Genomes and Genes
Experts and Doctors on membrane proteins in Ithaca, New York, United States
Locale: Ithaca, New York, United States
Topic: membrane proteins
Publications116 found, 100 shown here
- Pearson M, Reczek D, Bretscher A, Karplus P. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell. 2000;101:259-70 pubmed..This extended binding mode suggests a novel mechanism for how different signals could produce varying levels of activation. Sequence conservation suggests a similar regulation of the tumor suppressor merlin. ..
- Naithani S, Saracco S, Butler C, Fox T. Interactions among COX1, COX2, and COX3 mRNA-specific translational activator proteins on the inner surface of the mitochondrial inner membrane of Saccharomyces cerevisiae. Mol Biol Cell. 2003;14:324-33 pubmed..In addition, we found interactions between Nam1p/Mtf2p and the translational activators, suggesting an organized delivery of mitochondrial mRNAs to the translation system. ..
- Chambers D, Bretscher A. Ezrin mutants affecting dimerization and activation. Biochemistry. 2005;44:3926-32 pubmed..These results provide strong support for the conformational activation model of ezrin, elucidate the basis for dimer formation, and reveal that a mutant generally considered to be fully activated is not. ..
- Shayan G, Choi Y, Shusta E, Shuler M, Lee K. Murine in vitro model of the blood-brain barrier for evaluating drug transport. Eur J Pharm Sci. 2011;42:148-55 pubmed publisher..These results together establish the utility of this murine model for future drug transport, pathological, and pharmacological characterizations of the BBB. ..
- Valderrama Rincon J, Fisher A, Merritt J, Fan Y, Reading C, Chhiba K, et al. An engineered eukaryotic protein glycosylation pathway in Escherichia coli. Nat Chem Biol. 2012;8:434-6 pubmed publisher..By including the bacterial oligosaccharyltransferase PglB from Campylobacter jejuni, we successfully transferred glycans to eukaryotic proteins. ..
- Sengupta P, Hammond A, Holowka D, Baird B. Structural determinants for partitioning of lipids and proteins between coexisting fluid phases in giant plasma membrane vesicles. Biochim Biophys Acta. 2008;1778:20-32 pubmed..Our results demonstrate the value of GPMVs for characterizing the phase preference of proteins and lipid probes in the absence of detergents and other perturbations of membrane structure. ..
- Wang J. Beclin 1 bridges autophagy, apoptosis and differentiation. Autophagy. 2008;4:947-8 pubmed
- Pohlman R, Genetti H, Winans S. Entry exclusion of the IncN plasmid pKM101 is mediated by a single hydrophilic protein containing a lipid attachment motif. Plasmid. 1994;31:158-65 pubmed..The resulting plasmid was sufficient to mediate entry exclusion. The degree of exclusion was greatly enhanced by overexpression of this gene. ..
- Williams S, Stewart V. Discrimination between structurally related ligands nitrate and nitrite controls autokinase activity of the NarX transmembrane signal transducer of Escherichia coli K-12. Mol Microbiol. 1997;26:911-25 pubmed..Other changes (H45E and R59K) resulted in proteins that responded normally to nitrate but were unable to respond to nitrite. These results implicate the P-box region in discrimination between subtly different small molecules. ..
- Schetter A, Askjaer P, Piano F, Mattaj I, Kemphues K. Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans. Dev Biol. 2006;289:360-71 pubmed..These findings raise the possibility that these nucleoporins may have direct roles in orienting the mitotic spindle and the maintenance of cell polarity. ..
- Yang S, Yang H, Grisafi P, Sanchatjate S, Fink G, Sun Q, et al. The BON/CPN gene family represses cell death and promotes cell growth in Arabidopsis. Plant J. 2006;45:166-79 pubmed..Thus, the copine family in Arabidopsis may have effects in promoting growth and development in addition to repressing cell death, and these two processes might be intricately intertwined. ..
