Experts and Doctors on macrophages in Bozeman, Montana, United States

Summary

Locale: Bozeman, Montana, United States
Topic: macrophages

Top Publications

  1. Rhyan J, Stackhouse L, Quinn W. Fetal and placental lesions in bovine abortion due to Tritrichomonas foetus. Vet Pathol. 1988;25:350-5 pubmed
    ..Pyogranulomatous bronchopneumonia was in six of the 11 lungs which were examined. Trichomonad organisms were demonstrated within the placental stroma in all cases and free or phagocytized in pulmonary airways in seven cases...
  2. Schepetkin I, Faulkner C, Nelson Overton L, Wiley J, Quinn M. Macrophage immunomodulatory activity of polysaccharides isolated from Juniperus scopolorum. Int Immunopharmacol. 2005;5:1783-99 pubmed
    ..These data suggest that at least part of the beneficial therapeutic effects reported for extracts of juniper cones are due to modulation of monocyte/macrophage immune functions...
  3. Lubick K, Radke M, Jutila M. Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists. J Leukoc Biol. 2007;82:1062-9 pubmed
    ..Securinine has minimal toxicity in vivo, suggesting it or structurally similar compounds may represent novel, therapeutic adjuvants, which increase resistance to intracellular pathogens. ..
  4. Xie G, Schepetkin I, Quinn M. Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L. Int Immunopharmacol. 2007;7:1639-50 pubmed
    ..Taken together, our results provide a molecular basis to explain at least part of the beneficial therapeutic effects of Tansy extracts, and support the concept of using Tansy polysaccharides as an immunotherapeutic adjuvant...
  5. Schepetkin I, Xie G, Kirpotina L, Klein R, Jutila M, Quinn M. Macrophage immunomodulatory activity of polysaccharides isolated from Opuntia polyacantha. Int Immunopharmacol. 2008;8:1455-66 pubmed publisher
    ..Together, our results provide a molecular basis to explain a portion of the beneficial therapeutic properties of extracts from O. polyacantha and support the concept of using Opuntia polysaccharides as an immunotherapeutic adjuvant...
  6. Schepetkin I, Kirpotina L, Jakiw L, Khlebnikov A, Blaskovich C, Jutila M, et al. Immunomodulatory activity of oenothein B isolated from Epilobium angustifolium. J Immunol. 2009;183:6754-66 pubmed publisher
    ..The ability of oenothein B to modulate phagocyte functions in vitro and in vivo suggests that this compound is responsible for at least part of the therapeutic properties of E. angustifolium extracts...
  7. Yang X, Thornburg T, Walters N, Pascual D. DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidate. Vaccine. 2010;28:1069-74 pubmed publisher
    ..abortus 2308 conferred 0.79 log protection, similar to S19 as did a single dose of DeltaznuA B. abortus 2308. Thus, this study shows the DeltaznuA DeltapurE B. abortus 2308 strain to be a potential livestock vaccine candidate...
  8. Shepardson K, Ngo L, Aimanianda V, Latgé J, Barker B, Blosser S, et al. Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation. Microbes Infect. 2013;15:259-69 pubmed publisher
  9. Kouakou K, Schepetkin I, Jun S, Kirpotina L, Yapi A, Khramova D, et al. Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis. BMC Complement Altern Med. 2013;13:149 pubmed publisher
    ..However, little is known about the high-molecular weight active components conferring therapeutic properties to these extracts...

Detail Information

Publications9

  1. Rhyan J, Stackhouse L, Quinn W. Fetal and placental lesions in bovine abortion due to Tritrichomonas foetus. Vet Pathol. 1988;25:350-5 pubmed
    ..Pyogranulomatous bronchopneumonia was in six of the 11 lungs which were examined. Trichomonad organisms were demonstrated within the placental stroma in all cases and free or phagocytized in pulmonary airways in seven cases...
  2. Schepetkin I, Faulkner C, Nelson Overton L, Wiley J, Quinn M. Macrophage immunomodulatory activity of polysaccharides isolated from Juniperus scopolorum. Int Immunopharmacol. 2005;5:1783-99 pubmed
    ..These data suggest that at least part of the beneficial therapeutic effects reported for extracts of juniper cones are due to modulation of monocyte/macrophage immune functions...
  3. Lubick K, Radke M, Jutila M. Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists. J Leukoc Biol. 2007;82:1062-9 pubmed
    ..Securinine has minimal toxicity in vivo, suggesting it or structurally similar compounds may represent novel, therapeutic adjuvants, which increase resistance to intracellular pathogens. ..
  4. Xie G, Schepetkin I, Quinn M. Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L. Int Immunopharmacol. 2007;7:1639-50 pubmed
    ..Taken together, our results provide a molecular basis to explain at least part of the beneficial therapeutic effects of Tansy extracts, and support the concept of using Tansy polysaccharides as an immunotherapeutic adjuvant...
  5. Schepetkin I, Xie G, Kirpotina L, Klein R, Jutila M, Quinn M. Macrophage immunomodulatory activity of polysaccharides isolated from Opuntia polyacantha. Int Immunopharmacol. 2008;8:1455-66 pubmed publisher
    ..Together, our results provide a molecular basis to explain a portion of the beneficial therapeutic properties of extracts from O. polyacantha and support the concept of using Opuntia polysaccharides as an immunotherapeutic adjuvant...
  6. Schepetkin I, Kirpotina L, Jakiw L, Khlebnikov A, Blaskovich C, Jutila M, et al. Immunomodulatory activity of oenothein B isolated from Epilobium angustifolium. J Immunol. 2009;183:6754-66 pubmed publisher
    ..The ability of oenothein B to modulate phagocyte functions in vitro and in vivo suggests that this compound is responsible for at least part of the therapeutic properties of E. angustifolium extracts...
  7. Yang X, Thornburg T, Walters N, Pascual D. DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidate. Vaccine. 2010;28:1069-74 pubmed publisher
    ..abortus 2308 conferred 0.79 log protection, similar to S19 as did a single dose of DeltaznuA B. abortus 2308. Thus, this study shows the DeltaznuA DeltapurE B. abortus 2308 strain to be a potential livestock vaccine candidate...
  8. Shepardson K, Ngo L, Aimanianda V, Latgé J, Barker B, Blosser S, et al. Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation. Microbes Infect. 2013;15:259-69 pubmed publisher
  9. Kouakou K, Schepetkin I, Jun S, Kirpotina L, Yapi A, Khramova D, et al. Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis. BMC Complement Altern Med. 2013;13:149 pubmed publisher
    ..However, little is known about the high-molecular weight active components conferring therapeutic properties to these extracts...