Genomes and Genes
Experts and Doctors on animals in Lincoln, Nebraska, United States
Locale: Lincoln, Nebraska, United States
Publications109 found, 100 shown here
- Storz J, Natarajan C, Cheviron Z, Hoffmann F, Kelly J. Altitudinal variation at duplicated β-globin genes in deer mice: effects of selection, recombination, and gene conversion. Genetics. 2012;190:203-16 pubmed publisher..Observed patterns of diversity and haplotype structure are difficult to reconcile with expectations of a two-locus selection model with multiplicative fitness. ..
- Reddy J, Massilamany C, Buskiewicz I, Huber S. Autoimmunity in viral myocarditis. Curr Opin Rheumatol. 2013;25:502-8 pubmed publisher..Antigenic mimicry between microbes and cardiac proteins causes autoimmunity in myocarditis. Characteristics of innate immunity associated with cardiac infection determine relevant epitope expression (cryptic epitopes). ..
- Christianson K, Ingersoll J, Landon R, Pfeiffer N, Gerber J. Characterization of a temperature sensitive feline infectious peritonitis coronavirus. Arch Virol. 1989;109:185-96 pubmed..These unique characteristics possessed by TS-FIPV may account for its nonvirulent nature and ability to stimulate protective immune responses in cats. ..
- Bavitz J, Payne J, Dunning D, Glenn A, Koka R. The use of distraction osteogenesis to induce new suprabony periodontal attachment in the beagle dog. Int J Periodontics Restorative Dent. 2000;20:596-603 pubmed..Further studies using modifications of this technique are warranted to explore the potential of DO as an alternative to conventional regenerative approaches. ..
- Gopinath R, Ambagala A, Hinkley S, Srikumaran S. Effects of virion host shut-off activity of bovine herpesvirus 1 on MHC class I expression. Viral Immunol. 2002;15:595-608 pubmed..Absence of vhs activity should result in decreased pathogenicity and enhanced immunogenicity of BHV-1 vhs deletion mutant, making it a better vaccine candidate...
- Park Y, Kim Y, Putnam S, Stanley D. The bacterium Xenorhabdus nematophilus depresses nodulation reactions to infection by inhibiting eicosanoid biosynthesis in tobacco hornworms, Manduca sexta. Arch Insect Biochem Physiol. 2003;52:71-80 pubmed..These findings indicate that one or more factors from X. nematophilus depress nodulation reactions in tobacco hornworms by inhibiting eicosanoid biosynthesis...
- Thippareddi H, Juneja V, Phebus R, Marsden J, Kastner C. Control of Clostridium perfringens germination and outgrowth by buffered sodium citrate during chilling of roast beef and injected pork. J Food Prot. 2003;66:376-81 pubmed..0% Ional or Ional Plus into the formulation to reduce the potential risk of C. perfringens germination and outgrowth...
- Collins M, Janovy J. Host specificity among Ancyrocephalinae (Monogenoidea) of Nebraska sunfish. J Parasitol. 2003;89:80-3 pubmed
- Kim H, Gladyshev V. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. Mol Biol Cell. 2004;15:1055-64 pubmed..The data suggested that different cellular compartments in mammals maintain a system for repair of oxidized methionine residues and that this function is tuned in enzyme- and stereo-specific manner. ..
- Russell F, Louda S, Rand T, Kachman S. Variation in herbivore-mediated indirect effects of an invasive plant on a native plant. Ecology. 2007;88:413-23 pubmed
- Lehman A, Berg K, Dumpert J, Wood N, Visty A, Rentschler M, et al. Surgery with cooperative robots. Comput Aided Surg. 2008;13:95-105 pubmed publisher..These procedures demonstrate that miniature in vivo robots can address the visualization constraints of minimally invasive surgery by providing video feedback and task assistance from arbitrary orientations within the peritoneal cavity. ..
- Jiménez F, Braun J, Campbell M, Gardner S. Endoparasites of fat-tailed mouse opossums (Thylamys: Didelphidae) from northwestern Argentina and southern Bolivia, with the description of a new species of tapeworm. J Parasitol. 2008;94:1098-102 pubmed publisher..Didelphoxyuris thylamisis, H. simplicispicula, and Oligacanthorhynchus sp. appear to occur in marmosas from the Yungas region. In contrast, both P. kozeki and M. sanmartini n. sp. appear to occur exclusively in the Puna...
