Experts and Doctors on mice in Piscataway, New Jersey, United States


Locale: Piscataway, New Jersey, United States
Topic: mice

Top Publications

  1. Duncan M, Dicicco Bloom E, Xiang X, Benezra R, Chada K. The gene for the helix-loop-helix protein, Id, is specifically expressed in neural precursors. Dev Biol. 1992;154:1-10 pubmed
    ..Since Id transcript abundance inversely correlated with differentiation, this protein, similar to its Drosophila homolog, extramacrochaetae, may play a negative regulatory role in neural differentiation. ..
  2. Perez J, Shen X, Finkernagel S, Sciorra L, Jenkins N, Gilbert D, et al. Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain. Oncogene. 1994;9:211-9 pubmed
    ..Using fluorescence in situ hybridization and interspecific backcross mapping, the Cak gene was localized to human chromosome 6 and mouse chromosome 17. ..
  3. Zhu Y, Hsu M, Pintar J. Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse. J Neurosci. 1998;18:2538-49 pubmed
    ..Several examples of possible autocrine and paracrine loops of opioid peptide and receptor expression have been identified, suggesting a role for these local circuits in developmental processes. ..
  4. Zhu Y, King M, Schuller A, Nitsche J, Reidl M, Elde R, et al. Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice. Neuron. 1999;24:243-52 pubmed
    ..Together, these findings suggest the existence of a second delta-like analgesic system. Finally, DOR-1 mutant mice do not develop analgesic tolerance to morphine, genetically demonstrating a central role for DOR-1 in this process. ..
  5. Xiao H, Mao Y, Desai S, Zhou N, Ting C, Hwang J, et al. The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway. Proc Natl Acad Sci U S A. 2003;100:3239-44 pubmed
    ..By contrast, degradation of the large subunit of RNA polymerase II is due to a DNA-damage signal. ..
  6. Vernon H, Osborne C, Tzortzaki E, Yang M, Chen J, Rittling S, et al. Aprt/Opn double knockout mice: osteopontin is a modifier of kidney stone disease severity. Kidney Int. 2005;68:938-47 pubmed
    ..Thus, separate mechanisms appear responsible for the tissue changes seen in DKO males versus females. ..
  7. Vaidyanathan H, Opoku Ansah J, Pastorino S, Renganathan H, Matter M, Ramos J. ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15. Proc Natl Acad Sci U S A. 2007;104:19837-42 pubmed
    ..Thus, PEA-15 can integrate signal transduction to provide a specific physiological outcome from activation of the multipotent ERK MAP kinase pathway. ..
  8. Wu K, Kim S, Fela D, Baum J. Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation. J Mol Biol. 2008;378:1104-15 pubmed publisher
    ..These transient interchain interactions coupled with a non-A beta amyloid component (NAC) region that is both more exposed and has a higher propensity to beta structure may accelerate the rate of fibril formation of aS. ..
  9. Thakker Varia S, Jean Y, Parikh P, Sizer C, Jernstedt Ayer J, Parikh A, et al. The neuropeptide VGF is reduced in human bipolar postmortem brain and contributes to some of the behavioral and molecular effects of lithium. J Neurosci. 2010;30:9368-80 pubmed publisher
    ..The dysregulation of VGF in bipolar disorder as well as the behavioral effects of the neuropeptide similar to LiCl suggests that VGF may underlie the pathophysiology of bipolar disorder. ..

More Information

Publications459 found, 100 shown here

  1. Ko J, Choi K, Zhao X, Komazaki S, Pan Z, Weisleder N, et al. A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice. FASEB J. 2011;25:2638-49 pubmed publisher
  2. Lukić S, Chen K. Human piRNAs are under selection in Africans and repress transposable elements. Mol Biol Evol. 2011;28:3061-7 pubmed publisher
    ..Overall, our results elucidate the function and evolution of piRNAs in humans and highlight the utility of population genomics analysis for studying this rapidly evolving genetic system...
  3. Gibson C, Hossain M, Richardson J, Aleksunes L. Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia. J Pharmacol Exp Ther. 2012;343:650-60 pubmed publisher
    ..Decreased transporter efflux function in microglia may lead to the retention of toxic chemicals and aberrant cell-cell communication during neuroinflammation. ..
