Genomes and Genes
Experts and Doctors on neurons in St Louis, Missouri, United States
Locale: St Louis, Missouri, United States
Publications109 found, 100 shown here
- Zerbinatti C, Wahrle S, Kim H, Cam J, Bales K, Paul S, et al. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice. J Biol Chem. 2006;281:36180-6 pubmed..Our results support the hypothesis that LRP binds and endocytoses Abeta42 both directly and via apoE but that endocytosed Abeta42 is not completely degraded and accumulates in intraneuronal lysosomes. ..
- Miller B, Press C, Daniels R, Sasaki Y, Milbrandt J, DiAntonio A. A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat Neurosci. 2009;12:387-9 pubmed publisher..This pathway also promoted degeneration after chemotherapy exposure and may be a component of a general axon self-destruction program. ..
- Donlea J, Ramanan N, Shaw P. Use-dependent plasticity in clock neurons regulates sleep need in Drosophila. Science. 2009;324:105-8 pubmed publisher..The number of synaptic terminals was reduced during sleep and this decline was prevented by sleep deprivation. ..
- Sasaki Y, Vohra B, Lund F, Milbrandt J. Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide. J Neurosci. 2009;29:5525-35 pubmed publisher..These results provide the possibility of a role for new Nmnat enzymatic activity in axonal protection in addition to NAD(+) synthesis. ..
- Bero A, Yan P, Roh J, Cirrito J, Stewart F, Raichle M, et al. Neuronal activity regulates the regional vulnerability to amyloid-? deposition. Nat Neurosci. 2011;14:750-6 pubmed publisher..Long-term unilateral vibrissal deprivation decreased amyloid plaque formation and growth. Our results suggest a mechanism to account for the vulnerability of specific brain regions to A? deposition in Alzheimer's disease...
- Yellajoshyula D, Lim J, Thompson D, Witt J, Patterson E, Kroll K. Geminin regulates the transcriptional and epigenetic status of neuronal fate-promoting genes during mammalian neurogenesis. Mol Cell Biol. 2012;32:4549-60 pubmed publisher..Additional developmental signals acting in these cells can then control their transition toward terminal neuronal or glial differentiation during mammalian neurogenesis...
- Hoseini M, Wessel R. Coherent and intermittent ensemble oscillations emerge from networks of irregular spiking neurons. J Neurophysiol. 2016;115:457-69 pubmed publisher..In conclusion, the model network suggests biologically plausible mechanisms for the generation of episodes of coherent intermittent ensemble oscillations with irregular spiking neurons in cortical circuits. ..
- Fagan A, Garber M, Barbacid M, Silos Santiago I, Holtzman D. A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo. J Neurosci. 1997;17:7644-54 pubmed..Our data suggest that, in the absence of NGF/TrkA signaling, striatal cholinergic neurons and BFCNs do not mature fully and that BFCNs begin to atrophy and/or die surrounding the time of target innervation. ..
- Gan W, Grutzendler J, Wong W, Wong R, Lichtman J. Multicolor "DiOlistic" labeling of the nervous system using lipophilic dye combinations. Neuron. 2000;27:219-25 pubmed..In addition, the Golgi-like labeling of neurons with many different colors provides a novel way to study neuronal connectivity. ..
- Zhou Y, Zhang W, Easton R, Ray J, Lampe P, Jiang Z, et al. Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG. Neurobiol Dis. 2002;9:126-38 pubmed
- Laezza F, Gerber B, Lou J, Kozel M, Hartman H, Craig A, et al. The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability. J Neurosci. 2007;27:12033-44 pubmed
- Cho H, Proll S, Szretter K, Katze M, Gale M, Diamond M. Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses. Nat Med. 2013;19:458-64 pubmed publisher..Thus, neurons from evolutionarily distinct brain regions have unique innate immune signatures, which probably contribute to their relative permissiveness to infection. ..
- Arnson H, Holy T. Robust encoding of stimulus identity and concentration in the accessory olfactory system. J Neurosci. 2013;33:13388-97 pubmed publisher..Thus, we show that a biophysically plausible circuit model can reconstruct concentration ratios from observed neuronal firing, representing a powerful mechanism to separate stimulus identity from absolute concentration. ..
