publisher..Collectively, these data support a model in which beta-arrestins direct the localization of PIP5K Ialpha and PIP(2) production to agonist-activated 7TMRs, thereby regulating receptor internalization. ..
- Haskins K, Russell J, Gaddis N, Dressman H, Aballay A. Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity. Dev Cell. 2008;15:87-97 pubmed publisher..The results indicate that unfolded protein response genes, regulated in a CED-1-dependent manner, are involved in the C. elegans immune response to live bacteria. ..
- Hutson K, Durham D, Tucci D. Reversible conductive hearing loss: restored activity in the central auditory system. Audiol Neurootol. 2009;14:69-77 pubmed publisher..In CHL/R animals, there were no significant differences, suggesting that 1 week after CHL repair, the appearance of balanced afferent activity had been restored. ..
- Zhang X, Douglas K, Jin H, Eldaif B, Nassar R, Fraser M, et al. Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury. Am J Physiol Regul Integr Comp Physiol. 2008;295:R2084-96 pubmed publisher..These experiments show that tachykinin action at spinal NK1 receptors plays a major role in the spinal micturition reflex in SCI rats. ..
- Lord C, Savitsky D, Sitcheran R, Calame K, Wright J, Ting J, et al. Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1. J Immunol. 2009;182:2948-58 pubmed publisher..Analysis of Blimp-1(-/-) murine myeloid cells provides physiologic evidence that Blimp-1 reduces NLRP12 gene expression during cell differentiation. This demonstrates a novel role for Blimp-1 in the regulation of an NLR gene. ..
- Syn W, Witek R, Curbishley S, Jung Y, Choi S, Enrich B, et al. Role for hedgehog pathway in regulating growth and function of invariant NKT cells. Eur J Immunol. 2009;39:1879-92 pubmed publisher..Therefore, Hh pathway activation may contribute to the local expansion of pro-fibrogenic iNKT cell populations during certain types of fibrosing liver damage. ..
- Bell E, Richardson G, Jahoda C, Gledhill K, Phillips H, Henderson D, et al. Dermal stem cells can differentiate down an endothelial lineage. Stem Cells Dev. 2012;21:3019-30 pubmed publisher..Importantly, cells of neural crest origin that express markers of endothelial and mesenchymal lineages exist within the dermal sheath of the vibrissae follicle. ..
- Nijhout H, German R. Developmental causes of allometry: new models and implications for phenotypic plasticity and evolution. Integr Comp Biol. 2012;52:43-52 pubmed publisher..Large evolutionary changes in allometry can be produced by small and simple changes in growth kinetics, and we show how understanding the development of traits can greatly simplify the interpretation of how they evolved. ..
- Sun J, Liu Y, Aballay A. Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation. EMBO Rep. 2012;13:855-60 pubmed publisher..Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation. ..
- Emmenegger B, Hwang E, Moore C, Markant S, Brun S, Dutton J, et al. Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma. Oncogene. 2013;32:4181-8 pubmed publisher..These results suggest that activators of FGF signaling may be useful for targeting medulloblastoma and other Shh-dependent tumors. ..
- Nelson C, Hakim C, Ousterout D, Thakore P, Moreb E, Castellanos Rivera R, et al. In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. Science. 2016;351:403-7 pubmed publisher..This work establishes CRISPR-Cas9-based genome editing as a potential therapy to treat DMD. ..
- Bao X, Chandramohan V, Reynolds R, Norton J, Wetsel W, Rodriguiz R, et al. Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats. Invest New Drugs. 2016;34:149-58 pubmed publisher..10 and 0.35Â Î¼g, and the no-observed-adverse-effect-level was 0.05Â Î¼g in SD rats. Both parameters were utilized to design the Phase I/II D2C7-IT clinical trial. ..
- Smith M, Boyd W, Kissling G, Rice J, Snyder D, Portier C, et al. A discrete time model for the analysis of medium-throughput C. elegans growth data. PLoS ONE. 2009;4:e7018 pubmed publisher..In addition, extraneous matter and the inability to assign specific measurements to specific nematodes made it difficult to estimate growth rates. The present model addresses these problems through a population-based Markov model. ..
- Edwards K, Chang X, Kiehart D. Essential light chain of Drosophila nonmuscle myosin II. J Muscle Res Cell Motil. 1995;16:491-8 pubmed..The gene encoding Drosophila nonmuscle essential light chain (Mlc-c) localizes to cytological position 5A6 and we discuss prospects for genetic analysis in this region. ..
- Rae T, Koppe T. Isometric scaling of maxillary sinus volume in hominoids. J Hum Evol. 2000;38:411-23 pubmed..This result, in turn, has implications for the phylogenetic placement of fossil taxa and highlights the need for the careful delineation of character states in studies of hominoid systematics. ..
