Experts and Doctors on carrier proteins in Ann Arbor, Michigan, United States


Locale: Ann Arbor, Michigan, United States
Topic: carrier proteins

Top Publications

  1. Kanelakis K, Murphy P, Galigniana M, Morishima Y, Takayama S, Reed J, et al. hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1. Biochemistry. 2000;39:14314-21 pubmed
    ..We conclude that Hip is not a component of the assembly machinery but that it could play a regulatory role in opposition to BAG-1. ..
  2. Zhou H, Thiele D. Identification of a novel high affinity copper transport complex in the fission yeast Schizosaccharomyces pombe. J Biol Chem. 2001;276:20529-35 pubmed
    ..These studies in S. pombe identify Ctr4 and Ctr5 as components of a novel eukaryotic heteromeric plasma membrane complex that is essential for high affinity copper transport. ..
  3. Worby C, Simonson Leff N, Clemens J, Kruger R, Muda M, Dixon J. The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton. J Biol Chem. 2001;276:41782-9 pubmed
    ..This evidence places DSH3PX1 in a complex linking cell surface receptors like Dscam to proteins involved in cytoskeletal rearrangements and/or receptor trafficking. ..
  4. Keller E, Fu Z, Yeung K, Brennan M. Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene. Cancer Lett. 2004;207:131-7 pubmed
    ..In this review, RKIP biology and its role in cancer will be described. ..
  5. Patel S, Kim D, Levitan I, Dressler G. The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell. 2007;13:580-92 pubmed
    ..Embryonic lethal ptip-null mutants and conditional mutants both show reduced levels of methylated H3K4. Thus, PTIP bridges DNA-binding developmental regulators to histone methyltransferase-dependent epigenetic regulation. ..
  6. Maine G, Mao X, Muller P, Komarck C, Klomp L, Burstein E. COMMD1 expression is controlled by critical residues that determine XIAP binding. Biochem J. 2009;417:601-9 pubmed publisher
    ..In summary, our findings indicate that COMMD1 expression is controlled primarily by protein ubiquitination, and its interaction with IAP proteins plays an essential role. ..
  7. Guan K, Jenkins C, Li Y, Nichols M, Wu X, O Keefe C, et al. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 1994;8:2939-52 pubmed
    ..Ectopic expression of p18 or p16 suppresses cell growth with a correlated dependence on endogenous wild-type pRb. ..
  8. Brock T, Paine R, Peters Golden M. Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells. J Biol Chem. 1994;269:22059-66 pubmed
    ..The finding that a substantial proportion of enzyme is localized within the nucleus of unstimulated RBL cells suggests potentially novel roles for 5-LO or its products within the nucleus. ..
  9. Jones J, Ranscht B, Berglund E, Gruenheid S, Gros P, Meisler M. Close linkage of three neuronal genes on distal mouse chromosome 15. Mamm Genome. 1996;7:696-7 pubmed

More Information

Publications225 found, 100 shown here

  1. Guan K, Jenkins C, Li Y, O Keefe C, Noh S, Wu X, et al. Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. Mol Biol Cell. 1996;7:57-70 pubmed
  2. Su G, Klein R, Aminlari A, Zhang H, Steinstraesser L, Alarcon W, et al. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology. 2000;31:932-6 pubmed
    ..LBP plays an important role in mediating Kupffer cell activation by LPS, and these effects are dependent on the presence of functioning Tlr 4. ..
  3. Suzuki M, Desmond T, Albin R, Frey K. Vesicular neurotransmitter transporters in Huntington's disease: initial observations and comparison with traditional synaptic markers. Synapse. 2001;41:329-36 pubmed
    ..There is also markedly reduced expression of ChAT by surviving cholinergic striatal interneurons. ..
  4. Girard S, Vossman E, Misek D, Podevin P, Hanash S, Brechot C, et al. Hepatitis C virus NS5A-regulated gene expression and signaling revealed via microarray and comparative promoter analyses. Hepatology. 2004;40:708-18 pubmed
    ..Supplementary material for this article can be found on the HEPATOLOGY website ( ..
