Experts and Doctors on multiprotein complexes in Piscataway, New Jersey, United States


Locale: Piscataway, New Jersey, United States
Topic: multiprotein complexes

Top Publications

  1. Kiledjian M, DeMaria C, Brewer G, Novick K. Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex. Mol Cell Biol. 1997;17:4870-6 pubmed
    ..AUF1/hnRNP-D could, therefore, be a general mRNA turnover factor involved in both stabilization and decay of mRNA. ..
  2. Kusch T, Mei A, Nguyen C. Histone H3 lysine 4 trimethylation regulates cotranscriptional H2A variant exchange by Tip60 complexes to maximize gene expression. Proc Natl Acad Sci U S A. 2014;111:4850-5 pubmed publisher
    ..Furthermore, this mechanism prevents the accumulation of epigenetic noise caused by random complex-nucleosome collisions. ..
  3. Zhu B, Mandal S, Pham A, Zheng Y, Erdjument Bromage H, Batra S, et al. The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev. 2005;19:1668-73 pubmed
    ..Thus, in addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. ..
  4. Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung S, et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006;127:125-37 pubmed
    ..Our findings reveal that the SIN1-rictor-mTOR function in Akt-Ser473 phosphorylation is required for TORC2 function in cell survival but is dispensable for TORC1 function. ..
  5. Greenfield N, Huang Y, Swapna G, Bhattacharya A, Rapp B, Singh A, et al. Solution NMR structure of the junction between tropomyosin molecules: implications for actin binding and regulation. J Mol Biol. 2006;364:80-96 pubmed
  6. Togneri J, Cheng Y, Munson M, Hughson F, Carr C. Specific SNARE complex binding mode of the Sec1/Munc-18 protein, Sec1p. Proc Natl Acad Sci U S A. 2006;103:17730-5 pubmed
    ..We propose that vesicle fusion requires a specific interaction between the SM protein and the ternary SNARE complex. ..
  7. Tsang C, Li H, Zheng X. Nutrient starvation promotes condensin loading to maintain rDNA stability. EMBO J. 2007;26:448-58 pubmed
    ..Our data suggest that enrichment of condensin prevents rDNA instability during nutrient starvation. Together, these observations unravel a novel role for condensin in the maintenance of regional genomic stability. ..
  8. Chen C, Brill S. Binding and activation of DNA topoisomerase III by the Rmi1 subunit. J Biol Chem. 2007;282:28971-9 pubmed
    ..These results demonstrate that Top3-Rmi1 functions as a complex and suggest that Rmi1 stimulates Top3 by promoting its interaction with ssDNA. ..
  9. Sinsimer K, Gratacós F, Knapinska A, Lu J, Krause C, Wierzbowski A, et al. Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay. Mol Cell Biol. 2008;28:5223-37 pubmed publisher

More Information


  1. Tsang C, Zheng X. Opposing role of condensin and radiation-sensitive gene RAD52 in ribosomal DNA stability regulation. J Biol Chem. 2009;284:21908-19 pubmed publisher
    ..In contrast, deletion of RAD52 restores cell viability under the same conditions. These results reveal an opposing role of condensin and Rad52 in the control of rDNA stability under nutrient starvation conditions. ..
  2. Yamaguchi Y, Park J, Inouye M. Toxin-antitoxin systems in bacteria and archaea. Annu Rev Genet. 2011;45:61-79 pubmed publisher
    ..The elucidation of their cellular function and regulation is thus crucial for our understanding of bacterial physiology under various stress conditions. ..
  3. Destefano M, Jacinto E. Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2). Biochem Soc Trans. 2013;41:896-901 pubmed publisher
    ..Our findings reveal that, in addition to persistent mTORC1 signalling, increased mTORC2 signals can promote insulin resistance due to mTORC2-mediated degradation of IRS-1. ..
  4. Kim S, Destefano M, Oh W, Wu C, Vega Cotto N, Finlan M, et al. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8. Mol Cell. 2012;48:875-87 pubmed publisher
    ..Our findings reveal that in addition to persistent mTORC1 signaling, heightened mTORC2 signals can promote insulin resistance due to mTORC2-mediated degradation of IRS-1. ..
  5. Thomas J, Zhang Y, Wei Y, Cho J, Morris L, Wang H, et al. Rab1A is an mTORC1 activator and a colorectal oncogene. Cancer Cell. 2014;26:754-69 pubmed publisher
    ..Our results demonstrate that Rab1 is an mTORC1 activator and an oncogene and that hyperactive AA signaling through Rab1A overexpression drives oncogenesis and renders cancer cells prone to mTORC1-targeted therapy. ..
  6. Gleason R, Akintobi A, Grant B, Padgett R. BMP signaling requires retromer-dependent recycling of the type I receptor. Proc Natl Acad Sci U S A. 2014;111:2578-83 pubmed publisher
    ..Taken together, our results indicate a mechanism that separates the type I and type II receptors during receptor recycling, potentially terminating signaling while preserving both receptors for further rounds of activation. ..
  7. Lee H, Ragusano L, Martinez A, Gill J, Dimova D. A dual role for the dREAM/MMB complex in the regulation of differentiation-specific E2F/RB target genes. Mol Cell Biol. 2012;32:2110-20 pubmed publisher
    ..First, it is required for the stability of the repressive dE2F2/RBF complexes at their promoters during S phase. Second, we find that dREAM is indispensable for both transcriptional repression mechanisms employed at these genes. ..
  8. Oh W, Wu C, Kim S, Facchinetti V, Julien L, Finlan M, et al. mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 2010;29:3939-51 pubmed publisher
    ..Thus, mTORC2 can function cotranslationally by phosphorylating residues in nascent chains that are critical to attain proper conformation. Our findings reveal that mTOR links protein production with quality control. ..
  9. Hsu S, TerBush D, Abraham M, Guo W. The exocyst complex in polarized exocytosis. Int Rev Cytol. 2004;233:243-65 pubmed
    ..Here we review the progress made in the understanding of the exocyst and its role in polarized exocytosis. ..
  10. Kuzmichev A, Nishioka K, Erdjument Bromage H, Tempst P, Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 2002;16:2893-905 pubmed
    ..The presence of Su(z)12, a strong suppressor of position effect variegation, in PRC2 suggests that PRC2 may play a widespread role in heterochromatin-mediated silencing. ..