  4. Jiao X, Chang J, Kilic T, Tong L, Kiledjian M. A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol Cell. 2013;50:104-15 pubmed publisher
  5. Kong B, Huang J, Zhu Y, Li G, Williams J, Shen S, et al. Fibroblast growth factor 15 deficiency impairs liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol. 2014;306:G893-902 pubmed publisher
    ..The underlying mechanism is likely the result of disrupted bile acid homeostasis and impaired priming of hepatocyte proliferation. ..
  6. Zhou R, Copeland T, Kromer L, Schulz N. Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system. J Neurosci Res. 1994;37:129-43 pubmed
    ..5 day embryonic head extract. Our analysis shows that bsk is a growth factor receptor-like protein tyrosine kinase and that its greatest expression in the adult brain is associated with components of the limbic system. ..
  7. Chen S, Zhu H, Wetzel W, Philbert M. Spontaneous melanocytosis in transgenic mice. J Invest Dermatol. 1996;106:1145-51 pubmed
    ..This line of transgenic mice may provide a useful model for investigation of the etiology and progression of benign and malignant melanin-containing tumors. ..
  8. Xiang M, Gan L, Li D, Chen Z, Zhou L, O Malley B, et al. Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A. 1997;94:9445-50 pubmed
  9. Bendall A, Hu G, Levi G, Abate Shen C. Dlx5 regulates chondrocyte differentiation at multiple stages. Int J Dev Biol. 2003;47:335-44 pubmed
  10. Haspel J, Grumet M. The L1CAM extracellular region: a multi-domain protein with modular and cooperative binding modes. Front Biosci. 2003;8:s1210-25 pubmed
    ..Furthermore, these studies suggest that the extracellular region is a dynamic, integrated structure that depends on cooperative interactions among its Ig-like domains for proper functioning. ..
  11. Bourassa B, Monaghan S, Rittling S. Impaired anti-tumor cytotoxicity of macrophages from osteopontin-deficient mice. Cell Immunol. 2004;227:1-11 pubmed
    ..These data support the hypothesis that host-derived osteopontin may inhibit tumor growth and provide a mechanism for this effect. ..
  12. Dicicco Bloom E, Lelievre V, Zhou X, Rodriguez W, Tam J, Waschek J. Embryonic expression and multifunctional actions of the natriuretic peptides and receptors in the developing nervous system. Dev Biol. 2004;271:161-75 pubmed
  13. Du Y, Fischer T, Clinton Luke P, Lercher L, Dreyfus C. Distinct effects of p75 in mediating actions of neurotrophins on basal forebrain oligodendrocytes. Mol Cell Neurosci. 2006;31:366-75 pubmed
    ..On the other hand, K252a, an inhibitor of trk receptors, abolished the effects of the neurotrophins, including BDNF. All neurotrophins activated their respective trk receptors. ..
  14. Khor T, Hu R, Shen G, Jeong W, Hebbar V, Chen C, et al. Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Biopharm Drug Dispos. 2006;27:407-20 pubmed
  15. Kim K, PHAM C, Sleat D, Lobel P. Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis. Biochem J. 2008;415:225-32 pubmed publisher
    ..These results together indicate that DPPI cannot functionally compensate for the loss of TPPI. Therapeutic approaches to increase neuronal expression of DPPI are therefore unlikely to be effective for treatment of LINCL. ..
  16. Wen T, Peng B, Pintar J. The MOR-1 opioid receptor regulates glucose homeostasis by modulating insulin secretion. Mol Endocrinol. 2009;23:671-8 pubmed publisher
    ..These findings indicate that MOR-1 regulates body weight by a mechanism that involves insulin secretion and thus may represent a novel target for new diabetes therapies. ..
  17. Martel G, Hevi C, Friebely O, Baybutt T, Shumyatsky G. Zinc transporter 3 is involved in learned fear and extinction, but not in innate fear. Learn Mem. 2010;17:582-90 pubmed publisher
    ..By contrast, ZnT3 KO mice had normal anxiety. Thus, ZnT3 is involved in associative fear memory and extinction, but not in innate fear, consistent with the role of synaptic zinc in amygdala synaptic plasticity. ..