  5. Boorse G, Crespi E, Dautzenberg F, Denver R. Urocortins of the South African clawed frog, Xenopus laevis: conservation of structure and function in tetrapod evolution. Endocrinology. 2005;146:4851-60 pubmed
    ..Our findings show that the functional relationships among CRF ligands and binding proteins, and their anorexigenic actions mediated by the CRF2 receptor, arose early in vertebrate evolution. ..
  6. Fontugne J, Davis K, Palanisamy N, UDAGER A, Mehra R, MCDANIEL A, et al. Clonal evaluation of prostate cancer foci in biopsies with discontinuous tumor involvement by dual ERG/SPINK1 immunohistochemistry. Mod Pathol. 2016;29:157-65 pubmed publisher
  7. Wishart M, Denu J, Williams J, Dixon J. A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase. J Biol Chem. 1995;270:26782-5 pubmed
    ..We believe this is the first example of a naturally occurring "dominant negative" phosphotyrosine/serine/threonine-binding protein which is structurally related to dsPTPases. ..
  8. Inohara N, Ding L, Chen S, Nunez G. harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). EMBO J. 1997;16:1686-94 pubmed
  9. Swaroop M, Moussalli M, Pipe S, Kaufman R. Mutagenesis of a potential immunoglobulin-binding protein-binding site enhances secretion of coagulation factor VIII. J Biol Chem. 1997;272:24121-4 pubmed
    ..Introduction of the F309S mutation into other secretion defective FVIII mutants rescued their secretion, demonstrating the ability of the this mutation to improve secretion of mutant FVIII proteins retained in the cell. ..
  10. Meyer D, Liu A, Margolis B. Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. J Biol Chem. 1999;274:35113-8 pubmed
    ..The interaction of JIP-1 with rhoGEF and its subcellular localization suggests that JIP-1 may function to specifically localize a signaling complex in neuronal cells. ..
  11. Jiang P, Atkinson M, Srisawat C, Sun Q, Ninfa A. Functional dissection of the dimerization and enzymatic activities of Escherichia coli nitrogen regulator II and their regulation by the PII protein. Biochemistry. 2000;39:13433-49 pubmed
  12. Shu C, Shen H, Hopfer U, Smith D. Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: uptake and transport of fosinopril in cell cultures. Drug Metab Dispos. 2001;29:1307-15 pubmed
  13. Kim S, Vacratsis P, Firestein R, Cleary M, Dixon J. Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. Proc Natl Acad Sci U S A. 2003;100:4492-7 pubmed
    ..Through this interaction, MTMR5 increases the enzymatic activity of MTMR2 and dictates its subcellular localization. This article demonstrates an active MTM member being regulated by an inactive family member. ..
  14. Inohara N, Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol. 2003;3:371-82 pubmed
    ..Mammalian NOD proteins seem to function as cytosolic sensors for the induction of apoptosis, as well as for innate recognition of microorganisms and regulation of inflammatory responses. ..
  15. Liu J, Deyoung S, Hwang J, O Leary E, Saltiel A. The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. J Biol Chem. 2003;278:36754-62 pubmed
    ..Thus, both c-Cbl and Cbl-b can initiate a phosphatidylinositol 3-kinase/protein kinase B-independent signaling pathway critical to insulin-stimulated GLUT4 translocation. ..
  16. Buchner D, Trudeau M, George A, Sprunger L, Meisler M. High-resolution mapping of the sodium channel modifier Scnm1 on mouse chromosome 3 and identification of a 1.3-kb recombination hot spot. Genomics. 2003;82:452-9 pubmed
    ..5 cM/Mb. The role of the modifier in other disorders in human and mouse can be tested with linked markers described here. ..
