Experts and Doctors on viral nonstructural proteins in St Louis, Missouri, United States


Locale: St Louis, Missouri, United States
Topic: viral nonstructural proteins

Top Publications

  1. Lindenbach B, Rice C. Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function. J Virol. 1999;73:4611-21 pubmed
    ..These findings suggest a potential mechanism for integrating NS1 into the cytoplasmic process of RNA replication...
  2. Droll D, Krishna Murthy H, Chambers T. Yellow fever virus NS2B-NS3 protease: charged-to-alanine mutagenesis and deletion analysis define regions important for protease complex formation and function. Virology. 2000;275:335-47 pubmed publisher
    ..A role for the putative transmembrane regions of NS2B in targeting of NS3 to intracellular membranes is also suggested...
  3. Youn S, Li T, McCune B, Edeling M, Fremont D, Cristea I, et al. Evidence for a genetic and physical interaction between nonstructural proteins NS1 and NS4B that modulates replication of West Nile virus. J Virol. 2012;86:7360-71 pubmed publisher
    ..Mass spectrometry and coimmunoprecipitation studies established a novel physical interaction between NS1 and NS4B, suggesting a mechanism for how luminal NS1 conveys signals to the cytoplasm to regulate RNA replication. ..
  4. Amberg S, Nestorowicz A, McCourt D, Rice C. NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studies. J Virol. 1994;68:3794-802 pubmed
    ..This suggests that signalase-mediated cleavage in the lumen of the endoplasmic reticulum may be dependent on prior cleavage at the anchC dibasic site. Possible pathways for processing in the C-prM region are outlined and discussed...
  5. Amberg S, Rice C. Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processing. J Virol. 1999;73:8083-94 pubmed
    ..A block in the viral protease-mediated cleavage inhibits the production of prM by the signal peptidase, inhibits particle release, and eliminates plaque formation...
  6. Majumder M, Ghosh A, Steele R, Ray R, Ray R. Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner. J Virol. 2001;75:1401-7 pubmed publisher
    ..Together these results suggest that an association of NS5A and p53 allows transcriptional modulation of the p21/waf1 gene and may contribute to HCV-mediated pathogenesis...
  7. Barchet W, Krug A, Cella M, Newby C, Fischer J, Dzionek A, et al. Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways. Eur J Immunol. 2005;35:236-42 pubmed
    ..We conclude that DC and IPC are hard-wired to secrete IFN-alpha via different pathways, reflecting their complementary but distinct roles in anti-viral immunity. ..
  8. Diamond M. Mechanisms of evasion of the type I interferon antiviral response by flaviviruses. J Interferon Cytokine Res. 2009;29:521-30 pubmed publisher
    ..This review will summarize our current understanding of how mammalian cells recognize flaviviruses to induce an inhibitory IFN response and the countermeasures this group of viruses has evolved to antagonize this response. ..
  9. George S, Varmaz D, Tavis J, Chowdhury A. The GB virus C (GBV-C) NS3 serine protease inhibits HIV-1 replication in a CD4+ T lymphocyte cell line without decreasing HIV receptor expression. PLoS ONE. 2012;7:e30653 pubmed publisher
    ..The requirement for an intact catalytic serine at the active site indicates that inhibition was mediated by proteolytic cleavage of an unidentified target(s). ..

More Information


  1. Nice T, Strong D, McCune B, Pohl C, Virgin H. A single-amino-acid change in murine norovirus NS1/2 is sufficient for colonic tropism and persistence. J Virol. 2013;87:327-34 pubmed publisher
    ..These findings represent the first identified function for NoV NS1/2 during infection and establish a novel model system for the study of enteric viral persistence...
  2. Bittar C, Shrivastava S, Bhanja Chowdhury J, Rahal P, Ray R. Hepatitis C virus NS2 protein inhibits DNA damage pathway by sequestering p53 to the cytoplasm. PLoS ONE. 2013;8:e62581 pubmed publisher
    ..Together these results suggested that HCV NS2 inhibits DNA damage response by altering the localization of p53, and may play a role in the pathogenesis of HCV infection...
  3. Xu J, Mendez E, Caron P, Lin C, Murcko M, Collett M, et al. Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication. J Virol. 1997;71:5312-22 pubmed
    ..Finally, using a full-length functional BVDV cDNA clone, we demonstrate that a catalytically active NS3 serine proteinase is essential for pestivirus replication...