Experts and Doctors on germ cells in St Louis, Missouri, United States
Locale: St Louis, Missouri, United States
Topic: germ cells
Francis R, Barton M, Kimble J, Schedl T. gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans. Genetics. 1995;139:579-606 pubmed
..This function of gld-1 is inferred from a haplo-insufficient phenotype and from the properties of gain-of-function gld-1 mutations that cause alterations in the sexual identity of germ cells. ..
Lee M, Schedl T. Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development. Genes Dev. 2001;15:2408-20 pubmed
..Previous work identified tra-2 as a GLD-1 target for germ line sex determination. Comparisons of GLD-1-mediated translational control of rme-2 and tra-2 suggests that the mechanisms may differ for distinct target mRNA species. ..
Garza D, Medhora M, Koga A, Hartl D. Introduction of the transposable element mariner into the germline of Drosophila melanogaster. Genetics. 1991;128:303-10 pubmed
..These transformed strains of D. melanogaster presently contain numerous copies of mariner and may be useful in transposon tagging and other applications. ..
Lee M, Ohmachi M, Arur S, Nayak S, Francis R, Church D, et al
. Multiple functions and dynamic activation of MPK-1 extracellular signal-regulated kinase signaling in Caenorhabditis elegans germline development. Genetics. 2007;177:2039-62 pubmed
Chalker D, Meyer E, Mochizuki K. Epigenetics of ciliates. Cold Spring Harb Perspect Biol. 2013;5:a017764 pubmed publisher
..The mechanisms regulating ciliate DNA rearrangements reveal the surprising power of homologous RNAs to remodel the genome and transmit information transgenerationally. ..
Brenner J, Schedl T. Germline Stem Cell Differentiation Entails Regional Control of Cell Fate Regulator GLD-1 in Caenorhabditis elegans. Genetics. 2016;202:1085-103 pubmed publisher
Dorsett M, Westlund B, Schedl T. METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans. Genetics. 2009;183:233-47 pubmed publisher
..The finding that METT-10 functions to inhibit germ-cell proliferative fate, despite promoting mitotic cell cycle progression of those germ cells that do proliferate, separates the specification of proliferative fate from its execution. ..