Experts and Doctors on serpins in Detroit, Michigan, United States


Locale: Detroit, Michigan, United States
Topic: serpins

Top Publications

  1. Reddy K, McGowen R, Schuger L, Visscher D, Sheng S. Maspin expression inversely correlates with breast tumor progression in MMTV/TGF-alpha transgenic mouse model. Oncogene. 2001;20:6538-43 pubmed
    ..Furthermore, our data suggests that MMTV/TGF-alpha transgenic mouse model is advantageous for in vivo evaluation of both the expression and the biological function of maspin during the slow multi-stage carcinogenesis of mammary gland. ..
  2. Sheng S. The promise and challenge toward the clinical application of maspin in cancer. Front Biosci. 2004;9:2733-45 pubmed
    ..Specifically, this review discusses several likely molecular mechanisms underlying (1) the differential regulation of maspin expression, and (2) the biological activities of maspin in tumor progression. ..
  3. Yin S, Li X, Meng Y, Finley R, Sakr W, Yang H, et al. Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase. J Biol Chem. 2005;280:34985-96 pubmed
  4. Li X, Yin S, Meng Y, Sakr W, Sheng S. Endogenous inhibition of histone deacetylase 1 by tumor-suppressive maspin. Cancer Res. 2006;66:9323-9 pubmed
  5. Li X, Chen D, Yin S, Meng Y, Yang H, Landis Piwowar K, et al. Maspin augments proteasome inhibitor-induced apoptosis in prostate cancer cells. J Cell Physiol. 2007;212:298-306 pubmed
    ..Our results suggest that gene therapy involving ectopic maspin expression may dramatically improve the efficacy of proteasome inhibitors for the treatment of prostate cancer. ..
  6. Lonardo F, Li X, Kaplun A, Soubani A, Sethi S, Gadgeel S, et al. The natural tumor suppressor protein maspin and potential application in non small cell lung cancer. Curr Pharm Des. 2010;16:1877-81 pubmed
    ..In the current review, we discuss the evidence that maspin may be a marker that stratifies the progression and prognosis of different subtypes of NSCLC. ..
  7. Li X, Kaplun A, Lonardo F, Heath E, Sarkar F, Irish J, et al. HDAC1 inhibition by maspin abrogates epigenetic silencing of glutathione S-transferase pi in prostate carcinoma cells. Mol Cancer Res. 2011;9:733-45 pubmed publisher
    ..Because DNA hypermethylation-based silencing may couple with and depend on histone deacetylation, our study suggests that endogenous HDAC inhibition by maspin may prevent pathologic gene silencing in prostate tumor progression. ..
  8. Jiang N, Meng Y, Zhang S, Mensah Osman E, Sheng S. Maspin sensitizes breast carcinoma cells to induced apoptosis. Oncogene. 2002;21:4089-98 pubmed
    ..The sensitizing effect of maspin on apoptosis is to be contrasted by the pro-survival effect of several other serpins. ..
  9. Lockett J, Yin S, Li X, Meng Y, Sheng S. Tumor suppressive maspin and epithelial homeostasis. J Cell Biochem. 2006;97:651-60 pubmed
    ..Several recent studies dedicated to finding the maspin partners support a paradigm shift. The current review is intended to summarize these recent findings and discuss a new perspective of maspin in epithelial homeostasis. ..

More Information


  1. Biliran H, Sheng S. Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin. Cancer Res. 2001;61:8676-82 pubmed
    ..Furthermore, our results support a current hypothesis that maspin blocks tumor invasion and motility by inhibiting localized pericellular proteolysis. ..
  2. Cher M, Biliran H, Bhagat S, Meng Y, Che M, Lockett J, et al. Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis. Proc Natl Acad Sci U S A. 2003;100:7847-52 pubmed
  3. Frey A, Soubani A, Adam A, Sheng S, Pass H, Lonardo F. Nuclear, compared with combined nuclear and cytoplasmic expression of maspin, is linked in lung adenocarcinoma to reduced VEGF-A levels and in Stage I, improved survival. Histopathology. 2009;54:590-7 pubmed publisher
    ..N) maspin selects lung adenocarcinomas with distinct molecular and clinical features, supporting the hypothesis that its tumour inhibitor properties may be linked to its nuclear localization. ..
  4. Berndt S, Camp N, Skibola C, Vijai J, Wang Z, Gu J, et al. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Nat Commun. 2016;7:10933 pubmed publisher
    ..2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility. ..