Genomes and Genes
Experts and Doctors on amino acid sequence in Durham, North Carolina, United States
Locale: Durham, North Carolina, United States
Topic: amino acid sequence
Publications239 found, 100 shown here
- Kelley M, Jawien W, Ortel T, Korczak J. Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly. Nat Genet. 2000;26:106-8 pubmed
- Hamilton M, Tcherepanova I, Huibregtse J, McDonnell D. Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J Biol Chem. 2001;276:26324-31 pubmed..Cumulatively, these findings highlight a nuclear role for the ubiquitin ligase hRPF1/Nedd4 and underscore cytoplasmic/nuclear localization as an important regulatory component of hRPF1/Nedd4-substrate recognition. ..
- Driver D, McHeyzer Williams L, Cool M, Stetson D, McHeyzer Williams M. Development and maintenance of a B220- memory B cell compartment. J Immunol. 2001;167:1393-405 pubmed
- Looger L, Dwyer M, Smith J, Hellinga H. Computational design of receptor and sensor proteins with novel functions. Nature. 2003;423:185-90 pubmed..The biological and biosensing activities of the designed receptors illustrate potential applications of computational design. ..
- Wang X, Karbarz M, McGrath S, Cotter R, Raetz C. MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of francisella novicida LpxE expressed in Escherichia coli. J Biol Chem. 2004;279:49470-8 pubmed..Our findings provide the first direct evidence that lipid A 1-dephosphorylation catalyzed by LpxE occurs on the periplasmic surface of the inner membrane...
- Kiehart D, Franke J, Chee M, Montague R, Chen T, Roote J, et al. Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA. Genetics. 2004;168:1337-52 pubmed publisher..Together, our data suggest a key role for ck/myoVIIA in the formation of cellular projections and other actin-based functions required for viability...
- Allert M, Dwyer M, Hellinga H. Local encoding of computationally designed enzyme activity. J Mol Biol. 2007;366:945-53 pubmed
- Philip J, Fitches E, Harrison R, Bonning B, Gatehouse J. Characterisation of functional and insecticidal properties of a recombinant cathepsin L-like proteinase from flesh fly (Sarcophaga peregrina), which plays a role in differentiation of imaginal discs. Insect Biochem Mol Biol. 2007;37:589-600 pubmed..Production of a inactive mutant form of ScathL showed that enzyme activity was necessary for the complete proprotein processing observed during production as a recombinant protein, and for insecticidal activity. ..
- Wu J, Phatnani H, Hsieh T, Greenleaf A. The phosphoCTD-interacting domain of Topoisomerase I. Biochem Biophys Res Commun. 2010;397:117-9 pubmed publisher..The long-known in vivo association of Topo I with active genes presumably can be attributed, wholly or in part, to the TRI domain-mediated binding of Topo I to the phosphoCTD of transcribing RNAPII. ..
- Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villen J, et al. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A. 2010;107:15299-304 pubmed publisher..This study provides a system-based view of beta-arrestin-mediated phosphorylation events downstream of a 7TMR and opens avenues for research in a rapidly evolving area of 7TMR signaling. ..
- Malvar T, Biron R, Kaback D, Denis C. The CCR4 protein from Saccharomyces cerevisiae contains a leucine-rich repeat region which is required for its control of ADH2 gene expression. Genetics. 1992;132:951-62 pubmed..This leucine-rich repeat region may mediate the contact CCR4 makes with another factor. ..
- Deutscher S, Harley J, Keene J. Molecular analysis of the 60-kDa human Ro ribonucleoprotein. Proc Natl Acad Sci U S A. 1988;85:9479-83 pubmed..Possible functions of the Ro RNPs and their relationship to RNA polymerase III transcription are discussed. ..
- McAllister K, Grogg K, Johnson D, Gallione C, Baldwin M, Jackson C, et al. Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet. 1994;8:345-51 pubmed..We have identified endoglin as the HHT gene mapping to 9q3 and have established HHT as the first human disease defined by a mutation in a member of the TGF-beta receptor complex. ..
- Davis J, Bennett V. Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. J Biol Chem. 1994;269:27163-6 pubmed..Linkage of these ankyrin-binding cell adhesion molecules to spectrin-based structures may provide a major class of membrane-cytoskeletal connections in adult brain as well as earlier stages of development. ..
