Genomes and Genes
Experts and Doctors on animals in Ann Arbor, Michigan, United States
Locale: Ann Arbor, Michigan, United States
Publications971 found, 100 shown here
- Bagchi S, He Y, Zhang H, Cao L, Van Rhijn I, Moody D, et al. CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice. J Clin Invest. 2017;127:2339-2352 pubmed publisher..As a large proportion of psoriatic patients are dyslipidemic, this finding is of clinical significance and indicates that self-lipid-reactive T cells might serve as a possible link between hyperlipidemia and psoriasis. ..
- Distler J, Guo J, Sahagian G, Jourdian G. Bovine testicular beta-galactosidase: purification of enzyme fractions that exhibit high affinity for phosphomannosyl receptors. Anal Biochem. 1989;182:432-7 pubmed..The purification procedure also provides highly purified beta-galactosidase suitable for removing beta-galactosidase residues from a variety of complex carbohydrates. ..
- Didier A, Droy Lefaix M, Aurousseau C, Cazals Y. Effects of Ginkgo biloba extract (EGb 761) on cochlear vasculature in the guinea pig: morphometric measurements and laser Doppler flowmetry. Eur Arch Otorhinolaryngol. 1996;253:25-30 pubmed..These findings indicate that EGb 761 may help to improve oxygenation in cochleas with compromised blood flow...
- Schuh J, Power C, Proudfoot A, Kunkel S, Lukacs N, Hogaboam C. Airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4-/- mice. FASEB J. 2002;16:1313-5 pubmed..Peribronchial fibrosis and goblet cell hyperplasia were similar in both groups of mice throughout the course of this model. In summary, CCR4 modulates both innate and acquired immune responses associated with chronic fungal asthma. ..
- Ko M, Lee H, Harrison C, Clark M, Song H, Naughton N, et al. Studies of micro-, kappa-, and delta-opioid receptor density and G protein activation in the cortex and thalamus of monkeys. J Pharmacol Exp Ther. 2003;306:179-86 pubmed..In particular, the relative densities of opioid receptor binding sites in the two brain areas reflect their functional roles in the pharmacological actions of opioids in the central nervous system of primates...
- Malhotra J, Thyagarajan V, Chen C, Isom L. Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes. J Biol Chem. 2004;279:40748-54 pubmed..5 and pYbeta1 and that these complexes are in close association with both N-cadherin and connexin-43. beta1 phosphorylation appears to regulate its localization to differential subcellular domains. ..
- Boabaid F, Berry J, Koh A, Somerman M, McCcauley L. The role of parathyroid hormone-related protein in the regulation of osteoclastogenesis by cementoblasts. J Periodontol. 2004;75:1247-54 pubmed
- Clinton S, Miller S, Watson S, Akil H. Prenatal stress does not alter innate novelty-seeking behavioral traits, but differentially affects individual differences in neuroendocrine stress responsivity. Psychoneuroendocrinology. 2008;33:162-77 pubmed..Future work will explore neural mechanisms which underlie the different behavioral and neuroendocrine consequences of PS in HR versus LR animals. ..
- Zhou Z, Peng X, Insolera R, Fink D, Mata M. Interleukin-10 provides direct trophic support to neurons. J Neurochem. 2009;110:1617-27 pubmed publisher..These data indicate that in addition to known anti-inflammatory effects through astroglia in other inflammatory cells, IL-10 has direct neuronal effects with important implications for development and neuroprotection. ..
- Ning K, Fermin D. SAW: a method to identify splicing events from RNA-Seq data based on splicing fingerprints. PLoS ONE. 2010;5:e12047 pubmed publisher..Results demonstrated that this method could identify more than 90% of the known splicing events with a very low false discovery rate, as well as accurately identify, a number of novel splicing events between distant exons. ..
- Rohani P, King A. Never mind the length, feel the quality: the impact of long-term epidemiological data sets on theory, application and policy. Trends Ecol Evol. 2010;25:611-8 pubmed publisher..Here, we review some of the key intellectual developments in epidemiology facilitated by long-term data. We identify research frontiers at the interface of ecology and epidemiology and their associated data needs. ..