- Ozen G, Augustine G, Hall W. Contribution of superficial layer neurons to premotor bursts in the superior colliculus. J Neurophysiol. 2000;84:460-71 pubmed..Our results indicate that most superficial cells do not directly contribute to production of the EPSC bursts, but a small number do have the properties necessary to provide a prolonged excitatory drive to the premotor neurons...
- Gerald N, Damer C, O Halloran T, De Lozanne A. Cytokinesis failure in clathrin-minus cells is caused by cleavage furrow instability. Cell Motil Cytoskeleton. 2001;48:213-23 pubmed..We postulate that this morphology is the result of contraction at the rear of the presumptive daughter cells in concert with incomplete furrow ingression. ..
- Corcoran E, Joseph J, MacDonald J, Kane C, Haystead T, Means A. Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences. J Biol Chem. 2003;278:10516-22 pubmed..These differences in substrate specificities emphasize the need to consider these protein kinases independently despite their close homology. ..
- Chen B, Cui X, Sempowski G, Domen J, Chao N. Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation. Blood. 2004;103:4344-52 pubmed..Higher numbers of total thymocytes and signal joint T-cell receptor excision circles were observed in the higher dose stem cell recipients, suggesting that accelerated regeneration of T cells was due to enhanced thymopoiesis. ..
- Zhu M, Liu Y, Koonpaew S, Granillo O, Zhang W. Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med. 2004;200:991-1000 pubmed
- Grivna S, Beyret E, Wang Z, Lin H. A novel class of small RNAs in mouse spermatogenic cells. Genes Dev. 2006;20:1709-14 pubmed..Furthermore, a subpopulation of piRNAs are associated with polysomes, suggesting their potential role in translational regulation. ..
- Pua H, Dzhagalov I, Chuck M, Mizushima N, He Y. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med. 2007;204:25-31 pubmed..These results demonstrate a critical role for Atg5 in multiple aspects of lymphocyte development and function and suggest that autophagy may be essential for both T lymphocyte survival and proliferation. ..
- Choi M, Stottmann R, Yang Y, Meyers E, Klingensmith J. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res. 2007;100:220-8 pubmed..These data indicate that antagonism of BMP signaling by Noggin plays a critical role in ensuring proper levels of cell proliferation and EMT during cardiac morphogenesis in the mouse. ..
- Lassiter T, Ryde I, MacKillop E, Brown K, Levin E, Seidler F, et al. Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood. Environ Health Perspect. 2008;116:1456-62 pubmed publisher..Early-life toxicant exposure to organophosphates or other environmental chemicals may play a role in the increased incidence of obesity and diabetes. ..
- Freedland S, Aronson W. Dietary intervention strategies to modulate prostate cancer risk and prognosis. Curr Opin Urol. 2009;19:263-7 pubmed publisher..Larger and longer term studies are needed to determine the clinical relevance of these findings. ..
- Sullivan P, Han B, Liu F, Mace B, Ervin J, Wu S, et al. Reduced levels of human apoE4 protein in an animal model of cognitive impairment. Neurobiol Aging. 2011;32:791-801 pubmed publisher..Our findings suggest that a fraction of APOE4-linked AD may be due to insufficient levels of functional apoE required to maintain neuronal health. ..
- DiLillo D, Yanaba K, Tedder T. B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice. J Immunol. 2010;184:4006-16 pubmed publisher..Rather, targeting tumor Ags to B cells in addition to dendritic cells is likely to optimize tumor-directed vaccines and immunotherapies. ..
- Ledford J, Pastva A, Wright J. Review: Collectins link innate and adaptive immunity in allergic airway disease. Innate Immun. 2010;16:183-90 pubmed publisher..Future studies are needed to elucidate whether alterations in SP-A and SP-D are a consequence and/or cause of allergic airway disease. ..
- Ahmad S, Scott J. Estradiol enhances cell-associated paraoxonase 1 (PON1) activity in vitro without altering PON1 expression. Biochem Biophys Res Commun. 2010;397:441-6 pubmed publisher..Thus, E2 can enhance cell-associated PON1 activity in vitro without altering PON1 gene expression or protein level. Our data suggest that E2 may regulate the specific activity and/or stability of cell surface PON1. ..
- Schlekat C, Van Genderen E, De Schamphelaere K, Antunes P, Rogevich E, Stubblefield W. Cross-species extrapolation of chronic nickel Biotic Ligand Models. Sci Total Environ. 2010;408:6148-57 pubmed publisher..Our results confirm the influence of site-specific pH, hardness, and DOC on chronic nickel toxicity to aquatic organisms, and support the use of chronic nickel BLMs to manage this influence through normalizations of ecotoxicity data. ..
