Genomes and Genes
Experts and Doctors on molecular sequence data in Ann Arbor, Michigan, United States
Locale: Ann Arbor, Michigan, United States
Topic: molecular sequence data
Publications365 found, 100 shown here
- Peacock M, Murman D, Sima A, Warren J, Roses A, Fink J. Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease. Ann Neurol. 1994;35:432-8 pubmed..The BglII restriction fragment length polymorphism enables investigators to determine the frequency of this polymorphism in normal subjects and Alzheimer's disease patients. ..
- Chen M, Todd Turla K, Wang W, Cao X, Smart A, Brosius F, et al. Endothelin-1 mRNA in glomerular and epithelial cells of kidney. Am J Physiol. 1993;265:F542-50 pubmed..Our results are consistent with the proposal that ET-1 modifies tubular function in an autocrine or paracrine fashion...
- Griffith A, Radice G, Burgess D, Kohrman D, Hansen G, Justice M, et al. Location of the 9257 and ataxia mutations on mouse chromosome 18. Mamm Genome. 1996;7:417-9 pubmed..Two polymorphic microsatellite markers for proximal Chr 18 are described, D18Umi1 and D18Umi2. The Lama3 locus encoding the alpha 3 subunit of nicein was mapped distal to ataxia and did not recombine with Tg9257. ..
- Puro D, Hwang J, Kwon O, Chin H. Characterization of an L-type calcium channel expressed by human retinal Müller (glial) cells. Brain Res Mol Brain Res. 1996;37:41-8 pubmed
- Gong T, Hegeman A, Shin J, Lindberg K, Barald K, Lomax M. Novel genes expressed in the chick otocyst during development: identification using differential display of RNA. Int J Dev Neurosci. 1997;15:585-94 pubmed..These results identified both the avian and human homologues of an evolutionarily conserved gene encoding a small acidic protein of unknown function; however, expression of this gene was not restricted to otocysts. ..
- Stuckey J, Dixon J. Crystal structure of a phospholipase D family member. Nat Struct Biol. 1999;6:278-84 pubmed publisher..Large-scale genomic sequencing revealed that there are many PLD family members. Our results suggest that all of these proteins may possess a common structure and catalytic mechanism...
- Teter S, Eggerton K, Scott S, Kim J, Fischer A, Klionsky D. Degradation of lipid vesicles in the yeast vacuole requires function of Cvt17, a putative lipase. J Biol Chem. 2001;276:2083-7 pubmed..The active-site serine of this motif is required for subvacuolar vesicle lysis. This is the first characterization of a putative lipase implicated in vacuolar function in yeast. ..
- Chong H, Lee J, Guan K. Positive and negative regulation of Raf kinase activity and function by phosphorylation. EMBO J. 2001;20:3716-27 pubmed..elegans. Our results demonstrate that different members of the Raf family kinases have both common and distinct phosphorylation mechanisms to regulate kinase activity and biological function. ..
- Tyler J, Mills M, Friedman D. The operator and early promoter region of the Shiga toxin type 2-encoding bacteriophage 933W and control of toxin expression. J Bacteriol. 2004;186:7670-9 pubmed..This finding provides direct evidence that measurable expression of the stx genes encoded by a 933W prophage requires induction of that prophage with the concomitant initiation of phage gene expression. ..
- Fogg V, Liu C, Margolis B. Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells. J Cell Sci. 2005;118:2859-69 pubmed..Our results suggest that Crumbs3 plays an important role in epithelial tight junction formation, and also provide the first known functional role for the mammalian Crumbs FERM binding domain. ..
- Karow D, Pan D, Davis J, Behrends S, Mathies R, Marletta M. Characterization of functional heme domains from soluble guanylate cyclase. Biochemistry. 2005;44:16266-74 pubmed..003/min at 37 degrees C. This paper has identified and characterized the minimum functional ligand-binding heme domain derived from sGC, providing key details toward a comprehensive characterization. ..
- Zhao X, Nothwehr S, Lara Lemus R, Zhang B, Peter H, Arvan P. Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly. Traffic. 2007;8:1829-40 pubmed..These data underscore importance of the Vps35 PRLYL motif in retromer subcomplex interactions and function. ..