- Chen J, Wen L, Dupuis S, Wu J, Rao Y. The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons. J Neurosci. 2001;21:1548-56 pubmed..The fact that the same domains are involved in guiding axon projection and neuronal migration further strengthens the idea of a conserved guidance mechanism for these important processes. ..
- Ghasia F, Meng H, Angelaki D. Neural correlates of forward and inverse models for eye movements: evidence from three-dimensional kinematics. J Neurosci. 2008;28:5082-7 pubmed publisher..Therefore, EH cells may be functionally related to the output of a forward internal model thought to construct an efference copy of the actual eye movement. ..
- Tsunoda S, Salkoff L. The major delayed rectifier in both Drosophila neurons and muscle is encoded by Shab. J Neurosci. 1995;15:5209-21 pubmed..With the genetic identity of IK confirmed, all of the major K+ currents in embryonic Drosophila neurons and muscle are now known. ..
- Baloh R, Tansey M, Golden J, Creedon D, Heuckeroth R, Keck C, et al. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron. 1997;18:793-802 pubmed..Comparative analysis of TrnR1, TrnR2, and Ret expression indicates that multiple receptor complexes, capable of mediating GDNF and NTN signaling, exist in vivo. ..
- Lantz V, Miller K. A class VI unconventional myosin is associated with a homologue of a microtubule-binding protein, cytoplasmic linker protein-170, in neurons and at the posterior pole of Drosophila embryos. J Cell Biol. 1998;140:897-910 pubmed
- Shirasawa S, Arata A, Onimaru H, Roth K, Brown G, Horning S, et al. Rnx deficiency results in congenital central hypoventilation. Nat Genet. 2000;24:287-90 pubmed..Thus, Rnx is critical for the development of the ventral medullary respiratory centre and its deficiency results in a syndrome resembling congenital central hypoventilation...
- Taghert P, Hewes R, Park J, O Brien M, Han M, Peck M. Multiple amidated neuropeptides are required for normal circadian locomotor rhythms in Drosophila. J Neurosci. 2001;21:6673-86 pubmed..They also support the hypothesis that multiple amidated neuropeptides, acting upstream, downstream, or in parallel to PDF, help organize daily locomotor rhythms. ..
- Heidinger V, Manzerra P, Wang X, Strasser U, Yu S, Choi D, et al. Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. J Neurosci. 2002;22:5452-61 pubmed
- Perry A, Scheithauer B, Macaulay R, Raffel C, Roth K, Kros J. Oligodendrogliomas with neurocytic differentiation. A report of 4 cases with diagnostic and histogenetic implications. J Neuropathol Exp Neurol. 2002;61:947-55 pubmed..In any case, their occurrence suggests a histogenetic overlap between oligodendroglioma and extraventricular neurocytoma not previously recognized. ..
- Araki T, Milbrandt J. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. J Neurosci. 2003;23:9385-94 pubmed..These data suggest that ZNRF proteins play a role in the establishment and maintenance of neuronal transmission and plasticity via their ubiquitin ligase activity. ..
- Woodworth A, Pesheva P, Fiete D, Baenziger J. Neuronal-specific synthesis and glycosylation of tenascin-R. J Biol Chem. 2004;279:10413-21 pubmed..In addition, the 160-kDa form of TN-R is particularly enriched for terminal GalNAc-4-SO(4) later in development and in the adult, suggesting additional levels of regulation. ..
- Izumi Y, Matsukawa M, Benz A, Izumi M, Ishikawa M, Olney J, et al. Role of ammonia in reversal of glutamate-mediated Müller cell swelling in the rat retina. Glia. 2004;48:44-50 pubmed..Rather, conversion of glutamate to glutamine in a reaction involving ammonia helps reverse Müller cell swelling following exposure to exogenous glutamate. ..
- Liu G, Beggs H, Jurgensen C, Park H, Tang H, Gorski J, et al. Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat Neurosci. 2004;7:1222-32 pubmed..Our results show the biochemical and functional links between netrin, a prototypical neuronal guidance cue, and FAK, a central player in intracellular signaling that is crucial for cell migration. ..
- de Erausquin G. Transactivation of cell death signals by glutamate transmission in dopaminergic neurons. Crit Rev Neurobiol. 2004;16:107-19 pubmed..Post-translational modification of p53 may be an important target for neuroprotection in Parkinson's disease and perhaps in prevention of other neuropsychiatric disorders. ..
