Genomes and Genes
Experts and Doctors on signal transduction in St Louis, Missouri, United States
Locale: St Louis, Missouri, United States
Topic: signal transduction
Publications242 found, 100 shown here
- James M, Lu Y, Liu Y, Vikis H, You M. RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway. Cancer Res. 2009;69:2108-16 pubmed publisher..The prevalence of the induction of RGS17 in tumor tissues of various types further implicates its importance in the maintenance of tumor growth. ..
- Putcha G, Deshmukh M, Johnson E. Inhibition of apoptotic signaling cascades causes loss of trophic factor dependence during neuronal maturation. J Cell Biol. 2000;149:1011-8 pubmed..Therefore, inhibition of both BAX-dependent cytochrome c release and the development of competence-to-die contributed to the loss of trophic factor dependence associated with neuronal maturation. ..
- Lai C, Cheng S. Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells. J Biol Chem. 2002;277:15514-22 pubmed..Thus, ERK and p38 differentially mediate TGF-beta and BMP-2 function in osteoblasts. ..
- Whyte M, Mumm S. Heritable disorders of the RANKL/OPG/RANK signaling pathway. J Musculoskelet Neuronal Interact. 2004;4:254-67 pubmed..These disorders resemble PDB which can be inherited as an autosomal dominant trait with focal osteolytic disease, sometimes with deafness and tooth loss, and increasingly associated with mutations, but in other genes. ..
- Lu Z, Shvartsman M, Lee A, Shao J, Murray M, Kladney R, et al. Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis. Cancer Res. 2010;70:3287-98 pubmed publisher..Our findings offer direct evidence that RHEB facilitates multistage carcinogenesis through induction of multiple oncogenic mechanisms, perhaps contributing to the poor prognosis of patients with cancers overexpressing RHEB. ..
- McConechy M, Ding J, Cheang M, Wiegand K, Senz J, Tone A, et al. Use of mutation profiles to refine the classification of endometrial carcinomas. J Pathol. 2012;228:20-30 pubmed publisher..If used in practice, it may lead to improved diagnostic reproducibility and may also serve to stratify patients for targeted therapeutics...
- Dorn G. Molecular mechanisms that differentiate apoptosis from programmed necrosis. Toxicol Pathol. 2013;41:227-34 pubmed publisher..Here, the different molecular mechanisms, effects, and pathophysiological implications of apoptosis and programmed necrosis are reviewed as they relate to heart failure and diabetes mediated by the Bcl-2 family protein, Nix. ..
- Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, et al. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017;47:566-581.e9 pubmed publisher..Our work identifies the TREM2-APOE pathway as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia. ..
- Kuss Duerkop S, Wang J, Mena I, White K, Metreveli G, Sakthivel R, et al. Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication. PLoS Pathog. 2017;13:e1006635 pubmed publisher..As mTORC1 activation is optimal midway through the virus life cycle, the observed effects on viral protein expression likely support the late stages of influenza virus replication when infected cells undergo significant stress. ..
- Ouyang W, Ranganath S, Weindel K, Bhattacharya D, Murphy T, Sha W, et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity. 1998;9:745-55 pubmed..Thus, GATA-3 expression and IL-12 signaling are mutually antagonistic, which facilitates rapid dominance of one pathway during early Th development, producing a stable divergence in cytokine profiles. ..
- Yu K, Xu J, Liu Z, Sosic D, Shao J, Olson E, et al. Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development. 2003;130:3063-74 pubmed..Although differentiation of the osteoblast lineage was not disturbed, the proliferation of osteoprogenitors and the anabolic function of mature osteoblasts were severely affected. ..
- Tyner J, Kim E, Ide K, Pelletier M, Roswit W, Morton J, et al. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. J Clin Invest. 2006;116:309-21 pubmed
- Dick D, Wang J, Plunkett J, Aliev F, Hinrichs A, Bertelsen S, et al. Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. Alcohol Clin Exp Res. 2007;31:1645-53 pubmed..ANKK1 is involved in signal transduction pathways and is a plausible biological candidate for involvement in addictive disorders. ..
- Kang S, Bloom S, Norian L, Geske M, Flavell R, Stappenbeck T, et al. An antibiotic-responsive mouse model of fulminant ulcerative colitis. PLoS Med. 2008;5:e41 pubmed publisher..This model system will be useful in the future to explore the microbial factors that induce immune activation and characterize how these interactions produce disease. ..