  17. Chen C, Gong Y, Zhang M, Chen J. Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J Biol Chem. 2004;279:25876-82 pubmed
    ..Considered together, these findings demonstrate a critical role for TAK1 in Nod2-mediated innate immune responses and reveal a novel function for Nod2 in the regulation of the TAK1 signaling pathway. ..
  18. Yee E, Melkerson Watson L, Bloch C, Pierson C, Blackwood R. Genomic analysis of penicillin-resistant Streptococcus pneumoniae in Southeastern Michigan. J Infect. 2004;49:126-35 pubmed
    ..pneumoniae population in SE Michigan is not due to expansion of a single or limited number of resistant clones, is occurring most frequently in the paediatric population and is associated with a decreased susceptibility to penicillin. ..
  19. Rui L. A link between protein translation and body weight. J Clin Invest. 2007;117:310-3 pubmed
    ..These findings link protein synthesis, insulin sensitivity, and body weight. ..
  20. Franchi L, Eigenbrod T, Muñoz Planillo R, Nunez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol. 2009;10:241-7 pubmed publisher
    ..Thus, understanding inflammasome pathways may provide insight into disease pathogenesis that might identify potential targets for therapeutic intervention. ..
  21. Muñoz Planillo R, Kuffa P, Martínez Colón G, Smith B, Rajendiran T, Nunez G. K? efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 2013;38:1142-53 pubmed publisher
    ..These results provide a unifying model for the activation of the NLRP3 inflammasome in which a drop in cytosolic K? is the common step that is necessary and sufficient for caspase-1 activation. ..
  22. Bian C, Wu R, CHO K, Yu X. Loss of BRCA1-A complex function in RAP80 null tumor cells. PLoS ONE. 2012;7:e40406 pubmed publisher
    ..Thus, our results demonstrate that RAP80 is a scaffold protein in the BRCA1-A complex. Identification of TOV-21G as a RAP80 null tumor cell line will be very useful for the study of the molecular mechanism in DNA damage response. ..
  23. Olsen S, Uhler M. Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor. Mol Endocrinol. 1991;5:1246-56 pubmed
    ..In these studies, elimination of a conserved alternative translation start site in the 5' untranslated region of PKI was shown to potentiate the inhibitory activity of the PKI expression vector. ..
  24. del Peso L, Gonzalez Garcia M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science. 1997;278:687-9 pubmed
    ..Thus, the proapoptotic function of BAD is regulated by the PI 3-kinase-Akt pathway. ..
  25. Yin W, Fang J, Smiley E, Bonadio J. 8-Cysteine TGF-BP structural motifs are the site of covalent binding between mouse LTBP-3, LTBP-2, and latent TGF-beta 1. Biochim Biophys Acta. 1998;1383:340-50 pubmed
    ..Altogether, these results have important implications for TGF-beta biosynthesis and the regulation of TGF-beta activity. ..
  26. Humke E, Shriver S, Starovasnik M, Fairbrother W, Dixit V. ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell. 2000;103:99-111 pubmed
    ..The distribution of surface charge is complementary to the homologous prodomain of caspase-1, suggesting that charge-charge interactions mediate binding of ICEBERG to the prodomain of caspase-1. ..
  27. Rao D, Hyun T, Kumar P, Mizukami I, Rubin M, Lucas P, et al. Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. J Clin Invest. 2002;110:351-60 pubmed
    ..HIP1 represents a putative prognostic factor for prostate cancer and a potential therapy target in prostate as well as colon cancers. ..
  28. Wang X, Chen L, Maures T, Herrington J, Carter Su C. SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells. J Biol Chem. 2004;279:133-41 pubmed
    ..Taken together, these data indicate that SH2-B is a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway. ..
  29. Hyun T, Li L, Oravecz Wilson K, Bradley S, Provot M, Munaco A, et al. Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1. Mol Cell Biol. 2004;24:4329-40 pubmed
  30. Kukowska Latallo J, Candido K, Cao Z, Nigavekar S, Majoros I, Thomas T, et al. Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer Res. 2005;65:5317-24 pubmed
    ..Targeting methotrexate increased its antitumor activity and markedly decreased its toxicity, allowing therapeutic responses not possible with a free drug...