- Hankins G, De Souza A, Bentley R, Patel M, Marks J, Iglehart J, et al. M6P/IGF2 receptor: a candidate breast tumor suppressor gene. Oncogene. 1996;12:2003-9 pubmed..These findings provide evidence that M6P/IGF2r allelic loss is an early event in the etiology of breast cancer, that this gene functions as a tumor suppressor gene in the breast. ..
- Bachman E, McClay D. Molecular cloning of the first metazoan beta-1,3 glucanase from eggs of the sea urchin Strongylocentrotus purpuratus. Proc Natl Acad Sci U S A. 1996;93:6808-13 pubmed..A global phylogeny based on these regions strongly suggests that the glucanases are a very ancient family of genes. In particular, there is an especially deep split within genes taken from the bacterial genus Bacillus...
- Edwards K, Demsky M, Montague R, Weymouth N, Kiehart D. GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. Dev Biol. 1997;191:103-17 pubmed
- Dolinski K, Muir S, Cardenas M, Heitman J. All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1997;94:13093-8 pubmed..We propose that each cyclophilin and FKBP instead regulates a restricted number of unique partner proteins that remain to be identified. ..
- Spurney R. Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor. J Biol Chem. 1998;273:28496-503 pubmed
- Nash S, Giros B, Kingsmore S, Kim K, El Mestikawy S, Dong Q, et al. Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. Receptors Channels. 1998;6:113-28 pubmed
- Lindsey Boltz L, Chawla G, Srinivasan N, Vijayraghavan U, Garcia Blanco M. The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function. RNA. 2000;6:1289-305 pubmed..These data reinforce the functional significance of this region within the WD domain of Prp17p in the second step of splicing. ..
- Gonzalez P, Epstein D, Borras T. Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones. Invest Ophthalmol Vis Sci. 2000;41:3678-93 pubmed
- Chen J, Chiang Y, Denis C. CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase. EMBO J. 2002;21:1414-26 pubmed..The various regulatory effects of the CCR4-NOT complex on gene expression may be executed in part through these CCR4 exonuclease activities. ..
- Russell P, Benson J, Denis C. Characterization of mutations in NOT2 indicates that it plays an important role in maintaining the integrity of the CCR4-NOT complex. J Mol Biol. 2002;322:27-39 pubmed..These results indicate that it is the loss of the integrity of the CCR4-NOT complex which leads to severe not2 phenotypes and that the NOT2 contacts to ADA2 play a lesser role in NOT2 function. ..
- Freeman J, Gonzalo P, Pitcher J, Claing A, Lavergne J, Reboud J, et al. Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. Biochemistry. 2002;41:12850-7 pubmed
- Sweet C, Ribeiro A, Raetz C. Oxidation and transamination of the 3"-position of UDP-N-acetylglucosamine by enzymes from Acidithiobacillus ferrooxidans. Role in the formation of lipid a molecules with four amide-linked acyl chains. J Biol Chem. 2004;279:25400-10 pubmed..As shown in the accompanying papers, UDP-GlcNAc3N is selectively acylated by LpxAs of A. ferrooxidans, L. interrogans, and M. loti. UDP-GlcNAc3N may be useful as a substrate analog for diverse enzymes that utilize UDP-GlcNAc...
- Boon Hinckley M, Reynolds C, Ribeiro A, McGrath S, Cotter R, Lauw F, et al. A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A. J Biol Chem. 2005;280:30214-24 pubmed..In human cells, engineered to express the individual TLR subtypes, 1-phosphomethyl-lipid A purified from lmtA-expressing E. coli potently activated TLR4 but not TLR2. ..
- Cuneo M, Changela A, Warren J, Beese L, Hellinga H. The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites. J Mol Biol. 2006;362:259-70 pubmed..Comparison of ttGBP and MBP provides a clear example of structural adaptations by which the size of ligand binding sites can be controlled in the PBP super family. ..
- Bloomer W, VanDongen H, VanDongen A. Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies. Brain Res. 2007;1153:20-33 pubmed..These results suggest that Arc functions as a spectrin-binding protein, forming a complex that may provide a role at sites of transcriptional regulation within the nucleus. ..
- Orans J, McSweeney E, Iyer R, Hast M, Hellinga H, Modrich P, et al. Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell. 2011;145:212-23 pubmed publisher..The relative arrangement of substrate binding sites in these enzymes provides an elegant solution to a complex geometrical puzzle of substrate recognition and processing. ..
