Experts and Doctors on bile acids and salts in Piscataway, New Jersey, United States
Locale: Piscataway, New Jersey, United States
Topic: bile acids and salts
Howarth D, Hagey L, Law S, Ai N, Krasowski M, Ekins S, et al
. Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro. Aquat Toxicol. 2010;98:245-255 pubmed publisher
..These data demonstrate that both mammalian and teleost FXR (Fxralpha2 isoform) are activated by primary and secondary bile acids. ..
Kong B, Huang J, Zhu Y, Li G, Williams J, Shen S, et al
. Fibroblast growth factor 15 deficiency impairs liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol. 2014;306:G893-902 pubmed publisher
..The underlying mechanism is likely the result of disrupted bile acid homeostasis and impaired priming of hepatocyte proliferation. ..
Zhan L, Yang I, Kong B, Shen J, Gorczyca L, Memon N, et al
. Dysregulation of bile acid homeostasis in parenteral nutrition mouse model. Am J Physiol Gastrointest Liver Physiol. 2016;310:G93-G102 pubmed publisher
..This study shows that continuous PN infusion with SOLE in mice leads to dysregulation of BA homeostasis. Alterations of liver RORÎ± signaling in PN mice may be one of the mechanisms implicated in the pathogenesis of PNALD. ..
Schumacher J, Kong B, Pan Y, Zhan L, Sun R, Aa J, et al
. The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis. Toxicol Appl Pharmacol. 2017;330:1-8 pubmed publisher
..These data suggest that FGF15 improves lipid homeostasis and reduces bile acid synthesis, but promotes fibrosis during the development of NASH. ..
Bailey A, Zhan L, Maru D, Shureiqi I, Pickering C, Kiriakova G, et al
. FXR silencing in human colon cancer by DNA methylation and KRAS signaling. Am J Physiol Gastrointest Liver Physiol. 2014;306:G48-58 pubmed publisher
Rudraiah S, Moscovitz J, Donepudi A, Campion S, Slitt A, Aleksunes L, et al
. Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice. Toxicology. 2014;325:85-95 pubmed publisher
..The discrepancy with Fmo3 induction in cholestatic models, ANIT and BDL, is not entirely clear. Results from Nrf2 KO mice with APAP suggest that the transcriptional regulation of Fmo3 during liver injury may not involve Nrf2. ..