  18. Connor A, Laskin J, Laskin D. Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4. Exp Mol Pathol. 2012;92:229-35 pubmed publisher
    ..The observation that these responses to ozone were not evident in TLR4 mutant C3H/HeJ mice demonstrates that functional TLR4 contributes to ozone-induced sterile inflammation and macrophage activation. ..
  19. Lou Y, Peng Q, Li T, Nolan B, Bernard J, Wagner G, et al. Oral caffeine during voluntary exercise markedly inhibits skin carcinogenesis and decreases inflammatory cytokines in UVB-treated mice. Nutr Cancer. 2013;65:1002-13 pubmed publisher
  20. Milwid J, Elman J, Li M, Shen K, Manrai A, Gabow A, et al. Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators. Mol Ther. 2014;22:999-1007 pubmed publisher
    ..Greater than 85% of secreted factors were recaptured that were otherwise undetected by proteomic methods, and remarkable hit rates of 18% in vitro and 9% in vivo were achieved. ..
  21. Berezniuk I, Rodriguiz R, Zee M, Marcus D, Pintar J, Morgan D, et al. ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine. J Neurochem. 2017;143:268-281 pubmed publisher
    ..Taken together, these results suggest that proSAAS-derived peptides contribute differentially to the behavioral sensitization to psychostimulants, while the rewarding effects of cocaine appear intact in mice lacking proSAAS. ..
  22. Pillutla R, Shimamoto A, Furuichi Y, Shatkin A. Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. Genomics. 1999;56:217-20 pubmed
    ..Expression was lowest in hematopoietic cells of both normal and tumor origin. TCEAL1 was mapped to human chromosome Xq22.1 by fluorescence in situ hybridization. ..
  23. Huang M, Badmaev V, Ding Y, Liu Y, Xie J, Ho C. Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid. Biofactors. 2000;13:225-30 pubmed
    ..6 to 7.1 microM. These results indicate that beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities. ..
  24. Lin C, Lu Y, Lou Y, Ho C, Newmark H, MacDonald C, et al. Inhibition by dietary dibenzoylmethane of mammary gland proliferation, formation of DMBA-DNA adducts in mammary glands, and mammary tumorigenesis in Sencar mice. Cancer Lett. 2001;168:125-32 pubmed
    ..These results may explain the strong inhibitory actions of dietary DBM on mammary carcinogenesis in mice...
  25. Afonso S, Tovar C, Romagnano L, Babiarz B. Control and expression of cystatin C by mouse decidual cultures. Mol Reprod Dev. 2002;61:155-63 pubmed
    ..This work shows that decidualizing cultures are a good system to study cystatin C expression and that the expression is controlled in part by TGF-beta(1) and EGF signaling. ..
  26. Kawashima N, Fugate J, Kusnecov A. Immunological challenge modulates brain orphanin FQ/nociceptin and nociceptive behavior. Brain Res. 2002;949:71-8 pubmed
    ..Since SEA induces various cytokines, including TNF-alpha, these results are consistent with a growing literature documenting the effects of cytokines on nociceptive functions, and a possible involvement of the OFQ/nociceptin system. ..
  27. Li S, Misra K, Matise M, Xiang M. Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord. Proc Natl Acad Sci U S A. 2005;102:10688-93 pubmed
    ..However, coexpression of both Foxn4 and Mash1 promotes the V2b fate while inhibiting the V2a fate, indicating that Foxn4 cooperates with Mash1 to specify the identity of V2b neurons from bipotential p2 progenitors. ..
  28. Balakrishnan A, Wang L, Li X, Ohman Strickland P, Malatesta P, Fan H. Inhibition of chlamydial infection in the genital tract of female mice by topical application of a peptide deformylase inhibitor. Microbiol Res. 2009;164:338-46 pubmed
    ..On the basis of these data and our previous observations, we conclude that further evaluation of PDF inhibitors for prevention and treatment of sexually transmitted chlamydial infection is warranted. ..
  29. Qiu F, Jiang H, Xiang M. A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. J Neurosci. 2008;28:3392-403 pubmed publisher
    ..Our data suggest that Brn3b specifies the RGC fate from multipotential precursors not only by promoting RGC differentiation but also by suppressing non-RGC differentiation programs as a safeguard mechanism. ..
