Experts and Doctors on periplasmic proteins in Ann Arbor, Michigan, United States


Locale: Ann Arbor, Michigan, United States
Topic: periplasmic proteins

Top Publications

  1. Shao F, Bader M, Jakob U, Bardwell J. DsbG, a protein disulfide isomerase with chaperone activity. J Biol Chem. 2000;275:13349-52 pubmed
    ..DsbG is one of the first periplasmic proteins shown to have general chaperone activity. This ability to chaperone protein folding is likely to increase the effectiveness of DsbG as a protein disulfide isomerase. ..
  2. Hiniker A, Bardwell J. In vivo substrate specificity of periplasmic disulfide oxidoreductases. J Biol Chem. 2004;279:12967-73 pubmed
  3. Hiniker A, Ren G, Heras B, Zheng Y, Laurinec S, Jobson R, et al. Laboratory evolution of one disulfide isomerase to resemble another. Proc Natl Acad Sci U S A. 2007;104:11670-5 pubmed
    ..5 billion years of evolution. Our findings suggest that, for these two proteins at least, regions important in determining functional differences may represent only a tiny fraction of the overall protein structure. ..
  4. Collet J, Riemer J, Bader M, Bardwell J. Reconstitution of a disulfide isomerization system. J Biol Chem. 2002;277:26886-92 pubmed
    ..We also determined the redox potential of the gamma domain to be -241 mV, and that of the alpha domain was found to be -229 mV. This shows that the direction of electron flow within DsbD is thermodynamically driven. ..
  5. Koldewey P, Stull F, Horowitz S, Martin R, Bardwell J. Forces Driving Chaperone Action. Cell. 2016;166:369-379 pubmed publisher
    ..By allowing the client to fold itself, Spy circumvents the need for client-specific folding instructions. This mechanism might help explain how chaperones can facilitate the folding of various unrelated proteins. ..