- Wittkopp P, Stewart E, Arnold L, Neidert A, Haerum B, Thompson E, et al. Intraspecific polymorphism to interspecific divergence: genetics of pigmentation in Drosophila. Science. 2009;326:540-4 pubmed publisher..These alleles appear to predate speciation, which suggests that standing genetic variation present in the common ancestor gave rise to both intraspecific polymorphism and interspecific divergence. ..
- Lamanna A, Karbstein K. An RNA conformational switch regulates pre-18S rRNA cleavage. J Mol Biol. 2011;405:3-17 pubmed publisher..More generally, our data show that the intrinsic ability of RNA to form stable structural switches is exploited to order and regulate RNA-dependent biological processes. ..
- Lee K, Kuczera K, Banaszak Holl M. The severity of osteogenesis imperfecta: a comparison to the relative free energy differences of collagen model peptides. Biopolymers. 2011;95:182-93 pubmed publisher..The calculated free energy differences between an oxidized and a reduced form of the mutants containing two Cys residues are 0.8 and 2.6 kcal/mol for the disulfide bonds between Chains A and B and between Chains A and C, respectively. ..
- Zhang C, Walker A, Zand R, Moscarello M, Yan J, Andrews P. Myelin basic protein undergoes a broader range of modifications in mammals than in lower vertebrates. J Proteome Res. 2012;11:4791-802 pubmed publisher..The combined data from this study and information from previous studies extend the known MBP PTMs, and PTMs unique to higher vertebrates are proposed. ..
- Yadlapalli S, Yamashita Y. Chromosome-specific nonrandom sister chromatid segregation during stem-cell division. Nature. 2013;498:251-4 pubmed publisher..We propose that nonrandom sister chromatid segregation may serve to transmit distinct information carried on two sister chromatids to the daughters of asymmetrically dividing stem cells. ..
- Yao X, Grant B. Domain-opening and dynamic coupling in the ?-subunit of heterotrimeric G proteins. Biophys J. 2013;105:L08-10 pubmed publisher..Moreover simulations reveal nucleotide-dependent dynamical couplings of distal regions and residues potentially important for the allosteric link between functional sites. ..
- McGrath J, Terzaghi W, Sridhar P, Cashmore A, Pichersky E. Sequence of the fourth and fifth Photosystem II type I chlorophyll a/b-binding protein genes of Arabidopsis thaliana and evidence for the presence of a full complement of the extended CAB gene family. Plant Mol Biol. 1992;19:725-33 pubmed..thaliana. The number of genes encoding each CAB type in A. thaliana was estimated to be similar to that of tomato. ..
- Burrows H, Seasholtz A, Camper S. Localization of the corticotropin-releasing hormone receptor gene on mouse chromosome 11. Mamm Genome. 1995;6:55-6 pubmed
- Pei D, Weiss S. Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Nature. 1995;375:244-7 pubmed
- Albertson N, Koomey M. Molecular cloning and characterization of a proline iminopeptidase gene from Neisseria gonorrhoeae. Mol Microbiol. 1993;9:1203-11 pubmed..Pip expression was found to be non-essential for in vitro growth of N. gonorrhoeae, based on the viability of a Pip- gonococcal mutant. ..
- Richards J, Lichter P, Boehnke M, Uro J, Torrez D, Wong D, et al. Mapping of a gene for autosomal dominant juvenile-onset open-angle glaucoma to chromosome Iq. Am J Hum Genet. 1994;54:62-70 pubmed..This represents the second juvenile-glaucoma family, in which the disease has been mapped to the long arm of chromosome 1. ..
- Chiang P, Wang S, Smithivas P, Song W, Ramamoorthy S, Hillman J, et al. Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h. Genomics. 1996;34:328-33 pubmed..These data indicate that SUPT6H and Supt6h are functionally analogous to SPT6 and emb-5 and may therefore regulate transcription through establishment or maintenance of chromatin structure. ..