- Stewart R, Piccardo P, Ghetti B, Harris D. Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein. J Neurosci. 2005;25:3469-77 pubmed..Our results provide new insights into the cell biology of (Ctm)PrP, the mechanism by which it induces neurodegeneration, and possible cellular activities of PrP(C). ..
- Maas J, Vogt S, Chan G, Pineda V, Storm D, Muglia L. Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity. J Neurosci. 2005;25:4118-26 pubmed..These results indicate that the unique activation of PKA signaling mediated by the calcium-stimulated ACs is an important component of the neuronal response to ethanol. ..
- Vadivelu S, Platik M, Choi L, Lacy M, Shah A, Qu Y, et al. Multi-germ layer lineage central nervous system repair: nerve and vascular cell generation by embryonic stem cells transplanted in the injured brain. J Neurosurg. 2005;103:124-35 pubmed..The combination of ESC pluripotentiality and multiple germ layer differentiation provides a new conceptual framework for CNS repair. ..
- Geerling J, Engeland W, Kawata M, Loewy A. Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite. J Neurosci. 2006;26:411-7 pubmed..These unique aldosterone target neurons may represent a previously unrecognized central convergence point at which hormonal and neural signals can be integrated to drive sodium appetite. ..
- Mennerick S, Chisari M, Shu H, Taylor A, Vasek M, Eisenman L, et al. Diverse voltage-sensitive dyes modulate GABAA receptor function. J Neurosci. 2010;30:2871-9 pubmed publisher..Therefore, the dual effects of voltage-sensitive dyes on GABAergic inhibition require caution in dye use for studies of excitability and network activity. ..
- Li P, Ann J, Akk G. Activation and modulation of human ?4?2 nicotinic acetylcholine receptors by the neonicotinoids clothianidin and imidacloprid. J Neurosci Res. 2011;89:1295-301 pubmed publisher..Interestingly, subunit stoichiometry affected inhibition by CTD, with (?4)(2) (?2)(3) receptors significantly more strongly inhibited than the (?4)(3) (?2)(2) receptors. ..
- Shin J, DiAntonio A. Highwire regulates guidance of sister axons in the Drosophila mushroom body. J Neurosci. 2011;31:17689-700 pubmed publisher..Genetic interaction studies suggest that Highwire and Plexin A signals may interact to regulate normal morphogenesis of ?/? axons. ..
- Xiao Q, Ford A, Xu J, Yan P, Lee K, Gonzales E, et al. Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia. J Neurosci. 2012;32:13587-96 pubmed..These results suggest that alternative pre-mRNA splicing may be an important regulatory mechanism for cell death after acute neurological injury and may potentially provide novel targets for intervention. ..
- Zelle K, Lu B, Pyfrom S, Ben Shahar Y. The genetic architecture of degenerin/epithelial sodium channels in Drosophila. G3 (Bethesda). 2013;3:441-50 pubmed publisher..Some members of the family may have diversified to support the physiological functions of a yet unknown class of ligands. ..
- Wong K, Park H, Wu J, Rao Y. Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. Curr Opin Genet Dev. 2002;12:583-91 pubmed
- Vohra B, Fu M, Heuckeroth R. Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity. J Neurosci. 2007;27:9458-68 pubmed
- Kanekiyo T, Zhang J, Liu Q, Liu C, Zhang L, Bu G. Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake. J Neurosci. 2011;31:1644-51 pubmed publisher..Our findings demonstrate that LRP1 and HSPG function in a cooperative manner to mediate cellular A? uptake and define a major pathway through which A? gains entry to neuronal cells. ..
- Karch C, Jeng A, Goate A. Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies. J Biol Chem. 2012;287:42751-62 pubmed publisher..This study demonstrates that cells actively release Tau in the absence of disease or toxicity, and Tau release is modified by changes in the Tau protein that are associated with tauopathies...
- Deckwerth T, Easton R, Knudson C, Korsmeyer S, Johnson E. Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. Exp Neurol. 1998;152:150-62 pubmed..This order indicates that the physiological state of NGF-deprived neurons protected by Bax deficiency may be less perturbed than that of caspase inhibitor-saved neurons. ..