- Linney E, Perz Edwards A, Kelley B. Identification and characterization of a functional zebrafish smrt corepressor (ncor2). Gene. 2011;486:31-6 pubmed publisher..We suggest that this rar-corepressor complex may be part of an embryonic, epigenetic switch that keeps retinoic acid responsive genes off before retinoic becomes available to the embryo. ..
- Tan B, Bogdanov M, Zhao J, Dowhan W, Raetz C, Guan Z. Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates. Proc Natl Acad Sci U S A. 2012;109:16504-9 pubmed publisher..Unlike eukaryotic Cls (that use PG and CDP-diacylglycerol as substrates) or ClsA, the combined YmdB-ClsC used PE as the phosphatidyl donor to PG to form CL, which demonstrates a third and unique mode for CL synthesis. ..
- Cadwell C, Jenkins P, Bennett V, Kowalczyk A. Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. J Biol Chem. 2016;291:691-704 pubmed publisher..Our findings support a novel mechanism for regulation of VE-cadherin endocytosis through ankyrin association with cadherin engaged in lateral interactions. ..
- Ware R, Scearce R, Dietz M, Starmer C, Palker T, Haynes B. Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. J Immunol. 1989;143:3632-40 pubmed..Finally, comparison of the CD7 transmembrane sequence with CD4 and HIV transmembrane sequences and with respiratory syncytial virus fusion sequences demonstrated similar sequence motifs among these molecules. ..
- Ho Y, Howard A, Crapo J. Cloning and sequence of a cDNA encoding rat glucose-6-phosphate dehydrogenase. Nucleic Acids Res. 1988;16:7746 pubmed
- Dai Z, Pendergast A. Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Genes Dev. 1995;9:2569-82 pubmed..The properties of Abi-2 are consistent with a dual role as regulator and potential effector of the c-Abl protein and suggest that Abi-2 may function as a tumor suppressor in mammalian cells. ..
- Haribabu B, Hook S, Selbert M, Goldstein E, Tomhave E, Edelman A, et al. Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. EMBO J. 1995;14:3679-86 pubmed..Additionally, CaMKI kinase responds directly to Ca(2+)-CaM with increased activity. ..
- Lee D, Schanberg L, Fleenor D, Seldin M, Haynes B, Kaufman R. The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters. Immunogenetics. 1996;44:108-14 pubmed..Thus, the promoter regions and exonic organization were similar in the human CD7, mouse CD7, and mouse Thy-1 genes. ..
- Cardenas M, Heitman J. FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. EMBO J. 1995;14:5892-907 pubmed..These studies demonstrate that TOR2 is an essential, highly conserved component of a signal transduction pathway regulating cell cycle progression conserved from yeast to man. ..
- Quarles L, Hartle J, Siddhanti S, Guo R, Hinson T. A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor. J Bone Miner Res. 1997;12:393-402 pubmed..These findings suggest that an extra-cellular cation-sensing mechanism is present in murine-derived osteoblasts that is functionally similar to but molecularly distinct from CaR. ..
- Tuvia S, Garver T, Bennett V. The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation. Proc Natl Acad Sci U S A. 1997;94:12957-62 pubmed..These findings suggest a general mechanism for the patterning of cell contact based on external signals that regulate tyrosine phosphorylation of L1CAM members and modulate their binding to ankyrin. ..
- Kumar J, Erickson H, Sheetz M. Ultrastructural and biochemical properties of the 120-kDa form of chick kinectin. J Biol Chem. 1998;273:31738-43 pubmed..Immunoprecipitation with a 160-kDa kinectin-specific antibody brought down the 120-kDa kinectin. Thus, we suggest that kinectin is an extended parallel coiled-coil dimer, often a heterodimer. ..
- Del Poeta M, Toffaletti D, Rude T, Dykstra C, Heitman J, Perfect J. Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target. Genetics. 1999;152:167-78 pubmed..In summary, our studies reveal that topoisomerase I is essential in the human pathogen C. neoformans and represents a novel target for antifungal agents. ..
- Bieniasz P, Grdina T, Bogerd H, Cullen B. Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism. Mol Cell Biol. 1999;19:4592-9 pubmed
- Kwak E, Gerald N, Larochelle D, Vithalani K, Niswonger M, Maready M, et al. LvsA, a protein related to the mouse beige protein, is required for cytokinesis in Dictyostelium. Mol Biol Cell. 1999;10:4429-39 pubmed..Thus, on the basis of the sequence analysis of the LvsA protein and the phenotype of the lvsA mutants, we postulate that LvsA plays an important role in a membrane-processing pathway that is essential for cytokinesis. ..
