Experts and Doctors on rab2 gtp binding protein in Detroit, Michigan, United States

Summary

Locale: Detroit, Michigan, United States
Topic: rab2 gtp binding protein

Top Publications

  1. Tisdale E. Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway. J Biol Chem. 2002;277:3334-41 pubmed
    ..These combined results suggest that Rab2 stimulated PKCiota/lambda and GAPDH recruitment to VTCs, and the subsequent PKCiota/lambda phosphorylation of GAPDH ultimately influences MT dynamics in the early secretory pathway. ..
  2. Tisdale E, Wang J, Silver R, Artalejo C. Atypical protein kinase C plays a critical role in protein transport from pre-Golgi intermediates. J Biol Chem. 2003;278:38015-21 pubmed
  3. Tisdale E. Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation. J Biol Chem. 2003;278:52524-30 pubmed
    ..These results suggest that a downstream effector recruited to the VTC stimulates PKCiota/lambda-mediated GAPDH phosphorylation by alleviating the inhibition imposed by Rab2-PKCiota/lambda interaction. ..
  4. Tisdale E, Artalejo C. A GAPDH mutant defective in Src-dependent tyrosine phosphorylation impedes Rab2-mediated events. Traffic. 2007;8:733-41 pubmed
    ..Our results suggest that Src plays a pivotal role in regulating the interaction of Rab2 effectors on the VTC. ..
  5. Tisdale E, Kelly C, Artalejo C. Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity. J Biol Chem. 2004;279:54046-52 pubmed
    ..These data suggest that GAPDH imparts a unique function necessary for membrane trafficking from VTCs that does not require GAPDH glycolytic activity. ..
  6. Tisdale E, Azizi F, Artalejo C. Rab2 utilizes glyceraldehyde-3-phosphate dehydrogenase and protein kinase C{iota} to associate with microtubules and to recruit dynein. J Biol Chem. 2009;284:5876-84 pubmed publisher
    ..These combined results suggest a mechanism by which Rab2 controls MT and motor recruitment to vesicular tubular clusters. ..