- Del Valle J, Gantz I. Novel insights into histamine H2 receptor biology. Am J Physiol. 1997;273:G987-96 pubmed..The novel observation that histamine may stimulate c-fos gene expression lends further support to the possible role of this receptor in regulating cell growth and differentiation. ..
- Swain P, Chen S, Wang Q, Affatigato L, Coats C, Brady K, et al. Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration. Neuron. 1997;19:1329-36 pubmed..This data suggests that mutations in the CRX gene are associated with photoreceptor degeneration and that the Crx protein is necessary for the maintenance of normal cone and rod function. ..
- Drozdowski B, Gong T, Lomax M. The chicken cDNA for ornithine decarboxylase antizyme. Biochim Biophys Acta. 1998;1396:21-6 pubmed..The chick antizyme protein sequence predicted by translational frameshifting of the mRNA is 216 amino acids long and is more similar to Xenopus antizyme than to the mammalian protein. ..
- Welihinda A, Tirasophon W, Green S, Kaufman R. Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Mol Cell Biol. 1998;18:1967-77 pubmed..These results demonstrate that Ptc2p downregulates the UPR by dephosphorylating Ire1p and reveal a novel mechanism of regulation in the UPR pathway upstream of the HAC1 mRNA splicing event. ..
- Yang T, Cui J, Rehumtulla A, Yang A, Moussalli M, Kaufman R, et al. The structure and function of murine factor V and its inactivation by protein C. Blood. 1998;91:4593-9 pubmed..Thus, the structure and function of FV and its interaction with APC are highly conserved across mammalian species. ..
- Boore J, Daehler L, Brown W. Complete sequence, gene arrangement, and genetic code of mitochondrial DNA of the cephalochordate Branchiostoma floridae (Amphioxus). Mol Biol Evol. 1999;16:410-8 pubmed publisher..Protein genes end with complete (TAA or TAG) or incomplete (T or TA) stop codons; the latter are presumably converted to TAA by post-transcriptional polyadenylation...
- Wang Y, Johnson A, Ye Q, Dyer R. Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain. J Biol Chem. 1999;274:33043-9 pubmed..MT4-MMP is, therefore, a competent Zn(2+)-dependent MMP with unique specificity among synthetic substrates and the capability to both degrade gelatin and activate progelatinase A. ..
- Lee S, Fan S, Makarova O, Straight S, Margolis B. A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia. Mol Cell Biol. 2002;22:1778-91 pubmed..Our data identify evolutionarily conserved protein-protein interaction domains that link mLin-2/CASK to SAP97 and account for their common phenotype when mutated in mice. ..
- Chiang S, Hwang J, Legendre M, Zhang M, Kimura A, Saltiel A. TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J. 2003;22:2679-91 pubmed..Thus, TCGAP may act as a downstream effector of TC10 in the regulation of insulin-stimulated glucose transport. ..
- Abe A, Hiraoka M, Wild S, Wilcoxen S, Paine R, Shayman J. Lysosomal phospholipase A2 is selectively expressed in alveolar macrophages. J Biol Chem. 2004;279:42605-11 pubmed..Thus LPLA2 may be a major enzyme of pulmonary surfactant phospholipid degradation by alveolar macrophages and may be deficient in disorders of surfactant metabolism. ..
- Wilkinson J, Richter B, Wilkinson A, Burstein E, Rumble J, Balliu B, et al. VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. J Biol Chem. 2004;279:51091-9 pubmed..Finally, VIAF is a substrate for ubiquitination mediated by Op-IAP. Thus, VIAF is a novel IAP-interacting factor that functions in caspase activation during apoptosis. ..
- Zhou J, Xu Z. The structural view of bacterial translocation-specific chaperone SecB: implications for function. Mol Microbiol. 2005;58:349-57 pubmed..Recent studies also show the presence of a second zinc-independent SecB binding site in SecA and the new interaction might contribute to the function of SecB. ..
- Ulintz P, Bodenmiller B, Andrews P, Aebersold R, Nesvizhskii A. Investigating MS2/MS3 matching statistics: a model for coupling consecutive stage mass spectrometry data for increased peptide identification confidence. Mol Cell Proteomics. 2008;7:71-87 pubmed..This work also addresses the overall value of generating MS(3) data as compared with an MS(2)-only approach with a focus on the analysis of phosphopeptide data. ..
