Experts and Doctors on antimanic agents in Detroit, Michigan, United States
Locale: Detroit, Michigan, United States
Topic: antimanic agents
Chen G, Zeng W, Yuan P, Huang L, Jiang Y, Zhao Z, et al
. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. J Neurochem. 1999;72:879-82 pubmed
..These novel findings represent the first report of medication-induced increases in CNS bcl-2 levels and may have implications not only for mood disorders, but also for long-term treatment of various neurodegenerative disorders. ..
Manji H, McNamara R, Chen G, Lenox R. Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness. Aust N Z J Psychiatry. 1999;33 Suppl:S65-83 pubmed
Ding D, Shi Y, Shaltiel G, Azab A, Pullumbi E, Campbell A, et al
. Yeast bioassay for identification of inositol depleting compounds. World J Biol Psychiatry. 2009;10:893-9 pubmed publisher
..Inositol depletion in yeast may be exploited as an easy and inexpensive screening test for potential new inositol depleting anti-bipolar drugs. ..
Wang J, Michelhaugh S, Bannon M. Valproate robustly increases Sp transcription factor-mediated expression of the dopamine transporter gene within dopamine cells. Eur J Neurosci. 2007;25:1982-6 pubmed
..In summary, valproate treatment significantly increased DAT gene expression in a Sp transcription factor-dependent manner. Some of valproate's therapeutic effects may involve activation of DAT gene expression. ..
Yu W, Daniel J, Mehta D, Maddipati K, Greenberg M. MCK1 is a novel regulator of myo-inositol phosphate synthase (MIPS) that is required for inhibition of inositol synthesis by the mood stabilizer valproate. PLoS ONE. 2017;12:e0182534 pubmed publisher
..These findings indicate that VPA-induced MIPS inhibition is Mck1-dependent, and suggest a model that unifies two current hypotheses of the mechanism of action of VPA-inositol depletion and GSK3 inhibition. ..