- Chen Z, Koralov S, Gendelman M, Carroll M, Kelsoe G. Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence. J Immunol. 2000;164:4522-32 pubmed..These observations suggest that B cell activation/survival signals mediated by CD21 and/or the retention of Ag by CD21/CD35 play important roles in the generation, quality, and maintenance of serum Ab. ..
- Erickson H. The FtsZ protofilament and attachment of ZipA--structural constraints on the FtsZ power stroke. Curr Opin Cell Biol. 2001;13:55-60 pubmed..A model is proposed here for how membrane-bound ZipA can reach around the FtsZ protofilament to bind the carboxy-terminal peptide, which faces away from the membrane. ..
- Phillips R, Ramos S, Blackshear P. Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling. J Biol Chem. 2002;277:11606-13 pubmed..These findings suggest possible roles for nuclear import and export in the regulation of cellular TTP, CMG1, and TIS11D activity. ..
- Swenson K, Winkler K, Means A. A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. Mol Biol Cell. 2003;14:156-72 pubmed..Our studies suggest a new role for MLK3, separable from its function in the JNK pathway, that may contribute to promoting microtubule instability, a hallmark of M phase entry. ..
- Vining K, Davis T. Isolation of a Ve homolog, mVe1, and its relationship to Verticillium wilt resistance in Mentha longifolia (L.) Huds. Mol Genet Genomics. 2009;282:173-84 pubmed publisher..Therefore, further investigations of mVe1 and identification of additional candidate genes are both warranted...
- Reedy J, Filler S, Heitman J. Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. Fungal Genet Biol. 2010;47:107-16 pubmed publisher..These studies extend our understanding of the C. albicans calcineurin signaling cascade and its host-niche specific role in virulence. ..
- Zhong L, Bellemer A, Yan H, Ken H, Jessica R, Hwang R, et al. Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. Cell Rep. 2012;1:43-55 pubmed..The identification of these amino acids opens the door to a biophysical understanding of a molecular thermosensor. ..
- Lin Y, Jones Mason M, Inoue M, Lasorella A, Iavarone A, Li Q, et al. Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis. J Immunol. 2012;189:1400-5 pubmed publisher..This study reveals a critical role of Id2 in the control of effector CD4 T cell population size and the development of a Th17-mediated autoimmune disease. ..
- Go E, Ding H, Zhang S, Ringe R, Nicely N, Hua D, et al. Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers. J Virol. 2017;91: pubmed publisher..The data presented here give vaccine developers a "glycosylation target" for their immunogens, and they show how protein production variables can impact Env glycosylation. ..
- King K, Dohlman H, Thorner J, Caron M, Lefkowitz R. Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit. Science. 1990;250:121-3 pubmed..This in vivo reconstitution system provides a new approach for examining ligand binding and G protein coupling to cell surface receptors...
- De la Rosa J, Ostrowski J, Hryniewicz M, Kredich N, Kotb M, LeGros H, et al. Chromosomal localization and catalytic properties of the recombinant alpha subunit of human lymphocyte methionine adenosyltransferase. J Biol Chem. 1995;270:21860-8 pubmed..The data suggest that the alpha/alpha' subunits mediate the enzyme catalytic activity and that the beta subunit may be a regulatory subunit of extrahepatic MAT. ..
- El Mestikawy S, Giros B, Pohl M, Hamon M, Kingsmore S, Seldin M, et al. Characterization of an atypical member of the Na+/Cl(-)-dependent transporter family: chromosomal localization and distribution in GABAergic and glutamatergic neurons in the rat brain. J Neurochem. 1994;62:445-55 pubmed..The gene encoding for XT1 is localized to the mouse chromosome 3 in the vicinity of the locus for the mouse neurological disorder spastic (spa). ..
- Ren H, Stiles G. Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing. J Biol Chem. 1994;269:3104-10 pubmed..No evidence for expression of exons 1 and 2 could be discerned. Exon 4 contains two AUG initiation codons with reasonable Kozak consensus, suggesting the possibility of translational regulation. Exon 3 contains no AUG initiation codons. ..
- Johnson D, Berg J, Baldwin M, Gallione C, Marondel I, Yoon S, et al. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet. 1996;13:189-95 pubmed..Our data suggest a critical role for ALK1 in the control of blood vessel development or repair. ..