  31. He S, Parapuram S, Hurd T, Behnam B, Margolis B, Swaroop A, et al. Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies. Vision Res. 2008;48:366-76 pubmed
    ..Our findings indicate that multiple isotypes of RPGR may perform overlapping yet somewhat distinct transport-related functions in photoreceptors. ..
  32. Ikenoue T, Inoki K, Yang Q, Zhou X, Guan K. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008;27:1919-31 pubmed publisher
    ..Our study demonstrates that mTORC2 is involved in post-translational processing of PKC by facilitating TM and HM phosphorylation and reveals a novel function of mTORC2 in cellular regulation. ..
  33. Colston J, Peñataro Yori P, Colantuoni E, Moulton L, Ambikapathi R, Lee G, et al. A methodologic framework for modeling and assessing biomarkers of environmental enteropathy as predictors of growth in infants: an example from a Peruvian birth cohort. Am J Clin Nutr. 2017;106:245-255 pubmed publisher
    ..This association exhibited a complex interaction with age. This trial was registered at as NCT02441426. ..
  34. Hu H, O Rourke K, Boguski M, Dixit V. A novel RING finger protein interacts with the cytoplasmic domain of CD40. J Biol Chem. 1994;269:30069-72 pubmed
    ..This is the first identification of a molecule that interacts with CD40 and whose sequence suggests a potential role in signaling. ..
  35. Coffey M, Wilcoxen S, Peters Golden M. Increases in 5-lipoxygenase activating protein expression account for enhanced capacity for 5-lipoxygenase metabolism that accompanies differentiation of peripheral blood monocytes into alveolar macrophages. Am J Respir Cell Mol Biol. 1994;11:153-8 pubmed
  36. Chaudhry A, Zhang C, Granneman J. Characterization of RII(beta) and D-AKAP1 in differentiated adipocytes. Am J Physiol Cell Physiol. 2002;282:C205-12 pubmed
    ..These results demonstrate that D-AKAP1/S-AKAP84 does not interact with PKA in differentiated C3H/10T1/2 adipocytes under the conditions tested...
  37. Li Y, Inoki K, Yeung R, Guan K. Regulation of TSC2 by 14-3-3 binding. J Biol Chem. 2002;277:44593-6 pubmed
    ..Phosphorylation of Ser(1210) in TSC2 is required for its association with 14-3-3. Our data indicate that 14-3-3 association may inhibit the function of TSC2 and represents a possible mechanism of TSC2 regulation. ..
  38. Rao D, Bradley S, Kumar P, Hyun T, Saint Dic D, Oravecz Wilson K, et al. Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells. Cancer Cell. 2003;3:471-82 pubmed
    ..Thus, HIP1 overexpression promotes tumor formation and is associated with a general alteration in receptor trafficking. HIP1 is the first endocytic protein to be directly implicated in tumor formation. ..
  39. Wilkinson J, Richter B, Wilkinson A, Burstein E, Rumble J, Balliu B, et al. VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. J Biol Chem. 2004;279:51091-9 pubmed
    ..Finally, VIAF is a substrate for ubiquitination mediated by Op-IAP. Thus, VIAF is a novel IAP-interacting factor that functions in caspase activation during apoptosis. ..
  40. Berry J, Ealba E, Pettway G, Datta N, Swanson E, Somerman M, et al. JunB as a downstream mediator of PTHrP actions in cementoblasts. J Bone Miner Res. 2006;21:246-57 pubmed
    ..These data suggest that JunB may be a key mediator of PTHrP actions in cementoblasts. ..
  41. Kim D, Wang M, Cai Q, Brooks H, Dressler G. Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia. J Am Soc Nephrol. 2007;18:1458-65 pubmed
    ..The data suggest an essential role for ptip in regulating urine concentration and in controlling survival of collecting duct epithelial cells in high osmolality. ..