- Feliciano W, Yoshida S, Straight S, Swanson J. Coordination of the Rab5 cycle on macropinosomes. Traffic. 2011;12:1911-22 pubmed publisher..Overexpression of activating and inhibitory proteins indicated that active Rab5a stabilized macropinosomes. Thus, overall Rab5a activity on macropinosomes is coordinated by macropinosome structure and physiology. ..
- Magnuson B, Ekim B, Fingar D. Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J. 2012;441:1-21 pubmed publisher..As dysregulation of this signalling axis contributes to diverse disease states, improved understanding of S6K regulation and function within mTOR signalling networks may enable the development of novel therapeutics. ..
- Liu H, Komatsu Y, Mishina Y, Mistretta C. Neural crest contribution to lingual mesenchyme, epithelium and developing taste papillae and taste buds. Dev Biol. 2012;368:294-303 pubmed publisher..Our findings lead to a new concept about derivation of taste bud cells that include a NC origin. ..
- Quirós M, Nishio H, Neumann P, Siuda D, Brazil J, Azcutia V, et al. Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling. J Clin Invest. 2017;127:3510-3520 pubmed publisher..These findings define the involvement of macrophages in regulating an IL-10/CREB/WISP-1 signaling axis, with broad implications in linking innate immune activation to mucosal wound repair. ..
- Williams S, Langmore J. Small angle x-ray scattering of chromatin. Radius and mass per unit length depend on linker length. Biophys J. 1991;59:606-18 pubmed..A compilation of all published x-ray scattering data from the last decade indicates that the relationship between chromatin structure and linker length is consistent with data obtained by other investigators...
- Burrows H, Seasholtz A, Camper S. Localization of the corticotropin-releasing hormone receptor gene on mouse chromosome 11. Mamm Genome. 1995;6:55-6 pubmed
- Zhu W, Lossie A, Camper S, Gumucio D. Chromosomal localization of the transcription factor YY1 in the mouse and human. Mamm Genome. 1994;5:234-6 pubmed
- Thompson R, Mansour A, Akil H, Watson S. Cloning and pharmacological characterization of a rat mu opioid receptor. Neuron. 1993;11:903-13 pubmed..Based upon these observations, we conclude that pRMuR-12 encodes a mu opioid receptor. ..
- Fay W, Parker A, Ansari M, Zheng X, Ginsburg D. Vitronectin inhibits the thrombotic response to arterial injury in mice. Blood. 1999;93:1825-30 pubmed
- Hogikyan N, Johns M, Kileny P, Urbanchek M, Carroll W, Kuzon W. Motion-specific laryngeal reinnervation using muscle-nerve-muscle neurotization. Ann Otol Rhinol Laryngol. 2001;110:801-10 pubmed..This technique has great potential and should be further investigated. ..
- Onafuwa A, An W, Robson N, Telesnitsky A. Human immunodeficiency virus type 1 genetic recombination is more frequent than that of Moloney murine leukemia virus despite similar template switching rates. J Virol. 2003;77:4577-87 pubmed
- Scheiman J. Gastroduodenal safety of cyclooxygenase-2 inhibitors. Curr Pharm Des. 2003;9:2197-206 pubmed..Such data provide support for the COX-2 hypothesis and demonstrate that coxibs provide effective treatment of pain and inflammation with a reduced risk of gastropathy. ..
- Fantegrossi W, Woolverton W, Kilbourn M, Sherman P, Yuan J, Hatzidimitriou G, et al. Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys. Neuropsychopharmacology. 2004;29:1270-81 pubmed..The reinforcing effects of MDMA are selectively attenuated by chronic MDMA self-administration, although this behavioral change appears to occur in the absence of any frank neurochemical correlates of toxicity. ..
- Li X, Erbe J, Lockatell C, Johnson D, Jobling M, Holmes R, et al. Use of translational fusion of the MrpH fimbrial adhesin-binding domain with the cholera toxin A2 domain, coexpressed with the cholera toxin B subunit, as an intranasal vaccine to prevent experimental urinary tract infection by Proteus mirabilis. Infect Immun. 2004;72:7306-10 pubmed..This chimera, when administered intranasally without additional adjuvant, is sufficient to induce protective immunity in mice. ..