- Zhu J, Zeng X, Berkebile D, Du H, Tong Y, Qian K. Efficacy and safety of catnip (Nepeta cataria) as a novel filth fly repellent. Med Vet Entomol. 2009;23:209-16 pubmed publisher..In comparison with other U.S. Environmental Protection Agency-approved mosquito repellents (DEET, picaridin and p-menthane-3,8-diol), catnip oil can be considered as a relatively safe repellent, which may cause minor skin irritation...
- Doster A, Subramaniam S, Yhee J, Kwon B, Yu C, Kwon S, et al. Distribution and characterization of IL-10-secreting cells in lymphoid tissues of PCV2-infected pigs. J Vet Sci. 2010;11:177-83 pubmed..The increased IL-10 expression observed in PCV2 infection in this study suggests that IL-10-mediated immunosuppression may play an important role in the pathogenesis and maintenance of naturally occurring PCV2 infection. ..
- Das P, Vu H, Dinh P, Cooney J, Kwon B, Osorio F, et al. Glycosylation of minor envelope glycoproteins of porcine reproductive and respiratory syndrome virus in infectious virus recovery, receptor interaction, and immune response. Virology. 2011;410:385-94 pubmed publisher..These studies reveal the importance of glycosylation of these minor GPs in the biology of PRRSV. ..
- Willis M, Liu Y, Biterova E, Simpson M, Kim H, Lee J, et al. Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits. Biochemistry. 2011;50:6508-17 pubmed publisher..Strategies that promote heterodimer formation and persistence would be effective therapeutics for the treatment of GCL deficiency. ..
- Furtaw M, Steffens D, Urlacher T, Anderson J. A near-infrared, surface-enhanced, fluorophore-linked immunosorbent assay. Anal Chem. 2013;85:7102-8 pubmed publisher..This technique may prove superior to current protocols for biomarker research and clinical diagnoses, which require high sensitivity along with quantitation over an extended range. ..
- Thompson J, Ma F, Quinn M, Xiang S. Genome-Wide Search for Host Association Factors during Ovine Progressive Pneumonia Virus Infection. PLoS ONE. 2016;11:e0150344 pubmed publisher..The data from this RNA-seq study will be helpful in our understanding of OPPV infection, and also for further study in the prevention and intervention of this viral disease. ..
- Wang B, Wang Y, Frabutt D, Zhang X, Yao X, Hu D, et al. Mechanistic understanding of N-glycosylation in Ebola virus glycoprotein maturation and function. J Biol Chem. 2017;292:5860-5870 pubmed publisher..Together, we conclude that, although Asn563 and Asn618 are not required for EBOV GP expression, they synergistically regulate its maturation, which determines its functionality. ..
- Stromberg Z, Lewis G, Aly S, Lehenbauer T, Bosilevac J, Cernicchiaro N, et al. Prevalence and Level of Enterohemorrhagic Escherichia coli in Culled Dairy Cows at Harvest. J Food Prot. 2016;79:421-31 pubmed publisher..001) based on detection by culture. This study provides evidence that non-O157 EHEC are ubiquitous on hides of culled dairy cattle and that feces are an important source of non-O157 EHEC hide contamination. ..
- Levytskyy R, Bohovych I, Khalimonchuk O. Metalloproteases of the Inner Mitochondrial Membrane. Biochemistry. 2017;56:4737-4746 pubmed publisher..Herein, we will summarize the current biochemical knowledge of these proteolytic machines and discuss recent advances in our understanding of mechanistic aspects of their functioning...
- Fishilevich E, VÃ©lez A, Khajuria C, Frey M, Hamm R, Wang H, et al. Use of chromatin remodeling ATPases as RNAi targets for parental control of western corn rootworm (Diabrotica virgifera virgifera) and Neotropical brown stink bug (Euschistus heros). Insect Biochem Mol Biol. 2016;71:58-71 pubmed publisher..Additionally, knockdown of chd1 reduced the fecundity of E.Â heros. ..
- Dassanayake R, Sarath G, Duhamel G. Penicillin-binding proteins in the pathogenic intestinal spirochete Brachyspira pilosicoli. Antimicrob Agents Chemother. 2005;49:1561-3 pubmed..Identification of PBPs of B. pilosicoli provides a basis for characterization of the genes encoding these proteins among pathogenic intestinal spirochetes of humans and animals. ..
