Experts and Doctors on animals in Omaha, United States

Summary

Locale: Omaha, United States
Topic: animals

Top Publications

  1. Dale M, Fitzgerald M, Liu Z, Meisinger T, Karpisek A, Purcell L, et al. Premature aortic smooth muscle cell differentiation contributes to matrix dysregulation in Marfan Syndrome. PLoS ONE. 2017;12:e0186603 pubmed publisher
    ..This study indicates that an early phenotypic switch appears to be associated with initiation of important metabolic changes in SMCs that contribute to subsequent pathology in MFS. ..
  2. Petersen J, Hickman Miller H, McIlhaney M, Vargas S, Purcell A, Hildebrand W, et al. A charged amino acid residue in the transmembrane/cytoplasmic region of tapasin influences MHC class I assembly and maturation. J Immunol. 2005;174:962-9 pubmed
    ..Thus, the alanine substitution at position 408 in tapasin may interfere with the stable acquisition by MHC class I molecules of peptides that are sufficiently optimal to allow MHC class I release from tapasin...
  3. Dandekar R, Khan M. Involvement of histamine receptors in SAPK/JNK phosphorylation. Int Immunopharmacol. 2012;13:190-6 pubmed publisher
    ..This data showed that histamine acting through H4 receptors caused the phosphorylation of SAPK/JNK via TNFα. The role of H4 receptors in pro-inflammatory response is intriguing...
  4. Xie Y, Wolff D, Wei T, Wang B, Deng C, Kirui J, et al. Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4. Cancer Res. 2009;69:5743-51 pubmed publisher
    ....
  5. Sachs A, Schwendinger J, Yang A, Haider N, Nystuen A. The mouse mutants recoil wobbler and nmf373 represent a series of Grm1 mutations. Mamm Genome. 2007;18:749-56 pubmed
    ..The novel rcw mutants represent a resource that will have utility for further studies of inositol second-messenger-system defects in neurogenetic disorders. ..
  6. Oh K, Stanton M, West W, Todd G, Wagner K. Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. Oncogene. 2007;26:5950-9 pubmed
    ..Instead of cancer initiation, it is therefore likely that Tsg101 plays a more predominant role in the progression of a subset of spontaneously arising breast cancers. ..
  7. Bergeron S, Madathiparambil T, Swanson P. Both high mobility group (HMG)-boxes and the acidic tail of HMGB1 regulate recombination-activating gene (RAG)-mediated recombination signal synapsis and cleavage in vitro. J Biol Chem. 2005;280:31314-24 pubmed
    ..Box A or B mutants fail to promote RAG synaptic complex formation, but this defect is alleviated when the acidic tail is removed from these mutants. ..
  8. Rabl K, Cadetti L, Thoreson W. Kinetics of exocytosis is faster in cones than in rods. J Neurosci. 2005;25:4633-40 pubmed
    ..The initial rapid release of vesicles from cones can shape the postsynaptic response and may contribute to the faster responses of cone-driven cells observed at light offset...
  9. Pavletic A, Hawes S, Geske J, Bringe K, Polack S. Experience with routine vaginal pH testing in a family practice setting. Infect Dis Obstet Gynecol. 2004;12:63-8 pubmed
    ..06). Routine pH testing increased detection of trichomoniasis and bacterial vaginosis by prompting microscopy in a significant proportion of asymptomatic cases. ..
  10. Carstens M, Krempler A, Triplett A, Van Lohuizen M, Wagner K. Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells. J Biol Chem. 2004;279:35984-94 pubmed
    ....

Locale

Detail Information

Publications62

  1. Dale M, Fitzgerald M, Liu Z, Meisinger T, Karpisek A, Purcell L, et al. Premature aortic smooth muscle cell differentiation contributes to matrix dysregulation in Marfan Syndrome. PLoS ONE. 2017;12:e0186603 pubmed publisher
    ..This study indicates that an early phenotypic switch appears to be associated with initiation of important metabolic changes in SMCs that contribute to subsequent pathology in MFS. ..