  42. Kanneganti T, Lamkanfi M, Kim Y, Chen G, Park J, Franchi L, et al. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity. 2007;26:433-43 pubmed
  43. Howell V, De Haan G, Bergren S, Jones J, Culiat C, Michaud E, et al. A targeted deleterious allele of the splicing factor SCNM1 in the mouse. Genetics. 2008;180:1419-27 pubmed publisher
    ..The phenotypes of the Scnm1Delta3-5 mutant confirm the role of this splice factor in processing the Scn8a(medJ) transcript and provide a new allele of greater severity for future studies. ..
  44. Buis J, Stoneham T, Spehalski E, Ferguson D. Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2. Nat Struct Mol Biol. 2012;19:246-52 pubmed publisher
    ..Therefore, functions of MRN are not restricted to DNA damage responses but include regulating homologous recombination capacity during the normal mammalian cell cycle. ..
  45. Karasik A, Shanmuganathan A, Howard M, Fierke C, Koutmos M. Nuclear Protein-Only Ribonuclease P2 Structure and Biochemical Characterization Provide Insight into the Conserved Properties of tRNA 5' End Processing Enzymes. J Mol Biol. 2016;428:26-40 pubmed publisher
    ..Our data provide a biochemical and structural framework to begin understanding how nuclear localized PRORPs recognize and cleave their substrates. ..
  46. Syu L, Saltiel A. Lipotransin: a novel docking protein for hormone-sensitive lipase. Mol Cell. 1999;4:109-15 pubmed
    ..Thus, lipotransin is a novel docking protein that may direct the hormonally regulated redistribution of hormone-sensitive lipase. ..
  47. Felius J, Thompson D, Khan N, Bingham E, Jamison J, Kemp J, et al. Clinical course and visual function in a family with mutations in the RPE65 gene. Arch Ophthalmol. 2002;120:55-61 pubmed
    ..The retinal and functional changes in the father carrying a presumed functional null allele suggest that some RPE65 heterozygous carriers may manifest visual symptoms. ..
  48. Lanigan T, Liu A, Huang Y, Mei L, Margolis B, Guan K. Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. FASEB J. 2003;17:2048-60 pubmed
    ..The ability of CNK2 to interact with both Ras effector proteins Raf and Rlf suggests that CNK2 may integrate signals between MAPK and Ral pathways through a complex interplay of components. ..
  49. Yin W, Smiley E, Germiller J, Mecham R, Florer J, Wenstrup R, et al. Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3). J Biol Chem. 1995;270:10147-60 pubmed
    ..Bonadio, J., and Francke, U. (1995) Mamm. Genome 6, 42-45). Identification of a third binding protein provides further insight into a mechanism by which latent TGF-beta complexes can be targeted to connective tissue matrices and cells. ..
  50. Owens Grillo J, Czar M, Hutchison K, Hoffmann K, Perdew G, Pratt W. A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains. J Biol Chem. 1996;271:13468-75 pubmed
  51. Fang J, Li X, Smiley E, Francke U, Mecham R, Bonadio J. Mouse latent TGF-beta binding protein-2: molecular cloning and developmental expression. Biochim Biophys Acta. 1997;1354:219-30 pubmed
    ..Therefore, mouse LTBP-2 may play a critical role in the assembly of latent TGF-beta complexes in developing elastic tissues such as cartilage and blood vessel. ..
  52. Yin W, Smiley E, Bonadio J. Alternative splicing of LTBP-3. Biochem Biophys Res Commun. 1998;245:454-8 pubmed
    ..Therefore, alternative splicing may represent a molecular mechanism by which the uncomplexed form of LTBP-3 is produced, and, as a corollary, by which the 100-kDa latent TGF-beta 1 complex is produced. ..
  53. Wishart M, Dixon J. Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains. Trends Biochem Sci. 1998;23:301-6 pubmed
    ..Thus, the STYX domain adds to the repertoire of modular domains that can mediate intracellular signaling in response to protein phosphorylation. ..
