Experts and Doctors on glycine receptors in Ann Arbor, Michigan, United States

Summary

Locale: Ann Arbor, Michigan, United States
Topic: glycine receptors

Top Publications

  1. McDonald J, Garofalo E, Hood T, Sackellares J, Gilman S, McKeever P, et al. Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy. Ann Neurol. 1991;29:529-41 pubmed
    ..The data indicate that excitatory and inhibitory amino acid receptors are altered in the hippocampus of patients with temporal lobe epilepsy. ..
  2. Buckwalter M, Cook S, Davisson M, White W, Camper S. A frameshift mutation in the mouse alpha 1 glycine receptor gene (Glra1) results in progressive neurological symptoms and juvenile death. Hum Mol Genet. 1994;3:2025-30 pubmed
    ..The identification of the oscillator mutation suggests that severe loss of function alleles in humans would result in prenatal or neonatal lethality. ..
  3. Hirata H, Saint Amant L, Downes G, Cui W, Zhou W, Granato M, et al. Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor beta-subunit. Proc Natl Acad Sci U S A. 2005;102:8345-50 pubmed
    ..Because GlyR mutations in humans lead to hyperekplexia, a motor disorder characterized by startle responses, the zebrafish beo mutant should be a useful animal model for this condition. ..
  4. Holland K, Fleming M, Cheek S, Moran J, Beier D, Meisler M. De novo exon duplication in a new allele of mouse Glra1 (spasmodic). Genetics. 2006;174:2245-7 pubmed
    ..The mutant transcript results in premature protein truncation. A direct repeat of the pentamer GGGGC is present adjacent to the breakpoints and may have mediated the duplication event by a replication slippage mechanism...