  2. Petersen J, Hickman Miller H, McIlhaney M, Vargas S, Purcell A, Hildebrand W, et al. A charged amino acid residue in the transmembrane/cytoplasmic region of tapasin influences MHC class I assembly and maturation. J Immunol. 2005;174:962-9 pubmed
    ..Thus, the alanine substitution at position 408 in tapasin may interfere with the stable acquisition by MHC class I molecules of peptides that are sufficiently optimal to allow MHC class I release from tapasin...
  3. Dandekar R, Khan M. Involvement of histamine receptors in SAPK/JNK phosphorylation. Int Immunopharmacol. 2012;13:190-6 pubmed publisher
    ..This data showed that histamine acting through H4 receptors caused the phosphorylation of SAPK/JNK via TNFα. The role of H4 receptors in pro-inflammatory response is intriguing...
  4. Xie Y, Wolff D, Wei T, Wang B, Deng C, Kirui J, et al. Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4. Cancer Res. 2009;69:5743-51 pubmed publisher
    ....
  5. Sachs A, Schwendinger J, Yang A, Haider N, Nystuen A. The mouse mutants recoil wobbler and nmf373 represent a series of Grm1 mutations. Mamm Genome. 2007;18:749-56 pubmed
    ..The novel rcw mutants represent a resource that will have utility for further studies of inositol second-messenger-system defects in neurogenetic disorders. ..
  6. Oh K, Stanton M, West W, Todd G, Wagner K. Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. Oncogene. 2007;26:5950-9 pubmed
    ..Instead of cancer initiation, it is therefore likely that Tsg101 plays a more predominant role in the progression of a subset of spontaneously arising breast cancers. ..
  7. Bergeron S, Madathiparambil T, Swanson P. Both high mobility group (HMG)-boxes and the acidic tail of HMGB1 regulate recombination-activating gene (RAG)-mediated recombination signal synapsis and cleavage in vitro. J Biol Chem. 2005;280:31314-24 pubmed
    ..Box A or B mutants fail to promote RAG synaptic complex formation, but this defect is alleviated when the acidic tail is removed from these mutants. ..
  8. Rabl K, Cadetti L, Thoreson W. Kinetics of exocytosis is faster in cones than in rods. J Neurosci. 2005;25:4633-40 pubmed
    ..The initial rapid release of vesicles from cones can shape the postsynaptic response and may contribute to the faster responses of cone-driven cells observed at light offset...
  9. Pavletic A, Hawes S, Geske J, Bringe K, Polack S. Experience with routine vaginal pH testing in a family practice setting. Infect Dis Obstet Gynecol. 2004;12:63-8 pubmed
    ..06). Routine pH testing increased detection of trichomoniasis and bacterial vaginosis by prompting microscopy in a significant proportion of asymptomatic cases. ..
  10. Carstens M, Krempler A, Triplett A, Van Lohuizen M, Wagner K. Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells. J Biol Chem. 2004;279:35984-94 pubmed
    ....
  11. Zhang X, Kang L, Ding L, Vranic S, Gatalica Z, Wang Z. A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells. Oncogene. 2011;30:770-80 pubmed publisher
    ....
  12. Nair S, Rimerman R, Toran E, Chen S, Prapapanich V, Butts R, et al. Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. Mol Cell Biol. 1997;17:594-603 pubmed
    ..This observation provides a precedent for differential interactions between Hsp90-associated immunophilins and target proteins such as steroid receptors. ..
  13. Smith D, Baggenstoss B, Marion T, Rimerman R. Two FKBP-related proteins are associated with progesterone receptor complexes. J Biol Chem. 1993;268:18365-71 pubmed
    ..While p50 appears to be the chicken homolog of FKBP52, p54 is perhaps a novel member of the FKBP family that, in addition to FKBP52, interacts with progesterone receptor. ..
  14. Shikiya R, Bartz J. In vitro generation of high-titer prions. J Virol. 2011;85:13439-42 pubmed publisher
    ..These data demonstrate that PMCA efficiently replicates the prion agent and provide further support for the hypothesis that in vitro-generated prions are bona fide and are not due to contamination. ..
  15. Ali M, Knoop F, Vaudry H, Conlon J. Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. Peptides. 2003;24:955-61 pubmed
    ..It is proposed that the distribution and amino acid sequences of skin antimicrobial peptides may be useful markers for taxonomic classification of particular sub-populations and for an understanding of phylogenetic interrelationships...