  54. Atkinson M, Ninfa A. Characterization of the GlnK protein of Escherichia coli. Mol Microbiol. 1999;32:301-13 pubmed
  55. Lechner M, Levitan I, Dressler G. PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin. Nucleic Acids Res. 2000;28:2741-51 pubmed
    ..Pax2 and PTIP co-localize in the cell nucleus to actively expressed chromatin and the nuclear matrix fraction. For the first time, these results point to a link between Pax transcription factors and active chromatin. ..
  56. Tamura Y, Ozkan E, Bole D, Ueda T. IPF, a vesicular uptake inhibitory protein factor, can reduce the Ca(2+)-dependent, evoked release of glutamate, GABA and serotonin. J Neurochem. 2001;76:1153-64 pubmed
    ..These results raise the possibility that IPF may modulate synaptic transmission by acting as a quantal size regulator of one or more neurotransmitters. ..
  57. Zhao M, Berry J, Somerman M. Bone morphogenetic protein-2 inhibits differentiation and mineralization of cementoblasts in vitro. J Dent Res. 2003;82:23-7 pubmed
    ..These findings reflect the diverse responses of periodontal cells to BMP-2 and highlight the need to consider the complexity of factors involved in designing predictable regenerative therapies. ..
  58. Yanamadala S, Ljungman M. Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates. Mol Cancer Res. 2003;1:747-54 pubmed
    ..These findings suggest a novel mechanism of MLH1 in the induction p53 and apoptosis by inhibiting RNA polymerase II-dependent transcription on damaged DNA templates. ..
  59. Corradetti M, Inoki K, Bardeesy N, Depinho R, Guan K. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2004;18:1533-8 pubmed
    ..Our results suggest that PJS and other benign tumor syndromes could be caused by dysregulation of the TSC2/mTOR pathway. ..
  60. Cheong H, Yorimitsu T, Reggiori F, Legakis J, Wang C, Klionsky D. Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell. 2005;16:3438-53 pubmed
    ..As a result, it is defective in peroxisome degradation and is partially defective for autophagy. Atg17 interacts with both Atg1 and Atg13, via two coiled-coil domains, and these interactions facilitate its inclusion in the Atg1 complex. ..
  61. Westphal N, Seasholtz A. Gonadotropin-releasing hormone (GnRH) positively regulates corticotropin-releasing hormone-binding protein expression via multiple intracellular signaling pathways and a multipartite GnRH response element in alphaT3-1 cells. Mol Endocrinol. 2005;19:2780-97 pubmed
    ..These data demonstrate novel regulation of pituitary CRH-BP, highlighting the importance of the pituitary gonadotrope as a potential interface between the stress and reproductive axes. ..
  62. Zhang B, McGee B, Yamaoka J, Guglielmone H, Downes K, Minoldo S, et al. Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2. Blood. 2006;107:1903-7 pubmed
  63. Jiang H, Sha S, Schacht J. Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics. J Neurosci Res. 2006;83:1544-51 pubmed
    ..These changes will ultimately contribute to aminoglycoside-induced loss of hair cells. ..
  64. Allison W, Hallows T, Johnson T, Hawryshyn C, Allen D. Photic history modifies susceptibility to retinal damage in albino trout. Vis Neurosci. 2006;23:25-34 pubmed
    ..We conclude that apoptotic demise of rods, but not cones, occurred during light damage in retinas of albino trout and proliferative responses have a limited a capacity to replace lost rods. ..
  65. Lin J, Patel S, Wang M, Dressler G. The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia. Mol Cell Biol. 2006;26:4577-85 pubmed
  66. Hemmila M, Kim J, Sun J, Cannon J, Arbabi S, Minter R, et al. Gene therapy with lipopolysaccharide binding protein for gram-negative pneumonia: respiratory physiology. J Trauma. 2006;61:598-605; discussion 605-6 pubmed
    ..These changes can be prevented in LBP knockout mice by systemic gene therapy to restore innate immunity. ..