- Mahlios J, Zhuang Y. Contribution of IL-13 to early exocrinopathy in Id3-/- mice. Mol Immunol. 2011;49:227-33 pubmed publisher..These findings indicate a potentially important role for IL-13 in gland regulation and disease pathology. ..
- Schiffman S. Rationale for further medical and health research on high-potency sweeteners. Chem Senses. 2012;37:671-9 pubmed publisher..Nine research needs are described that address some of the major unknown issues associated with ingestion of high-potency sweeteners. ..
- Choi M, Cohen T, Barrientos T, Wang B, Li M, Simmons B, et al. A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program. Mol Cell. 2012;47:122-32 pubmed publisher..Our findings establish an HDAC4-MAPK-AP1 signaling axis essential for neurogenic muscle atrophy and uncover a direct crosstalk between acetylation- and phosphorylation-dependent signaling cascades. ..
- Chan I, Guy C, Chen Y, Lu J, Swiderska Syn M, Michelotti G, et al. Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma. Cancer Res. 2012;72:6344-50 pubmed publisher..This discovery reveals new diagnostic and therapeutic targets that might be exploited to improve the outcomes of cirrhotic patients with HCCs. ..
- Auvin S, Walker L, Gallentine W, Jozwiak S, Tombini M, Sills G. Prospective clinical trials to investigate clinical and molecular biomarkers. Epilepsia. 2017;58 Suppl 3:20-26 pubmed publisher..In addition, it is crucial that those involved in the design and support of relevant clinical studies recognize this gap and act accordingly, and in the interests of improving the diagnosis and prognosis for epilepsy. ..
- DiChiara T, Reinhart P. Distinct effects of Ca2+ and voltage on the activation and deactivation of cloned Ca(2+)-activated K+ channels. J Physiol. 1995;489 ( Pt 2):403-18 pubmed
- Zhang L, Tschantz W, Casey P. Isolation and characterization of a prenylcysteine lyase from bovine brain. J Biol Chem. 1997;272:23354-9 pubmed..These findings suggest that prenylcysteine lyase is a specific enzyme involved in prenylcysteine metabolism in mammalian cells, most likely comprising the final step in the degradation of prenylated proteins. ..
- Barndt R, Dai M, Zhuang Y. A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. J Immunol. 1999;163:3331-43 pubmed..These findings suggest an essential function of HEB in early T cell development, downstream or parallel to the pre-TCR signaling pathway. ..
- Connor J, Weiser D, Li S, Hallenbeck J, Shenolikar S. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol Cell Biol. 2001;21:6841-50 pubmed publisher..These studies suggested that modification of the I-1/GADD34/PP1 signaling complex regulates the initiation of protein translation in mammalian tissues...
- Misra U, Adlakha C, Gawdi G, McMillian M, Pizzo S, Laskowitz D. Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages. J Leukoc Biol. 2001;70:677-83 pubmed..ApoE-dependent signal transduction might play a role in mediating the functional properties of this lipoprotein. ..
- Foster W, Wagner E. Bronchial edema alters (99m)Tc-DTPA clearance from the airway surface in sheep. J Appl Physiol (1985). 2001;91:2567-73 pubmed..We suggest that the interplay between vascular and mucociliary clearance routes will impact the resident time for clearance of soluble air toxins and/or therapeutic agents from the epithelial surface. ..
- Borel C, McKee A, Parra A, Haglund M, Solan A, Prabhakar V, et al. Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage. Stroke. 2003;34:427-33 pubmed..Proliferation of cells in the vascular wall is associated with perivascular thrombus. Cellular proliferation and subsequent vessel wall thickening may contribute to the syndrome of delayed cerebral vasospasm. ..
- Le Corvoisier P, Park H, Carlson K, Donahue M, Marchuk D, Rockman H. Impact of genetic polymorphisms on heart failure prognosis. Arch Mal Coeur Vaiss. 2003;96:197-206 pubmed
- Taylor A, Vinyard C. Comparative analysis of masseter fiber architecture in tree-gouging (Callithrix jacchus) and nongouging (Saguinus oedipus) callitrichids. J Morphol. 2004;261:276-85 pubmed..Collectively, these results suggest that the fiber architecture of the common marmoset masseter is part of a suite of features of the masticatory apparatus that facilitates the production of relatively large gapes during tree gouging...
- Jacobsen J, Rodriguiz R, Mørk A, Wetsel W. Monoaminergic dysregulation in glutathione-deficient mice: possible relevance to schizophrenia?. Neuroscience. 2005;132:1055-72 pubmed..Thus, GSH-deficiency can lead to disturbances in DA, 5-HT and NMDA function, a finding that may have relevance for schizophrenia. ..
- Arcasoy M, Karayal A. Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain. Biochim Biophys Acta. 2005;1740:17-28 pubmed..These findings suggest that both tyrosine residues Y285 and Y344 in the cytoplasmic domain of EPOR-ME may contribute to increased Epo sensitivity that is characteristic of PFCP phenotype. ..
