Experts and Doctors on drosophila proteins in Detroit, Michigan, United States


Locale: Detroit, Michigan, United States
Topic: drosophila proteins

Top Publications

  1. Dong Y, Friedrich M. Comparative analysis of Wingless patterning in the embryonic grasshopper eye. Dev Genes Evol. 2005;215:177-97 pubmed
  2. Jiang Q, Akashi S, Miyake K, Petty H. Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-kappa B. J Immunol. 2000;165:3541-4 pubmed
    ..Therefore, we suggest that a close interaction between CD14 and TLR4 participates in LPS signaling, leading to nuclear translocation of NF-kappaB. ..
  3. Dey B, Lightbody J, Boschelli F. CDC37 is required for p60v-src activity in yeast. Mol Biol Cell. 1996;7:1405-17 pubmed
    ..These results suggest that Cdc37p is required for maintenance of p60v-src in a soluble, biologically active form. ..
  4. McDonald P, Maizi B, Arking R. Chemical regulation of mid- and late-life longevities in Drosophila. Exp Gerontol. 2013;48:240-9 pubmed publisher
    ..These studies may help to shed light on the frailty syndrome affecting some aging organisms. ..
  5. Deng X, Meller V. Molecularly severe roX1 mutations contribute to dosage compensation in Drosophila. Genesis. 2009;47:49-54 pubmed publisher
    ..We propose that this represents genetic complementation between a source of roX RNA (the autosomal transgene) and the severely mutated X-linked allele. ..
  6. Yu J, Pacifico S, Liu G, Finley R. DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions. BMC Genomics. 2008;9:461 pubmed publisher
    ..DroID is available at ..
  7. Kolonin M, Finley R. A role for cyclin J in the rapid nuclear division cycles of early Drosophila embryogenesis. Dev Biol. 2000;227:661-72 pubmed
    ..We obtained similar results by injecting cyclin J antibodies into embryos. Our results suggest that a cyclin J-associated kinase activity is required for the early embryonic division cycles. ..
  8. Dorsten J, Kolodziej P, VanBerkum M. Frazzled regulation of myosin II activity in the Drosophila embryonic CNS. Dev Biol. 2007;308:120-32 pubmed
    ..Therefore, the P3 motif of Frazzled appears to initiate Rho and Abl dependent signals to directly or indirectly regulate myosin II activity in growth cones. ..
  9. Swaminathan A, Pile L. Regulation of cell proliferation and wing development by Drosophila SIN3 and String. Mech Dev. 2010;127:96-106 pubmed publisher
    ..A SIN3 knock down phenotype can be suppressed by overexpression either of STG or of Cdk1, the target of STG phosphatase. These data link SIN3 and STG in a genetic pathway that affects cell cycle progression in a developing tissue. ..