- Park S, Lowder B, Bilwes A, Blair D, Crane B. Structure of FliM provides insight into assembly of the switch complex in the bacterial flagella motor. Proc Natl Acad Sci U S A. 2006;103:11886-91 pubmed publisher..The localization of counterclockwise- and clockwise-biasing mutations to distinct surfaces suggests that the binding of phosphorylated CheY cooperatively realigns FliM around the ring...
- Li Y, Yang S, Yang H, Hua J. The TIR-NB-LRR gene SNC1 is regulated at the transcript level by multiple factors. Mol Plant Microbe Interact. 2007;20:1449-56 pubmed..The regulation of SNC1 possibly exemplifies a universally complex control of R genes to ensure a repression of R activation under nonstress conditions and a robust activation of defense responses once the R gene is induced. ..
- Foehr M, Liu J. Dorsoventral patterning of the C. elegans postembryonic mesoderm requires both LIN-12/Notch and TGFbeta signaling. Dev Biol. 2008;313:256-66 pubmed..Our work provides a model for how combined Notch and TGFbeta signaling regulates the developmental potential of two equipotent cells along the dorsoventral axis. ..
- Botelho R, Efe J, Teis D, Emr S. Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase. Mol Biol Cell. 2008;19:4273-86 pubmed publisher..We propose a model explaining the dual roles of Vac14 and Fig4 in the synthesis and turnover of PtdIns(3,5)P(2). ..
- Wang Y, Evans J, Rodriguez F, Fields P, Mueller C, Chitnis T, et al. A tale of two STAT6 knock out mice in the induction of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2009;206:76-85 pubmed publisher..These results suggest that an altered STAT6 gene can be more efficient than wild type STAT6 in regulating the autoimmune response in EAE. ..
- Manford A, Stefan C, Yuan H, MacGurn J, Emr S. ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology. Dev Cell. 2012;23:1129-40 pubmed publisher..These results reveal critical roles for ER-PM contacts in cell signaling, organelle morphology, and ER function. ..
- Wiesenberger G, Costanzo M, Fox T. Analysis of the Saccharomyces cerevisiae mitochondrial COX3 mRNA 5' untranslated leader: translational activation and mRNA processing. Mol Cell Biol. 1995;15:3291-300 pubmed..Our results indicate that the site of this cleavage in Saccharomyces cerevisiae is determined solely by the position of the tRNA. ..
- Calero M, Collins R. Saccharomyces cerevisiae Pra1p/Yip3p interacts with Yip1p and Rab proteins. Biochem Biophys Res Commun. 2002;290:676-81 pubmed..The interactions between Pra1p/Yip3p and Rab proteins are dependent on the presence of the Rab protein C-terminal cysteines and require C-terminal prenylation. ..
- Chen C, Collins R. Insights into biological functions across species: examining the role of Rab proteins in YIP1 family function. Biochem Soc Trans. 2005;33:614-8 pubmed..e. independent or dependent activities of Yip1p. ..
- Welsh I, Hagge Greenberg A, O Brien T. A dosage-dependent role for Spry2 in growth and patterning during palate development. Mech Dev. 2007;124:746-61 pubmed..Our results demonstrate the importance of proper FGF signaling thresholds in regulation of epithelial-mesenchymal interactions and cellular responses necessary for coordinated morphogenesis of the face and palate...
- Moran Mirabal J, Craighead H. Zero-mode waveguides: sub-wavelength nanostructures for single molecule studies at high concentrations. Methods. 2008;46:11-7 pubmed publisher..In this review, the concept and implementation of ZMWs is outlined, along with their application to the study of freely diffusing, and membrane-bound fluorescent biomolecules. ..
- Gadi D, Wagenknecht Wiesner A, Holowka D, Baird B. Sequestration of phosphoinositides by mutated MARCKS effector domain inhibits stimulated Ca(2+) mobilization and degranulation in mast cells. Mol Biol Cell. 2011;22:4908-17 pubmed publisher..These results show the capacity of MARCKS-ED to regulate granule exocytosis in a PKC-dependent manner, consistent with regulated sequestration of phosphoinositides that mediate granule fusion at the plasma membrane. ..