- Huang Y, Dennis R, Baar K. Cultured slow vs. fast skeletal muscle cells differ in physiology and responsiveness to stimulation. Am J Physiol Cell Physiol. 2006;291:C11-7 pubmed..We conclude that myogenic cells associated with a slow muscle are imprinted to produce muscle that contracts and relaxes slowly and that calcineurin activity cannot explain the response to a slow pattern of electrical stimulation. ..
- Ballaz S, Akil H, Watson S. Analysis of 5-HT6 and 5-HT7 receptor gene expression in rats showing differences in novelty-seeking behavior. Neuroscience. 2007;147:428-38 pubmed..Taken together, these results provide new insight into the potential contribution of 5-HT to novelty-seeking behavior and associated behaviors such as substance abuse. ..
- Cheng Z, Arscott L, Ballou D, Williams C. The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila. Biochemistry. 2007;46:7875-85 pubmed..melanogaster where glutathione reductase is absent. ..
- Coomes S, Wilke C, Moore T, Moore B. Induction of TGF-beta 1, not regulatory T cells, impairs antiviral immunity in the lung following bone marrow transplant. J Immunol. 2010;184:5130-40 pubmed publisher..Thus, our results indicate that overexpression of TGF-beta1 following myeloablative conditioning post-BMT results in impaired effector T cell responses to viral infection...
- Cheng H, Dauch J, Oh S, Hayes J, Hong Y, Feldman E. p38 mediates mechanical allodynia in a mouse model of type 2 diabetes. Mol Pain. 2010;6:28 pubmed publisher..Our findings suggest that NGF activated-p38 phosphorylation mediates mechanical allodynia in the db/db mouse by upregulation of multiple inflammatory mediators in LDRG. ..
- Qian M, Tsai B. Lipids and proteins act in opposing manners to regulate polyomavirus infection. J Virol. 2010;84:9840-52 pubmed publisher..Thus, glycolipids and glycoproteins, two major constituents of the plasma membrane, execute opposing functions in regulating infection by a defined virus. ..
- Rao R, Jiao A, Kohn D, Stegemann J. Exogenous mineralization of cell-seeded and unseeded collagen-chitosan hydrogels using modified culture medium. Acta Biomater. 2012;8:1560-5 pubmed publisher..The ability to mineralize protein matrices in the presence of cells could be useful in creating mechanically stable tissue constructs, as well as to study the effects of the tissue microenvironment on cell function. ..
- Wan J, Ramachandran R, Goldman D. HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration. Dev Cell. 2012;22:334-47 pubmed publisher..These data provide a link between extracellular signaling and regeneration-associated gene expression in the injured retina and suggest strategies for stimulating retina regeneration in mammals. ..
- Klionsky D, Abdalla F, Abeliovich H, Abraham R, Acevedo Arozena A, Adeli K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012;8:445-544 pubmed..Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field. ..
- Kothari V, Wei I, Shankar S, Kalyana Sundaram S, Wang L, Ma L, et al. Outlier kinase expression by RNA sequencing as targets for precision therapy. Cancer Discov. 2013;3:280-93 pubmed publisher..Our results suggest that outlier kinases represent effective precision therapeutic targets that are readily identifiable through RNA sequencing of tumors. ..
- Gibbs E, Davidson A, Trickey Glassman A, Backus C, Hong Y, Sakowski S, et al. Two dynamin-2 genes are required for normal zebrafish development. PLoS ONE. 2013;8:e55888 pubmed publisher..Our findings suggest that dnm2 and dnm2-like are orthologs to human DNM2, and that they are required for normal zebrafish development. ..
- Guan J, Simon A, Prescott M, Menendez J, Liu F, Wang F, et al. Autophagy in stem cells. Autophagy. 2013;9:830-49 pubmed publisher..We also highlight the many unanswered questions that will help to drive further research at the intersection of autophagy and stem cell biology in the near future. ..