- Das R, Rich J, Kim H, McAlinden A, Thomopoulos S. Effects of botulinum toxin-induced paralysis on postnatal development of the supraspinatus muscle. J Orthop Res. 2011;29:281-8 pubmed publisher..Understanding the molecular and compositional changes in developing supraspinatus muscles may be useful for identifying and addressing the pathological changes that occur in shoulder injuries such as neonatal brachial plexus palsy...
- Yin X, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature. 1999;400:886-91 pubmed..This loss-of-function model indicates that Bid is a critical substrate in vivo for signalling by death-receptor agonists, which mediates a mitochondrial amplification loop that is essential for the apoptosis of selected cells. ..
- McHugh K, Hodivala Dilke K, Zheng M, Namba N, Lam J, Novack D, et al. Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest. 2000;105:433-40 pubmed..Thus, although it is not required for osteoclastogenesis, the integrin alphavbeta3 is essential for normal osteoclast function. ..
- Kanungo J, Pratt S, Marie H, Longmore G. Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions. Mol Biol Cell. 2000;11:3299-313 pubmed..These results suggest that the cytosolic LIM protein Ajuba may provide a new mechanism to transduce signals from sites of cell adhesion to the nucleus, regulating cell growth and differentiation decisions during early development. ..
- Tarakanova V, Wold W. Transforming growth factor beta1 receptor II is downregulated by E1A in adenovirus-infected cells. J Virol. 2003;77:9324-36 pubmed..These results raise the possibility that inhibition of TGF-beta signaling by E1A is a means by which adenovirus counters the antiviral defenses of the host. ..
- Kato A, Groisman E. Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor. Genes Dev. 2004;18:2302-13 pubmed..This is the first example of a protein that enables a two-component system to respond to the signal governing a different two-component system by protecting the phosphorylated form of a response regulator. ..
- Faccio R, Takeshita S, Colaianni G, Chappel J, Zallone A, Teitelbaum S, et al. M-CSF regulates the cytoskeleton via recruitment of a multimeric signaling complex to c-Fms Tyr-559/697/721. J Biol Chem. 2007;282:18991-9 pubmed..Furthermore, this same add-back approach identifies important roles for Tyr-697 and Tyr-721 in collaborating with Tyr-559 to recruit a multimeric signaling complex that can transduce signals from c-Fms to the actin cytoskeleton. ..
- Mabon M, Scott B, Crowder C. Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/insulin/IGF-receptor pathway. PLoS ONE. 2009;4:e7937 pubmed publisher..However, RNAi knockdown of these genes did not prolong lifespan. These genes definitively separate the mechanisms of hypoxic sensitivity and lifespan and identify biological strategies to survive hypoxic injury. ..
- Khan A, Dace D, Ryazanov A, Kelly J, Apte R. Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway. Am J Pathol. 2010;177:481-92 pubmed publisher..In addition, these results have uncovered a sirtuin-independent pathway by which resveratrol regulates angiogenesis...
- Decker C, Hesker P, Zhang K, Faccio R. Targeted inhibition of phospholipase C ?2 adaptor function blocks osteoclastogenesis and protects from pathological osteolysis. J Biol Chem. 2013;288:33634-41 pubmed publisher..Collectively, these data indicate that inflammatory osteolysis can be abrogated by treatment with a molecule composed of the tandem SH2 domains of PLC?2. ..
- Zha J, Harada H, Yang E, Jockel J, Korsmeyer S. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell. 1996;87:619-28 pubmed..The rapid phosphorylation of BAD following IL-3 connects a proximal survival signal with the BCL-2 family, modulating this checkpoint for apoptosis. ..
- Kopan R, Turner D. The Notch pathway: democracy and aristocracy in the selection of cell fate. Curr Opin Neurobiol. 1996;6:594-601 pubmed..Molecular models for Notch-mediated cell-fate selection within groups of developmentally equivalent cells are presented. ..
- Dasgupta B, Dugan L, Gutmann D. The neurofibromatosis 1 gene product neurofibromin regulates pituitary adenylate cyclase-activating polypeptide-mediated signaling in astrocytes. J Neurosci. 2003;23:8949-54 pubmed..These results demonstrate that neurofibromin positively influences cAMP generation and activation of cAMP growth regulatory targets in astrocytes and expands the role of the NF1 gene in astrocyte growth regulation. ..
