Experts and Doctors on nicotinic receptors in St Louis, Missouri, United States


Locale: St Louis, Missouri, United States
Topic: nicotinic receptors

Top Publications

  1. Buonanno A, Mudd J, Merlie J. Isolation and characterization of the beta and epsilon subunit genes of mouse muscle acetylcholine receptor. J Biol Chem. 1989;264:7611-6 pubmed
    ..The analysis showed that the first 4 exons and the last exon of all muscle and brain nAChR subunit genes have the same boundaries, with the exception of a nAChR-related gene in Drosophila. ..
  2. Tansey M, Chu G, Merlie J. ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway. J Cell Biol. 1996;134:465-76 pubmed
    ..Thus, synaptic induction of AChR genes requires activation of both Ras/MAPK and PI3K signal transduction pathways. ..
  3. Apel E, Glass D, Moscoso L, Yancopoulos G, Sanes J. Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold. Neuron. 1997;18:623-35 pubmed
    ..This signaling requires the kinase domain of MuSK, but not its ectodomain. Thus, MuSK may interact with rapsyn in multiple ways to play both structural and signaling roles in agrin-induced differentiation. ..
  4. Ehringer M, McQueen M, Hoft N, Saccone N, Stitzel J, Wang J, et al. Association of CHRN genes with "dizziness" to tobacco. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:600-609 pubmed publisher
    ..In addition, a novel finding of association between SNPs in the CHRNA10 gene reached experiment-wide empirical significance (P = 0.048), which implicates another CHRN gene as being involved in early subjective response to tobacco. ..
  5. Frail D, Musil L, Buonanno A, Merlie J. Expression of RAPsyn (43K protein) and nicotinic acetylcholine receptor genes is not coordinately regulated in mouse muscle. Neuron. 1989;2:1077-86 pubmed
    ..We conclude that the expression of RAPsyn and the acetylcholine receptor is not coordinately regulated in mouse muscle. ..
  6. Gautam M, Noakes P, Mudd J, Nichol M, Chu G, Sanes J, et al. Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice. Nature. 1995;377:232-6 pubmed
    ..We report that rapsyn is essential for the formation of AChR clusters, but that synapse-specific transcription of AChR subunit genes can proceed in its absence. ..
  7. Gautam M, Mudd J, Copeland N, Gilbert D, Jenkins N, Merlie J. Characterization and mapping of the Rapsn gene encoding the 43-kDa acetylcholine receptor-associated protein. Genomics. 1994;24:366-9 pubmed
    ..Finally, the 43K locus, designated Rapsn, has been mapped to the central region of mouse chromosome 2. ..
  8. Lobos E. Five subunit genes of the human muscle nicotinic acetylcholine receptor are mapped to two linkage groups on chromosomes 2 and 17. Genomics. 1993;17:642-50 pubmed
    ..The linkage analysis placed the nAChR genes at two sites on chromosome 2q about equidistant from the marker CRYGP1, with the alpha-nAChR gene about 27 cM proximal and the gamma/delta-nAChR gene complex about 31 cM distal to CRYGP1. ..
  9. Noakes P, Phillips W, Hanley T, Sanes J, Merlie J. 43K protein and acetylcholine receptors colocalize during the initial stages of neuromuscular synapse formation in vivo. Dev Biol. 1993;155:275-80 pubmed
    ..The precise colocalization of 43K and AChRs persisted through development. These results are consistent with 43K being involved in the nerve-induced clustering of AChRs during synapse formation. ..

More Information


  1. Bao J, Lei D, Du Y, Ohlemiller K, Beaudet A, Role L. Requirement of nicotinic acetylcholine receptor subunit beta2 in the maintenance of spiral ganglion neurons during aging. J Neurosci. 2005;25:3041-5 pubmed
    ..Our findings clearly established a requirement for beta2 nAChR subunit in the maintenance of SGNs during aging. ..
  2. Grucza R, Wang J, Stitzel J, Hinrichs A, Saccone S, Saccone N, et al. A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Biol Psychiatry. 2008;64:922-9 pubmed publisher
    ..The goal of this study was to examine the association of this variant with cocaine dependence...
  3. Apel E, Roberds S, Campbell K, Merlie J. Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex. Neuron. 1995;15:115-26 pubmed
    ..Rapsyn may therefore be a molecular link connecting the AChR to the DGC. At the neuromuscular synapse, rapsyn-mediated linkage of the AChR to the cytoskeleton-anchored DGC may underlie AChR cluster stabilization. ..
  4. Feng G, Steinbach J, Sanes J. Rapsyn clusters neuronal acetylcholine receptors but is inessential for formation of an interneuronal cholinergic synapse. J Neurosci. 1998;18:4166-76 pubmed
    ..Thus, rapsyn is dispensable for clustering of ganglionic neuronal nicotinic AChRs. ..
  5. Saccone N, Saccone S, Hinrichs A, Stitzel J, Duan W, Pergadia M, et al. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:453-66 pubmed publisher
  6. Saccone N, Wang J, Breslau N, Johnson E, Hatsukami D, Saccone S, et al. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res. 2009;69:6848-56 pubmed publisher
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations. ..