- Maine G, Mao X, Muller P, Komarck C, Klomp L, Burstein E. COMMD1 expression is controlled by critical residues that determine XIAP binding. Biochem J. 2009;417:601-9 pubmed publisher..In summary, our findings indicate that COMMD1 expression is controlled primarily by protein ubiquitination, and its interaction with IAP proteins plays an essential role. ..
- Brender J, Nanga R, Popovych N, Soong R, Macdonald P, Ramamoorthy A. The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency. Biochim Biophys Acta. 2011;1808:1161-9 pubmed publisher..This is another noticeable difference between PAP(248-286) and other amyloid peptides, which generally show penetration into at least the headgroup region of the bilayer, and may explain some of the unusual properties of SEVI...
- Li X, Rydzewski N, Hider A, Zhang X, Yang J, Wang W, et al. A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation. Nat Cell Biol. 2016;18:404-17 pubmed publisher..Ca(2+) release from lysosomes thus provides an on-demand mechanism regulating lysosome motility, positioning and tubulation. ..
- Bachman N, Lomax M, Grossman L. Two bovine genes for cytochrome c oxidase subunit IV: a processed pseudogene and an expressed gene. Gene. 1987;55:219-29 pubmed
- Meng F, Xie G, Thompson R, Mansour A, Goldstein A, Watson S, et al. Cloning and pharmacological characterization of a rat kappa opioid receptor. Proc Natl Acad Sci U S A. 1993;90:9954-8 pubmed..These observations indicate that we have cloned a cDNA encoding a rat kappa receptor of the kappa 1 subtype. ..
- Salleh H, Patel M, Woodard R. Essential cysteines in 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase from Escherichia coli: analysis by chemical modification and site-directed mutagenesis. Biochemistry. 1996;35:8942-7 pubmed
- Malhotra J, Kazen Gillespie K, Hortsch M, Isom L. Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. J Biol Chem. 2000;275:11383-8 pubmed..It is hypothesized that sodium channel beta subunits serve as a critical communication link between the extracellular and intracellular environments of the neuron and may play a role in sodium channel placement at nodes of Ranvier. ..
- Hall D, Jordan Starck T, Loo R, Ludwig M, Matthews R. Interaction of flavodoxin with cobalamin-dependent methionine synthase. Biochemistry. 2000;39:10711-9 pubmed..Identification of these cross-linked residues provides evidence in support of a docking model that will be useful in predicting the effects of mutations observed in mammalian homologues of E. coli flavodoxin and methionine synthase. ..
- Lee M, Schiefelbein J. Developmentally distinct MYB genes encode functionally equivalent proteins in Arabidopsis. Development. 2001;128:1539-46 pubmed..These results provide new insights into the evolution of the MYB gene family in Arabidopsis, and, more generally, they demonstrate that novel developmental gene function may arise solely by the modification of cis-regulatory sequences. ..
- Figueroa C, Tarras S, Taylor J, Vojtek A. Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. J Biol Chem. 2003;278:47922-7 pubmed
- Ling S, Lai A, Borschukova O, Pumpens P, Holoshitz J. Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope. Arthritis Rheum. 2006;54:3423-32 pubmed..SE-triggered increased NO levels inhibited cytolytic elimination of target cells. The SE can trigger NO-mediated signaling events in opposite cells, and may thereby contribute to RA pathogenesis. ..
- He C, Bartholomew C, Zhou W, Klionsky D. Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. Autophagy. 2009;5:520-6 pubmed..In addition, zebrafish Gabarap accumulates within lysosomes upon autophagy induction. Thus, we established a convenient zebrafish tool to assay autophagic activity during embryogenesis in vivo. ..
- Contreras Galindo R, Kaplan M, Contreras Galindo A, Gonzalez Hernandez M, Ferlenghi I, Giusti F, et al. Characterization of human endogenous retroviral elements in the blood of HIV-1-infected individuals. J Virol. 2012;86:262-76 pubmed publisher..This study suggests that HERV-K (HML-2) is active in HIV-1-infected patients, and the resulting RNA message reveals previously undiscovered HERV-K (HML-2) genomic sequences. ..