- Toubai T, Sun Y, Luker G, Liu J, Luker K, Tawara I, et al. Host-derived CD8+ dendritic cells are required for induction of optimal graft-versus-tumor responses after experimental allogeneic bone marrow transplantation. Blood. 2013;121:4231-41 pubmed publisher..Thus, strategies that modulate host APC subsets without direct manipulation of donor T cells could augment GVT responses and enhance the efficacy of allo-HCT. ..
- Todd T, Tibi O, Lin Y, Sayers S, Bronner D, Xiang Z, et al. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013;14 Suppl 6:S3 pubmed publisher..The results obtained provide critical information for rational vaccine study design. Literature meta-analysis is generic and can be applied to analyze variables critical for vaccine protection against other infectious diseases. ..
- Lyon A, Tesmer J. Structural insights into phospholipase C-? function. Mol Pharmacol. 2013;84:488-500 pubmed publisher..A better understanding of the molecular mechanisms underlying the control of its activity will greatly facilitate the search for selective small molecule modulators of PLC?. ..
- Lundquist M, Storaska A, Liu T, Larsen S, Evans T, Neubig R, et al. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. Cell. 2014;156:563-76 pubmed publisher..These data identify redox modification of nuclear actin as a regulatory switch that mediates SRF/MRTF-A-dependent gene transcription. ..
- Hortsch M, Wang Y, Marikar Y, Bieber A. The cytoplasmic domain of the Drosophila cell adhesion molecule neuroglian is not essential for its homophilic adhesive properties in S2 cells. J Biol Chem. 1995;270:18809-17 pubmed
- Nemzek J, Ebong S, Kim J, Bolgos G, Remick D. Keratinocyte growth factor pretreatment is associated with decreased macrophage inflammatory protein-2alpha concentrations and reduced neutrophil recruitment in acid aspiration lung injury. Shock. 2002;18:501-6 pubmed..23 +/- 1.19) at 8 h. In this study, KGF pretreatment after acid aspiration was associated with reduced neutrophil recruitment into the lung and a decrease in MIP-2alpha gradients between BAL fluid and plasma. ..
- Yang S, Wei D, Wang D, Phimphilai M, Krebsbach P, Franceschi R. In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation. J Bone Miner Res. 2003;18:705-15 pubmed..These results suggest that Runx2 and BMP2 have distinct, but complementary, roles in osteogenesis and that their combined actions may be necessary for optimal bone formation. ..
- Murphy P, Morishima Y, Chen H, Galigniana M, Mansfield J, Simons S, et al. Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft. J Biol Chem. 2003;278:34764-73 pubmed
- Mistretta C, Grigaliunas A, Liu H. Development of gustatory organs and innervating sensory ganglia. Chem Senses. 2005;30 Suppl 1:i52-3 pubmed
- Roof R, Jin Y, Roman D, Sunahara R, Ishii M, Mosberg H, et al. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chem Biol Drug Des. 2006;67:266-74 pubmed..These data support the proposed mechanism of action of peptide RGS inhibitors, demonstrate their action in native cells, and provide a starting point for the design of RGS inhibitor drugs. ..
- Straight S, Pieczynski J, Whiteman E, Liu C, Margolis B. Mammalian lin-7 stabilizes polarity protein complexes. J Biol Chem. 2006;281:37738-47 pubmed..Taken together, these results indicate that Lin-7 functions in tight junction formation by stabilizing its membrane-associated guanylate kinase binding partner PALS1. ..
- Jin Q, Cirelli J, Park C, Sugai J, Taba M, Kostenuik P, et al. RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis. J Periodontol. 2007;78:1300-8 pubmed..Systemic delivery of OPG-Fc inhibits alveolar bone resorption in experimental periodontitis, suggesting that RANKL inhibition may represent an important therapeutic strategy for the prevention of progressive alveolar bone loss. ..