  30. Wallenstein E, Barminko J, Schloss R, Yarmush M. Transient gene delivery for functional enrichment of differentiating embryonic stem cells. Biotechnol Bioeng. 2008;101:859-72 pubmed publisher
    ..And engineering cellular systems without making permanent gene changes will be critical for the generation of clinically acceptable cellular material in the future. ..
  31. Wang K, Shi Y, Ron Y, Kazanecki C, Denhardt D. Plasma osteopontin modulates chronic restraint stress-induced thymus atrophy by regulating stress hormones: inhibition by an anti-osteopontin monoclonal antibody. J Immunol. 2009;182:2485-91 pubmed publisher
    ..These studies reveal that circulating OPN plays a significant role in the regulation of the hypothalamus-pituitary-adrenal axis hormones and that it augments CRS-induced organ atrophy. ..
  32. Kavukcuoglu N, Patterson Buckendahl P, Mann A. Effect of osteocalcin deficiency on the nanomechanics and chemistry of mouse bones. J Mech Behav Biomed Mater. 2009;2:348-54 pubmed publisher
    ..The addition of these defects to the apatite's crystal lattice has little effect on elasticity, but does appear to reduce the bone's hardness. ..
  33. Jiao X, Chen H, Chen J, Herrup K, Firestein B, Kiledjian M. Modulation of neuritogenesis by a protein implicated in X-linked mental retardation. J Neurosci. 2009;29:12419-27 pubmed publisher
    ..It is plausible that defects of these functions in the absence of the VCX genes could contribute to a mental retardation phenotype. ..
  34. Vondran M, Singh H, Honeywell J, Dreyfus C. Levels of BDNF impact oligodendrocyte lineage cells following a cuprizone lesion. J Neurosci. 2011;31:14182-90 pubmed publisher
    ..These data indicate that BDNF may play a role following a demyelinating lesion by regulating the numbers of progenitors and the abilities of demyelinating and differentiating cells to express myelin proteins. ..
  35. Goel S, Krishnamurthy S, Hampsey M. Mechanism of start site selection by RNA polymerase II: interplay between TFIIB and Ssl2/XPB helicase subunit of TFIIH. J Biol Chem. 2012;287:557-67 pubmed publisher
    ..These results define a novel, functional interaction between TFIIB and Ssl2 that affects start site selection and gene looping. ..
  36. Son A, Park J, Zhou R. The role of Eph receptors in lens function and disease. Sci China Life Sci. 2012;55:434-43 pubmed publisher
    ..In recent years the Eph family of receptor tyrosine kinases has been identified as a key regulator in lens clarity. In this review we discuss the roles of the Eph receptors in lens biology and cataract development. ..
  37. Yan Y, Zhou X, Pan Z, Ma J, Waschek J, Dicicco Bloom E. Pro- and anti-mitogenic actions of pituitary adenylate cyclase-activating polypeptide in developing cerebral cortex: potential mediation by developmental switch of PAC1 receptor mRNA isoforms. J Neurosci. 2013;33:3865-78 pubmed publisher
    ..5. These observations suggest that PACAP elicits temporally specific effects on cortical proliferation via developmentally regulated expression of specific receptor isoforms. ..
  38. Coffey K, Nader M, West M. Single body parts are processed by individual neurons in the mouse dorsolateral striatum. Brain Res. 2016;1636:200-207 pubmed publisher
  39. Kim T, Wu K, Xu J, Black I. Detection of dystrophin in the postsynaptic density of rat brain and deficiency in a mouse model of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 1992;89:11642-4 pubmed
  40. Wydner K, Sechler J, Boyd C, Passmore H. Use of an intron polymorphism to localize the tropoelastin gene to mouse chromosome 5 in a region of linkage conservation with human chromosome 7. Genomics. 1994;23:125-31 pubmed
    ..The linkage and genetic distances between Eln and the closest molecular markers used in this study are centromere-D5Mit95, D5Mit96-6.7 cM-Gus, Eln-4.0 cM-Zp3-telomere. ..