More Information


  1. Menon D, Meller V. Imprinting of the Y chromosome influences dosage compensation in roX1 roX2 Drosophila melanogaster. Genetics. 2009;183:811-20 pubmed publisher
    ..We believe that the Y chromosome is likely to act through modulation of a process that is defective in roX1 roX2 mutants: X chromosome recognition or chromatin modification by the MSL complex...
  2. Barnes V, Strunk B, Lee I, Huttemann M, Pile L. Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function. BMC Biochem. 2010;11:26 pubmed publisher
    ..The findings that both yeast and Drosophila SIN3 affect mitochondrial activity suggest an evolutionarily conserved role for SIN3 in the control of cellular energy production. ..
  3. Deng X, Koya S, Kong Y, Meller V. Coordinated regulation of heterochromatic genes in Drosophila melanogaster males. Genetics. 2009;182:481-91 pubmed publisher
    ..roX transcripts may thus participate in two distinct regulatory systems that have evolved in response to highly differentiated sex chromosomes: compensation of X-linked gene dosage and modulation of heterochromatin. ..
  4. Friedrich M, Caravas J. New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone. J Exp Zool B Mol Dev Evol. 2011;316:387-92 pubmed publisher
    ..Taken together, these findings identify Drosophila eyg as the baptizing member of an ancient Pax gene subfamily and recommend abandoning its classification as Pax6(5a)-related gene. ..
  5. Menon D, Meller V. A role for siRNA in X-chromosome dosage compensation in Drosophila melanogaster. Genetics. 2012;191:1023-8 pubmed publisher
    ..Our findings are consistent with a role for siRNA in selective recognition of X chromatin. ..
  6. Ristić G, Tsou W, Guzi E, Kanack A, SCAGLIONE K, Todi S. USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila. J Biol Chem. 2016;291:9161-72 pubmed publisher
    ..Our work indicates that a primary physiological role of USP5 is not to recycle monoubiquitin for reutilization, but that it may involve disassembly of conjugated ubiquitin to maintain proteasome function. ..
  7. Pacifico S, Liu G, Guest S, Parrish J, Fotouhi F, Finley R. A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila. BMC Bioinformatics. 2006;7:195 pubmed
    ..By providing access to all of the available information from a variety of data types, the program will also facilitate advanced computational analyses. ..
  8. Kim Y, Furman S, Sink H, VanBerkum M. Calmodulin and profilin coregulate axon outgrowth in Drosophila. J Neurobiol. 2001;47:26-38 pubmed
    ..Together, our data indicate that the growth cone must coordinate the activity of both calmodulin and profilin in order to advance past selected choice points, including those dictating midline crossovers. ..
  9. Deng X, Rattner B, Souter S, Meller V. The severity of roX1 mutations is predicted by MSL localization on the X chromosome. Mech Dev. 2005;122:1094-105 pubmed
    ..This ability predicts the level of male survival that each allele supports. This points to a peripheral or transient role for roX in the RNA and protein complex that binds to and regulates the X chromosome. ..
  10. Murali T, Pacifico S, Yu J, Guest S, Roberts G, Finley R. DroID 2011: a comprehensive, integrated resource for protein, transcription factor, RNA and gene interactions for Drosophila. Nucleic Acids Res. 2011;39:D736-43 pubmed publisher
    ..Improvements have been made to the web and graphical interfaces to help biologists gain a comprehensive view of the interaction networks relevant to the genes and systems that they study. ..
  11. Kolonin M, Finley R. Targeting cyclin-dependent kinases in Drosophila with peptide aptamers. Proc Natl Acad Sci U S A. 1998;95:14266-71 pubmed
    ..Combined, our results demonstrate that peptide aptamers generated by yeast two-hybrid methods can serve as inhibitory reagents to target specific proteins in vivo. ..
  12. Hsouna A, Kim Y, VanBerkum M. Abelson tyrosine kinase is required to transduce midline repulsive cues. J Neurobiol. 2003;57:15-30 pubmed
    ..How Abl functions in this role is not yet clear, but we suggest that Abl may help regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. ..
  13. Spain M, Caruso J, Swaminathan A, Pile L. Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. J Biol Chem. 2010;285:27457-67 pubmed publisher
    ..Together our findings suggest that SIN3 isoforms serve distinct roles in transcriptional regulation by partnering with different histone-modifying enzymes. ..
  14. Deng X, Meller V. roX RNAs are required for increased expression of X-linked genes in Drosophila melanogaster males. Genetics. 2006;174:1859-66 pubmed
    ..These results implicate failure to compensate X-linked genes, rather than inappropriate upregulation of autosomal genes at ectopic sites of MSL binding, as the primary cause of male lethality upon loss of roX RNAs. ..
  15. de Mendoza A, Jones J, Friedrich M. Methuselah/Methuselah-like G protein-coupled receptors constitute an ancient metazoan gene family. Sci Rep. 2016;6:21801 pubmed publisher
    ..In addition, our findings identify Mthl1, Mthl5, Mthl14, and Mthl15 as the oldest Mth/Mthl gene family paralogs in Drosophila. Future studies of these genes have the potential to define ancestral functions of the Mth/Mthl gene family. ..
  16. Liu Z, Friedrich M. The Tribolium homologue of glass and the evolution of insect larval eyes. Dev Biol. 2004;269:36-54 pubmed publisher
