Experts and Doctors on protein interaction mapping in Detroit, Michigan, United States


Locale: Detroit, Michigan, United States
Topic: protein interaction mapping

Top Publications

  1. Zhang X, Damacharla D, Ma D, Qi Y, Tagett R, Draghici S, et al. Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cells. Mol Cell Endocrinol. 2016;424:1-11 pubmed publisher
    ..Our data suggest that PP2A interacts with various signaling proteins necessary for physiological insulin secretion as well as signaling proteins known to regulate cell dysfunction and apoptosis in the pancreatic β-cells. ..
  2. Kekulandara D, Nagi S, Seo H, Chow C, Ahn Y. Redox-Inactive Peptide Disrupting Trx1-Ask1 Interaction for Selective Activation of Stress Signaling. Biochemistry. 2018;57:772-780 pubmed publisher
    ..Overall, 2GTP1 will serve as a useful probe for investigating protein interactions of Trx1. ..
  3. Yu J, Pacifico S, Liu G, Finley R. DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions. BMC Genomics. 2008;9:461 pubmed publisher
    ..DroID is available at ..
  4. Houle T, Ram M, Cala S. Calsequestrin mutant D307H exhibits depressed binding to its protein targets and a depressed response to calcium. Cardiovasc Res. 2004;64:227-33 pubmed
    ..We conclude that the point mutation D307H leads to a profoundly altered conformation that no longer responds normally to Ca(2+) and fails to bind normally to triadin and junctin. ..
  5. Yu J, Finley R. Combining multiple positive training sets to generate confidence scores for protein-protein interactions. Bioinformatics. 2009;25:105-11 pubmed publisher
    ..We applied the method to protein interaction data from both Drosophila melanogaster and Homo sapiens. Independent evaluations show that the resulting confidence scores accurately reflect the biological significance of the interactions. ..
  6. Mairiang D, Zhang H, Sodja A, Murali T, Suriyaphol P, Malasit P, et al. Identification of new protein interactions between dengue fever virus and its hosts, human and mosquito. PLoS ONE. 2013;8:e53535 pubmed publisher
    ..These data should be useful for understanding the interplay between dengue and its hosts and may provide candidates for drug targets and vector control strategies. ..
  7. Zhong J, Zhang H, Stanyon C, Tromp G, Finley R. A strategy for constructing large protein interaction maps using the yeast two-hybrid system: regulated expression arrays and two-phase mating. Genome Res. 2003;13:2691-9 pubmed
    ..We also present a three-dimensional pooling scheme to further increase the efficiency of large-scale two-hybrid analyses. ..
  8. Murali T, Pacifico S, Yu J, Guest S, Roberts G, Finley R. DroID 2011: a comprehensive, integrated resource for protein, transcription factor, RNA and gene interactions for Drosophila. Nucleic Acids Res. 2011;39:D736-43 pubmed publisher
    ..Improvements have been made to the web and graphical interfaces to help biologists gain a comprehensive view of the interaction networks relevant to the genes and systems that they study. ..
  9. Li C, Naren A. Analysis of CFTR interactome in the macromolecular complexes. Methods Mol Biol. 2011;741:255-70 pubmed publisher
    ..This chapter describes methods we developed to cross-link CFTR into a macromolecular complex to identify and analyze the assembly and regulation of CFTR-containing complexes in the plasma membrane. ..

More Information


  1. Henderson M, Wirak G, Zhang Y, Dai F, Ginsberg S, Dolzhanskaya N, et al. Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Acta Neuropathol. 2016;131:621-37 pubmed publisher
    ..Our findings establish a functional link between two forms of NCL and serve as a springboard for investigations of NCL disease pathways. ..
  2. Pacifico S, Liu G, Guest S, Parrish J, Fotouhi F, Finley R. A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila. BMC Bioinformatics. 2006;7:195 pubmed
    ..By providing access to all of the available information from a variety of data types, the program will also facilitate advanced computational analyses. ..
  3. Sbrissa D, Ikonomov O, Fenner H, Shisheva A. ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality. J Mol Biol. 2008;384:766-79 pubmed publisher
    ..Our data indicate that the PAS complex is organized to provide optimal PIKfyve functionality and is maintained via ArPIKfyve homomeric and heteromeric interactions. ..
  4. Puliyappadamba V, Wu W, Bevis D, Zhang L, Polin L, Kilkuskie R, et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011;286:38000-17 pubmed publisher
  5. Gu H, Zheng Y, Roizman B. Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention. J Virol. 2013;87:10244-54 pubmed publisher
    ..A faithful execution of these steps defines the ultimate productivity of the virus. ..