- Milam J, Herring Palmer A, Pandrangi R, McDonald R, Huffnagle G, Toews G. Modulation of the pulmonary type 2 T-cell response to Cryptococcus neoformans by intratracheal delivery of a tumor necrosis factor alpha-expressing adenoviral vector. Infect Immun. 2007;75:4951-8 pubmed
- Liu T, Chung M, Ullenbruch M, Yu H, Jin H, Hu B, et al. Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice. J Clin Invest. 2007;117:3800-9 pubmed..Moreover, TERT induction is associated with increased survival of lung fibroblasts, which favors the development of fibrosis instead of injury resolution. ..
- Monrad S, Killen P, Anderson M, Bradke A, Kaplan M. The role of aldosterone blockade in murine lupus nephritis. Arthritis Res Ther. 2008;10:R5 pubmed publisher..It appears to modulate inflammatory changes during the progression of glomerulonephritis and may also have a previously undescribed role in attenuating apoptosis. ..
- Sun Y, Pedersen E, Shiozawa Y, Havens A, Jung Y, Wang J, et al. CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12. Clin Exp Metastasis. 2008;25:765-76 pubmed publisher..Together, these data suggest that the degradation of CXCL12 by CD26/DPPIV may be involved in the metastatic cascades of PCa, and suggests that inhibition of CD26/DPPIV may be a trigger of PCa metastasis. ..
- Xie C, Huang H, Sun X, Guo Y, Hamblin M, Ritchie R, et al. MicroRNA-1 regulates smooth muscle cell differentiation by repressing Kruppel-like factor 4. Stem Cells Dev. 2011;20:205-10 pubmed publisher..We conclude that miR-1 plays a critical role in the determination of SMC fate during retinoid acid-induced ESC/SMC differentiation, which may indicate that miR-1 has a role to promote SMC differentiation. ..
- Morris M, Mandair G. Raman assessment of bone quality. Clin Orthop Relat Res. 2011;469:2160-9 pubmed publisher..Methodology for noninvasive in vivo assessments is still under development. ..
- Standiford L, Standiford T, Newstead M, Zeng X, Ballinger M, Kovach M, et al. TLR4-dependent GM-CSF protects against lung injury in Gram-negative bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012;302:L447-54 pubmed publisher..Based on these observations, we conclude that TLR4 plays a protective role on lung epithelium during Gram-negative bacterial pneumonia, an effect that is partially mediated by GM-CSF. ..
- Brzezinski J, Prasov L, Glaser T. Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle. Dev Biol. 2012;365:395-413 pubmed publisher..These data are consistent with progressive and temporal restriction models for retinal neurogenesis, in which environmental factors influence the final histotypic choice. ..
- Kim D, Park J, Franchi L, Backert S, Nunez G. The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1? production in Helicobacter pylori infected dendritic cells. Eur J Immunol. 2013;43:2650-8 pubmed publisher..These studies identify bacterial cag pathogenicity island and the cooperative interaction among host innate receptors TLR2, NOD2, and NLRP3 as important regulators of IL-1? production in H. pylori infected DCs. ..
- Samie M, Wang X, Zhang X, Goschka A, Li X, Cheng X, et al. A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis. Dev Cell. 2013;26:511-24 pubmed publisher..Thus phagocytic ingestion of large particles activates a phosphoinositide- and Ca2+-dependent exocytosis pathway to provide membranes necessary for pseudopod extension, leading to clearance of senescent and apoptotic cells in vivo. ..
- Krebs C, Zhang D, Yin L, Robins D. The KRAB zinc finger protein RSL1 modulates sex-biased gene expression in liver and adipose tissue to maintain metabolic homeostasis. Mol Cell Biol. 2014;34:221-32 pubmed publisher..This ability to buffer against gene expression noise, coupled with extensive individual genetic variation, highlights the enormous potential of KRAB-Zfp genes as candidate risk factors for complex diseases. ..
- Malhotra R, Tyson D, Sone H, Aoki K, Kumagai A, Brosius F. Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1alpha levels in cardiac myocytes. J Mol Cell Cardiol. 2002;34:1063-73 pubmed..This represents a novel feedback mechanism that may play an important role in adaptation of cardiac myocytes to hypoxia and ischemia. ..