- Tan J, Jones M, Koseki H, Nakayama M, Muntean A, Maillard I, et al. CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell. 2011;20:563-75 pubmed publisher..Surprisingly, Cbx8-deficient mice are viable and display no apparent hematopoietic defects. Together, our findings demonstrate that CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis. ..
- Parmacek M, Leiden J. Structure and expression of the murine slow/cardiac troponin C gene. J Biol Chem. 1989;264:13217-25 pubmed
- Wu J, Dunham W, Weiss B. Overproduction and physical characterization of SoxR, a [2Fe-2S] protein that governs an oxidative response regulon in Escherichia coli. J Biol Chem. 1995;270:10323-7 pubmed..The protein is active in its oxidized ([2Fe-2S]2+) state. The presence of a prosthetic group capable of univalent redox reactions may help to explain the activation of the regulon in vivo by compounds that can mediate such reactions...
- Buckwalter M, Cook S, Davisson M, White W, Camper S. A frameshift mutation in the mouse alpha 1 glycine receptor gene (Glra1) results in progressive neurological symptoms and juvenile death. Hum Mol Genet. 1994;3:2025-30 pubmed..The identification of the oscillator mutation suggests that severe loss of function alleles in humans would result in prenatal or neonatal lethality. ..
- Bodmer R. The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development. 1993;118:719-29 pubmed
- Zheng C, Friedman D. Reduced Rho-dependent transcription termination permits NusA-independent growth of Escherichia coli. Proc Natl Acad Sci U S A. 1994;91:7543-7 pubmed..Thus, NusA-dependent coupling should be less important in a mutant with low Rho activity. The fact that E. coli grows without NusA argues that NusA should be considered an accessory factor rather than a subunit of RNA polymerase. ..
- Zheng C, Guan K. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J Biol Chem. 1993;268:11435-9 pubmed..However, the recombinant MEK2 can be activated by serum-stimulated cell extract in vitro. MEKs, in a manner similar to ERKs, are likely to consist of a family of related proteins playing critical roles in signal transduction. ..
- Pan G, O Rourke K, Chinnaiyan A, Gentz R, Ebner R, Ni J, et al. The receptor for the cytotoxic ligand TRAIL. Science. 1997;276:111-3 pubmed..Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis. ..
- Bespalova I, Burmeister M. Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse. Genomics. 2000;63:69-74 pubmed..Radiation hybrid mapping localized human LMCD1 to the telomeric region of chromosome 3p, and genetic mapping assigned the mouse Lmcd1 locus to the central region of chromosome 6. ..
- Park I, Klug C, Li K, Jerabek L, Li L, Nanamori M, et al. Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. J Biol Chem. 2001;276:915-23 pubmed..This suggests RGS18 can act on G(q)-mediated signaling pathways in vivo. ..
- Chen P, Cho S, Jin S, Ellis R. Specification of germ cell fates by FOG-3 has been conserved during nematode evolution. Genetics. 2001;158:1513-25 pubmed..elegans hermaphrodites, we propose that alterations in the upstream sex-determination pathway, perhaps acting through TRA-1A, allow spermatogenesis in C. elegans and C. briggsae XX larvae but not in C. remanei. ..
- Yuri T, Mindell D. Molecular phylogenetic analysis of Fringillidae, "New World nine-primaried oscines" (Aves: Passeriformes). Mol Phylogenet Evol. 2002;23:229-43 pubmed publisher..Consequently, the thraupine clade includes only Neotropical species. Increasing evidence suggests that Fringillidae, often called "New World nine-primaried oscines," does not in fact have a New World origin...
- Kent C, Gee P, Lee S, Bian X, Fenno J. A CDP-choline pathway for phosphatidylcholine biosynthesis in Treponema denticola. Mol Microbiol. 2004;51:471-81 pubmed..Thus it appears that T. denticola does contain a licCA-dependent CDP-choline pathway for phosphatidylcholine biosynthesis. ..