- Lu Y, Ratnakar P, Mohanty B, Bastia D. Direct physical interaction between DnaG primase and DnaB helicase of Escherichia coli is necessary for optimal synthesis of primer RNA. Proc Natl Acad Sci U S A. 1996;93:12902-7 pubmed..Thus, the physical interaction reported here appears to be physiologically significant. ..
- Wong M, Ramayya M, Chrousos G, Driggers P, Parker K. Cloning and sequence analysis of the human gene encoding steroidogenic factor 1. J Mol Endocrinol. 1996;17:139-47 pubmed
- Steeber D, Engel P, Miller A, Sheetz M, Tedder T. Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes. J Immunol. 1997;159:952-63 pubmed..Signaling through L-selectin may enhance leukocyte-endothelial cell interactions by serving as an activation/priming step during rolling, thereby promoting subsequent firm cell-cell adhesion in the presence of inflammatory mediators. ..
- Glick J, Meigs T, Miron A, Casey P. RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. J Biol Chem. 1998;273:26008-13 pubmed..Phosphorylation of Gzalpha by protein kinase C, an event known to occur in cells and that was previously shown to influence alpha-betagamma interactions of Gz, rendered the G protein much less susceptible to RGSZ1 action. ..
- Chang C, Norris J, Grøn H, Paige L, Hamilton P, Kenan D, et al. Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta. Mol Cell Biol. 1999;19:8226-39 pubmed
- Tcherepanova I, Bhattacharyya L, Rubin C, Freedman J. Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1. J Biol Chem. 2000;275:26359-69 pubmed..Furthermore, transcription predominantly occurs in eight anterior cells of the intestine (int6-int8). Analyses of ASP-1 nucleotide and amino acid sequences revealed the presence of five additional C. elegans aspartic proteases. ..
- Gibbons H, Lin S, Cotter R, Raetz C. Oxygen requirement for the biosynthesis of the S-2-hydroxymyristate moiety in Salmonella typhimurium lipid A. Function of LpxO, A new Fe2+/alpha-ketoglutarate-dependent dioxygenase homologue. J Biol Chem. 2000;275:32940-9 pubmed..We hypothesize that 2-hydroxymyristate chains released from lipopolysaccharide inside infected macrophages might be converted to 2-hydroxymyristoyl coenzyme A, a well characterized, potent inhibitor of protein N-myristoyl transferase. ..
- Karbarz M, Kalb S, Cotter R, Raetz C. Expression cloning and biochemical characterization of a Rhizobium leguminosarum lipid A 1-phosphatase. J Biol Chem. 2003;278:39269-79 pubmed..leguminosarum symbiosis with plants. Possible orthologs of LpxE are present in some intracellular human pathogens, including Francisella tularensis, Brucella melitensis, and Legionella pneumophila. ..
- Dagenbach E, Endow S. A new kinesin tree. J Cell Sci. 2004;117:3-7 pubmed
- Armbruster B, Linardic C, Veldman T, Bansal N, Downie D, Counter C. Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. Mol Cell Biol. 2004;24:3552-61 pubmed..However, this rescue depended on the ability of hPot1 to localize to telomeres rather than binding to DNA per se. These data support a model whereby the DAT domain of hTERT is implicated in telomere-telomerase associations. ..
- Dill A, Thomas S, Hu J, Steber C, Sun T. The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation. Plant Cell. 2004;16:1392-405 pubmed..This effect of sly1-d appears to be caused by an enhanced interaction between sly1-d and the DELLA proteins. ..
- Mohler P, Yoon W, Bennett V. Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. J Biol Chem. 2004;279:40185-93 pubmed..This work also establishes a functional hierarchy in which ankyrin-B determines the localization of beta(2)-spectrin and operates independently of beta(2)-spectrin in its role in organizing membrane-spanning proteins. ..
- Mosher R, Durrant W, Wang D, Song J, Dong X. A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity. Plant Cell. 2006;18:1750-65 pubmed publisher..The structural similarity of SNI1 to Armadillo repeat proteins implies that SNI1 may form a scaffold for interaction with proteins that modulate transcription...
- Cho K, Cai Y, Yi H, Yeh A, Aslanukov A, Ferreira P. Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. Traffic. 2007;8:1722-35 pubmed..The data also strengthen a model whereby the selection of a large array of cargoes for transport by a restricted number of motor proteins is mediated by adaptor proteins such as RanBP2. ..