  16. Zhang X, Goodsell J, Norgren R. Limitations of the rhesus macaque draft genome assembly and annotation. BMC Genomics. 2012;13:206 pubmed publisher
    ..The problems identified in this work likely apply to all draft vertebrate genomes annotated with any automated gene model pipeline and thus represent a pervasive challenge to the analysis of draft genomes. ..
  17. Xiong J, Kielian T. Microglia in juvenile neuronal ceroid lipofuscinosis are primed toward a pro-inflammatory phenotype. J Neurochem. 2013;127:245-58 pubmed publisher
    ..Collectively, aberrant microglial activation may contribute to the pathological chain of events leading to neurodegeneration during later stages of JNCL. ..
  18. Lv K, Jiang J, Donaghy R, Riling C, Cheng Y, Chandra V, et al. CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies. Genes Dev. 2017;31:1007-1023 pubmed publisher
    ..Hence, our studies reveal a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBLmut myeloid malignancies. ..
  19. Peng Y, Zallocchi M, Meehan D, Delimont D, Chang B, Hawes N, et al. Progressive morphological and functional defects in retinas from alpha1 integrin-null mice. Invest Ophthalmol Vis Sci. 2008;49:4647-54 pubmed publisher
    ..Further, this report demonstrates a direct link between integrin alpha1beta1 function in retinal pigment epithelial and molecular defects in photoreceptor cell function before retinal abnormality is apparent. ..
  20. Li H, Schopfer L, Masson P, Lockridge O. Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers. Biochem J. 2008;411:425-32 pubmed publisher
    ..We propose that the proline-rich peptides organize the 4 subunits of BChE into a 340 kDa tetramer, by interacting with the C-terminal BChE tetramerization domain...
  21. Sadanandam A, Futakuchi M, Lyssiotis C, Gibb W, Singh R. A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling. BMC Cancer. 2011;11:304 pubmed publisher
    ..Characterization of the gene expression signature specific to the TB interface in our model revealed signaling mechanisms operative in human breast cancer metastases and predicted a therapeutic inhibitor of cancer-mediated osteolysis. ..
  22. Mercer A, Rabl K, Riccardi G, Brecha N, Stella S, Thoreson W. Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse. J Neurophysiol. 2011;105:321-35 pubmed publisher
    ..A diffuse distribution of Cl(Ca) channels may allow Ca(2+) influx at one site to influence relatively distant Ca(2+) channels...
  23. Lei R, Brenneman R, Schmitt D, Louis E. Detection of cytonuclear genomic dissociation in the North American captive African elephant collection. J Hered. 2009;100:675-80 pubmed publisher
    ..These results are important for resolving questions that can potentially impact future management and breeding programs related to the collection...
  24. Morris C, Grandin T, Irlbeck N. Companion Animals Symposium: Environmental enrichment for companion, exotic, and laboratory animals. J Anim Sci. 2011;89:4227-38 pubmed publisher
    ....
  25. Yang J, Pollock J, Carmines P. NADPH oxidase and PKC contribute to increased Na transport by the thick ascending limb during type 1 diabetes. Hypertension. 2012;59:431-6 pubmed publisher
    ....
  26. Gao L, Wang W, Wang W, Zucker I. Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: potential mechanism for sympathetic overactivity in heart failure. Hypertension. 2008;52:708-14 pubmed publisher
    ..These data implicate a downregulation in the AT(2)R as a contributory factor in the sympathoexcitation in CHF. ..
  27. Fatma N, Kubo E, Sen M, Agarwal N, Thoreson W, Camras C, et al. Peroxiredoxin 6 delivery attenuates TNF-alpha-and glutamate-induced retinal ganglion cell death by limiting ROS levels and maintaining Ca2+ homeostasis. Brain Res. 2008;1233:63-78 pubmed publisher
    ..Results provide a rationale for use of PRDX6 for blocking ROS-mediated pathophysiology in glaucoma and other neuronal disorders. ..
  28. Birt D, Merrill A, Barnett T, Enkvetchakul B, Pour P, Liotta D, et al. Inhibition of skin carcinomas but not papillomas by sphingosine, N-methylsphingosine, and N-acetylsphingosine. Nutr Cancer. 1998;31:119-26 pubmed
    ..5 mumol of NAS. Thus low doses of sphingolipids that were not effective in inhibiting ODC activity, reducing hyperplasia, or preventing epidermal papilloma development were, nonetheless, effective in inhibiting carcinoma development...