- Hernandez Y, Arora S, Erb Downward J, McDonald R, Toews G, Huffnagle G. Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis. J Immunol. 2005;174:1027-36 pubmed..Thus, although IL-10 has been reported to down-regulate pulmonary T2 responses to isolated fungal Ags, IL-10 can augment pulmonary T2 responses if they occur in the context of fungal infection...
- Fontaine J, Sun X, Hoppe A, Simon S, Vicart P, Welsh M, et al. Abnormal small heat shock protein interactions involving neuropathy-associated HSP22 (HSPB8) mutants. FASEB J. 2006;20:2168-70 pubmed..Increased interactions involving mutant sHSPs may be the molecular basis for their increased tendency to form cytoplasmic protein aggregates, and for the occurrence of the associated neuropathies. ..
- Acevedo N, Wang X, Dunn R, Smith G. Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos. Mol Reprod Dev. 2007;74:178-88 pubmed..Inhibition of GSK-3 also resulted in abnormal chromatin segregation, evidenced by incomplete karyokinesis and micronuclei formation. These results suggest that GSK-3 activity is critical for early preimplantation embryonic development. ..
- Tawara I, Maeda Y, Sun Y, Lowler K, Liu C, Toubai T, et al. Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease. Exp Hematol. 2008;36:988-96 pubmed publisher..Our data thus unequivocally demonstrate that deficiency of the four classical Th2 cytokine enhances T-cell proliferative responses and aggravates GVHD. ..
- Cho E, Dressler G. TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs. Mech Dev. 1998;77:9-18 pubmed..5 and is limited to mesenchymal cells surrounding the areas of chondrification. These data indicate a function for Tcf-4 in neural and limb development, two tissues where Wnt signaling plays an essential role. ..
- Mancuso P, Nana Sinkam P, Peters Golden M. Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae. Infect Immun. 2001;69:2011-6 pubmed..In conclusion, we have identified a novel role for leukotriene B4 in the augmentation of neutrophil phagocytosis mediated by either the Fc or complement receptor. ..
- Morenko B, Bove S, Chen L, Guzman R, Juneau P, Bocan T, et al. In vivo micro computed tomography of subchondral bone in the rat after intra-articular administration of monosodium iodoacetate. Contemp Top Lab Anim Sci. 2004;43:39-43 pubmed..In light of these data, in vivo microCT imaging represents a valuable tool for investigating bone remolding and has the potential to be used for routine, high-throughput analysis and screening of investigation therapeutics...
- Zavros Y, Waghray M, Tessier A, Bai L, Todisco A, L Gumucio D, et al. Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation. J Biol Chem. 2007;282:33265-74 pubmed..Moreover parietal cell atrophy, a known pre-neoplastic lesion, correlates with loss of Shh processing. ..
- Chaib H, Hoskins B, Ashraf S, Goyal M, Wiggins R, Hildebrandt F. Identification of BRAF as a new interactor of PLCepsilon1, the protein mutated in nephrotic syndrome type 3. Am J Physiol Renal Physiol. 2008;294:F93-9 pubmed..By immunohistochemistry in rat kidney, we demonstrate that both proteins are coexpressed and colocalize in developing and mature glomerular podocytes, reporting for the first time the expression of BRAF in the glomerular podocyte. ..
- Zhou Z, Peng X, Hao S, Fink D, Mata M. HSV-mediated transfer of interleukin-10 reduces inflammatory pain through modulation of membrane tumor necrosis factor alpha in spinal cord microglia. Gene Ther. 2008;15:183-90 pubmed..The results emphasize the key role played by membrane TNFalpha in the spinal neuroimmune response in pain caused by peripheral inflammation. ..
- Dai J, Lu Y, Yu C, Keller J, Mizokami A, Zhang J, et al. Reversal of chemotherapy-induced leukopenia using granulocyte macrophage colony-stimulating factor promotes bone metastasis that can be blocked with osteoclast inhibitors. Cancer Res. 2010;70:5014-23 pubmed publisher..Our findings indicate that it is possible to dissociate the bone-resorptive effects of GM-CSF, to reduce metastatic risk, from the benefits of this growth factor in reversing leukopenia caused by treatment with chemotherapy...