- Lipscomb H, Dement J, Epling C, McDonald M, Schoenfisch A. Are we failing vulnerable workers? The case of black women in poultry processing in rural North Carolina. New Solut. 2007;17:17-40 pubmed
- Koeberl D, Pinto C, Sun B, Li S, Kozink D, Benjamin D, et al. AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia. Mol Ther. 2008;16:665-72 pubmed publisher..These preclinical data demonstrated the efficacy of correcting hepatic G6Pase deficiency, and support the further preclinical development of AAV vector-mediated gene therapy for GSD-Ia. ..
- Slotkin T, Lassiter T, Ryde I, Wrench N, Levin E, Seidler F. Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions. Environ Health Perspect. 2009;117:916-22 pubmed publisher..Further, cryptic neurodevelopmental deficits evoked by environmental exposures may thus engender a later preference for a high-fat diet to maintain normal ACh function, ultimately contributing to obesity. ..
- Ingram B, Sohlenkamp C, Geiger O, Raetz C. Altered lipid A structures and polymyxin hypersensitivity of Rhizobium etli mutants lacking the LpxE and LpxF phosphatases. Biochim Biophys Acta. 2010;1801:593-604 pubmed publisher..Therefore, the dephosphorylation of lipid A molecules in R. etli is not required for nodulation but may instead play a role in protecting the bacteria from cationic antimicrobial peptides or other immune responses of plants...
- Homi H, Jones W, de Lange F, Mackensen G, Grocott H. Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat. J Thorac Cardiovasc Surg. 2010;140:660-6, 666.e1 pubmed publisher..0124). Cardiopulmonary bypass increased cerebral infarct size after focal cerebral ischemia in rats. This worsening of outcome may in part be related to an augmented inflammatory response that accompanies cardiopulmonary bypass. ..
- Bohórquez D, Chandra R, Samsa L, Vigna S, Liddle R. Characterization of basal pseudopod-like processes in ileal and colonic PYY cells. J Mol Histol. 2011;42:3-13 pubmed publisher..The anatomical arrangement of these structures suggests a dual function as a dock for receptors to survey absorbed nutrients and as a launching platform for hormone secretion in a paracrine fashion. ..
- Dodds K. Effects of habitat type and trap placement on captures of bark (Coleoptera: Scolytidae) and longhorned (Coleoptera: Cerambycidae) beetles in semiochemical-baited traps. J Econ Entomol. 2011;104:879-88 pubmed..Abundance and species richness were generally higher in the closed canopy and edge placements compared with traps in the open area. The highest number of unique species were captured in the edge and clearing. ..
- Liang J, Jung Y, Tighe R, Xie T, Liu N, Leonard M, et al. A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. Am J Physiol Lung Cell Mol Physiol. 2012;302:L933-40 pubmed publisher..Our data suggested a previously undiscovered role for MHCII IA/IE(int)CD11c(int) cells in apoptotic cell clearance and inflammation resolution. ..
- Shih H, Verma Gaur J, Torkamani A, Feeney A, Galjart N, Krangel M. Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub. Proc Natl Acad Sci U S A. 2012;109:E3493-502 pubmed publisher..Our data indicate that E(?) and CTCF cooperate to create a developmentally regulated chromatin hub that supports V(?)-J(?) synapsis and recombination. ..
- Hara M, Sachs B, Caron M, Lefkowitz R. Pharmacological blockade of a ?(2)AR-?-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle. 2013;12:219-24 pubmed publisher..These data suggest that the ?(2)AR-?-arrestin-1 signaling pathway may represent an attractive therapeutic target to prevent some of the negative consequences of stress in the treatment of stress-related disorders. ..
- Grizzle R, Ward K, AlShihi R, Burt J. Current status of coral reefs in the United Arab Emirates: Distribution, extent, and community structure with implications for management. Mar Pollut Bull. 2016;105:515-23 pubmed publisher..Distinct communities occur in the Sea of Oman, where cover and richness were low. We provide management recommendations to enhance conservation of vulnerable coral reefs in the UAE. ..
- Cho K, Haney V, Yoon D, Hao Y, Ferreira P. Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2). FEBS Lett. 2015;589:3959-68 pubmed publisher..Hence, insidious functional impairment of SBM of Ranbp2's CLD promotes neuroprotection and uncoupling of photoreceptor degeneration and death against phototoxicity. ..
- Bogers W, Barnett S, Oostermeijer H, Nieuwenhuis I, Beenhakker N, Mortier D, et al. Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site. J Virol. 2017;91: pubmed publisher..We found superior and durable B-cell responses in macaques vaccinated with an occluded CD4 binding site on the HIV envelope antigen, demonstrating a potentially important new direction in future design of new HIV vaccines. ..