- Baloh R, Tansey M, Lampe P, Fahrner T, Enomoto H, Simburger K, et al. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. Neuron. 1998;21:1291-302 pubmed
- Renn S, Armstrong J, Yang M, Wang Z, An X, Kaiser K, et al. Genetic analysis of the Drosophila ellipsoid body neuropil: organization and development of the central complex. J Neurobiol. 1999;41:189-207 pubmed..The experiments performed here demonstrate the degree of resolution possible from the analysis of enhancer-trap lines and form a useful library of tools for future structure/function studies of the ellipsoid body. ..
- Tansey M, Baloh R, Milbrandt J, Johnson E. GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. Neuron. 2000;25:611-23 pubmed..Therefore, proper membrane localization of RET via interaction with a raft-localized, GPI-linked coreceptor is of fundamental importance in GFL signaling. ..
- Encinas M, Crowder R, Milbrandt J, Johnson E. Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival. J Biol Chem. 2004;279:18262-9 pubmed..Mutation of tyrosine 981 to phenylalanine reduces GDNF-mediated survival in a transfected cerebellar granule neuron paradigm. ..
- Kim E, Clark A, Kiss A, Hahn J, Wesselschmidt R, Coscia C, et al. Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors. J Biol Chem. 2006;281:33749-60 pubmed..Finally, opioid modulation of ERK activity may play an important role in ES cell fate decisions by directing the cells to specific lineages. ..
- Nodari F, Hsu F, Fu X, Holekamp T, Kao L, Turk J, et al. Sulfated steroids as natural ligands of mouse pheromone-sensing neurons. J Neurosci. 2008;28:6407-18 pubmed publisher..These results provide an unprecedented characterization of the signals available for chemical communication among mice. ..
- Lu B, Lamora A, Sun Y, Welsh M, Ben Shahar Y. ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster. PLoS Genet. 2012;8:e1002587 pubmed publisher..Together, these data indicate that ppk23 and the cells expressing it play an important role in the peripheral sensory system that determines sexual behavior in Drosophila. ..
- Purgert C, Izumi Y, Jong Y, Kumar V, Zorumski C, O Malley K. Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus. J Neurosci. 2014;34:4589-98 pubmed publisher..These data suggest a physiologically relevant and important role for intracellular mGluR5 in hippocampal synaptic plasticity. ..
- Viader A, Golden J, Baloh R, Schmidt R, Hunter D, Milbrandt J. Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J Neurosci. 2011;31:10128-40 pubmed publisher..Mitochondrial function in SCs is therefore essential for maintenance of axonal survival and normal peripheral nerve function, suggesting that SC mitochondrial dysfunction contributes to human peripheral neuropathies. ..
- Kumar V, Fahey P, Jong Y, Ramanan N, O Malley K. Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein. J Biol Chem. 2012;287:5412-25 pubmed publisher..Taken together, these data highlight the importance of intracellular mGluR5 in the cascade of events associated with sustained synaptic transmission. ..
- Gu Y, DeAngelis G, Angelaki D. Causal links between dorsal medial superior temporal area neurons and multisensory heading perception. J Neurosci. 2012;32:2299-313 pubmed publisher..Our results support a causal link between MSTd neurons and multisensory heading perception but suggest that other multisensory brain areas also contribute. ..
- Duvall L, Taghert P. The circadian neuropeptide PDF signals preferentially through a specific adenylate cyclase isoform AC3 in M pacemakers of Drosophila. PLoS Biol. 2012;10:e1001337 pubmed publisher..These findings support a hypothesis that PDF signaling components within target cells are sequestered into "circadian signalosomes," whose compositions differ between E and M pacemaker cell types. ..
- Shrestha B, Pinto A, Green S, Bosch I, Diamond M. CD8+ T cells use TRAIL to restrict West Nile virus pathogenesis by controlling infection in neurons. J Virol. 2012;86:8937-48 pubmed publisher..Collectively, our results suggest that TRAIL produced by CD8(+) T cells contributes to disease resolution by helping to clear WNV infection from neurons in the central nervous system. ..
- Coleman P, Miller R. Do N-methyl-D-aspartate receptors mediate synaptic responses in the mudpuppy retina?. J Neurosci. 1988;8:4728-33 pubmed..Nevertheless, our results suggest that the racemic mixture of AP5 should not be used as an NMDA antagonist in retinal research, due to the AP4-like actions of its L-enantiomer...