- Duclos L, Danner B, Nickol B. Virulence of Corynosoma constrictum (Acanthocephala: Polymorphidae) in Hyalella azteca (Amphipoda) throughout parasite ontogeny. J Parasitol. 2006;92:749-55 pubmed..Results from this study suggest that developing C. constrictum satisfies energy requirements by depriving amphipod hosts of resources normally used for somatic growth and maintenance...
- LaRosa P, Riethoven J, Chen H, Xia Y, Zhou Y, Chen M, et al. Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes. Physiol Genomics. 2007;31:544-53 pubmed..The release of proinflammatory cytokines may explain how the ISR in early stage adipocytes causes lipid loss in mature adipocytes. ..
- Moxley R, Smith D, Luebbe M, Erickson G, Klopfenstein T, Rogan D. Escherichia coli O157:H7 vaccine dose-effect in feedlot cattle. Foodborne Pathog Dis. 2009;6:879-84 pubmed publisher..These results are consistent with previous estimates of vaccine efficacy against fecal shedding, and agree with our previous finding that efficacy of two or three doses of this vaccine product exhibit a dose-response. ..
- Gladyshev V, Krause M, Xu X, Korotkov K, Kryukov G, Sun Q, et al. Selenocysteine-containing thioredoxin reductase in C. elegans. Biochem Biophys Res Commun. 1999;259:244-9 pubmed..The data show that TR-Se is the major naturally occurring selenoprotein in C. elegans, and suggest an important role for selenium and the thioredoxin system in this organism...
- Zera A, Zhao Z. Effect of a juvenile hormone analogue on lipid metabolism in a wing-polymorphic cricket: implications for the endocrine-biochemical bases of life-history trade-offs. Physiol Biochem Zool. 2004;77:255-66 pubmed..This is the first evidence for endocrine regulation of a genetically based life-history trade-off operating via hormonal effects on specific metabolic pathways and enzymes of intermediary metabolism. ..
- Johnson R, Dahlgren L, Siegfried B, Ellis M. Acaricide, fungicide and drug interactions in honey bees (Apis mellifera). PLoS ONE. 2013;8:e54092 pubmed publisher..Evidence of non-transivity, year-to-year variation and induction of detoxication enzymes indicates that pesticide interactions in bees may be as complex as drug interactions in mammals. ..
- Inoguchi N, Oshlo J, Natarajan C, Weber R, Fago A, Storz J, et al. Deer mouse hemoglobin exhibits a lowered oxygen affinity owing to mobility of the E helix. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013;69:393-8 pubmed publisher..In addition, deer mouse hemoglobin has a unique hydrogen bond at the ?1?1 interface between residues ?1Cys34 and ?1Ser128. ..
- Abdalla M, Hoke T, Seravalli J, Switzer B, Bavitz M, Fliege J, et al. Pseudomonas Quinolone Signal Induces Oxidative Stress and Inhibits Heme Oxygenase-1 Expression in Lung Epithelial Cells. Infect Immun. 2017;85: pubmed publisher..1 cells (P < 0.05, n = 3), as determined by immunoblotting and densitometry. These PQS effects on host cells could play an important role in the pathogenicity of P. aeruginosa infections. ..
- Jiménez Ruiz F, Gardner S. Aspidoderid nematodes from bolivian armadillos, with the description of a new species of Lauroia (Heterakoidea: Aspidoderidae). J Parasitol. 2003;89:978-83 pubmed..This is the first record of a member of Lauroia Proença, 1938, for Bolivia. ..
- Nawshad A. Palatal seam disintegration: to die or not to die? that is no longer the question. Dev Dyn. 2008;237:2643-56 pubmed publisher..In this review, I discuss those two mechanisms and the differences between them. ..
- Gangaplara A, Massilamany C, Steffen D, Reddy J. Mimicry epitope from Ehrlichia canis for interphotoreceptor retinoid-binding protein 201-216 prevents autoimmune uveoretinitis by acting as altered peptide ligand. J Neuroimmunol. 2013;263:98-107 pubmed publisher..The data provide new insights as to how microbes containing mimicry sequences for retinal antigens can prevent ocular inflammation by acting as naturally occurring altered peptide ligands. ..
- Rundus A, Sullivan Beckers L, Wilgers D, Hebets E. Females are choosier in the dark: environment-dependent reliance on courtship components and its impact on fitness. Evolution. 2011;65:268-82 pubmed publisher..Together, this comprehensive set of experiments demonstrates that female choosiness varies across environments, leading to direct fitness consequences. ..