- Bao Z, Yang H, Hua J. Perturbation of cell cycle regulation triggers plant immune response via activation of disease resistance genes. Proc Natl Acad Sci U S A. 2013;110:2407-12 pubmed publisher..Taken together, our findings reveal an unexpected link between cell cycle progression and plant immunity, suggesting that cell cycle misregulation could have an impact on expression of genes, including R genes, in plant immunity. ..
- Lu S, Van Eck J, Zhou X, Lopez A, O Halloran D, Cosman K, et al. The cauliflower Or gene encodes a DnaJ cysteine-rich domain-containing protein that mediates high levels of beta-carotene accumulation. Plant Cell. 2006;18:3594-605 pubmed..We show here that controlling the formation of chromoplasts is an important mechanism by which carotenoid accumulation is regulated in plants. ..
- Mansell T, Fisher A, DeLisa M. Engineering the protein folding landscape in gram-negative bacteria. Curr Protein Pept Sci. 2008;9:138-49 pubmed..Specifically highlighted are a variety of different techniques to intentionally alter the folding environment of the cell as a means to understand and engineer intracellular protein folding and stability. ..
- Lin H, Song K, Hutcheson G, Goutte C, Wolfner M. A maternally encoded nuclear envelope protein required for embryonic mitosis in Drosophila. Cold Spring Harb Symp Quant Biol. 1991;56:719-27 pubmed
- Russell D. Mycobacterium tuberculosis: here today, and here tomorrow. Nat Rev Mol Cell Biol. 2001;2:569-77 pubmed..As the macrophage is key to clearing the infection, the interplay between the pathogen and its host cell reflects a constant battle for control. ..
- Ha K, Clarke B, Brown W. Regulation of the Golgi complex by phospholipid remodeling enzymes. Biochim Biophys Acta. 2012;1821:1078-88 pubmed publisher..This article is part of a Special Issue entitled Lipids and Vesicular Transport. ..
- Winans S, Burns D, Christie P. Adaptation of a conjugal transfer system for the export of pathogenic macromolecules. Trends Microbiol. 1996;4:64-8 pubmed
- Williams S, Stewart V. Nitrate- and nitrite-sensing protein NarX of Escherichia coli K-12: mutational analysis of the amino-terminal tail and first transmembrane segment. J Bacteriol. 1997;179:721-9 pubmed..We conclude that the amino terminus of the NarX protein is important for the differential response to nitrate and nitrite. ..
- Lopez J, Wolfner M. The developmentally regulated Drosophila embryonic nuclear lamina protein 'Young Arrest' (fs(1)Ya) is capable of associating with chromatin. J Cell Sci. 1997;110 ( Pt 5):643-51 pubmed..These observations suggest that YA may be required for the interaction between chromatin and the nuclear envelope during early embryogenesis. ..
- Li Y, Gou M, Sun Q, Hua J. Requirement of calcium binding, myristoylation, and protein-protein interaction for the Copine BON1 function in Arabidopsis. J Biol Chem. 2010;285:29884-91 pubmed publisher..This analysis reveals an unanticipated regulation of copine protein localization and function by calcium and lipid modification and suggests an important role in protein-protein interaction for the VWA domain of copines. ..
- Hokanson D, Bretscher A. EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking. Mol Biol Cell. 2012;23:701-15 pubmed publisher..We propose that EPI64 regulates membrane trafficking both by stabilizing Arf6-GTP and by inhibiting the recycling of membrane through the tubular endosome by decreasing Rab8a-GTP levels...
- Dzikovski B, Borbat P, Freed J. Spin-labeled gramicidin a: channel formation and dissociation. Biophys J. 2004;87:3504-17 pubmed..4-1 mol %) accessible to the ESR methods employed in the study, since this yields non-interacting dimer channels. ..
