Experts and Doctors on inositol in Detroit, Michigan, United States


Locale: Detroit, Michigan, United States
Topic: inositol

Top Publications

  1. Ikonomov O, Petrov T, Soden K, Shisheva A, Manji H. Lithium treatment in ovo: effects on embryonic heart rate, natural death of ciliary ganglion neurons, and brain expression of a highly conserved chicken homolog of human MTG8/ETO. Brain Res Dev Brain Res. 2000;123:13-24 pubmed
    ..We propose that the induction of ETO expression, in concert with lithium-induced upregulation of other genes, such as PEBP2beta and bcl-2, is participating in the neuroprotective effect of chronic lithium treatment. ..
  2. Zhong Q, Greenberg M. Regulation of phosphatidylglycerophosphate synthase by inositol in Saccharomyces cerevisiae is not at the level of PGS1 mRNA abundance. J Biol Chem. 2003;278:33978-84 pubmed
    ..Thus, whereas inositol controls phosphatidylglycerophosphate synthase activity, regulation of PGS1 expression occurs primarily in response to mitochondrial development cues. ..
  3. Gardocki M, Lopes J. Expression of the yeast PIS1 gene requires multiple regulatory elements including a Rox1p binding site. J Biol Chem. 2003;278:38646-52 pubmed
    ..Furthermore, PI levels were elevated under anaerobic conditions. This is the first evidence that PI levels are affected by regulation of PIS1 transcription. ..
  4. Ju S, Greenberg M. Valproate disrupts regulation of inositol responsive genes and alters regulation of phospholipid biosynthesis. Mol Microbiol. 2003;49:1595-603 pubmed
    ..Thus, in contrast to the effect of chronic VPA treatment, short-term exposure to VPA abrogated the normal response to inositol depletion of inositol responsive genes and led to aberrant synthesis of phospholipids. ..
  5. He Q, Greenberg M. Post-translational regulation of phosphatidylglycerolphosphate synthase in response to inositol. Mol Microbiol. 2004;53:1243-9 pubmed
    ..This is the first evidence of phosphorylation of a phospholipid biosynthetic enzyme in response to inositol and identifies a new mechanism of inositol-mediated regulation. ..
  6. Shi Y, Vaden D, Ju S, Ding D, Geiger J, Greenberg M. Genetic perturbation of glycolysis results in inhibition of de novo inositol biosynthesis. J Biol Chem. 2005;280:41805-10 pubmed
    ..This study is the first to establish a connection between perturbation of glycolysis and inhibition of de novo inositol biosynthesis. ..
  7. Li G, Chen S, Thompson M, Greenberg M. New insights into the regulation of cardiolipin biosynthesis in yeast: implications for Barth syndrome. Biochim Biophys Acta. 2007;1771:432-41 pubmed
    ..Further characterization of these regulatory mechanisms holds great potential for the identification of novel functions of CL in mitochondrial and cellular processes. ..
  8. Ding D, Shi Y, Shaltiel G, Azab A, Pullumbi E, Campbell A, et al. Yeast bioassay for identification of inositol depleting compounds. World J Biol Psychiatry. 2009;10:893-9 pubmed publisher
    ..Inositol depletion in yeast may be exploited as an easy and inexpensive screening test for potential new inositol depleting anti-bipolar drugs. ..
  9. Yu W, Daniel J, Mehta D, Maddipati K, Greenberg M. MCK1 is a novel regulator of myo-inositol phosphate synthase (MIPS) that is required for inhibition of inositol synthesis by the mood stabilizer valproate. PLoS ONE. 2017;12:e0182534 pubmed publisher
    ..These findings indicate that VPA-induced MIPS inhibition is Mck1-dependent, and suggest a model that unifies two current hypotheses of the mechanism of action of VPA-inositol depletion and GSK3 inhibition. ..

More Information


  1. Murray M, Greenberg M. Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate. Mol Microbiol. 2000;36:651-61 pubmed
    ..Both lithium and valproate, which cause a decrease in intracellular inositol, effect a decrease in INM1 expression. A model is presented to account for regulation of INM1 expression. ..
  2. Yu W, Ye C, Greenberg M. Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells. J Biol Chem. 2016;291:10437-44 pubmed publisher
    ..This is the first demonstration of IP6K1 as a novel negative regulator of inositol synthesis in mammalian cells. ..
  3. Chen L, Lopes J. Multiple bHLH proteins regulate CIT2 expression in Saccharomyces cerevisiae. Yeast. 2010;27:345-59 pubmed publisher
    ..Collectively, these results support the model that yeast bHLH proteins coordinate different biological pathways. ..
  4. O Leary Moore S, Galloway M, McMechan A, Irtenkauf S, Hannigan J, Bowen S. Neurochemical changes after acute binge toluene inhalation in adolescent and adult rats: a high-resolution magnetic resonance spectroscopy study. Neurotoxicol Teratol. 2009;31:382-9 pubmed publisher
  5. Jani N, Lopes J. Transcription regulation of the Saccharomyces cerevisiae PIS1 gene by inositol and the pleiotropic regulator, Ume6p. Mol Microbiol. 2008;70:1529-39 pubmed publisher
    ..Thus, we demonstrate novel regulation of the PIS1 gene by Ume6p. ..
  6. Azab A, He Q, Ju S, Li G, Greenberg M. Glycogen synthase kinase-3 is required for optimal de novo synthesis of inositol. Mol Microbiol. 2007;63:1248-58 pubmed
    ..These results demonstrate for the first time that GSK-3 is required for optimal myo-inositol-3 phosphate synthase activity and de novo inositol biosynthesis, and that loss of GSK-3 activity causes inositol depletion. ..
  7. Hancock L, Behta R, Lopes J. Genomic analysis of the Opi- phenotype. Genetics. 2006;173:621-34 pubmed
    ..Regulation in response to inositol is also coordinated with the unfolded protein response (UPR). Consistent with this, several Opi(-) mutants were found to affect the UPR (yhi9, ede1, and vps74). ..
  8. Ju S, Shaltiel G, Shamir A, Agam G, Greenberg M. Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast. J Biol Chem. 2004;279:21759-65 pubmed
    ..Because inositol metabolism may play a key role in the etiology and treatment of bipolar illness, functional conservation of the key enzyme in inositol biosynthesis underscores the power of the yeast model in studies of this disorder. ..