- Workman A, Eudy J, Smith L, da Silva L, Sinani D, Bricker H, et al. Cellular transcription factors induced in trigeminal ganglia during dexamethasone-induced reactivation from latency stimulate bovine herpesvirus 1 productive infection and certain viral promoters. J Virol. 2012;86:2459-73 pubmed publisher
- Gladyshev V, Liu A, Novoselov S, Krysan K, Sun Q, Kryukov V, et al. Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2. J Biol Chem. 2001;276:30374-80 pubmed..The Grx2 structural model suggested a common reaction mechanism for this class of proteins. The data provide the first example of a mitochondrial Grx and also indicate the occurrence of a second functional Grx in mammals. ..
- Zhang Y, Gladyshev V. Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project. PLoS Genet. 2008;4:e1000095 pubmed publisher..Overall, our study provides insights into global trends in microbial selenium utilization in marine environments. ..
- Nayak D, Panda D, Das S, Luo M, Pattnaik A. Single-amino-acid alterations in a highly conserved central region of vesicular stomatitis virus N protein differentially affect the viral nucleocapsid template functions. J Virol. 2009;83:5525-34 pubmed publisher..These results suggest that the structure of the N protein and the resulting N-RNA complex, in part, regulate the viral template functions in transcription and replication...
- Bickel R, Kopp A, Nuzhdin S. Composite effects of polymorphisms near multiple regulatory elements create a major-effect QTL. PLoS Genet. 2011;7:e1001275 pubmed publisher..These findings have important design and conceptual implications for basic and medical genomics. ..
- Zhu J, Li A, Pritchard S, Tangtrakulwanich K, Baxendale F, Brewer G. Contact and fumigant toxicity of a botanical-based feeding deterrent of the stable fly, Stomoxys calcitrans (Diptera: Muscidae). J Agric Food Chem. 2011;59:10394-400 pubmed publisher..This study demonstrated that catnip oil has both contact and fumigant toxicity against the stable fly and thus has the potential as an alternative for stable fly control...
- Yegorova S, Liu A, Lou M. Human lens thioredoxin: molecular cloning and functional characterization. Invest Ophthalmol Vis Sci. 2003;44:3263-71 pubmed..The upregulation of Trx1 in HLE B3 cells under oxidative stress and the presence of Trx1 in the lens suggest that the thioredoxin system may be an effective defense system that protects the lens against oxidative stress. ..
- Thurston Enriquez J, Haas C, Jacangelo J, Gerba C. Inactivation of enteric adenovirus and feline calicivirus by chlorine dioxide. Appl Environ Microbiol. 2005;71:3100-5 pubmed..U.S. Environmental Protection Agency guidance manual Ct99.99% values are higher than Ct99.99% values calculated from bench-scale experiments and from EFH model application. ..
- Kim H, Gladyshev V. Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases. PLoS Biol. 2005;3:e375 pubmed..The data also suggested that Sec- and Cys-containing oxidoreductases require distinct sets of active-site features that maximize their catalytic efficiencies and provide strategies for protein design with improved catalytic properties. ..
- Ellsworth M, Fairbanks K, Behan S, Jackson J, Goodyear M, Oien N, et al. Fetal protection following exposure to calves persistently infected with bovine viral diarrhea virus type 2 sixteen months after primary vaccination of the dams. Vet Ther. 2006;7:295-304 pubmed..One calf born to a control heifer was persistently infected. No calves from BVDV-vaccinated heifers were persistently infected...
- Su D, May J, Koury M, Asard H. Human erythrocyte membranes contain a cytochrome b561 that may be involved in extracellular ascorbate recycling. J Biol Chem. 2006;281:39852-9 pubmed..These results suggest that the DCytb present in human erythrocytes may contribute to their ability to reduce extracellular monodehydroascorbate. ..
- Storz J, Baze M, Waite J, Hoffmann F, Opazo J, Hayes J. Complex signatures of selection and gene conversion in the duplicated globin genes of house mice. Genetics. 2007;177:481-500 pubmed..The alternative two-locus beta-globin haplotypes are associated with pronounced differences in intraerythrocyte glutathione and nitric oxide metabolism, suggesting a possible mechanism for selection on hemoglobin function. ..