  29. Zheng J, Thylin M, Ghorpade A, Xiong H, Persidsky Y, Cotter R, et al. Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia. J Neuroimmunol. 1999;98:185-200 pubmed
    ..These data, taken together, suggest that CXCR4-mediated signal transduction may be a potential mechanism for neuronal dysfunction during HAD. ..
  30. Kim M, Turnquist H, Jackson J, Sgagias M, Yan Y, Gong M, et al. The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin Cancer Res. 2002;8:22-8 pubmed
    ..These results suggest that Hoechst 33342 is a substrate for the ABCG2 transporter and that ABCG2/Bcrp1 expression may serve as a marker for hematopoietic stem cells in hematopoietic cells...
  31. Zallocchi M, Sisson J, Cosgrove D. Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells. Biochemistry. 2010;49:1236-47 pubmed publisher
    ..This complex(es) is present primarily in transport vesicles at the apical pole of tracheal epithelial cells, predicting that Usher proteins may be directionally transported as complexes in hair cells and photoreceptors. ..
  32. Yadav R, Gupta S, Hillman B, Bhatt J, Stairs D, Dravid S. Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors. PLoS ONE. 2012;7:e32969 pubmed publisher
    ....
  33. Marsh R, Kincaid A, Bessen R, Bartz J. Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus). J Virol. 2005;79:13794-6 pubmed
    ..Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates...
  34. Chen S, Sullivan W, Toft D, Smith D. Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants. Cell Stress Chaperones. 1998;3:118-29 pubmed
    ..These results and others further suggest that the N- and C-terminal regions of Hsp90 maintain important conformational links through intramolecular interactions and/or intermolecular influences in homodimers. ..
  35. Kakiuchi Kiyota S, Crabbs T, Arnold L, Pennington K, Cook J, Malarkey D, et al. Evaluation of expression profiles of hematopoietic stem cell, endothelial cell, and myeloid cell antigens in spontaneous and chemically induced hemangiosarcomas and hemangiomas in mice. Toxicol Pathol. 2013;41:709-21 pubmed publisher
    ..In addition, myeloid lineage cells do not appear to contribute to hemangiosarcoma and hemangioma formation in mice. ..
  36. Rahajeng J, Caplan S, Naslavsky N. Common and distinct roles for the binding partners Rabenosyn-5 and Vps45 in the regulation of endocytic trafficking in mammalian cells. Exp Cell Res. 2010;316:859-74 pubmed publisher
    ....
  37. Smolsky J, Kaur S, Hayashi C, Batra S, Krasnoslobodtsev A. Surface-Enhanced Raman Scattering-Based Immunoassay Technologies for Detection of Disease Biomarkers. Biosensors (Basel). 2017;7: pubmed publisher
    ..Finally, it introduces recently developed strategies for in vivo biomarker detection using SERS. ..
  38. Cavalieri E, Rogan E, Li K, Todorovic R, Ariese F, Jankowiak R, et al. Identification and quantification of the depurinating DNA adducts formed in mouse skin treated with dibenzo[a,l]pyrene (DB[a,l]P) or its metabolites and in rat mammary gland treated with DB[a,l]P. Chem Res Toxicol. 2005;18:976-83 pubmed
    ..Only one depurinating diol epoxide adduct was formed. Tumorigenicity, mutations, and DNA adduct data suggest that depurinating Ade adducts play a major role in the initiation of tumors by DB[a,l]P. ..
  39. Kreiling J, Byrd J, Deisz R, Mizukami I, Todd R, MacDonald R. Binding of urokinase-type plasminogen activator receptor (uPAR) to the mannose 6-phosphate/insulin-like growth factor II receptor: contrasting interactions of full-length and soluble forms of uPAR. J Biol Chem. 2003;278:20628-37 pubmed
    ..We conclude that, contrary to previous reports, the interaction between uPAR and Man-6-P/IGF2R is a low percentage binding event and that suPAR and full-length uPAR bind the Man-6-P/IGF2R by different mechanisms. ..
