Research Topics

Genomes and Genes

Locale: Holland, Michigan, United States

Topic: signal transduction

Burnatowska Hledin M, Zhao P, Capps B, Poel A, Parmelee K, Mungall C, et al. VACM-1, a cullin gene family member, regulates cellular signaling. Am J Physiol Cell Physiol. 2000;279:C266-73 pubmed

..Our data demonstrate that VACM-1, the first mammalian cullin protein to be characterized, is involved in the regulation of signaling...
Van Dort C, Zhao P, Parmelee K, Capps B, Poel A, Listenberger L, et al. VACM-1, a cul-5 gene, inhibits cellular growth by a mechanism that involves MAPK and p53 signaling pathways. Am J Physiol Cell Physiol. 2003;285:C1386-96 pubmed

..In summary, VACM-1 inhibits cellular growth by a mechanism that involves cAMP, MAPK phosphorylation, and p53 expression. ..
Putzke A, Rothman J. Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase. Proc Natl Acad Sci U S A. 2010;107:16154-9 pubmed publisher

..These findings highlight a role for a Fer-type kinase in setting the proper levels of Wnt signaling and demonstrate the importance of this modulation in ensuring appropriate cell division. ..