- Seo S, Herr A, Lim J, Richardson G, Richardson H, Kroll K. Geminin regulates neuronal differentiation by antagonizing Brg1 activity. Genes Dev. 2005;19:1723-34 pubmed
- Tokuda K, O Dell K, Izumi Y, Zorumski C. Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis. J Neurosci. 2010;30:16788-95 pubmed publisher..Thus, dual activation of CBRs and TSPO appears to result in unique actions of clinically important BDZs. Furthermore, endogenous neurosteroids are shown to be important regulators of pyramidal neuron function and synaptic plasticity. ..
- Viader A, Wright Jin E, Vohra B, Heuckeroth R, Milbrandt J. Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction. PLoS ONE. 2011;6:e27727 pubmed publisher..Mitochondrial dysfunction, therefore, is likely to be an important driving force of neurodegeneration in the ENS and contribute to gastrointestinal symptoms in people with neurodegenerative disorders. ..
- Geerling J, Loewy A. Sodium deprivation and salt intake activate separate neuronal subpopulations in the nucleus of the solitary tract and the parabrachial complex. J Comp Neurol. 2007;504:379-403 pubmed..These findings offer new perspectives on the roles of sensory information from the brainstem in the regulation of sodium appetite. ..
- Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, et al. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017;47:566-581.e9 pubmed publisher..Our work identifies the TREM2-APOE pathway as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia. ..
- Zhu Y, Yu T, Zhang X, Nagasawa T, Wu J, Rao Y. Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nat Neurosci. 2002;5:719-20 pubmed
- Ding Y, Marklund U, Yuan W, Yin J, Wegman L, Ericson J, et al. Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci. 2003;6:933-8 pubmed..Moreover, our data indicate that genetic cascades controlling the caudal and rostral 5-HT neurons are distinct, despite their shared components. ..
- Bao J, Lei D, Du Y, Ohlemiller K, Beaudet A, Role L. Requirement of nicotinic acetylcholine receptor subunit beta2 in the maintenance of spiral ganglion neurons during aging. J Neurosci. 2005;25:3041-5 pubmed..Our findings clearly established a requirement for beta2 nAChR subunit in the maintenance of SGNs during aging. ..
- Daniels R, Gelfand M, Collins C, DiAntonio A. Visualizing glutamatergic cell bodies and synapses in Drosophila larval and adult CNS. J Comp Neurol. 2008;508:131-52 pubmed publisher..This description of the glutamatergic system in Drosophila highlights the prevalence of glutamatergic neurons in the CNS and presents tools for future study and manipulation of glutamatergic transmission. ..
- Daffis S, Samuel M, Suthar M, Keller B, Gale M, Diamond M. Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. J Virol. 2008;82:8465-75 pubmed publisher..In contrast, in these cells the IFN-beta response remained largely intact. Our data suggest that the early protective IFN-alpha response against WNV occurs through an IRF-7-dependent transcriptional signal. ..
- Yeh T, Lee D, Gianino S, Gutmann D. Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation. Glia. 2009;57:1239-49 pubmed publisher..These findings provide molecular evidence for CNS astroglial cell heterogeneity, and suggest that differences in tumor suppressor gene expression might contribute to the regional localization of human brain tumors. ..
- Tian L, Karimi M, Loftin S, Brown C, Xia H, Xu J, et al. No differential regulation of dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) binding in a primate model of Parkinson disease. PLoS ONE. 2012;7:e31439 pubmed publisher..0005). These similar changes in DAT and VMAT2 binding sites in the striatal terminal fields of the surviving nigrostriatal neurons demonstrate that there is no differential regulation of these two sites at 2 months after MPTP infusion...
- Silos Santiago I, Molliver D, Ozaki S, Smeyne R, Fagan A, Barbacid M, et al. Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice. J Neurosci. 1995;15:5929-42 pubmed..These neurons must either depend on NGF via a novel, indirect mechanism or alternatively, downregulate TrkA expression during development. ..
- Ho N, Liauw J, Blaeser F, Wei F, Hanissian S, Muglia L, et al. Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. J Neurosci. 2000;20:6459-72 pubmed
- Sasaki Y, Araki T, Milbrandt J. Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. J Neurosci. 2006;26:8484-91 pubmed..These results indicate that stimulation of NAD biosynthetic pathways via a variety of interventions may be useful in preventing or delaying axonal degeneration. ..