- Voltz J, Brush M, Sikes S, Steplock D, Weinman E, Shenolikar S. Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. J Biol Chem. 2007;282:33879-87 pubmed
- Cramer R, Perfect B, Pinchai N, Park S, Perlin D, Asfaw Y, et al. Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryot Cell. 2008;7:1085-97 pubmed publisher..In addition, the importance of CrzA to the production of disease is critical, and thus CrzA is an attractive fungus-specific antifungal target for the treatment of invasive aspergillosis. ..
- Lieberman A, Kuraoka M, Davila M, Kelsoe G, Cowell L. Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells. BMC Immunol. 2009;10:37 pubmed publisher..The extent to which these sequences are conserved, and their pattern of conservation, suggest that they may serve an as yet unidentified purpose. ..
- Kosloff M, Travis A, Bosch D, Siderovski D, Arshavsky V. Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. Nat Struct Mol Biol. 2011;18:846-53 pubmed publisher..Finally, we show that our approach can be extended to analyze interaction specificity across other large protein families. ..
- Brietzke A, Goldammer T, Rebl H, Korytář T, Köllner B, Yang W, et al. Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells. Fish Shellfish Immunol. 2014;36:206-14 pubmed publisher..Our data unexpectedly imply that IRAK4 is involved in establishing threshold levels of active NF-?B in resting cells. ..
- Hu R, Watanabe M, Bennett V. Characterization of human brain cDNA encoding the general isoform of beta-spectrin. J Biol Chem. 1992;267:18715-22 pubmed..beta-Spectrins are likely to perform related but distinct functions, with beta G in a general, constitutive role and beta R-spectrin involved in more specialized activities of differentiated cells. ..
- Shafqat S, Tamarappoo B, Kilberg M, Puranam R, McNamara J, Guadaño Ferraz A, et al. Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. J Biol Chem. 1993;268:15351-5 pubmed..SATT may represent one of multiple activities that exhibit System ASC-like transport characteristics in diverse tissues and cell lines. ..
- Huang P, Gaitan A, Hao Y, Petters R, Wong F. Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene. Proc Natl Acad Sci U S A. 1993;90:8484-8 pubmed..Our results demonstrate non-autonomy of gene action for the mutated rhodopsin gene and imply that cellular interactions between photoreceptors in the retina probably play a role in degeneration. ..
- Davis J, McLaughlin T, Bennett V. Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brain. J Cell Biol. 1993;121:121-33 pubmed
- Saravitz D, Siedow J. The differential expression of wound-inducible lipoxygenase genes in soybean leaves. Plant Physiol. 1996;110:287-99 pubmed
- Chin D, Winkler K, Means A. Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. J Biol Chem. 1997;272:31235-40 pubmed..This result demonstrates the critical role of the N-terminal domain of CaM in regulating the access of ATP to CaMKI. ..
- Zhang Y, Fan W, Kinkema M, Li X, Dong X. Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. Proc Natl Acad Sci U S A. 1999;96:6523-8 pubmed..thaliana PR-1 gene. These data suggest that NPR1 may regulate PR-1 gene expression by interacting with a subclass of basic leucine zipper protein transcription factors. ..
- Joseph J, Heitman J, Means A. Molecular cloning and characterization of Aspergillus nidulans cyclophilin B. Fungal Genet Biol. 1999;27:55-66 pubmed..nidulans to cyclosporin A. cypB mRNA levels were significantly elevated under severe heat shock conditions, indicating a possible role for the A. nidulans cyclophilin B protein during growth in high stress environments. ..
- Wuebbens M, Liu M, Rajagopalan K, Schindelin H. Insights into molybdenum cofactor deficiency provided by the crystal structure of the molybdenum cofactor biosynthesis protein MoaC. Structure. 2000;8:709-18 pubmed..This residue is located near the N-terminal end of helix alpha4 at an interface between two monomers. The MoaC structure provides a framework for the analysis of additional dysfunctional mutations in the corresponding human gene. ..
- Goldstrohm A, Albrecht T, Suñé C, Bedford M, Garcia Blanco M. The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. Mol Cell Biol. 2001;21:7617-28 pubmed..These results support a model for the recruitment of CA150 to repress transcription elongation. In this model, CA150 binds to the phosphorylated CTD of elongating RNAPII and SF1 targets the nascent transcript. ..
- Kim S, Merchant K, Nudelman R, Beyer W, Keng T, Deangelo J, et al. OxyR: a molecular code for redox-related signaling. Cell. 2002;109:383-96 pubmed