  41. Dambach D, Watson L, Gray K, Durham S, Laskin D. Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse. Hepatology. 2002;35:1093-103 pubmed
    ..In conclusion, these data indicate that MCP-1 and CCR2 contribute to the recruitment of a subset of activated macrophages into the liver during acetaminophen-induced hepatotoxicity that may be important in resolution of tissue injury. ..
  42. Villanueva R, Jonsson C, Jones J, Georgiadis M, Roth M. Differential multimerization of Moloney murine leukemia virus integrase purified under nondenaturing conditions. Virology. 2003;316:146-60 pubmed
    ..This specific target-site selection was not observed with a shorter 20-mer U5 substrate. These studies provide the foundation for biophysical and structural analysis on M-MuLV IN and the mechanism of retroviral integration. ..
  43. Yurchenco P, Cheng Y, Campbell K, Li S. Loss of basement membrane, receptor and cytoskeletal lattices in a laminin-deficient muscular dystrophy. J Cell Sci. 2004;117:735-42 pubmed
  44. Halladay A, Tessarollo L, Zhou R, Wagner G. Neurochemical and behavioral deficits consequent to expression of a dominant negative EphA5 receptor. Brain Res Mol Brain Res. 2004;123:104-11 pubmed
    ..Collectively, these data suggest that animals expressing a truncated EphA5 receptor show deficits related to striatal functioning. ..
  45. Qing G, Qu Z, Xiao G. Regulation of NF-kappa B2 p100 processing by its cis-acting domain. J Biol Chem. 2005;280:18-27 pubmed
    ..Taken together, these studies highlight the mechanism by which the different sequences within p100 work in concert to regulate its processing and shed light on the mechanisms of how p100 processing is tightly and delicately controlled. ..
  46. Kaneta T, Kusnecov A. The role of central corticotropin-releasing hormone in the anorexic and endocrine effects of the bacterial T cell superantigen, Staphylococcal enterotoxin A. Brain Behav Immun. 2005;19:138-46 pubmed
    ..More importantly, it appears that central activation of CRH receptors is a consequence of SEA challenge, and this likely contributes to its anorexic effects. ..
  47. Zhu L, Thomas P, Lu G, Reuhl K, Yang G, Wang L, et al. CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody. Drug Metab Dispos. 2006;34:1672-6 pubmed
  48. Xu G, Zhang L, Ren G, Yuan Z, Zhang Y, Zhao R, et al. Immunosuppressive properties of cloned bone marrow mesenchymal stem cells. Cell Res. 2007;17:240-8 pubmed
  49. Yang J, Oza J, Bridges K, Chen K, Liu A. Neural differentiation and the attenuated heat shock response. Brain Res. 2008;1203:39-50 pubmed publisher
    ..Together, our results show that neural differentiation is associated with a decreased induction of the heat shock response and an increased vulnerability to stress induced pathologies and death. ..
  50. Lin W, Wu R, Wu T, Khor T, Wang H, Kong A. Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem Pharmacol. 2008;76:967-73 pubmed publisher
    ..Interestingly, the anti-inflammatory effect was attenuated in Nrf2 (-/-) primary peritoneal macrophages. We concluded that SFN exerts its anti-inflammatory activity mainly via activation of Nrf2 in mouse peritoneal macrophages. ..
  51. Zhang J, Li H, Herrup K. Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation. J Biol Chem. 2010;285:14052-61 pubmed publisher
    ..These data suggest a model in which Cdk5 exerts a double protective function in neurons: chronically suppressing the cell cycle when located in the nucleus and transiently delaying cell death in the cytoplasm. ..
  52. Cotella D, Hernández Enríquez B, Duan Z, Wu X, Gazula V, Brown M, et al. An evolutionarily conserved mode of modulation of Shaw-like K? channels. FASEB J. 2013;27:1381-93 pubmed publisher
    ..1b were colocalized in subsets of neurons, including in the brain stem and the ventricular zone. Taken together, this body of evidence suggests that acid phosphatases are general regulatory partners of Shaw-like K(+) channels. ..
  53. Lin M, Cheng X, Tammineni P, Xie Y, Zhou B, Cai Q, et al. Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions. Neuron. 2017;94:595-610.e6 pubmed publisher
    ..Our study provides new mechanistic insights into the maintenance of axonal mitochondrial quality through SNPH-mediated coordination of mitochondrial stress and motility before activation of Parkin-mediated mitophagy. VIDEO ABSTRACT. ..