- Goeckeler Z, Wysolmerski R. Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation. J Biol Chem. 2005;280:33083-95 pubmed
- Su X, Lodhi I, Saltiel A, Stahl P. Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5. J Biol Chem. 2006;281:27982-90 pubmed..Down-regulation of GAPex-5 impaired insulin-stimulated PKB/Akt activation. Collectively, this study indicates the involvement of Rab5 in insulin signaling. ..
- Harmon B, Ratner L. Induction of the Galpha(q) signaling cascade by the human immunodeficiency virus envelope is required for virus entry. J Virol. 2008;82:9191-205 pubmed publisher..These results could provide a new focus for therapeutic intervention with drugs targeting host signaling mediators rather than viral molecules, a strategy which is less likely to result in resistance. ..
- Laszlo A, Fleischer I. Heat-induced perturbations of DNA damage signaling pathways are modulated by molecular chaperones. Cancer Res. 2009;69:2042-9 pubmed publisher..Our results support the notion that heat-induced perturbations in the earliest events of the cellular response to ionizing radiation-induced DNA damage play a role in heat radiosensitization. ..
- Wang Q, FROLOVA A, Purcell S, Adastra K, Schoeller E, Chi M, et al. Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice. PLoS ONE. 2010;5:e15901 pubmed publisher..Together the deleterious effects on cumulus cells may disrupt trophic and signaling interactions with the oocyte, contributing to oocyte incompetence and thus poor pregnancy outcomes in diabetic females. ..
- Gill J, Langer E, Lindsley R, Cai M, Murphy T, Murphy K. Snail promotes the cell-autonomous generation of Flk1(+) endothelial cells through the repression of the microRNA-200 family. Stem Cells Dev. 2012;21:167-76 pubmed publisher..We hypothesize that this mechanism of Snail-induced vasculogenesis may be conserved in both the early developing embryo and malignant cancers. ..
- Lee J, Cella M, McDonald K, Garlanda C, Kennedy G, Nukaya M, et al. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol. 2011;13:144-51 pubmed publisher..Thus, AHR was essential for ILC22 cells and postnatal intestinal lymphoid tissues. Moreover, ILC22 subsets were heterogeneous in their requirement for Notch and their effect on the generation of intestinal lymphoid tissues. ..
- Pinto A, Daffis S, Brien J, Gainey M, Yokoyama W, Sheehan K, et al. A temporal role of type I interferon signaling in CD8+ T cell maturation during acute West Nile virus infection. PLoS Pathog. 2011;7:e1002407 pubmed publisher..Collectively, our results suggest that cell non-autonomous type I IFN signaling shapes maturation of antiviral CD8(+) T cell response at a stage distinct from the initial priming event...
- Rao S, Sengupta R, Choe E, Woerner B, Jackson E, Sun T, et al. CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma. PLoS ONE. 2012;7:e33005 pubmed publisher..Therapeutic disruption of endothelial cell trophic functions could complement the structural disruption of anti-angiogenic regimens and, in combination, might also improve the efficacy of radiation and chemotherapy in treating GBMs. ..
- Kaliberov S, Buchsbaum D. Chapter seven--Cancer treatment with gene therapy and radiation therapy. Adv Cancer Res. 2012;115:221-63 pubmed publisher..In this review, we summarize the results from experimental cancer therapy studies on the combination of radiation therapy and gene therapy. ..
- Shen H, Gelberman R, Silva M, Sakiyama Elbert S, Thomopoulos S. BMP12 induces tenogenic differentiation of adipose-derived stromal cells. PLoS ONE. 2013;8:e77613 pubmed publisher..Collectively, results support the conclusion that BMP12 induces tenogenic differentiation of ASCs via the Smad1/5/8 pathway. ..
- Chandrasekaran S, Caparon M. The NADase-Negative Variant of the Streptococcus pyogenes Toxin NADâº Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis. MBio. 2016;7:e02215-15 pubmed publisher..This helps us to understand how different forms of toxins alter host cell signaling to help S. pyogenes cause different types of diseases. ..
- Wang K, Yin X, Chao D, Milliman C, Korsmeyer S. BID: a novel BH3 domain-only death agonist. Genes Dev. 1996;10:2859-69 pubmed..This BH3-only molecule supports BH3 as a death domain and favors a model in which BID represents a death ligand for the membrane-bound receptor BAX. ..