- Kelly V, Xu B, Kuick R, Koenig R, Hammer G. Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA. Mol Endocrinol. 2010;24:2281-91 pubmed publisher..Thus, our results indicate that Dax1 plays an important role in the maintenance of pluripotency in mES cells through interaction with LRH-1 and transcriptional activation of Oct4 and other genes. ..
- Higgins P, Johnson L, Luther J, Zhang M, Sauder K, Blanco L, et al. Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestine. Inflamm Bowel Dis. 2011;17:1398-408 pubmed publisher..H. pylori represses the lower gastrointestinal tract Th17 response to bacterially induced colitis via extragastric immunomodulatory effects, illustrating immunological crosstalk between the upper and lower gastrointestinal tract. ..
- Bank L, Bianchi L, Ebisu F, Lerman Sinkoff D, Smiley E, Shen Y, et al. Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear. Development. 2012;139:4666-74 pubmed publisher..Furthermore, mouse embryonic stem cells become neuron-like when exposed to picomolar levels of MIF, suggesting the general importance of this cytokine in neural development. ..
- Baik J, Stringer K, Mane G, Rosania G. Multiscale distribution and bioaccumulation analysis of clofazimine reveals a massive immune system-mediated xenobiotic sequestration response. Antimicrob Agents Chemother. 2013;57:1218-30 pubmed publisher..These experiments indicate an inducible, immune system-dependent, xenobiotic sequestration response affecting the atypical pharmacokinetics of a small molecule chemotherapeutic agent...
- Leto D, Uhm M, Williams A, Chen X, Saltiel A. Negative regulation of the RalGAP complex by 14-3-3. J Biol Chem. 2013;288:9272-83 pubmed publisher..Together, these data show that 14-3-3 negatively regulates the RGC downstream of the PI3-kinase/Akt signaling pathway. ..
- Hockley B, Stewart M, Sherman P, Quesada C, Kilbourn M, Albin R, et al. (-)-[(18) F]Flubatine: evaluation in rhesus monkeys and a report of the first fully automated radiosynthesis validated for clinical use. J Labelled Comp Radiopharm. 2013;56:595-9 pubmed publisher..Injection of 2.5?µg/kg of nifene at 60?min initiated a slow washout of [(18) F]flubatine, with about 25% clearance from the thalamus by the end of imaging at 90?min...
- Itoga C, Berridge K, Aldridge J. Ventral pallidal coding of a learned taste aversion. Behav Brain Res. 2016;300:175-83 pubmed publisher..Such neuronal coding of hedonic impact by VP circuitry may contribute both to normal pleasure and disgust, and disruptions of VP coding could result in affective disorders, addictions and eating disorders. ..
- Miyahira A, Cheng H, Abida W, Ellis L, Harshman L, Spratt D, et al. Beyond the androgen receptor II: New approaches to understanding and treating metastatic prostate cancer; Report from the 2017 Coffey-Holden Prostate Cancer Academy Meeting. Prostate. 2017;77:1478-1488 pubmed publisher..The 2017 Coffey-Holden Prostate Cancer Academy (CHPCA) Meeting, "Beyond the Androgen Receptor II: New Approaches to Understanding and Treating Metastatic Prostate Cancer," was held in Carlsbad, California from June 14-17, 2017...
- Easter S, Ross L, Frankfurter A. Initial tract formation in the mouse brain. J Neurosci. 1993;13:285-99 pubmed..Those that can be identified in the adult brain are very deep structures. These results are compared with previous descriptions of the embryonic brains of amphibians, fish, birds, and other mammals, including humans. ..
- Fink J, Jones S, Esposito C, Wilkowski J. Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression. Genomics. 1996;35:577-85 pubmed..Strong, interspecies conservation between human and rat MAP1a cDNA and amino acid sequences indicates important relationships between MAP1a's function and its primary amino acid sequence. ..
- Wu D, Chen P, Chen S, Hu Y, Nunez G, Ellis R. C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death. Development. 1999;126:2021-31 pubmed..These results suggest that MAC-1 identifies a new class of proteins that are essential for development, and which might regulate cell death in specific circumstances. ..