Experts and Doctors on nitric oxide synthase type iii in Ann Arbor, Michigan, United States
Locale: Ann Arbor, Michigan, United States
Topic: nitric oxide synthase type iii
DiMagno M, Hao Y, Tsunoda Y, Williams J, Owyang C. Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice. Am J Physiol Gastrointest Liver Physiol. 2004;286:G428-36 pubmed
..eNOS likely plays a dominant role, because eNOS deletion mimics NOS blockade by inhibiting CCK-8 and carbachol-stimulated secretion, whereas nNOS deletion augments CCK-8 but not carbachol-stimulated secretion. ..
Duan S, Ivashchenko C, Whitesall S, D Alecy L, Duquaine D, Brosius F, et al
. Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J Clin Invest. 2007;117:812-22 pubmed
..Surprisingly, genetic loss of PPARgamma function, like activation by agonists, lowered blood pressure, likely through a mechanism involving increased vascular relaxation. ..
Shu L, Park J, Byun J, Pennathur S, Kollmeyer J, Shayman J. Decreased nitric oxide bioavailability in a mouse model of Fabry disease. J Am Soc Nephrol. 2009;20:1975-85 pubmed publisher
..These findings are consistent with a loss of NO bioavailability, associated with eNOS uncoupling, in the alpha-galactosidase A-knockout mouse. ..
DiMagno M, Williams J, Hao Y, Ernst S, Owyang C. Endothelial nitric oxide synthase is protective in the initiation of caerulein-induced acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2004;287:G80-7 pubmed
..Thus eNOS is the main isoform influencing the initiation of caerulein-induced AP. eNOS-derived NO exerts a protective effect through actions on nonacinar cell types, most likely endothelial cells, to produce greater PMBF. ..
Bodary P, Shen Y, Vargas F, Bi X, Ostenso K, Gu S, et al
. Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency. Circulation. 2005;111:629-32 pubmed
..These findings suggest that deficiency of Gla leads to increased inducible nitric oxide synthase expression and accelerated atherosclerosis. ..
Kang J, Shu L, Park J, Shayman J, Bodary P. Endothelial nitric oxide synthase uncoupling and microvascular dysfunction in the mesentery of mice deficient in ?-galactosidase A. Am J Physiol Gastrointest Liver Physiol. 2014;306:G140-6 pubmed publisher
..Overall, the mesenteric microvessels in the setting of Fabry disease were observed to have an early and profound endothelial dysfunction associated with elevated reactive nitrogen species and decreased nitric oxide bioavailability. ..