- Samson W, Zhang J, Avsian Kretchmer O, Cui K, Yosten G, Klein C, et al. Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions. J Biol Chem. 2008;283:31949-59 pubmed publisher..Our findings demonstrate diverse neuronal, neuroendocrine, and cardiovascular actions of a somatostatin gene-encoded hormone and provide the basis to investigate the physiological roles of this endogenously produced brain/gut peptide. ..
- Norris A, Nerbonne J. Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits. J Neurosci. 2010;30:5092-101 pubmed publisher..4-encoded component. The experimental findings also demonstrate that the targeted deletion of the individual Kv alpha-subunits encoding components of I(A) results in electrical remodeling that is Kv alpha-subunit specific. ..
- Baumrind N, Parkinson D, Wayne D, Heuser J, Pearlman A. EMA: a developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones. Dev Dyn. 1992;194:311-25 pubmed..Expression of EMA is a very early manifestation of neuronal differentiation; its distribution on growth cones suggests a role in mediating the interactions between growth cones and the external cues that guide them. ..
- Heuckeroth R, Enomoto H, Grider J, Golden J, Hanke J, Jackman A, et al. Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron. 1999;22:253-63 pubmed..The loss of GFR alpha2-expressing neurons, in conjunction with earlier studies, provides strong support for GFR alpha2/Ret receptor complexes as the critical mediators of NTN function in vivo. ..
- Osman A, Saito M, Makepeace C, Permutt M, Schlesinger P, Mueckler M. Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium. J Biol Chem. 2003;278:52755-62 pubmed..Disruption of this function may place cells at risk to suffer inappropriate death decisions, thus accounting for the progressive beta-cell loss and neuronal degeneration associated with the disease. ..
- Bao J, Lin H, Ouyang Y, Lei D, Osman A, Kim T, et al. Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos. Nat Neurosci. 2004;7:1250-8 pubmed..This upregulation of PSD-95 expression by the Nrg-ICD-Eos complex provides a molecular basis for activity-dependent synaptic plasticity. ..
- Kotzbauer P, Lampe P, Heuckeroth R, Golden J, Creedon D, Johnson E, et al. Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature. 1996;384:467-70 pubmed..Thus, neurturin and GDNF together now define a new family of neurotrophic factors. ..
- Ray W, Bain G, Yao M, Gottlieb D. CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family. J Biol Chem. 1997;272:18702-8 pubmed..Thus, we report the cloning of a member of a novel cytochrome P450 family that is expressed in mammalian embryos and in brain and is induced by RA in the liver. ..
- Powell P, Wesley C, Spencer S, Cagan R. Scabrous complexes with Notch to mediate boundary formation. Nature. 2001;409:626-30 pubmed..The result is a regulation of Notch activity that sharpens proneural cluster boundaries and ensures establishment of single pioneer neurons. ..
- Ariel M, Kogo N. Direction tuning of inhibitory inputs to the turtle accessory optic system. J Neurophysiol. 2001;86:2919-30 pubmed..Such synaptic interactions may serve a functional role in the visual processing necessary to create retinal slip signals for oculomotor control...
- Krout K, Belzer R, Loewy A. Brainstem projections to midline and intralaminar thalamic nuclei of the rat. J Comp Neurol. 2002;448:53-101 pubmed..The discussion focuses on brainstem-thalamic pathways that are likely involved in arousal, somatosensory, and visceral functions. ..
- Fawcett G, Santi C, Butler A, Harris T, Covarrubias M, Salkoff L. Mutant analysis of the Shal (Kv4) voltage-gated fast transient K+ channel in Caenorhabditis elegans. J Biol Chem. 2006;281:30725-35 pubmed..SHL-1 channels are apparently important in fine-tuning complex behaviors, such as mating, that play a crucial role in the survival and propagation of the species. ..
- Szretter K, Daffis S, Patel J, Suthar M, Klein R, Gale M, et al. The innate immune adaptor molecule MyD88 restricts West Nile virus replication and spread in neurons of the central nervous system. J Virol. 2010;84:12125-38 pubmed publisher..Our experiments suggest that MyD88 restricts WNV by inhibiting replication in subsets of cells and modulating expression of chemokines that regulate immune cell migration into the central nervous system...
- Li C, Sathyamurthy A, Oldenborg A, Tank D, Ramanan N. SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J Neurosci. 2014;34:4027-42 pubmed publisher..Thus, our findings reveal a novel phosphorylation and activation of SRF by GSK-3 that is critical for SRF-dependent axon growth in mammalian central neurons. ..