- Li G, D SOUZA SCHOREY C, Barbieri M, Cooper J, Stahl P. Uncoupling of membrane ruffling and pinocytosis during Ras signal transduction. J Biol Chem. 1997;272:10337-40 pubmed..Our data indicate that Ha-Ras(G12V) separately activates Rab5-dependent pinocytosis and Rac1-dependent membrane ruffling. ..
- Baloh R, Tansey M, Golden J, Creedon D, Heuckeroth R, Keck C, et al. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron. 1997;18:793-802 pubmed..Comparative analysis of TrnR1, TrnR2, and Ret expression indicates that multiple receptor complexes, capable of mediating GDNF and NTN signaling, exist in vivo. ..
- Mumm J, Schroeter E, Saxena M, Griesemer A, Tian X, Pan D, et al. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell. 2000;5:197-206 pubmed..Our data demonstrate that S2 cleavage is a ligand-regulated step in the proteolytic cascade leading to Notch activation. ..
- Shui Y, Wang X, Hu J, Wang S, Garcia C, Potts J, et al. Vascular endothelial growth factor expression and signaling in the lens. Invest Ophthalmol Vis Sci. 2003;44:3911-9 pubmed..An active VEGF-A signaling system of unknown function appears to be active in the lens. It is likely that VEGF-A expression is regulated by tissue hypoxia at all stages of lens development. ..
- Dasgupta B, Yi Y, Chen D, Weber J, Gutmann D. Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors. Cancer Res. 2005;65:2755-60 pubmed..These results suggest that mTOR pathway inhibition may represent a logical and tractable biologically based therapy for brain tumors in NF1. ..
- Saito K, Meyer K, Warner R, Basu A, Ray R, Ray R. Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein. J Virol. 2006;80:4372-9 pubmed..Taken together, our results suggested that the TNF-alpha-induced apoptotic pathway is inhibited by a sustained c-FLIP expression associated with the expression of HCV core protein, which may play a role in HCV-mediated pathogenesis. ..
- Schneider J, Finck B, Ren J, Standley K, Takagi M, Maclean K, et al. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab. 2006;4:377-89 pubmed..These results suggest that ATM-dependent stress pathways mediate susceptibility to the metabolic syndrome and that chloroquine or related agents promoting ATM activity could modulate insulin resistance and decrease vascular disease. ..
- Saporita A, Maggi L, Apicelli A, Weber J. Therapeutic targets in the ARF tumor suppressor pathway. Curr Med Chem. 2007;14:1815-27 pubmed..We will discuss potential therapeutic targets in the ARF pathway, and some preliminary attempts at enhancing or restoring the activity of this important tumor suppressor. ..
- Lavine K, Kovacs A, Ornitz D. Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. J Clin Invest. 2008;118:2404-14 pubmed publisher..Together, these data demonstrate that HH signaling is essential for cardiac function at the level of the coronary vasculature and caution against the use of HH antagonists in patients with prior or ongoing heart disease. ..
- Adderley S, Sridharan M, Bowles E, Stephenson A, Sprague R, Ellsworth M. Inhibition of ATP release from erythrocytes: a role for EPACs and PKC. Microcirculation. 2011;18:128-35 pubmed publisher..These results support the hypothesis that cAMP not localized to a specific signaling pathway can activate EPACs which inhibit ATP release via activation of PKC and suggest a novel role for EPACs in erythrocytes. ..
- Harikumar K, Yester J, Surace M, Oyeniran C, Price M, Huang W, et al. K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5. Nat Immunol. 2014;15:231-8 pubmed publisher..Thus, IL-1 triggered a hitherto unknown signaling cascade that controlled the induction of IRF1-dependent genes that encode molecules important for sterile inflammation. ..
- Huang H, Yoo C, Bindbeutel R, Goldsworthy J, Tielking A, Alvarez S, et al. PCH1 integrates circadian and light-signaling pathways to control photoperiod-responsive growth in Arabidopsis. elife. 2016;5:e13292 pubmed publisher..Thus, PCH1 is a new factor that regulates photoperiod-responsive growth by integrating the clock with light perception pathways through modulating daily phyB-signaling. ..
- Srinivasan S, Bernal Mizrachi E, Ohsugi M, Permutt M. Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway. Am J Physiol Endocrinol Metab. 2002;283:E784-93 pubmed..The results of these studies defined a novel pathway for glucose-mediated activation of a PI 3-kinase/Akt survival-signaling pathway in islet beta-cells. This pathway may provide important targets for therapeutic intervention. ..