- Brender J, Hartman K, Reid K, Kennedy R, Ramamoorthy A. A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicity. Biochemistry. 2008;47:12680-8 pubmed publisher..Our results indicate that the modulation of the peptide orientation in the membrane by His18 plays a key role in the toxicity of nonamyloidogenic forms of hIAPP. ..
- Bates C, Pomerantz W, Mapp A. Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators. Biopolymers. 2011;95:17-23 pubmed publisher..Collectively these small KIX-binding molecules will be useful tools for dissecting the role of the KIX domain in a variety of pathological processes. ..
- Maricic N, Anderson E, Opipari A, Yu E, Dawid S. Characterization of a Multipeptide Lantibiotic Locus in Streptococcus pneumoniae. MBio. 2016;7:e01656-15 pubmed publisher..The broad inhibitory activity of pneumolancidin makes it an ideal candidate for further characterization and development. ..
- Marchuk D, Saulino A, Tavakkol R, Swaroop M, Wallace M, Andersen L, et al. cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. Genomics. 1991;11:931-40 pubmed..The gene extends for approximately 300 kb on chromosome 17, with its promoter in a CpG-rich island. ..
- Kendall S, Gordon D, Birkmeier T, Petrey D, Sarapura V, O Shea K, et al. Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone alpha-subunit transgene in thyrotropes, gonadotropes, and developing pituitary gland. Mol Endocrinol. 1994;8:1420-33 pubmed
- Gersten K, Natsuka S, Trinchera M, Petryniak B, Kelly R, Hiraiwa N, et al. Molecular cloning, expression, chromosomal assignment, and tissue-specific expression of a murine alpha-(1,3)-fucosyltransferase locus corresponding to the human ELAM-1 ligand fucosyl transferase. J Biol Chem. 1995;270:25047-56 pubmed..Epithelial cell-specific expression of this gene suggests function(s) in addition to, and distinct from, its proposed role in selectin ligand synthesis. ..
- Nicoletti A, Wong D, Kawase K, Gibson L, Yang Feng T, Richards J, et al. Molecular characterization of the human gene encoding an abundant 61 kDa protein specific to the retinal pigment epithelium. Hum Mol Genet. 1995;4:641-9 pubmed
- Begley D, Murphy A, Hiu C, Tsubota S. Modifier of rudimentary p1, mod(r)p1, a trans-acting regulatory mutation of rudimentary. Mol Gen Genet. 1995;248:69-78 pubmed..Consistent with this possibility is the fact that mod(r) acts through the 5' control region of the rudimentary gene to control its expression. ..
- Chinnaiyan A, O Rourke K, Yu G, Lyons R, Garg M, Duan D, et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science. 1996;274:990-2 pubmed..DR3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD, TRAF2, FADD, and FLICE. Thus, DR3 likely plays a role in regulating lymphocyte homeostasis. ..
- Payne A, Abbaszade I, Clarke T, Bain P, Park C. The multiple murine 3 beta-hydroxysteroid dehydrogenase isoforms: structure, function, and tissue- and developmentally specific expression. Steroids. 1997;62:169-75 pubmed..Further analysis of mouse genomic DNA by pulse field gel electrophoresis suggests that all of the Hsd3b gene family is found within a 400-kb fragment. ..
- Labbe S, Zhu Z, Thiele D. Copper-specific transcriptional repression of yeast genes encoding critical components in the copper transport pathway. J Biol Chem. 1997;272:15951-8 pubmed..Therefore, yeast cells coordinately express genes involved in high affinity copper transport through the action of a common signaling pathway. ..
- Domino S, Hiraiwa N, Lowe J. Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells. Biochem J. 1997;327 ( Pt 1):105-15 pubmed
- Muse W, Bender R. The nac (nitrogen assimilation control) gene from Escherichia coli. J Bacteriol. 1998;180:1166-73 pubmed..Attempts to purify NAC(E) by using methods established for NAC(K) failed, and NAC(E) appears to be degraded with a half-life at 30 degrees C as short as 15 min during inhibition of protein synthesis. ..