  17. Liu L, Jiang Y, Steinle J. Inhibition of HMGB1 protects the retina from ischemia-reperfusion, as well as reduces insulin resistance proteins. PLoS ONE. 2017;12:e0178236 pubmed publisher
    ..Taken together, these results suggest that inhibition of HMGB1 can reduce retinal insulin resistance, as well as protect the retina against I/R-induced damage. ..
  18. Yee J, Szamosfalvi B. A new mesangial triumvirate: sulfonylureas, their receptors and endosulfines. Exp Nephrol. 2002;10:1-6 pubmed
    ..In this article, the current knowledge regarding the metabolic and functional consequences of a mesangial triumvirate of sulfonylureas, their sulfonylurea receptors and sulfonylurea-like ligands termed endosulfines will be reviewed...
  19. Yang X, Weber M, Zarinkamar N, Posnien N, Friedrich F, Wigand B, et al. Probing the Drosophila retinal determination gene network in Tribolium (II): The Pax6 genes eyeless and twin of eyeless. Dev Biol. 2009;333:215-27 pubmed publisher
    ..The results from embryonic knockdown and comparative protein sequence analysis lead us further to conclude that Tribolium represents an ancestral state of redundant control by ey and toy...
  20. Balan V, Miller G, Kaplun L, Balan K, Chong Z, Li F, et al. Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem. 2008;283:27810-9 pubmed publisher
    ..Together, our findings establish a life span extending the ability of nicotinamidase in flies and offer a role for nicotinamide-modulating genes in oxidative stress regulated pathways influencing longevity and neuronal cell survival. ..
  21. Kondapalli K, Kok N, Dancis A, Stemmler T. Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly. Biochemistry. 2008;47:6917-27 pubmed publisher
    ..Finally, frataxin mediates the delivery of Fe(II) to Isu, promoting Fe-S cluster assembly in vitro. The Dfh-assisted assembly of Fe-S clusters occurs with an observed kinetic rate constant ( k obs) of 0.096 min (-1). ..
  22. Deng X, Meller V. Non-coding RNA in fly dosage compensation. Trends Biochem Sci. 2006;31:526-32 pubmed
    ..Several recent studies in Drosophila provide new insight into the principles of X-chromosome recognition and the function of non-coding RNA in this process. ..
  23. Liu D, Finley R. Cyclin Y is a novel conserved cyclin essential for development in Drosophila. Genetics. 2010;184:1025-35 pubmed publisher
    ..Like CycY, the Eip63E gene has essential functions during embryogenesis, larval development, and metamorphosis. Our data suggest that CycY/Eip63E form a cyclin/Cdk complex that is essential for several developmental processes. ..
  24. Dorsten J, Varughese B, Karmo S, Seeger M, VanBerkum M. In the absence of frazzled over-expression of Abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS. PLoS ONE. 2010;5:e9822 pubmed publisher
    ..In the absence of Fra, increased Abl activity appears to be incorrectly utilized downstream of other guidance receptors resulting in a loss of commissures and the abnormal projections of some axons beyond the CNS/PNS border. ..
  25. Fritz J, VanBerkum M. Calmodulin and son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS. Development. 2000;127:1991-2000 pubmed
    ..These data suggest that Calmodulin and Son of sevenless signaling pathways function to interpret midline repulsive cues which prevent axons crossing the midline. ..
  26. Yang Y, Cochran D, Gargano M, King I, Samhat N, Burger B, et al. Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50. Mol Biol Cell. 2011;22:976-87 pubmed publisher
    ..We hypothesize that the CG34110/Ccdc135/FAP50 family of conserved flagellar proteins functions within the axoneme to mediate Pkd2-dependent processes in the sperm flagellum and other motile cilia. ..
  27. Patel M, Hallal D, Jones J, Bronner D, Zein R, Caravas J, et al. Dramatic expansion and developmental expression diversification of the methuselah gene family during recent Drosophila evolution. J Exp Zool B Mol Dev Evol. 2012;318:368-87 pubmed publisher
    ..Taken together, our findings shed novel light on mth as a young member of an adaptively evolving developmental gene family. ..
  28. Kambouris M, Jackson C, Feldman G. Diagnosis of multiple endocrine neoplasia [MEN] 2A, 2B and familial medullary thyroid cancer [FMTC] by multiplex PCR and heteroduplex analyses of RET proto-oncogene mutations. Hum Mutat. 1996;8:64-70 pubmed
    ..Confirmation of the specific mutation can be achieved by restriction enzymatic digestion (if feasible) or by DNA sequencing...
  29. Hsouna A, VanBerkum M. Abelson tyrosine kinase and Calmodulin interact synergistically to transduce midline guidance cues in the Drosophila embryonic CNS. Int J Dev Neurosci. 2008;26:345-54 pubmed publisher
  30. Whetstine J, Witt T, Matherly L. The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism. J Biol Chem. 2002;277:43873-80 pubmed
    ..Moreover, they document a functionally novel polymorphism that increases promoter activity and may contribute to interpatient variations in hRFC expression and effects on tissue folate homeostasis and antitumor response to antifolates. ..
  31. Yang X, Zarinkamar N, Bao R, Friedrich M. Probing the Drosophila retinal determination gene network in Tribolium (I): The early retinal genes dachshund, eyes absent and sine oculis. Dev Biol. 2009;333:202-14 pubmed publisher
    ..Taken together, our data reveal conservation but also evolutionary plasticity of the Drosophila retinal determination gene network in insects...
  32. Kagey J, Brown J, Moberg K. Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched. Mech Dev. 2012;129:339-49 pubmed publisher