- Jesch S, Liu P, Zhao X, Wells M, Henry S. Multiple endoplasmic reticulum-to-nucleus signaling pathways coordinate phospholipid metabolism with gene expression by distinct mechanisms. J Biol Chem. 2006;281:24070-83 pubmed..We propose that these signals are generated in the ER by increased flux through the pathway of phosphatidylinositol synthesis. ..
- Li Y, Pennington B, Hua J. Multiple R-like genes are negatively regulated by BON1 and BON3 in arabidopsis. Mol Plant Microbe Interact. 2009;22:840-8 pubmed publisher..Further, their activation in the bon1bon3 mutants appears to be through different regulatory modes, and BON1 and BON3 may repress the transcript accumulation or protein activities of these R-like genes. ..
- de Figueiredo P, Polizotto R, Drecktrah D, Brown W. Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists. Mol Biol Cell. 1999;10:1763-82 pubmed..In addition, they implicate a role for cytoplasmic PLA2 enzymes in mediating these membrane trafficking events. ..
- Straub S, Daniel S, Sharp G. Hyposmotic shock stimulates insulin secretion by two distinct mechanisms. Studies with the betaHC9 cell. Am J Physiol Endocrinol Metab. 2002;282:E1070-6 pubmed..Moreover, these two mechanisms may be associated with the release of two distinct pools of insulin-containing granules. ..
- Stefan C, Manford A, Baird D, Yamada Hanff J, Mao Y, Emr S. Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites. Cell. 2011;144:389-401 pubmed publisher..Our findings further suggest that the conserved Osh proteins control PI metabolism at additional membrane contact sites. ..
- Rairdan G, Donofrio N, Delaney T. Salicylic acid and NIM1/NPR1-independent gene induction by incompatible Peronospora parasitica in arabidopsis. Mol Plant Microbe Interact. 2001;14:1235-46 pubmed
- Bartnikas T, Wang Y, Bobo T, Veselov A, Scholes C, Shapleigh J. Characterization of a member of the NnrR regulon in Rhodobacter sphaeroides 2.4.3 encoding a haem-copper protein. Microbiology. 2002;148:825-33 pubmed publisher..Genes encoding putative orthologues of NnrS are sometimes but not always found in bacteria encoding nitrite and/or nitric oxide reductase...
- Bretscher A, Edwards K, Fehon R. ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol. 2002;3:586-99 pubmed..The closely related tumour suppressor merlin shares many properties with ERM proteins, yet also provides a distinct and essential function. ..
- Garbett D, Bretscher A. PDZ interactions regulate rapid turnover of the scaffolding protein EBP50 in microvilli. J Cell Biol. 2012;198:195-203 pubmed publisher..Thus, the linking of relatively stable microvillar components can be mediated by surprisingly dynamic EBP50, a finding that may have important ramifications for other scaffolding proteins...
- Beyenbach K, Pannabecker T, Nagel W. Central role of the apical membrane H+-ATPase in electrogenesis and epithelial transport in Malpighian tubules. J Exp Biol. 2000;203:1459-68 pubmed..Furthermore, electrical coupling offers a balance between electroconductive entry of cations across the basolateral membrane and extrusion across the apical membrane to support steady-state conditions during transepithelial transport. ..
- Tian C, Sen D, Shi H, Foehr M, Plavskin Y, Vatamaniuk O, et al. The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans. Development. 2010;137:2375-84 pubmed publisher..Our work provides a direct link between RGM proteins and BMP signaling in vivo and a simple and genetically tractable system for mechanistic studies of RGM protein regulation of BMP pathways. ..
- Kim M, Wainwright H, Locketz M, Bekker L, Walther G, Dittrich C, et al. Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism. EMBO Mol Med. 2010;2:258-74 pubmed publisher..These results provide molecular and biochemical evidence that the development of the human TB granuloma to caseation correlates with pathogen-mediated dysregulation of host lipid metabolism. ..
