Experts and Doctors on multigene family in St Louis, Missouri, United States


Locale: St Louis, Missouri, United States
Topic: multigene family

Top Publications

  1. Heusel J, Wesselschmidt R, Shresta S, Russell J, Ley T. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 1994;76:977-87 pubmed
    ..We conclude that gzm B serves a critical and nonredundant role for the rapid induction of target cell DNA fragmentation and apoptosis by alloreactive cytotoxic T lymphocytes. ..
  2. Hourcade D, Miesner D, Bee C, Zeldes W, Atkinson J. Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene. An example of concerted (horizontal) evolution within a gene. J Biol Chem. 1990;265:974-80 pubmed
    ..Similar mechanisms have been important in the evolution of tandemly repeated genes and could provide the means for generation of the CR1 polymorphic size variants. ..
  3. Svaren J, Apel E, Simburger K, Jenkins N, Gilbert D, Copeland N, et al. The Nab2 and Stat6 genes share a common transcription termination region. Genomics. 1997;41:33-9 pubmed
    ..Analysis of Nab2 cDNA revealed that there is an alternatively spliced form of the Nab2 transcript (lacking exon 3) that produces a protein that lacks the ability to repress transcription by NGFI-A and Krox20. ..
  4. Govero J, Doray B, Bai H, Kornfeld S. Analysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during development. PLoS ONE. 2012;7:e30184 pubmed publisher
    ..We conclude that the three mammalian GGAs are essential proteins that are not fully redundant. ..
  5. Bandyopadhyay A, Elvitigala T, Welsh E, Stöckel J, Liberton M, Min H, et al. Novel metabolic attributes of the genus cyanothece, comprising a group of unicellular nitrogen-fixing Cyanothece. MBio. 2011;2: pubmed publisher
    ..strain 7425 and the concomitant loss of its aerobic nitrogen-fixing ability suggest that a similar mechanism might have been at play in cyanobacterial strains that eventually lost their nitrogen-fixing ability...
  6. Hunt C, Gasser D, Chaplin D, Pierce J, Kozak C. Chromosomal localization of five murine HSP70 gene family members: Hsp70-1, Hsp70-2, Hsp70-3, Hsc70t, and Grp78. Genomics. 1993;16:193-8 pubmed
  7. Warren W, Clayton D, Ellegren H, Arnold A, Hillier L, Künstner A, et al. The genome of a songbird. Nature. 2010;464:757-62 pubmed publisher
    ..These results indicate an active involvement of the genome in neural processes underlying vocal communication and identify potential genetic substrates for the evolution and regulation of this behaviour...
  8. Wei A, Butler A, Salkoff L. KCNQ-like potassium channels in Caenorhabditis elegans. Conserved properties and modulation. J Biol Chem. 2005;280:21337-45 pubmed
    ..elegans and vertebrate KCNQ/KQT channels, which is dependent upon the carboxyl-terminal domains of channel subunits and activated protein kinase C. ..
  9. Woo H, Dittmer T, Richards E. Three SRA-domain methylcytosine-binding proteins cooperate to maintain global CpG methylation and epigenetic silencing in Arabidopsis. PLoS Genet. 2008;4:e1000156 pubmed publisher
    ..Our findings demonstrate that VIM1, VIM2, and VIM3 have overlapping functions in maintenance of global CpG methylation and epigenetic transcriptional silencing. ..

