Experts and Doctors on hela cells in New Brunswick, New Jersey, United States
Locale: New Brunswick, New Jersey, United States
Topic: hela cells
Ginjala V, Nacerddine K, Kulkarni A, Oza J, Hill S, Yao M, et al
. BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol Cell Biol. 2011;31:1972-82 pubmed publisher
..Loss of BMI1 leads to impaired repair of DNA double-strand breaks by homologous recombination and the accumulation of cells in G(2)/M. These data support a crucial role for BMI1 in the cellular response to DNA damage. ..
Jackson V, Mehmood S, Chavent M, Roversi P, Carrasquero M, del Toro D, et al
. Super-complexes of adhesion GPCRs and neural guidance receptors. Nat Commun. 2016;7:11184 pubmed publisher
..Our data exemplify how receptors increase their functional repertoire by forming different context-dependent higher-order complexes. ..
Rasheed Z, Saleem A, Ravee Y, Pandolfi P, Rubin E. The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies. Exp Cell Res. 2002;277:152-60 pubmed
..These results identify topors as a new member of the group of proteins that associate dynamically with PML nuclear bodies and suggest that topors may be involved in the cellular response to camptothecin. ..
Huo H, Magro P, Pietsch E, Patel B, Scotto K. Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance. Cancer Res. 2010;70:8726-35 pubmed publisher
..This is the first identification of a histone methyltransferase and its leukemogenic rearrangement that regulates expression of an ABC drug transporter, suggesting a new target for circumvention of tumor multidrug resistance. ..
Huhn S, Liu J, Ye C, Lu H, Jiang X, Feng X, et al
. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017;36:4750-4766 pubmed publisher
..Our study identifies BCCIP as a novel factor critical for microtubule regulation and explicates a mechanism utilized by BCCIP in tumor suppression. ..
Lu K, Alcivar A, Ma J, Foo T, Zywea S, Mahdi A, et al
. NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction. Cancer Res. 2017;77:2881-2892 pubmed publisher
..Our studies reveal novel insights into the regulation of NRF2 and identify DPP3 and an NRF2 transcriptional signature as potential biomarkers for breast cancer prognosis and treatment. Cancer Res; 77(11); 2881-92. ©2017 AACR. ..