Experts and Doctors on liver microsomes in Ann Arbor, Michigan, United States
Locale: Ann Arbor, Michigan, United States
Topic: liver microsomes
You Z, Brezzell M, Das S, Espadas Torre M, Hooberman B, Sinsheimer J. ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives. Mutat Res. 1993;319:19-30 pubmed
..In contrast to the in vitro results, while all the amines were genotoxic in vivo, only the 3-nitro derivative had a significant increase in toxicity over benzidine. ..
Das A, Uhler M, Hajra A. Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs. J Biol Chem. 2000;275:24333-40 pubmed publisher
..Northern blot analysis demonstrated that a single transcript of 1.3 kilobases is present in most mouse tissues, with particularly high concentrations in liver and kidney...
Peterkin V, Bauman J, Goosen T, Menning L, Man M, Paulauskis J, et al
. Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes. Br J Clin Pharmacol. 2007;64:458-68 pubmed
..For the UGT2B7*2 polymorphism, genotype had no influence on immunoreactive UGT2B7 protein or the rate of 3'-azido-3'-deoxythymidine glucuronidation. ..
Kostrubsky S, Strom S, Ellis E, Nelson S, Mutlib A. Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites. Chem Res Toxicol. 2007;20:1503-12 pubmed
..The data also suggest a possible drug-drug interaction between flutamide and APAP, resulting in inhibition of flutamide metabolism and increased APAP bioactivation and toxicity...