  40. Naslavsky N, Boehm M, Backlund P, Caplan S. Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane. Mol Biol Cell. 2004;15:2410-22 pubmed
    ..Our studies suggest that Rabenosyn-5 and EHD1 act sequentially in the transport of proteins from early endosomes to the endosomal recycling compartment and back to the plasma membrane. ..
  41. Kang L, Zhang X, Xie Y, Tu Y, Wang D, Liu Z, et al. Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signaling. Mol Endocrinol. 2010;24:709-21 pubmed publisher
    ..The selective G protein-coupled receptor (GPR)30 agonist G1 actually interacts with ER-alpha36. Thus, the ER-alpha variant ER-alpha36, not GPR30, is involved in nongenomic estrogen signaling. ..
  42. Freeman T, Thiele G, Tuma D, Machu T, Mailliard M. ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane. Arch Biochem Biophys. 2002;400:215-22 pubmed
    ..In addition, the pattern of expression of System A activity in oocytes, transport kinetics, and sensitivity to chemical modification indicate the presence of a second System A isoform in liver that differs substantially from ATA2. ..
  43. Naramura M, Nadeau S, Mohapatra B, Ahmad G, Mukhopadhyay C, Sattler M, et al. Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders. Oncotarget. 2011;2:245-50 pubmed
    ..Here we discuss insights gained from the analyses of Cbl mutants both in human patients and in animal models and propose potential mechanisms of oncogenesis through this pathway. ..
  44. Abdalla M, Hoke T, Seravalli J, Switzer B, Bavitz M, Fliege J, et al. Pseudomonas Quinolone Signal Induces Oxidative Stress and Inhibits Heme Oxygenase-1 Expression in Lung Epithelial Cells. Infect Immun. 2017;85: pubmed publisher
    ..1 cells (P < 0.05, n = 3), as determined by immunoblotting and densitometry. These PQS effects on host cells could play an important role in the pathogenicity of P. aeruginosa infections. ..
  45. Thorell W, Leibrock L, Agrawal S. Role of RyRs and IP3 receptors after traumatic injury to spinal cord white matter. J Neurotrauma. 2002;19:335-42 pubmed
    ..9+/-7.9%; p < 0.05). In conclusion, the injurious effects of Ca2+i in traumatic central nervous system (CNS) white matter injury appear to be mediated both by RyRs and through IP3Rs calcium-induced calcium release receptors (CICRs). ..
  46. Wilder P, Kelly D, Brigman K, Peterson C, Nowling T, Gao Q, et al. Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny. Dev Biol. 1997;192:614-29 pubmed
    ..Thus, ES cells with both FGF-4 alleles inactivated should shed light on the important roles of FGF-4 during the early stages of mammalian development and help determine why FGF-4-/- embryos die shortly after implantation. ..
  47. Rosenbaugh E, Savalia K, Manickam D, Zimmerman M. Antioxidant-based therapies for angiotensin II-associated cardiovascular diseases. Am J Physiol Regul Integr Comp Physiol. 2013;304:R917-28 pubmed publisher
    ....
  48. Fritzsch B, Farinas I, Reichardt L. Lack of neurotrophin 3 causes losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion. J Neurosci. 1997;17:6213-25 pubmed
    ..Despite these impressive innervation deficiencies, the morphology of the organ of Corti and the development of inner and outer hair cells appeared comparatively normal. ..
  49. Hjermstad S, Peters K, Briggs S, Glazer R, Smithgall T. Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713). Oncogene. 1993;8:2283-92 pubmed
    ..These results indicate that the c-fes SH2 domain and consensus autophosphorylation site (Tyr-713) play major roles in the positive regulation of p93c-fes tyrosine kinase activity, possibly through intramolecular interaction. ..
  50. Simone L, Georgesen C, Simone P, Wang X, Solheim J. Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain. Mol Immunol. 2012;49:628-39 pubmed publisher
    ..Together, these findings demonstrate that the tapasin C-terminal and transmembrane/cytoplasmic regions are critical to tapasin's capacity to associate effectively with the MHC class I molecule...