- Sun Y. Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection. Carcinogenesis. 1999;20:1899-903 pubmed..The results indicate that the C-terminal zinc RING finger domain is required for anti-apoptosis activity of SAG. ..
- Escayg A, Heils A, MacDonald B, Haug K, Sander T, Meisler M. A novel SCN1A mutation associated with generalized epilepsy with febrile seizures plus--and prevalence of variants in patients with epilepsy. Am J Hum Genet. 2001;68:866-73 pubmed..The SCN1A haplotypes and SNPs identified here will be useful in future association and linkage studies. ..
- Kalikin L, Bugeaud E, Palmbos P, Lyons R, Petty E. Genomic characterization of human SEC14L1 splice variants within a 17q25 candidate tumor suppressor gene region and identification of an unrelated embedded expressed sequence tag. Mamm Genome. 2001;12:925-9 pubmed..Coding exon-specific PCR primers were designed to aid in future expression and mutational analyses. ..
- Zhao J, Peng P, Schmitz R, Decker A, Tax F, Li J. Two putative BIN2 substrates are nuclear components of brassinosteroid signaling. Plant Physiol. 2002;130:1221-9 pubmed..We propose that BES1/BZR1 are two nuclear components of BR signaling that are negatively regulated by BIN2 through a phosphorylation-initiated process. ..
- Hou P, Estrada L, Kinley A, Parsons J, Vojtek A, Gorski J. Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape. Hum Mol Genet. 2003;12:1981-93 pubmed
- Chen F, D Auria J, Tholl D, Ross J, Gershenzon J, Noel J, et al. An Arabidopsis thaliana gene for methylsalicylate biosynthesis, identified by a biochemical genomics approach, has a role in defense. Plant J. 2003;36:577-88 pubmed..Upon thrip damage to leaves, AtBSMT1 promoter activity was induced specifically around the lesions. ..
- Mandal M, Heckenlively J, Burch T, Chen L, Vasireddy V, Koenekoop R, et al. Sequencing arrays for screening multiple genes associated with early-onset human retinal degenerations on a high-throughput platform. Invest Ophthalmol Vis Sci. 2005;46:3355-62 pubmed..In addition, these arrays offer a unique opportunity to interrogate complex patterns of inheritance due to the involvement of more than one gene by screening multiple genes on a single platform. ..
- Barnhart M, Chapman M. Curli biogenesis and function. Annu Rev Microbiol. 2006;60:131-47 pubmed..Curli provide a unique system to study macromolecular assembly in bacteria and in vivo amyloid fiber formation. Here, we review curli biogenesis, regulation, role in biofilm formation, and role in pathogenesis. ..
- Graves C, Philips S, Bradley S, Oravecz Wilson K, Li L, Gauvin A, et al. Use of a cryptic splice site for the expression of huntingtin interacting protein 1 in select normal and neoplastic tissues. Cancer Res. 2008;68:1064-73 pubmed publisher..Our data show how knowledge of the transcript that is produced by a knockout allele can lead to discovery of novel types of molecular compensation at the level of splicing. ..
- Yang Y, Xu R, Ma C, Vlot A, Klessig D, Pichersky E. Inactive methyl indole-3-acetic acid ester can be hydrolyzed and activated by several esterases belonging to the AtMES esterase family of Arabidopsis. Plant Physiol. 2008;147:1034-45 pubmed publisher..Our results demonstrate that MeIAA is an inactive form of IAA, and the manifestations of MeIAA in vivo activity are due to the action of free IAA that is generated from MeIAA upon hydrolysis by one or more plant esterases. ..
- Zhou W, Hildebrandt F. Molecular cloning and expression of phospholipase C epsilon 1 in zebrafish. Gene Expr Patterns. 2009;9:282-8 pubmed publisher..Our results suggest that zebrafish may be used as a model organism to address the function of PLCepsilon during the development of these organs. ..
- Chen Y, Kelly V, Stachura S, Garcia G. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. RNA. 2010;16:958-68 pubmed publisher..hQTRTD1 has been implicated as the salvage enzyme that generates free queuine from QMP. Work is ongoing in our laboratory to confirm this activity. ..