Experts and Doctors on agrin in Durham, North Carolina, United States


Locale: Durham, North Carolina, United States
Topic: agrin

Top Publications

  1. Finn A, Feng G, Pendergast A. Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. Nat Neurosci. 2003;6:717-23 pubmed
    ..Our findings suggest that Abl kinases provide the developing synapse with the kinase activity required for signal amplification and the intrinsic cytoskeletal regulatory capacity required for assembly and remodeling. ..
  2. Liu I, Uversky V, Munishkina L, Fink A, Halfter W, Cole G. Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation. Glycobiology. 2005;15:1320-31 pubmed
    ..These findings may indicate shared molecular mechanisms leading to the pathophysiology in these two neurodegenerative disorders. ..
  3. Liu I, Zhang C, Kim M, Cole G. Retina development in zebrafish requires the heparan sulfate proteoglycan agrin. Dev Neurobiol. 2008;68:877-98 pubmed publisher
    ..Collectively, these agrin morphant phenotypes provide support for a crucial role of agrin in retina development and formation of an ordered retinotectal topographic map in the optic tectum of zebrafish. ..
  4. Zhang C, Turton Q, Mackinnon S, Sulik K, Cole G. Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish. Birth Defects Res A Clin Mol Teratol. 2011;91:129-41 pubmed publisher
    ..The results of this work suggest that agrin expression and function may be a target of ethanol exposure during embryogenesis. ..
  5. Zhang C, Ojiaku P, Cole G. Forebrain and hindbrain development in zebrafish is sensitive to ethanol exposure involving agrin, Fgf, and sonic hedgehog function. Birth Defects Res A Clin Mol Teratol. 2013;97:8-27 pubmed publisher
  6. Bassat E, Mutlak Y, Genzelinakh A, Shadrin I, Baruch Umansky K, Yifa O, et al. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature. 2017;547:179-184 pubmed publisher
    ..Together, our results uncover a new inducer of mammalian heart regeneration and highlight fundamental roles of the extracellular matrix in cardiac repair. ..