  54. Ning Y, Schuller A, Conover C, Pintar J. Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo. Mol Endocrinol. 2008;22:1213-25 pubmed publisher
  55. Wu Y, Zhang Y, Wang M, Li Q, Qu Z, Shi V, et al. Downregulation of HER3 by a novel antisense oligonucleotide, EZN-3920, improves the antitumor activity of EGFR and HER2 tyrosine kinase inhibitors in animal models. Mol Cancer Ther. 2013;12:427-37 pubmed publisher
  56. Kumar C, Muthukumaran G, Frost L, Noe M, Ahn Y, Mariano T, et al. Molecular characterization of the murine interferon gamma receptor cDNA. J Biol Chem. 1989;264:17939-46 pubmed
  57. Yurchenco P, Sung U, Ward M, Yamada Y, O Rear J. Recombinant laminin G domain mediates myoblast adhesion and heparin binding. J Biol Chem. 1993;268:8356-65 pubmed
    ..Finally rG did not inhibit laminin polymerization. These data support the role of G domain in cell and heparin binding, but not laminin self-assembly, and the approach provides a means to further characterize these functions. ..
  58. Babiarz B, Romagnano L, Afonso S, Kurila G. Localization and expression of fibronectin during mouse decidualization in vitro: mechanisms of cell:matrix interactions. Dev Dyn. 1996;206:330-42 pubmed
    ..This work shows that during decidual matrix remodeling, constitutive levels of FN are maintained to provide an extracellular framework to stabilize the decidual cytoskeleton and support morphological differentiation of decidual cells. ..
  59. Shin D, Pan Z, Bandyopadhyay A, Bhat M, Kim D, Ma J. Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle. Biophys J. 2002;83:2539-49 pubmed
  60. Nitsche J, Schuller A, King M, Zengh M, Pasternak G, Pintar J. Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice. J Neurosci. 2002;22:10906-13 pubmed
  61. Michna L, Lu Y, Lou Y, Wagner G, Conney A. Stimulatory effect of oral administration of green tea and caffeine on locomotor activity in SKH-1 mice. Life Sci. 2003;73:1383-92 pubmed
  62. Long J, Matsuura I, He D, Wang G, Shuai K, Liu F. Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT. Proc Natl Acad Sci U S A. 2003;100:9791-6 pubmed
    ..Taken together, our studies indicate that PIASy can inhibit TGF-beta/Smad transcriptional responses through interactions with Smad proteins and HDAC. ..
  63. Matsuura I, Denissova N, Wang G, He D, Long J, Liu F. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature. 2004;430:226-31 pubmed
    ..Because cancer cells often contain high levels of CDK activity, diminishing Smad3 activity by CDK phosphorylation may contribute to tumorigenesis and TGF-beta resistance in cancers. ..
  64. Michna L, Wagner G, Lou Y, Xie J, Peng Q, Lin Y, et al. Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice. Carcinogenesis. 2006;27:2108-15 pubmed
    ..The effects described here indicate that voluntary running wheel exercise inhibits UVB-induced skin tumorigenesis and may also inhibit tumor growth. ..
  65. Gupta N, Delrow J, Drawid A, Sengupta A, Fan G, Gelinas C. Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins. Cancer Res. 2008;68:808-14 pubmed publisher
  66. Fu X, Wan S, Lyu Y, Liu L, Qi H. Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. PLoS ONE. 2008;3:e2009 pubmed publisher
    ..We propose that ATM-dependent mitochondrial biogenesis may play a role in DNA damage response and ROS regulation, and that defect in ATM-dependent mitochondrial biogenesis could contribute to the manifestations of A-T disease. ..
  67. Zhang Y, Goldman S, BAERGA R, Zhao Y, Komatsu M, Jin S. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci U S A. 2009;106:19860-5 pubmed publisher
  68. Kim J, Shen S, Dietz K, He Y, Howell O, Reynolds R, et al. HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage. Nat Neurosci. 2010;13:180-9 pubmed publisher
    ..Together these data identify nuclear export of HDAC1 as a critical event for impaired mitochondrial transport in damaged neurons. ..