More Information


  1. Miner J, Patton B, Lentz S, Gilbert D, Snider W, Jenkins N, et al. The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. J Cell Biol. 1997;137:685-701 pubmed
    ..Together, these results reveal remarkable diversity in BL composition and complexity in BL development. ..
  2. Yin Y, Martin J, Abubucker S, Wang Z, Wyrwicz L, Rychlewski L, et al. Molecular determinants archetypical to the phylum Nematoda. BMC Genomics. 2009;10:114 pubmed publisher
  3. Kuehn M, Jacob Dubuisson F, Dodson K, Slonim L, Striker R, Hultgren S. Genetic, biochemical, and structural studies of biogenesis of adhesive pili in bacteria. Methods Enzymol. 1994;236:282-306 pubmed
  4. Yin X, Oltvai Z, Veis Novack D, Linette G, Korsmeyer S. Bcl-2 gene family and the regulation of programmed cell death. Cold Spring Harb Symp Quant Biol. 1994;59:387-93 pubmed
  5. Abubucker S, Segata N, Goll J, Schubert A, Izard J, Cantarel B, et al. Metabolic reconstruction for metagenomic data and its application to the human microbiome. PLoS Comput Biol. 2012;8:e1002358 pubmed publisher
  6. Zelle K, Lu B, Pyfrom S, Ben Shahar Y. The genetic architecture of degenerin/epithelial sodium channels in Drosophila. G3 (Bethesda). 2013;3:441-50 pubmed publisher
    ..Some members of the family may have diversified to support the physiological functions of a yet unknown class of ligands. ..
  7. Bo M, Boime I. Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. J Biol Chem. 1992;267:3179-84 pubmed
    ..The results indicate that at least five, and possibly all six, CG beta genes are transcribed in vivo, and at least one of them (CG beta 1 and/or CG beta 2) undergoes alternative splicing. ..
  8. Lewis A, Lubin J, Argade S, Naidu N, Choudhury B, Boyd E. Genomic and metabolic profiling of nonulosonic acids in Vibrionaceae reveal biochemical phenotypes of allelic divergence in Vibrio vulnificus. Appl Environ Microbiol. 2011;77:5782-93 pubmed publisher
    ..Taken together, the data implicate the family Vibrionaceae as a "hot spot" of NulO evolution and suggest that these molecules may have diverse roles in environmental persistence and/or animal virulence...
  9. Watson M, Fleming T. Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer. Cancer Res. 1996;56:860-5 pubmed
    ..The breast-specific expression of this potentially secreted protein and its frequent overexpression in primary human breast tumors suggest that mammaglobin may be a novel marker for the management of breast cancer. ..
  10. Clevenger K, Bok J, Ye R, Miley G, Verdan M, Velk T, et al. A scalable platform to identify fungal secondary metabolites and their gene clusters. Nat Chem Biol. 2017;13:895-901 pubmed publisher
    ..The ability to regularize access to fungal secondary metabolites at an unprecedented scale stands to revitalize drug discovery platforms with renewable sources of natural products. ..
  11. Greene J, Li Y, Yourey P, Gruber J, Carter K, Shell B, et al. Identification and characterization of a novel member of the fibroblast growth factor family. Eur J Neurosci. 1998;10:1911-25 pubmed
    ..We have identified a novel member of the FGF family that is expressed in the central nervous system (CNS) and increases the number as well as the level of phenotypic differentiation of cortical neurons in vitro. ..
  12. Korsmeyer S. BCL-2 gene family and the regulation of programmed cell death. Cancer Res. 1999;59:1693s-1700s pubmed
    ..Aberrations in the BCL-2 family result in disordered homeostasis, a pathogenic event in diseases, including cancer. ..
  13. Wong S, Weber J. Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem J. 2007;407:451-60 pubmed
    ..This increase was augmented further when siRNA against SIRT1 was used in conjunction with nicotinamide. In conclusion, our results demonstrate that SIRT1 is an in vitro and in vivo deacetylase for the Rb tumour suppressor protein. ..
  14. Yi H, Richards E. Gene duplication and hypermutation of the pathogen Resistance gene SNC1 in the Arabidopsis bal variant. Genetics. 2009;183:1227-34 pubmed publisher
    ..We propose that the high degree of variation in SNC1-related sequences among Arabidopsis natural accessions follows the two-step mechanism observed in the bal variant: gene duplication followed by hypermutation. ..
  15. Chen C, Chen H, Yeh S, Vittore G, Ho T. Autophagy is enhanced and floral development is impaired in AtHVA22d RNA interference Arabidopsis. Plant Physiol. 2009;149:1679-89 pubmed publisher
    ..Potential mechanisms of this suppression and the roles of abscisic acid-induced HVA22 expression in vegetative and reproductive tissues are discussed. ..
  16. Hourcade D, Garcia A, Post T, Taillon Miller P, Holers V, Wagner L, et al. Analysis of the human regulators of complement activation (RCA) gene cluster with yeast artificial chromosomes (YACs). Genomics. 1992;12:289-300 pubmed
    ..The RCA YACs will now serve as convenient DNA sources for the subcloning and further characterization of this region. ..
  17. Hug B, Wesselschmidt R, Fiering S, Bender M, Epner E, Groudine M, et al. Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3. Mol Cell Biol. 1996;16:2906-12 pubmed
  18. Kersulyte D, Velapati o B, Mukhopadhyay A, Cahuayme L, Bussalleu A, Combe J, et al. Cluster of type IV secretion genes in Helicobacter pylori's plasticity zone. J Bacteriol. 2003;185:3764-72 pubmed
    ..These patterns suggested insertion by a transposition-like event, but one in which targets are chosen with little or no specificity at the left end and high specificity at the right end, thereby deleting the intervening DNA...
  19. Kapoor M, Wang J, Bertelsen S, Bucholz K, Budde J, Hinrichs A, et al. Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. PLoS ONE. 2012;7:e33513 pubmed publisher