- Goel R, Phillips Mason P, Gardner A, Raben D, Baldassare J. Alpha-thrombin-mediated phosphatidylinositol 3-kinase activation through release of Gbetagamma dimers from Galphaq and Galphai2. J Biol Chem. 2004;279:6701-10 pubmed
- Hilton M, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, et al. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008;14:306-14 pubmed publisher..Thus, mesenchymal progenitors may be expanded in vitro by activating the Notch pathway, whereas bone formation in vivo may be enhanced by transiently suppressing this pathway. ..
- Guo L, Mishra G, Markham J, Li M, Tawfall A, Welti R, et al. Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis. J Biol Chem. 2012;287:8286-96 pubmed publisher..PA is involved in the activation of SPHK, and activation of PLD?1 requires SPHK activity. The data suggest that SPHK/phyto-S1P and PLD?1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis. ..
- Gorvel L, Korenfeld D, Tung T, Klechevsky E. Dendritic Cell-Derived IL-32?: A Novel Inhibitory Cytokine of NK Cell Function. J Immunol. 2017;199:1290-1300 pubmed publisher..Blocking IL-32? during DC:NK cell coculture enhanced NK cell effector molecule expression as well as their cytolytic capacity. Taken together, our findings suggest a feedback inhibition of IL-15-mediated NK cell activity by IL-32?. ..
- Guan Z, Buckman S, Miller B, Springer L, Morrison A. Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. J Biol Chem. 1998;273:28670-6 pubmed..This study suggests that the activation of both JNK/SAPK and p38 MAPK signaling cascades is required for IL-1beta-induced Cox-2 expression and PGE2 synthesis. ..
- Wong K, Park H, Wu J, Rao Y. Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. Curr Opin Genet Dev. 2002;12:583-91 pubmed
- Crowder R, Ellis M. Treating breast cancer through novel inhibitors of the phosphatidylinositol 3'-kinase pathway. Breast Cancer Res. 2005;7:212-4 pubmed
- Bae J, Yang L, Manithody C, Rezaie A. Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties. J Biol Chem. 2007;282:9251-9 pubmed
- Doherty J, Geske M, Stappenbeck T, Mills J. Diverse adult stem cells share specific higher-order patterns of gene expression. Stem Cells. 2008;26:2124-30 pubmed publisher..g., that of transit-amplifying cells) and, potentially, any biological state that is reflected in changes in global gene expression patterns. Disclosure of potential conflicts of interest is found at the end of this article. ..
- Tang Y, Yi S, Zhuang W, Zinder S, Keasling J, Alvarez Cohen L. Investigation of carbon metabolism in "Dehalococcoides ethenogenes" strain 195 by use of isotopomer and transcriptomic analyses. J Bacteriol. 2009;191:5224-31 pubmed publisher..e., a novel Re-citrate synthase that is apparently different from the one recently reported in Clostridium kluyveri. ..
- Tanabe K, Liu Y, Hasan S, Martinez S, Cras Méneur C, Welling C, et al. Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3? independent of JNK activation. PLoS ONE. 2011;6:e18146 pubmed publisher..The data support the importance of controlling both hyperglycemia and hyperlipidemia in the management of Type 2 diabetes, and identify pancreatic islet ?-cell Gsk3? as a potential therapeutic target. ..
- Heller E, Hurchla M, Xiang J, Su X, Chen S, Schneider J, et al. Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment. Cancer Res. 2012;72:897-907 pubmed publisher..Hh may be a promising therapeutic target for solid cancers and bone metastases. ..
- Tan C, Day R, Bao S, Turk J, Zhao Q. Group VIA phospholipase A2 mediates enhanced macrophage migration in diabetes mellitus by increasing expression of nicotinamide adenine dinucleotide phosphate oxidase 4. Arterioscler Thromb Vasc Biol. 2014;34:768-78 pubmed publisher..Taken together, these observations identify iPLA2? and lysophosphatidic acid derived from its action as critical in regulating macrophage Nox4 activity and migration in the diabetic state in vivo and under similar conditions ex vivo. ..