  69. Duffield D, Cai L, Kim S. Simultaneous determination of multiple mRNA levels utilizing MALDI-TOF mass spectrometry and biotinylated dideoxynucleotides. RNA. 2010;16:1285-91 pubmed publisher
    ..Thus the approach enhances the parallel analysis of multiple gene transcripts by MS. Utilizing the method we have simultaneously measured mRNA levels of four genes (Rho, Nrl, Hprt, and Lhx2) in mouse retinal tissue. ..
  70. Anumolu S, Menjoge A, Deshmukh M, Gerecke D, Stein S, LASKIN J, et al. Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries. Biomaterials. 2011;32:1204-17 pubmed publisher
    ..In conclusion, PEG-based doxycycline hydrogels are promising for dermal wound healing application of mustard injuries. ..
  71. Su L, Liu W, Chen H, González Pagán O, Habas R, Runnels L. TRPM7 regulates polarized cell movements. Biochem J. 2011;434:513-21 pubmed publisher
    ..The results of the present study uncover an essential role for Mg²+ in the control of TRPM7 over the cytoskeleton and its ability to regulate polarized cell movements. ..
  72. Smolarek A, So J, Burgess B, Kong A, Reuhl K, Lin Y, et al. Dietary administration of ?- and ?-tocopherol inhibits tumorigenesis in the animal model of estrogen receptor-positive, but not HER-2 breast cancer. Cancer Prev Res (Phila). 2012;5:1310-20 pubmed publisher
    ..Both ?- and ?-tocopherols, but not ?-tocopherol, seem to be promising agents for the prevention of hormone-dependent breast cancer. ..
  73. Zhu L, Cheng X, Ding Y, Shi J, Jin H, Wang H, et al. Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway. Cancer Lett. 2014;343:80-9 pubmed publisher
    ..When co-injected, BMFs significantly enhanced tumorigenesis of colon cancer cells in mice. Our results demonstrate that BMFs promote tumorigenesis via the activation of the IL-6/JAK2/STAT3 pathway. ..
  74. Kass M, Rosenthal M, Pottackal J, McGann J. Fear learning enhances neural responses to threat-predictive sensory stimuli. Science. 2013;342:1389-1392 pubmed publisher
    ..These results indicate that affective information about a stimulus can be encoded in its very earliest representation in the nervous system. ..
  75. Laskin D, Chen L, Hankey P, Laskin J. Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia. J Leukoc Biol. 2010;88:373-82 pubmed publisher
    ..These data suggest that MSP/STK signaling plays a role in up-regulating macrophage and endothelial cell anti-inflammatory activity during hepatic inflammatory responses. This may be important in protecting the liver from tissue injury. ..
  76. Wolff D, Lubeskie A. Inactivation of nitric oxide synthase isoforms by diaminoguanidine and NG-amino-L-arginine. Arch Biochem Biophys. 1996;325:227-34 pubmed
    ..Methylguanidine and 1,1-dimethylguanidine exhibited a reversible inhibition pattern in contrast to all three NOS isoforms. Neither agent exhibited significant isoform selectivity. ..
  77. Zhou X, Benson K, Przybysz K, Liu J, Hou Y, Cherath L, et al. Genomic structure and expression of the murine Hmgi-c gene. Nucleic Acids Res. 1996;24:4071-7 pubmed
    ..Since the human homolog is disrupted in a number of tumors, HMGI-C could play an important role in cell proliferation and differentiation during mammalian development. ..
  78. Tregoning J, Nixon P, Kuroda H, Svab Z, Clare S, Bowe F, et al. Expression of tetanus toxin Fragment C in tobacco chloroplasts. Nucleic Acids Res. 2003;31:1174-9 pubmed
    ..Thus, expression of TetC in chloroplasts provides a potential route towards the development of a safe, plant-based tetanus vaccine for nasal and oral applications. ..
  79. Pan M, Kalie E, Scaglione B, Raveche E, Schreiber G, Langer J. Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonists. Biochemistry. 2008;47:12018-27 pubmed publisher
    ..e., they are type I IFN antagonists. These prototype IFN antagonists can be developed further for possible therapeutic use in systemic lupus erythematosus, and analogous molecules can be designed for use in animal models. ..
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