Experts and Doctors on pax2 transcription factor in Ann Arbor, Michigan, United States


Locale: Ann Arbor, Michigan, United States
Topic: pax2 transcription factor

Top Publications

  1. Lechner M, Levitan I, Dressler G. PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin. Nucleic Acids Res. 2000;28:2741-51 pubmed
    ..Pax2 and PTIP co-localize in the cell nucleus to actively expressed chromatin and the nuclear matrix fraction. For the first time, these results point to a link between Pax transcription factors and active chromatin. ..
  2. MCDANIEL A, Palanisamy N, Smith S, Robinson D, Wu Y, Chinnaiyan A, et al. A subset of solitary fibrous tumors express nuclear PAX8 and PAX2: a potential diagnostic pitfall. Histol Histopathol. 2016;31:223-30 pubmed publisher
    ..This presents a diagnostic pitfall when evaluating possible metastases from the kidney, particularly when primary tumors show sarcomatoid or spindle cell morphologies. ..
  3. Cho E, Patterson L, Brookhiser W, Mah S, Kintner C, Dressler G. Differential expression and function of cadherin-6 during renal epithelium development. Development. 1998;125:803-12 pubmed
    ..These data suggest that cadherin-6 function is required for the early aggregation of induced mesenchymal cells and their subsequent conversion to epithelium. ..
  4. Cai Y, Lechner M, Nihalani D, Prindle M, Holzman L, Dressler G. Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation. J Biol Chem. 2002;277:1217-22 pubmed
    ..The data demonstrate that Pax2 is a new target for the JNK signaling module and point to a novel mechanism for mediating Pax-dependent transcription regulation. ..
  5. Brophy P, Lang K, Dressler G. The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor. J Biol Chem. 2003;278:52401-5 pubmed
  6. Patel S, Dressler G. Expression of Pax2 in the intermediate mesoderm is regulated by YY1. Dev Biol. 2004;267:505-16 pubmed
    ..These data point to a novel role for YY1 in the establishment of high level tissue-specific expression within the intermediate mesoderm. ..
  7. Gong K, Yallowitz A, Sun H, Dressler G, Wellik D. A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol Cell Biol. 2007;27:7661-8 pubmed
    ..Thus, anterior-posterior-patterning Hox proteins interact with Pax2 and Eya1, factors important for nephrogenic mesoderm specification, to directly regulate the activation of downstream target genes during early kidney development. ..
  8. Patel S, Kim D, Levitan I, Dressler G. The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell. 2007;13:580-92 pubmed
    ..Embryonic lethal ptip-null mutants and conditional mutants both show reduced levels of methylated H3K4. Thus, PTIP bridges DNA-binding developmental regulators to histone methyltransferase-dependent epigenetic regulation. ..
  9. Yallowitz A, Gong K, Swinehart I, Nelson L, Wellik D. Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo. Dev Biol. 2009;335:156-65 pubmed publisher

More Information


  1. Roh M, Yassin Y, Miron A, Mehra K, Mehrad M, Monte N, et al. High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression. Mod Pathol. 2010;23:1316-24 pubmed publisher
    ..PAX2 and PTEN, in addition to p53 and p16(ink4), comprise a potentially important gene combination in high-grade pelvic carcinogenesis...
  2. Chervenak A, Hakim I, Barald K. Spatiotemporal expression of Zic genes during vertebrate inner ear development. Dev Dyn. 2013;242:897-908 pubmed publisher
    ..Zic expression domains overlap with sites of WNT and SHH signaling during otocyst patterning, suggesting a role for Zic genes in modulating signaling from these pathways. ..
  3. Brophy P, Ostrom L, Lang K, Dressler G. Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development. 2001;128:4747-56 pubmed
    ..Thus, activation of GDNF by Pax2 coordinates the position and outgrowth of the ureteric bud such that kidney development can begin. ..
  4. Warner S, Hutson M, Oh S, Gerlach Bank L, Lomax M, Barald K. Expression of ZIC genes in the development of the chick inner ear and nervous system. Dev Dyn. 2003;226:702-12 pubmed
    ..These observations suggest that ZIC genes, in addition to their known roles in brain development, may play an important role in the development of the chick inner ear. ..
  5. Wasco M, Pu R. Comparison of PAX-2, RCC antigen, and antiphosphorylated H2AX antibody (gamma-H2AX) in diagnosing metastatic renal cell carcinoma by fine-needle aspiration. Diagn Cytopathol. 2008;36:568-73 pubmed publisher
    ..A combination of all 3 markers identified 87% of cases, and failure to stain for both PAX-2 and gamma-H2AX suggests against, but does not disprove, a diagnosis of RCC. ..
  6. Swanson C, Evans N, Barolo S. Structural rules and complex regulatory circuitry constrain expression of a Notch- and EGFR-regulated eye enhancer. Dev Cell. 2010;18:359-70 pubmed publisher
  7. Soofi A, Levitan I, Dressler G. Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys. Dev Biol. 2012;365:241-50 pubmed publisher
    ..These experiments provide new insight into the role of Pax2 protein levels in determining correct renal architecture and cell fate. These new Pax2 alleles are valuable genetic reagents for in vivo studies of urogenital development. ..
  8. Knoepp S, Kunju L, Roh M. Utility of PAX8 and PAX2 immunohistochemistry in the identification of renal cell carcinoma in diagnostic cytology. Diagn Cytopathol. 2012;40:667-72 pubmed publisher
    ..Overall, the results indicate that PAX8 and PAX2 are diagnostically useful adjuncts in confirming the diagnosis of RCC in cytology specimens. ..