  67. Ballou D. Crystallography gets the jump on the enzymologists. Proc Natl Acad Sci U S A. 2007;104:15587-8 pubmed
  68. Albertus D, Seder C, Chen G, Wang X, Hartojo W, Lin L, et al. AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma. J Thorac Oncol. 2008;3:1236-44 pubmed publisher
    ..The presence of AZGP1 serum autoantibody may be used as a prognostic marker in patients with AD. Furthermore, up-regulation of AZGP1 mRNA in AD may be affected by chromatin remodeling by means of histone acetylation. ..
  69. Mao X, Gluck N, Li D, Maine G, Li H, Zaidi I, et al. GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Genes Dev. 2009;23:849-61 pubmed publisher
    ..Collectively, the data indicate that GCN5 participates in the ubiquitination process as an accessory factor for a ubiquitin ligase, where it provides a novel link between phosphorylation and ubiquitination. ..
  70. Jia L, Bickel J, Wu J, Morgan M, Li H, Yang J, et al. RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. J Biol Chem. 2011;286:3379-86 pubmed publisher
    ..RBX-1 silencing also induces lethality during development of embryos and in adulthood. Thus, RBX1 E3 ligase is essential for the maintenance of mammalian genome integrity and the proper development and viability in C. elegans. ..
  71. Venkatareddy M, Cook L, Abuarquob K, Verma R, Garg P. Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin. PLoS ONE. 2011;6:e28710 pubmed publisher
    ..These data provide evidence that Nephrin not only initiates actin polymerization but also assembles a protein complex that is necessary to regulate the architecture of the generated actin filament network and focal adhesion dynamics. ..
  72. Wang M, Miller R. Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress. Aging Cell. 2012;11:668-74 pubmed publisher
    ..Our results suggested that increased autophagy, regulated by TOR-dependent processes, may contribute to stress resistance in fibroblasts from long-lived mutant mice. ..
  73. Nakamura Y, Franchi L, Kambe N, Meng G, Strober W, Nunez G. Critical role for mast cells in interleukin-1?-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Immunity. 2012;37:85-95 pubmed publisher
    ..Thus, the microbiota and MCs initiate cellular events leading to dysregulated IL-1? production and skin inflammation in neonatal mice with the CAPS-associated Nlrp3 mutation. ..
  74. Soofi A, Zhang P, Dressler G. Kielin/chordin-like protein attenuates both acute and chronic renal injury. J Am Soc Nephrol. 2013;24:897-905 pubmed publisher
    ..Thus, these data suggest that extracellular regulation of the TGF-?/BMP signaling axis by KCP, and by extension possibly other cysteine-rich domain proteins, can attenuate both acute and chronic renal injury. ..
  75. Grailer J, Canning B, Kalbitz M, Haggadone M, Dhond R, Andjelkovic A, et al. Critical role for the NLRP3 inflammasome during acute lung injury. J Immunol. 2014;192:5974-83 pubmed publisher
    ..These data indicate an interaction between extracellular histones and the NLRP3 inflammasome, resulting in ALI. Such findings suggest novel targets for treatment of ALI, for which there is currently no known efficacious drug. ..
  76. Elder J, Astrom A, Pettersson U, Voorhees J, Trent J. Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization. Hum Genet. 1992;89:487-90 pubmed
    ..The hCRABP-II gene is therefore localized to a band known to contain several other genes that are expressed in the context of epidermal differentiation, including profilaggrin, loricrin, involucrin, and calcyclin. ..
  77. Williamson R, Oxender D. Sequence and structural similarities between the leucine-specific binding protein and leucyl-tRNA synthetase of Escherichia coli. Proc Natl Acad Sci U S A. 1990;87:4561-5 pubmed
    ..coli may be performed by evolutionarily interrelated proteins. ..
  78. Chinnaiyan A, O Rourke K, Tewari M, Dixit V. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995;81:505-12 pubmed
    ..These findings suggest that FADD may play an important role in the proximal signal transduction of Fas. ..
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