Genomes and Genes
Experts and Doctors on caenorhabditis elegans proteins in Minneapolis, Minnesota, United States
Locale: Minneapolis, Minnesota, United States
Topic: caenorhabditis elegans proteins
- Zhou S, Chen L. Neural integrity is maintained by dystrophin in C. elegans. J Cell Biol. 2011;192:349-63 pubmed publisher..elegans. This study provides biochemical data that show that SAX-7 associates with DYS-1 in an STN-2/?-syntrophin-dependent manner. These results reveal a recruitment of L1CAMs to the DPC to ensure neural integrity is maintained. ..
- Govindan J, Nadarajan S, Kim S, Starich T, Greenstein D. Somatic cAMP signaling regulates MSP-dependent oocyte growth and meiotic maturation in C. elegans. Development. 2009;136:2211-21 pubmed publisher..Our findings highlight a remarkable similarity between the regulation of meiotic resumption by soma-germline interactions in C. elegans and mammals...
- Spartz A, Herman R, Shaw J. SMU-2 and SMU-1, Caenorhabditis elegans homologs of mammalian spliceosome-associated proteins RED and fSAP57, work together to affect splice site choice. Mol Cell Biol. 2004;24:6811-23 pubmed..In vitro and in vivo coimmunoprecipitation experiments indicate that SMU-2 and SMU-1 bind to each other. We propose that SMU-2 and SMU-1 function together to regulate splice site choice in the pre-mRNAs of unc-52 and other genes. ..
- Spike C, Davies A, Shaw J, Herman R. MEC-8 regulates alternative splicing of unc-52 transcripts in C. elegans hypodermal cells. Development. 2002;129:4999-5008 pubmed..Indeed, our analysis of unc-52 genetic mosaics has shown that the focus of unc-52 action is not in body-wall muscle but most likely is in hypodermis. ..
- Wang X, Zhang W, Cheever T, Schwarz V, Opperman K, Hutter H, et al. The C. elegans L1CAM homologue LAD-2 functions as a coreceptor in MAB-20/Sema2 mediated axon guidance. J Cell Biol. 2008;180:233-46 pubmed publisher..In vertebrates, L1 binds neuropilin1, the obligate receptor to the secreted Sema3A. However, invertebrates lack neuropilins. LAD-2 may thus function in the semaphorin complex by combining the roles of neuropilins and L1CAMs. ..
- Bell L, Stone S, Yochem J, Shaw J, Herman R. The molecular identities of the Caenorhabditis elegans intraflagellar transport genes dyf-6, daf-10 and osm-1. Genetics. 2006;173:1275-86 pubmed..Movement of DYF-6::GFP within the ciliated endings of the neurons indicates that DYF-6 is involved in IFT. In addition, IFT can be observed in dauer larvae. ..
- Starich T, Xu J, Skerrett I, Nicholson B, Shaw J. Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system. Neural Dev. 2009;4:16 pubmed publisher..elegans, and other factors must influence the determination of synaptic partners. ..
- Raymond C, Shamu C, Shen M, Seifert K, Hirsch B, Hodgkin J, et al. Evidence for evolutionary conservation of sex-determining genes. Nature. 1998;391:691-5 pubmed..DMT1 maps to the distal short arm of chromosome 9, a location implicated in human XY sex reversal. Proteins with DM domains may therefore also regulate sexual development in mammals. ..
- Ross J, Kalis A, Murphy M, Zarkower D. The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins. Dev Cell. 2005;8:881-92 pubmed..Proteins related to MAB-3 (DM domain proteins) control sexual differentiation in diverse metazoans. We therefore suggest that regulation of Hes genes by DM domain proteins may be a general mechanism for specifying sex-specific neurons. ..
- Kim S, Kettlewell J, Anderson R, Bardwell V, Zarkower D. Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad. Gene Expr Patterns. 2003;3:77-82 pubmed..Our data suggest that multiple DM domain genes may be involved in mammalian sexual development, and that they may function in both testis and ovary development. ..
- Zarkower D. Invertebrates may not be so different after all. Novartis Found Symp. 2002;244:115-26; discussion 126-35, 203-6, 253-7 pubmed..Mutant females are unaffected. Other DM domain genes are expressed in embryonic gonad and are currently under study. ..
- Chang W, Lloyd C, Zarkower D. DSH-2 regulates asymmetric cell division in the early C. elegans somatic gonad. Mech Dev. 2005;122:781-9 pubmed..We suggest that DSH-2 functions as an upstream regulator of POP-1 in the somatic gonad to control asymmetric cell division, thereby establishing proximal-distal polarity of the developing organ. ..
- Chang W, Tilmann C, Thoemke K, Markussen F, Mathies L, Kimble J, et al. A forkhead protein controls sexual identity of the C. elegans male somatic gonad. Development. 2004;131:1425-36 pubmed..We conclude that fkh-6 regulates gonadogenesis in both sexes, but is male specific in establishing sexual dimorphism in the early gonad. ..
- Grill B, Chen L, Tulgren E, Baker S, Bienvenut W, Anderson M, et al. RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans. J Neurosci. 2012;32:2628-36 pubmed publisher..Further, we show that RAE-1 colocalizes with RPM-1 in neurons, and that rae-1 functions downstream of rpm-1. These studies establish a novel postmitotic function for rae-1 in neuronal development. ..
- Kim S, Govindan J, Tu Z, Greenstein D. SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans. Genetics. 2012;192:905-28 pubmed publisher..This work provides insights into the genetic control of meiotic maturation signaling in C. elegans, and the conserved factors identified here might inform analysis in other systems through either homology or analogy. ..