  20. Kehl Fie T, St Geme J. Identification and characterization of an RTX toxin in the emerging pathogen Kingella kingae. J Bacteriol. 2007;189:430-6 pubmed publisher
    ..The possible roles for this toxin in the pathogenesis of K. kingae disease include breaching of the epithelial barrier and destruction of target tissues, such as synovium (joint lining)...
  21. Downes G, Gautam N. The G protein subunit gene families. Genomics. 1999;62:544-52 pubmed
  22. Brown M, Scalzo A, Matsumoto K, Yokoyama W. The natural killer gene complex: a genetic basis for understanding natural killer cell function and innate immunity. Immunol Rev. 1997;155:53-65 pubmed
    ..Thus, further elucidation of the NKC and its gene products will provide a genetic basis for understanding innate immunity and NK-cell activity at the molecular level. ..
  23. Saccone N, Wang J, Breslau N, Johnson E, Hatsukami D, Saccone S, et al. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res. 2009;69:6848-56 pubmed publisher
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations. ..
  24. Young M, Karpova T, Brugger B, Moschenross D, Wang G, Schneiter R, et al. The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation. Mol Cell Biol. 2002;22:927-34 pubmed
    ..In particular, the sphingoid base length and number of hydroxyl groups in inositol phosphorylceramides were altered in sur7Delta, ydl222Delta, and yne194Delta strains. ..
  25. Mueller T, Welsh E, Pakrasi H, Maranas C. Identifying Regulatory Changes to Facilitate Nitrogen Fixation in the Nondiazotroph Synechocystis sp. PCC 6803. ACS Synth Biol. 2016;5:250-8 pubmed publisher
    ..Lessons learned in the incorporation of nitrogen fixation into a nondiazotrophic prokaryote may be leveraged to further progress the incorporation of nitrogen fixation in plants. ..
  26. Strauss B, Pittman R, Pixley M, Nilson J, Boime I. Expression of the beta subunit of chorionic gonadotropin in transgenic mice. J Biol Chem. 1994;269:4968-73 pubmed
    ..Additionally, a different subset of CG beta genes (CG beta 1 and beta 2) is active in the mouse brain. ..
  27. Kou K, James P, Clemmons D, Copeland N, Gilbert D, Jenkins N, et al. Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11. Genomics. 1994;21:653-5 pubmed
    ..These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group. ..
  28. Brown M, Fulmek S, Matsumoto K, Cho R, Lyons P, Levy E, et al. A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6. Genomics. 1997;42:16-25 pubmed
    ..The high-resolution NKC map will facilitate investigation of NKC gene regulation and identification of phenotypically defined gene products that confer NK cell defense against viral pathogens. ..
  29. Cheney C, Kravit N, Verbsky J. A new myosin I gene in Drosophila. Biochem Biophys Res Commun. 1993;195:1280-8 pubmed
    ..The identification of a myosin-I gene in Drosophila will allow genetic analysis of myosin-I function in a metazoan organism. ..
  30. Blanc Potard A, Solomon F, Kayser J, Groisman E. The SPI-3 pathogenicity island of Salmonella enterica. J Bacteriol. 1999;181:998-1004 pubmed
  31. Xie Q, Alpers D. The two isozymes of rat intestinal alkaline phosphatase are products of two distinct genes. Physiol Genomics. 2000;3:1-8 pubmed
    ..Isolation of the IAP-II gene will allow determination of the sequences responsible for dietary fat response in the enterocyte...
  32. Wilhelm S, Collier I, Marmer B, Eisen A, Grant G, Goldberg G. SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. J Biol Chem. 1989;264:17213-21 pubmed
  33. Araki T, Milbrandt J. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. J Neurosci. 2003;23:9385-94 pubmed
    ..These data suggest that ZNRF proteins play a role in the establishment and maintenance of neuronal transmission and plasticity via their ubiquitin ligase activity. ..
  34. Russell D, Sachs M. Differential expression and sequence analysis of the maize glyceraldehyde-3-phosphate dehydrogenase gene family. Plant Cell. 1989;1:793-803 pubmed
    ..Through the use of hybrid selection, in vitro translation, and immune precipitation, the relative expression of the three genes is shown. The role of the observed changes in gene expression is discussed in relation to stress physiology. ..
  35. Rubocki R, Lee D, Lie W, Myers N, Hansen T. Molecular evidence that the H-2D and H-2L genes arose by duplication. Differences between the evolution of the class I genes in mice and humans. J Exp Med. 1990;171:2043-61 pubmed
    ..These and other recent molecular studies provide multiple examples of expansion and contraction of the class I genes in the D region.(ABSTRACT TRUNCATED AT 400 WORDS) ..
  36. Stark B, Cooper J. Differential expression of CARMIL-family genes during zebrafish development. Cytoskeleton (Hoboken). 2015;72:534-41 pubmed publisher
    ..These results provide new tools and offer insight into understanding the role of the regulation of actin assembly dynamics during embryonic development and tissue morphogenesis. ..
  37. Dutcher S. The tubulin fraternity: alpha to eta. Curr Opin Cell Biol. 2001;13:49-54 pubmed
    ..Recent genetic analyses and database searches have added four new members of the tubulin superfamily, which now includes alpha-, beta-, gamma-, delta-, epsilon-, zeta-, and eta-tubulin. ..
  38. Heusel J, Hanson R, Silverman G, Ley T. Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2. J Biol Chem. 1991;266:6152-8 pubmed
    ..Further experiments will be required to determine the critical cis-acting regulatory sequences required for tissue- and development-specific expression of each of these genes. ..