- Clark T, Lin T, Jackwood D, Sherrill J, Lin Y, Dickerson H. The gene for an abundant parasite coat protein predicts tandemly repetitive metal binding domains. Gene. 1999;229:91-100 pubmed
- Vilinsky I, Stewart B, Drummond J, Robinson I, Deitcher D. A Drosophila SNAP-25 null mutant reveals context-dependent redundancy with SNAP-24 in neurotransmission. Genetics. 2002;162:259-71 pubmed..These results suggest that the apparent redundancy between SNAP-25 and SNAP-24 is due to inappropriate genetic substitution. ..
- Fiumera H, Broadley S, Fox T. Translocation of mitochondrially synthesized Cox2 domains from the matrix to the intermembrane space. Mol Cell Biol. 2007;27:4664-73 pubmed..Our data suggest that the C-tail domain is recognized posttranslationally by a specialized translocation apparatus after the N-tail has been translocated by Oxa1. ..
- Tsai C, Chen C, Winans S. Most mutant OccR proteins that are defective in positive control hold operator DNA in a locked high-angle bend. J Bacteriol. 2011;193:5442-9 pubmed publisher..One mutant, the L26A mutant, showed ligand-responsive DNA binding similar to that of wild-type OccR and therefore must be impaired in a subsequent step in activation. ..
- Infante J, Huszagh V. Zellweger syndrome knockout mouse models challenge putative peroxisomal beta-oxidation involvement in docosahexaenoic acid (22:6n-3) biosynthesis. Mol Genet Metab. 2001;72:1-7 pubmed..Similar experiments using brain of the acyl-CoA oxidase knockout mouse model are proposed to confirm the lack of peroxisomal beta-oxidation involvement in 22:6n-3 synthesis, since this mutation would not impair plasmalogen synthesis. ..
- Ingraffea J, Reczek D, Bretscher A. Distinct cell type-specific expression of scaffolding proteins EBP50 and E3KARP: EBP50 is generally expressed with ezrin in specific epithelia, whereas E3KARP is not. Eur J Cell Biol. 2002;81:61-8 pubmed..These results document a preference for co-expression of EBP50, but not E3KARP, with ezrin in polarized epithelia. These results place constraints on the physiological roles that can be proposed for these scaffolding molecules. ..
- Brady O, Zheng Y, Murphy K, Huang M, Hu F. The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function. Hum Mol Genet. 2013;22:685-95 pubmed publisher..These results shed light on the cellular functions of TMEM106B and the roles of TMEM106B in the pathogenesis of FTLD-U with PGRN mutations. ..
- Reardon B, Hansen J, Crystal R, Houston D, Kritchevsky S, Harris T, et al. Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function. BMC Med Genet. 2013;14:122 pubmed publisher..SGPP2, a sphingosine-1-phosphate phosphatase, is a novel vitamin D-responsive gene associated with lung function. The identified associations will need to be followed up in further studies. ..
- Basu J, Li Z. The Des-1 protein, required for central spindle assembly and cytokinesis, is associated with mitochondria along the meiotic spindle apparatus and with the contractile ring during male meiosis in Drosophila melanogaster. Mol Gen Genet. 1998;259:664-73 pubmed
- Liu J, Lee K, Segura Totten M, Neufeld E, Wilson K, Gruenbaum Y. MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2003;100:4598-603 pubmed..These findings show that LEM domain proteins are essential for cell division and that Ce-emerin and Ce-MAN1 share at least one and possibly multiple overlapping functions, which may be relevant to Emery-Dreifuss muscular dystrophy...
- HACKETT C, FLAMINIO M, Fortier L. Analysis of CD14 expression levels in putative mesenchymal progenitor cells isolated from equine bone marrow. Stem Cells Dev. 2011;20:721-35 pubmed publisher..By definition, MPCs are considered nonhematopoietic because they lack expression of molecules such as CD14. Our results challenge this assumption, as equine MPCs appear to represent a descendant of a CD14-positive cell. ..
- Byrnes L, Singh A, Szeto K, Benvin N, O Donnell J, Zipfel W, et al. Structural basis for conformational switching and GTP loading of the large G protein atlastin. EMBO J. 2013;32:369-84 pubmed publisher..Perturbation of these mechanisms may be implicated in a group of atlastin-associated hereditary neurodegenerative diseases. ..
