Experts and Doctors on pancreatitis in Ann Arbor, Michigan, United States

Summary

Locale: Ann Arbor, Michigan, United States
Topic: pancreatitis

Top Publications

  1. Collins M, Bednar F, Zhang Y, Brisset J, Galban S, Galban C, et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest. 2012;122:639-53 pubmed publisher
    ..They also strongly support the notion that inhibiting KrasG12D, or its downstream effectors, could provide a new approach for the treatment of pancreatic cancer. ..
  2. Elmunzer B, Scheiman J, Lehman G, Chak A, Mosler P, Higgins P, et al. A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis. N Engl J Med. 2012;366:1414-22 pubmed publisher
    ..03). Among patients at high risk for post-ERCP pancreatitis, rectal indomethacin significantly reduced the incidence of the condition. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT00820612.). ..
  3. Elmunzer B, Noureldin M, Morgan K, Adams D, Cote G, Waljee A. The Impact of Cholecystectomy After Endoscopic Sphincterotomy for Complicated Gallstone Disease. Am J Gastroenterol. 2017;112:1596-1602 pubmed publisher
    ..This benefit did not appear to be outweighed by surgical complications, highlighting the importance of cholecystectomy, even in elderly patients whose lifespans may be limited by unrelated conditions. ..
  4. Sans M, DiMagno M, D Alecy L, Williams J. Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F. Am J Physiol Gastrointest Liver Physiol. 2003;285:G517-28 pubmed
  5. Hong S, Misek D, Wang H, Puravs E, Giordano T, Greenson J, et al. An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer. Cancer Res. 2004;64:5504-10 pubmed
    ..The detection of autoantibodies to calreticulin isoforms may have utility for the early diagnosis of pancreatic cancer. ..
  6. Sanchez R, Lobert P, Herman R, O Malley R, Mychaliska G. Wandering spleen causing gastric outlet obstruction and pancreatitis. Pediatr Radiol. 2010;40 Suppl 1:S89-91 pubmed publisher
    ..We present an unusual case of wandering spleen causing pancreatitis and gastric outlet obstruction via direct external compression. ..
  7. Elmunzer B, Higgins P, Saini S, Scheiman J, Parker R, Chak A, et al. Does rectal indomethacin eliminate the need for prophylactic pancreatic stent placement in patients undergoing high-risk ERCP? Post hoc efficacy and cost-benefit analyses using prospective clinical trial data. Am J Gastroenterol. 2013;108:410-5 pubmed publisher
    ..A RCT comparing rectal indomethacin alone vs. indomethacin plus PSP is needed. ..
  8. Cotton P, Durkalski V, Romagnuolo J, Pauls Q, Fogel E, Tarnasky P, et al. Effect of endoscopic sphincterotomy for suspected sphincter of Oddi dysfunction on pain-related disability following cholecystectomy: the EPISOD randomized clinical trial. JAMA. 2014;311:2101-9 pubmed publisher
    ..Abdominal pain after cholecystectomy is common and may be attributed to sphincter of Oddi dysfunction. Management often involves endoscopic retrograde cholangiopancreatography (ERCP) with manometry and sphincterotomy...
  9. Vaughn V, Shuster D, Rogers M, Mann J, Conte M, Saint S, et al. Early Versus Delayed Feeding in Patients With Acute Pancreatitis: A Systematic Review. Ann Intern Med. 2017;166:883-892 pubmed publisher
    ..Acute pancreatitis is among the most common and costly reasons for hospitalization in the United States. Bowel rest, pain control, and intravenous fluids are the cornerstones of treatment, but early feeding might also be beneficial...

More Information

Publications15

  1. Ham J, Ordóñez E, Wilkerson R. Care of Acute Gastrointestinal Conditions in the Observation Unit. Emerg Med Clin North Am. 2017;35:571-587 pubmed publisher
  2. Ji B, Chen X, Misek D, Kuick R, Hanash S, Ernst S, et al. Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator. Physiol Genomics. 2003;14:59-72 pubmed
    ..Thus this study identified EGR-1 and several other novel genes likely to be important in the development and severity of acute pancreatitis. ..
  3. DiMagno M, Williams J, Hao Y, Ernst S, Owyang C. Endothelial nitric oxide synthase is protective in the initiation of caerulein-induced acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2004;287:G80-7 pubmed
    ..Thus eNOS is the main isoform influencing the initiation of caerulein-induced AP. eNOS-derived NO exerts a protective effect through actions on nonacinar cell types, most likely endothelial cells, to produce greater PMBF. ..
  4. Ivashchenko C, Duan S, Usher M, Mortensen R. PPAR-gamma knockout in pancreatic epithelial cells abolishes the inhibitory effect of rosiglitazone on caerulein-induced acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2007;293:G319-26 pubmed
    ..These data show that the PPAR-gamma in the pancreatic epithelia and islets is important in suppressing inflammation and is required for the anti-inflammatory effects of TZDs in acute pancreatitis. ..
  5. Chen X, Sans M, Strahler J, Karnovsky A, Ernst S, Michailidis G, et al. Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas. J Proteome Res. 2010;9:885-96 pubmed publisher
    ..These results suggest that the early stages of AP involve changes of multiple RER proteins that may affect the synthesis and processing of digestive enzymes. ..
  6. DelGiorno K, Hall J, Takeuchi K, Pan F, Halbrook C, Washington M, et al. Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology. 2014;146:233-44.e5 pubmed publisher
    ..Tuft cells express a number of tumorigenic factors that can alter the microenvironment. Expression of SOX17 induces pancreatitis and promotes Kras(G12D)-induced tumorigenesis in mice. ..