- Massilamany C, Steffen D, Reddy J. An epitope from Acanthamoeba castellanii that cross-react with proteolipid protein 139-151-reactive T cells induces autoimmune encephalomyelitis in SJL mice. J Neuroimmunol. 2010;219:17-24 pubmed publisher..These results may provide insights into the pathogenesis of multiple sclerosis and ACA-induced granulomatous encephalitis...
- Jaber T, Workman A, Jones C. Small noncoding RNAs encoded within the bovine herpesvirus 1 latency-related gene can reduce steady-state levels of infected cell protein 0 (bICP0). J Virol. 2010;84:6297-307 pubmed publisher..During dexamethasone-induced reactivation from latency, XP-specific sncRNA levels were reduced, suggesting that these sncRNAs support the establishment and maintenance of lifelong latency in cattle. ..
- Lin J, Prahlad J, Wilson M. Conservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1. Biochemistry. 2012;51:3799-807 pubmed publisher..More generally, most close DJ-1 homologues are likely stabilized by cysteine-sulfinic acid formation but destabilized by further oxidation, suggesting that they are biphasically regulated by oxidative modification. ..
- Prendeville H, Ye X, Morris T, Pilson D. Virus infections in wild plant populations are both frequent and often unapparent. Am J Bot. 2012;99:1033-42 pubmed publisher..Our results indicate that risk assessments for virus-resistant transgenic crops should not rely on visual symptoms or ELISA and should include data from multiple populations over multiple years. ..
- McKnite A, Perez Muñoz M, Lu L, Williams E, Brewer S, Andreux P, et al. Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS ONE. 2012;7:e39191 pubmed publisher..Relationships between gut microflora, morphological and metabolic traits were uncovered, some potentially a result of common genetic sources of variation. ..
- Parida R, Choi I, Peterson D, Pattnaik A, Laegreid W, Zuckermann F, et al. Location of T-cell epitopes in nonstructural proteins 9 and 10 of type-II porcine reproductive and respiratory syndrome virus. Virus Res. 2012;169:13-21 pubmed publisher..The identified epitopes may be important in the formulation of immunogens to provide broad cross-protection against diverse PRRSV strains. ..
- Hyde A, Farmer E, Easley K, van Lammeren K, Christoffels V, Barycki J, et al. UDP-glucose dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly. J Biol Chem. 2012;287:32708-16 pubmed..The identification of these polymorphisms in patient populations will help identify families genetically at risk for valve defects. ..
- Hall J, French R, Hein G, Morris T, Stenger D. Three distinct mechanisms facilitate genetic isolation of sympatric wheat streak mosaic virus lineages. Virology. 2001;282:230-6 pubmed..Collectively, these three distinct mechanisms enhance genetic isolation of individual viral lineages, and together with stochastic processes, may explain generation and maintenance of genetic diversity in field populations. ..
- Langford G, Janovy J. Comparative life cycles and life histories of North American Rhabdias spp. (Nematoda: Rhabdiasidae): lungworms from snakes and anurans. J Parasitol. 2009;95:1145-55 pubmed publisher..Overall, these observations suggest that snake and anuran lungworms have discrepant life cycles and life history strategies...
- Gerashchenko M, Su D, Gladyshev V. CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes. J Biol Chem. 2010;285:4595-602 pubmed publisher..This study shows that CUG codon is used as an inefficient start codon to generate protein isoforms in mouse...
- Peng A, Wang L, Fisher L. Greatwall and Polo-like kinase 1 coordinate to promote checkpoint recovery. J Biol Chem. 2011;286:28996-9004 pubmed publisher..Coordinated interplays between Plx1 and Gwl are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery...
- Stella J, Luchansky J, Miller K, Shoyer B, Shane L, McGeary L, et al. Use of an Electrostatic Spraying System or the Sprayed Lethality in Container Method To Deliver Antimicrobial Agents onto the Surface of Beef Subprimals To Control Shiga Toxin-Producing Escherichia coli. J Food Prot. 2017;80:1393-1400 pubmed publisher..Application of LAE, PAA, or CPC, either alone or in combination, via ESS or SLIC is effective for reducing low levels (ca. 0.3 to 1.6 log CFU) of STEC that may be naturally present on the surface of beef subprimals. ..
- Oltean S, Banerjee R. A B12-responsive internal ribosome entry site (IRES) element in human methionine synthase. J Biol Chem. 2005;280:32662-8 pubmed..Modulation of the IRES-dependent translation of an essential gene by the cofactor of the encoded enzyme represents a novel example of a gene-nutrient interaction. ..