- Green Willms N, Fox T, Costanzo M. Functional interactions between yeast mitochondrial ribosomes and mRNA 5' untranslated leaders. Mol Cell Biol. 1998;18:1826-34 pubmed..We propose that mitochondrial ribosomes themselves recognize a common feature of mRNA 5'-UTLs which, in conjunction with mRNA-specific translational activation, is required for organellar translation initiation. ..
- Calero M, Whittaker G, Collins R. Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth. J Biol Chem. 2001;276:12100-12 pubmed..These results suggest that Yop1p acts in conjunction with Yip1p to mediate a common step in membrane traffic. ..
- Rao S, Stewart B, Rivlin P, Vilinsky I, Watson B, Lang C, et al. Two distinct effects on neurotransmission in a temperature-sensitive SNAP-25 mutant. EMBO J. 2001;20:6761-71 pubmed..Our data suggest that at 22 degrees C the mutation causes the SNARE complex to be more fusion competent but, at 37 degrees C the same mutation leads to SNARE multimer instability and fusion incompetence. ..
- Saracco S, Fox T. Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane. Mol Biol Cell. 2002;13:1122-31 pubmed..The inner membrane proteins Mss2p and Pnt1p both coimmunoprecipitate with Cox18p, suggesting that they work together in translocation of Cox2p domains, an inference supported by functional interactions among the three genes. ..
- Bu P, Chen K, Chen J, Wang L, Walters J, Shin Y, et al. A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. Cell Stem Cell. 2013;12:602-15 pubmed publisher..Altogether, our findings highlight a unique microRNA-regulated mechanism that converts noisy input into a toggle switch for robust cell-fate decisions in CCSCs. ..
- Zhou Y, Johnson J, Cerione R, Erickson J. Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7. Biochemistry. 2013;52:4354-63 pubmed publisher..The positive cooperativity observed in our reconstituted system suggests that the action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac signaling in the context of the membrane recruitment of a DOCK7 GEF complex. ..
- Brown N, Costanzo M, Fox T. Interactions among three proteins that specifically activate translation of the mitochondrial COX3 mRNA in Saccharomyces cerevisiae. Mol Cell Biol. 1994;14:1045-53 pubmed..Taken together with previous work, these data suggest that a complex containing PET54, PET122, and PET494 mediates the interaction of the COX3 mRNA with mitochondrial ribosomes at the surface of the inner membrane. ..
- Reczek D, Berryman M, Bretscher A. Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J Cell Biol. 1997;139:169-79 pubmed..Since PDZ domains are known to mediate associations with integral membrane proteins, one mode of membrane attachment of ezrin is likely to be mediated through EBP50. ..
- Calero M, Winand N, Collins R. Identification of the novel proteins Yip4p and Yip5p as Rab GTPase interacting factors. FEBS Lett. 2002;515:89-98 pubmed
- Green Willms N, Butler C, Dunstan H, Fox T. Pet111p, an inner membrane-bound translational activator that limits expression of the Saccharomyces cerevisiae mitochondrial gene COX2. J Biol Chem. 2001;276:6392-7 pubmed..8-fold in a strain bearing extra copies of PET111 on a high-copy plasmid. Thus, Pet111p could play dual roles in both membrane localization and regulation of Cox2p synthesis within mitochondria. ..
- Jeffers G, Bruce J, McDonough P, Scarlett J, Boor K, Wiedmann M. Comparative genetic characterization of Listeria monocytogenes isolates from human and animal listeriosis cases. Microbiology. 2001;147:1095-104 pubmed..This study also establishes baseline data describing the genetic diversity of human and animal L. monocytogenes isolates which can be utilized in future surveillance programmes to track the emergence of new strains. ..
- Bhatnagar J, Borbat P, Pollard A, Bilwes A, Freed J, Crane B. Structure of the ternary complex formed by a chemotaxis receptor signaling domain, the CheA histidine kinase, and the coupling protein CheW as determined by pulsed dipolar ESR spectroscopy. Biochemistry. 2010;49:3824-41 pubmed publisher..In the context of the hexagonal lattice formed by trimeric transmembrane chemoreceptors, the PDS structure is best accommodated with the P3 domain in the center of a honeycomb edge...