- Li Y, Liu D, López Paz C, OLSON B, Umen J. A new class of cyclin dependent kinase in Chlamydomonas is required for coupling cell size to cell division. elife. 2016;5:e10767 pubmed publisher..Cell-size-dependent accumulation of limiting cell cycle regulators such as CDKG1 is a potentially general mechanism for size control. ..
- Bach E, Aguet M, Schreiber R. The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu Rev Immunol. 1997;15:563-91 pubmed..Together these insights have produced a model of IFN gamma signaling that is nearly complete and that serves as a paradigm for signaling by other members of the cytokine receptor superfamily. ..
- Barbieri M, Roberts R, Gumusboga A, Highfield H, Alvarez Dominguez C, Wells A, et al. Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a. J Cell Biol. 2000;151:539-50 pubmed..The results point to an interdependent relationship between receptor activation, signal generation and endocytosis. ..
- Huang J, Feldmeier M, Shui Y, Beebe D. Evaluation of fibroblast growth factor signaling during lens fiber cell differentiation. Invest Ophthalmol Vis Sci. 2003;44:680-90 pubmed..Fiber differentiation factors that are not members of the FGF family are present in chicken and mammalian vitreous humor. The factors that stimulate fiber cell differentiation in avian and mammalian eyes are similar. ..
- Bai S, Kitaura H, Zhao H, Chen J, Müller J, Schüle R, et al. FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. J Clin Invest. 2005;115:2742-51 pubmed..FHL2 is, therefore, an antiosteoclastogenic molecule exerting its effect by attenuating TRAF6-mediated RANK signaling. ..
- Naughton C, Jain S, Strickland A, Gupta A, Milbrandt J. Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate. Biol Reprod. 2006;74:314-21 pubmed..Our results demonstrate that GDNF-mediated RET signaling is critical for the fate of undifferentiated spermatogonia and that abnormalities in this pathway may contribute to male infertility and testicular germ cell tumors. ..
- Lai C, Bai S, Uthgenannt B, Halstead L, McLoughlin P, Schafer B, et al. Four and half lim protein 2 (FHL2) stimulates osteoblast differentiation. J Bone Miner Res. 2006;21:17-28 pubmed..Moreover, FHL2-deficient female mice exhibited greater bone loss than the wildtype littermates after ovariectomy. Thus, FHL2 plays an important role in osteoblast differentiation and bone formation. ..
- Yu K, Ornitz D. FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis. Development. 2008;135:483-91 pubmed
- Seugnet L, Suzuki Y, Vine L, Gottschalk L, Shaw P. D1 receptor activation in the mushroom bodies rescues sleep-loss-induced learning impairments in Drosophila. Curr Biol. 2008;18:1110-7 pubmed publisher..However, the underlying molecular mechanisms triggered by extended waking and restored by sleep are unknown. Moreover, the neuronal circuits that depend on sleep for optimal learning remain unidentified...
- Ito Y, Teitelbaum S, Zou W, Zheng Y, Johnson J, Chappel J, et al. Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization. J Clin Invest. 2010;120:1981-93 pubmed publisher..These data suggest that Cdc42 regulates osteoclast formation and function and may represent a promising therapeutic target for prevention of pathological bone loss. ..
- Naylor S, DiAntonio A. EGFR signaling modulates synaptic connectivity via Gurken. Dev Neurobiol. 2012;72:1229-42 pubmed publisher..These results identify a new pathway mediating cell-type and branch-specific synaptic repulsion, a novel role for EGFR signaling in synaptic target selection, and an unexpected role for Gurken as a muscle-secreted repulsive ligand. ..
- Shrivastava S, Bhanja Chowdhury J, Steele R, Ray R, Ray R. Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling. J Virol. 2012;86:8705-12 pubmed publisher..Together, these results suggested that HCV induces autophagy by upregulating Beclin1 and activates mTOR signaling pathway, which in turn may promote hepatocyte growth. ..
- Dougherty J, Fomchenko E, Akuffo A, Schmidt E, Helmy K, Bazzoli E, et al. Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma. Cancer Res. 2012;72:4856-68 pubmed publisher..Together, our findings show that comparison of the molecular phenotype of progenitor cells in tumors to the equivalent cells in the normal brain represents a novel approach for the identification of targeted therapies. ..
- Wacker B, Perfater J, Gidday J. Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway. J Neurochem. 2012;123:954-62 pubmed publisher..The identification of these common molecular mediators involved in signaling the genomic response to multiple preconditioning stimuli provides several targets for therapeutic manipulation. ..