- Novoselov S, Kryukov G, Xu X, Carlson B, Hatfield D, Gladyshev V. Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. J Biol Chem. 2007;282:11960-8 pubmed..Overall, these data establish SelH as a novel nucleolar oxidoreductase and suggest that some functions in this compartment are regulated by redox and dependent on the trace element selenium. ..
- Prokupek A, Hoffmann F, Eyun S, Moriyama E, Zhou M, Harshman L. An evolutionary expressed sequence tag analysis of Drosophila spermatheca genes. Evolution. 2008;62:2936-47 pubmed publisher..In general, candidate genes discovered in this study could play a key role in sperm competition, cryptic female choice of sperm, and sexually antagonistic coevolution, and ultimately speciation. ..
- Lund A, Blum P, Bhattramakki D, Elthon T. Heat-stress response of maize mitochondria. Plant Physiol. 1998;116:1097-110 pubmed..A cDNA for maize mitochondrial HSP22 was cloned and extended to full length with sequences from an expressed sequence tag database. Sequence analysis indicated that HSP22 is a member of the plant small heat-shock protein superfamily. ..
- Dasgupta S, Jana M, Liu X, Pahan K. Role of very-late antigen-4 (VLA-4) in myelin basic protein-primed T cell contact-induced expression of proinflammatory cytokines in microglial cells. J Biol Chem. 2003;278:22424-31 pubmed..This study illustrates a novel role of VLA-4 in regulating neuroantigen-primed T cell-induced activation of microglia through C/EBPbeta ..
- Jiménez Ruiz F, Gardner S. The nematode fauna of long-nosed mice Oxymycterus spp. from the Bolivian Yungas. J Parasitol. 2003;89:299-308 pubmed..A redescription of N. rodentophilus is provided, and Nematomystes scapteromi is transferred from Ansiruptodera to Nematomystes...
- Löfgren S, Fernando M, Xing K, Wang Y, Kuszynski C, Ho Y, et al. Effect of thioltransferase (glutaredoxin) deletion on cellular sensitivity to oxidative stress and cell proliferation in lens epithelial cells of thioltransferase knockout mouse. Invest Ophthalmol Vis Sci. 2008;49:4497-505 pubmed publisher..These findings confirm the importance of TTase in regulating redox homeostasis and suggest a new physiological function in controlling cell proliferation in the lens epithelial cells. ..
- Meyer F, Jones C. The cellular transcription factor, CCAAT enhancer-binding protein alpha (C/EBP-alpha), has the potential to activate the bovine herpesvirus 1 immediate-early transcription unit 1 promoter. J Neurovirol. 2009;15:123-30 pubmed publisher..These studies suggest that C/EBPalpha stimulates productive infection and reactivation from latency, in part, by cooperating with bTIF to activate IEtu1 promoter activity. ..
- Kryukov G, Kryukov V, Gladyshev V. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. J Biol Chem. 1999;274:33888-97 pubmed..SelR homologs were present in every organism characterized by complete genome sequencing. The data suggest applicability of SECISearch for identification of new selenoprotein genes in nucleotide data bases. ..
- Olteanu H, Banerjee R. Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation. J Biol Chem. 2001;276:35558-63 pubmed..The K(m) for NADPH is 2.6 +/- 0.5 microm, and the K(act) for methionine synthase reductase is 80.7 +/- 13.7 nm for NADPH-dependent activity of methionine synthase. ..
- Olteanu H, Munson T, Banerjee R. Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry. 2002;41:13378-85 pubmed..These results reveal differences in the interactions between the natural and artificial electron acceptors and MSR variants in vitro, which are predicted to result in less efficient reductive repair of methionine synthase in vivo. ..
- Zera A, Zhao Z. Life-history evolution and the microevolution of intermediary metabolism: activities of lipid-metabolizing enzymes in life-history morphs of a wing-dimorphic cricket. Evolution. 2003;57:586-96 pubmed..Wing polymorphism is a powerful experimental model in such integrative studies. ..
- Hansen K, Kittok R, Sarath G, Toombs C, Caceres N, Beck M. Estrogen receptor-alpha populations change with age in commercial laying hens. Poult Sci. 2003;82:1624-9 pubmed..05). The results suggest that failure of calcium regulating mechanisms with age may be mediated at least in part through the reduced populations of estrogen receptors in certain critical tissues. ..