- Gou M, Shi Z, Zhu Y, Bao Z, Wang G, Hua J. The F-box protein CPR1/CPR30 negatively regulates R protein SNC1 accumulation. Plant J. 2012;69:411-20 pubmed publisher..Thus, this study reveals a new mechanism in R protein regulation likely through protein degradation and suggests negative regulation as a critical component in fine control of plant immunity. ..
- Huang H, He S, Bauer D, Collmer A. The Pseudomonas syringae pv. syringae 61 hrpH product, an envelope protein required for elicitation of the hypersensitive response in plants. J Bacteriol. 1992;174:6878-85 pubmed..These results suggest that the P. syringae pv. syringae HrpH protein is involved in the secretion of a proteinaceous HR elicitor...
- Lin H, Wolfner M. The Drosophila maternal-effect gene fs(1)Ya encodes a cell cycle-dependent nuclear envelope component required for embryonic mitosis. Cell. 1991;64:49-62 pubmed..These results suggest that the fs(1)Ya protein is a cell cycle-dependent component of the nuclear envelope that specifically functions in embryonic mitosis. ..
- Lopez J, Song K, Hirshfeld A, Lin H, Wolfner M. The Drosophila fs(1)Ya protein, which is needed for the first mitotic division, is in the nuclear lamina and in the envelopes of cleavage nuclei, pronuclei, and nonmitotic nuclei. Dev Biol. 1994;163:202-11 pubmed..Finally, our immunoelectron microscopy shows that the fs(1)Ya protein distribution parallels that of lamin, indicating that it is a nuclear lamina protein. ..
- Savvides S, Boone T, Andrew Karplus P. Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots. Nat Struct Biol. 2000;7:486-91 pubmed..Furthermore, we identify recognition features common to all helical and cystine-knot protein ligands that activate type III tyrosine kinase receptors, and the closely related type V tyrosine kinase receptors. ..
- Yang H, Li Y, Hua J. The C2 domain protein BAP1 negatively regulates defense responses in Arabidopsis. Plant J. 2006;48:238-48 pubmed..Furthermore, the BAP1 protein probably functions together with an evolutionarily conserved C2 domain protein BON1/CPN1 to negatively regulate defense responses in plants. ..
- Park S, Borbat P, Gonzalez Bonet G, Bhatnagar J, Pollard A, Freed J, et al. Reconstruction of the chemotaxis receptor-kinase assembly. Nat Struct Mol Biol. 2006;13:400-7 pubmed publisher..Linking layers of ternary complexes with close-packed receptors generates a lattice with reasonable component ratios, cooperative interactions among receptors and accessible sites for modification enzymes...
- Williams E, Butler C, Bonnefoy N, Fox T. Translation initiation in Saccharomyces cerevisiae mitochondria: functional interactions among mitochondrial ribosomal protein Rsm28p, initiation factor 2, methionyl-tRNA-formyltransferase and novel protein Rmd9p. Genetics. 2007;175:1117-26 pubmed
- Oh C, Beer S. AtHIPM, an ortholog of the apple HrpN-interacting protein, is a negative regulator of plant growth and mediates the growth-enhancing effect of HrpN in Arabidopsis. Plant Physiol. 2007;145:426-36 pubmed publisher..Overexpression of AtHIPM conversely resulted in smaller plants. These results indicate that AtHIPM functions as a negative regulator of plant growth and mediates enhanced growth that results from treatment with HrpN...
- Tian C, Shi H, Xiong S, Hu F, Xiong W, Liu J. The neogenin/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans. Development. 2013;140:4070-80 pubmed publisher..Mouse neogenin lacking the intracellular domain is also capable of mediating BMP signaling. These findings reveal an unexpected mode of action for neogenin regulation of BMP signaling. ..