  51. Kassmeier M, Mondal K, Palmer V, Raval P, Kumar S, Perry G, et al. VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity. EMBO J. 2012;31:945-58 pubmed publisher
    ..These data suggest full-length RAG1 recruits a cullin RING E3 ligase complex to ubiquitylate an unknown protein(s) to limit error-prone repair during V(D)J recombination. ..
  52. Rao E, Jiang C, Ji M, Huang X, Iqbal J, Lenz G, et al. The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. Leukemia. 2012;26:1064-72 pubmed publisher
    ..Targeting the miR-17∼92 cluster may therefore provide a novel therapeutic approach for patients with MCL. ..
  53. Bidasee K, Nallani K, Besch H, Dincer U. Streptozotocin-induced diabetes increases disulfide bond formation on cardiac ryanodine receptor (RyR2). J Pharmacol Exp Ther. 2003;305:989-98 pubmed
    ..These data suggest that the dysfunction of RyR2 induced by diabetes may be due in part to formation of disulfide bonds between adjacent sulfhydryl groups and that these changes were attenuated with insulin treatment. ..
  54. Nannuru K, Futakuchi M, Varney M, Vincent T, Marcusson E, Singh R. Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface. Cancer Res. 2010;70:3494-504 pubmed publisher
    ..Together, our data indicate that upregulation of MMP13 at the TB interface is important in tumor-induced osteolysis and suggest that MMP13 is a potential therapeutic target for breast cancer bone metastasis. ..
  55. Sachs A, David S, Haider N, Nystuen A. Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4. PLoS ONE. 2009;4:e8270 pubmed publisher
    ..Our data suggest that Purkinje cell loss in the Inpp4a(wbl) mutant is due to glutamate excitotoxicity initiated by the climbing fiber, and that Eaat4 may exert a protective effect...
  56. Pendyala G, Trauger S, Kalisiak E, Ellis R, Siuzdak G, Fox H. Cerebrospinal fluid proteomics reveals potential pathogenic changes in the brains of SIV-infected monkeys. J Proteome Res. 2009;8:2253-60 pubmed publisher
    ..This study reveals new central nervous system alterations in lentivirus-induced neurological disease, and this technique can be applied to other systems in which limited amounts of biofluids can be obtained. ..
  57. Sosa L, Vidlak D, Strachota J, Pavlik J, Jerrells T. Rescue of in vivo FAS-induced apoptosis of hepatocytes by corticosteroids either associated with alcohol consumption by mice or provided exogenously. Int Immunopharmacol. 2005;5:301-14 pubmed
    ..These data support the suggestion that ethanol increases hepatocyte sensitivity to FAS-mediated damage. ..
  58. Jensen R, Berndt W. Epinephrine and norepinephrine enhance p-aminohippurate transport into basolateral membrane vesicles. J Pharmacol Exp Ther. 1988;244:543-9 pubmed
    ..Activation of Na+-K+-adenosine triphosphatase is a possible mechanism whereby adrenergic agonists may exert effects on Na+-coupled transport across the basolateral membrane...
  59. Gelineau van Waes J, Maddox J, Smith L, van Waes M, Wilberding J, Eudy J, et al. Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex. BMC Genomics. 2008;9:156 pubmed publisher
    ....
  60. Yang S, Zhang L, Purohit V, Shukla S, Chen X, Yu F, et al. Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3. Oncotarget. 2015;6:36019-31 pubmed publisher
    ..Together, this work identifies YAP as a novel regulator of pancreatic cancer cell motility, invasion and metastasis, and as a potential therapeutic target for invasive pancreatic cancer. ..
  61. Lockridge O, Blong R, Masson P, Froment M, Millard C, Broomfield C. A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase. Biochemistry. 1997;36:786-95 pubmed
    ..Echothiophate and paraoxon were hydrolyzed with the same kcat of 0.75 min-1. This calculates to a rate acceleration of 100,000-fold for hydrolysis of echothiophate and paraoxon by the G117H mutant compared to the nonenzymatic rate. ..
  62. Tuli A, Sharma M, McIlhaney M, Talmadge J, Naslavsky N, Caplan S, et al. Amyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I molecule. J Immunol. 2008;181:1978-87 pubmed
    ..Correspondingly, K(d) thermostability and surface expression were increased by down-regulation of APLP2 expression. Overall, these data suggest that APLP2 modulates the stability and endocytosis of K(d) molecules. ..