- Sun Q, Su D, Novoselov S, Carlson B, Hatfield D, Gladyshev V. Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase. Biochemistry. 2005;44:14528-37 pubmed
- Doukhanina E, Chen S, van der Zalm E, Godzik A, Reed J, Dickman M. Identification and functional characterization of the BAG protein family in Arabidopsis thaliana. J Biol Chem. 2006;281:18793-801 pubmed..We further show that plant BAG family members are also multifunctional and remarkably similar to their animal counterparts, as they regulate apoptosis-like processes ranging from pathogen attack to abiotic stress and development. ..
- Workman A, Perez S, Doster A, Jones C. Dexamethasone treatment of calves latently infected with bovine herpesvirus 1 leads to activation of the bICP0 early promoter, in part by the cellular transcription factor C/EBP-alpha. J Virol. 2009;83:8800-9 pubmed publisher..Activation of bICP0 early promoter activity does not necessarily lead to late gene expression and virus shedding. ..
- Iordanskaia T, Nawshad A. Mechanisms of transforming growth factor ? induced cell cycle arrest in palate development. J Cell Physiol. 2011;226:1415-24 pubmed publisher..Thus, TGF?1 and TGF?3 play separate yet complimentary roles in achieving cell cycle arrest and EMT/apoptosis and cell cycle arrest is a prerequisite for later cellular changes. ..
- Durso L, Miller D, Wienhold B. Distribution and quantification of antibiotic resistant genes and bacteria across agricultural and non-agricultural metagenomes. PLoS ONE. 2012;7:e48325 pubmed publisher..We raise questions regarding whether the underlying biology of each type of bacteria contributes to the likelihood of transfer via the food chain. ..
- Alkheraif A, Topliff C, Reddy J, Massilamany C, Donis R, Meyers G, et al. Type 2 BVDV Npro suppresses IFN-1 pathway signaling in bovine cells and augments BRSV replication. Virology. 2017;507:123-134 pubmed publisher..This data supports the synergistic action of BVDV2-wt and BRSV inhibition of IFN-1. ..
- Miner J, Hahn K, Spurlock M, Staten N. Expression and complement d activity of porcine adipsin. Protein Expr Purif. 2001;23:14-21 pubmed
- Zatechka D, Kador P, GARCIA CASTINEIRAS S, Lou M. Diabetes can alter the signal transduction pathways in the lens of rats. Diabetes. 2003;52:1014-22 pubmed..The causes for these alterations can be attributed to elevated vitreal bFGF in conjunction with osmotic stress and associated attenuation in redox status of the lens. ..
- Lovato L, Inman M, Henderson G, Doster A, Jones C. Infection of cattle with a bovine herpesvirus 1 strain that contains a mutation in the latency-related gene leads to increased apoptosis in trigeminal ganglia during the transition from acute infection to latency. J Virol. 2003;77:4848-57 pubmed..Taken together, these results suggest that the antiapoptotic properties of the LR gene play an important role during the establishment of latency...
- Jana M, Dasgupta S, Saha R, Liu X, Pahan K. Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages. J Neurochem. 2003;86:519-28 pubmed..This study delineates a novel biological function of p40 in inducing TNF-alpha in microglia and macrophages. ..
- Henderson G, Perng G, Nesburn A, Wechsler S, Jones C. The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection. J Neurovirol. 2004;10:64-70 pubmed..These studies demonstrate a correlation between the enhanced pathogenic potential of CJLAT and the LR gene inhibiting caspase 3 cleavage during productive infection...
- Rocha J, Eisen E, Siewerdt F, Van Vleck L, Pomp D. A large-sample QTL study in mice: III. Reproduction. Mamm Genome. 2004;15:878-86 pubmed..This is unfortunate as traits with low heritability are among those that could most benefit from QTL-complemented breeding and selection strategies in food animal production. ..
- Lobanov A, Hatfield D, Gladyshev V. Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis. Protein Sci. 2008;17:176-82 pubmed..Since SPS1 evolved from a protein that utilizes selenium for Sec biosynthesis, an attractive possibility is that SPS1 may define a new pathway of selenium utilization in animals. ..
- Storz J, Kelly J. Effects of spatially varying selection on nucleotide diversity and linkage disequilibrium: insights from deer mouse globin genes. Genetics. 2008;180:367-79 pubmed publisher..Simulation and empirical results indicate that sliding-window analyses of Z(g) between allele classes may provide an effective means of pinpointing causal substitutions...