Experts and Doctors on amino acid sequence homology in Ann Arbor, Michigan, United States


Locale: Ann Arbor, Michigan, United States
Topic: amino acid sequence homology

Top Publications

  1. Halloran M, Severance S, Yee C, Gemza D, Kuwada J. Molecular cloning and expression of two novel zebrafish semaphorins. Mech Dev. 1998;76:165-8 pubmed
    ..We describe the cloning and expression of two n ovel zebrafish semaphorins that represent an increase in the size and diversity of the family. These semaphorins are expressed in unique and dynamic patterns during development. ..
  2. Zhou G, Bao Z, Dixon J. Components of a new human protein kinase signal transduction pathway. J Biol Chem. 1995;270:12665-9 pubmed
    ..Both MEK5 and ERK5 are expressed in many adult tissue and are abundant in heart and skeletal muscle. A recombinant GST-ERK5 kinase domain displays autophosphorylation on Ser/Thr and Tyr residues. ..
  3. Russell M, Kemp P, Wang L, Brody L, Izumo S. Molecular cloning of the human HAND2 gene. Biochim Biophys Acta. 1998;1443:393-9 pubmed
    ..Northern analysis indicates that the HAND2 transcript is 2.3 kb in length and strongly expressed in the human heart. ..
  4. Hilgers M, Ludwig M. Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site. Proc Natl Acad Sci U S A. 2001;98:11169-74 pubmed
    ..Our analysis represents a test of structure-based functional assignment. ..
  5. Dickinson C, Delvalle J, Todisco A, Gantz I, Tong L, Finniss S, et al. Canine prosomatostatin: isolation of a cDNA, regulation of gene expression, and characterization of post-translational processing intermediates. Regul Pept. 1996;67:145-52 pubmed
    ..Furthermore, equivalent amounts of SS-14 and SS-28(1-12) were co-released from canine fundic D-cells by CCK (10(-8) M) suggesting that the generation of these products occurs within the same regulated pathway of secretion. ..
  6. Uhler J, Garbern J, Yang L, Kamholz J, Mellerick D. Nk6, a novel Drosophila homeobox gene regulated by vnd. Mech Dev. 2002;116:105-16 pubmed
    ..Conversely, vnd-overexpression leads to ectopic Nk6 expression in the brain. These findings further highlight the importance of interactions between Nk(x)-type genes in regulating their expression. ..
  7. Li Y, Inoki K, Vacratsis P, Guan K. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem. 2003;278:13663-71 pubmed
    ..Phosphorylation of TSC2 by MK2 creates a 14-3-3 binding site and thus regulates the cellular function of the TSC2 tumor suppressor protein. ..
  8. Buchner D, Seburn K, Frankel W, Meisler M. Three ENU-induced neurological mutations in the pore loop of sodium channel Scn8a (Na(v)1.6) and a genetically linked retinal mutation, rd13. Mamm Genome. 2004;15:344-51 pubmed
    ..The new alleles of Scn8a will be valuable for analysis of sodium channel physiology and disease. ..
  9. Halloran M, Severance S, Yee C, Gemza D, Raper J, Kuwada J. Analysis of a Zebrafish semaphorin reveals potential functions in vivo. Dev Dyn. 1999;214:13-25 pubmed
    ..Analysis of mutant zebrafish with reduced semaZ2 expression reveals axon pathfinding errors that implicate SemaZ2 in normal guidance. ..

More Information

Publications109 found, 100 shown here

  1. Duan H, Wang Y, Aviram M, Swaroop M, Loo J, Bian J, et al. SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Mol Cell Biol. 1999;19:3145-55 pubmed
    ..Thus, SAG is a cellular protective molecule that appears to act as an antioxidant to inhibit apoptosis induced by metal ions and reactive oxygen species. ..
  2. Payne A, Abbaszade I, Clarke T, Bain P, Park C. The multiple murine 3 beta-hydroxysteroid dehydrogenase isoforms: structure, function, and tissue- and developmentally specific expression. Steroids. 1997;62:169-75 pubmed
    ..Further analysis of mouse genomic DNA by pulse field gel electrophoresis suggests that all of the Hsd3b gene family is found within a 400-kb fragment. ..
  3. Vickerman M, Heath D, Clewell D. Construction of recombination-deficient strains of Streptococcus gordonii by disruption of the recA gene. J Bacteriol. 1993;175:6354-7 pubmed
    ..The resulting PCR fragment was cloned into the suicide vector pAM6199 and introduced into strain Challis, giving rise to recombination-deficient strains in which the recA gene was specifically inactivated. ..
  4. Pasteris N, Nagata K, Hall A, Gorski J. Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue. Gene. 2000;242:237-47 pubmed
    ..We conclude that Fgd3 is a new and novel member of the FGD1 family of RhoGEF proteins. ..
  5. Lee J, Wang X, Di Jeso B, Arvan P. The cholinesterase-like domain, essential in thyroglobulin trafficking for thyroid hormone synthesis, is required for protein dimerization. J Biol Chem. 2009;284:12752-61 pubmed publisher
    ..Thus, although the ChEL domain provides a nidus for Tg dimerization, interactions of upstream Tg regions with the ChEL domain actively stabilizes the Tg dimer complex for intracellular transport. ..
  6. Meng F, Xie G, Chalmers D, Morgan C, Watson S, Akil H. Cloning and characterization of a pharmacologically distinct A1 adenosine receptor from guinea pig brain. Brain Res Mol Brain Res. 1994;26:143-55 pubmed
    ..Northern blotting for different guinea pig tissues and in situ hybridization for guinea pig brain sections reveal an abundant and broad distribution of mRNA of this A1 subtype receptor in the brain. ..
  7. Skaggs L, Bergenhem N, Venta P, Tashian R. The deduced amino acid sequence of human carbonic anhydrase-related protein (CARP) is 98% identical to the mouse homologue. Gene. 1993;126:291-2 pubmed
    ..The sequence has an 89.3% sequence identity with mouse CARP at the nucleotide level and 97.9% at the amino acid level. This extremely high evolutionary conservation suggests an important function for the CARP gene product. ..
  8. McClure C, Rusche K, Peariso K, Jackman J, Fierke C, Penner Hahn J. EXAFS studies of the zinc sites of UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). J Inorg Biochem. 2003;94:78-85 pubmed
    ..Results of the outer-shell scattering analysis, combined with previous studies of the LpxC enzyme, indicate a novel zinc binding motif not found in any previously studied zinc metalloproteins. ..
  9. Zhang J. Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys. Nat Genet. 2006;38:819-23 pubmed
    ..These results demonstrate that despite the overall stochasticity, even molecular evolution has a certain degree of repeatability and predictability under the pressures of natural selection. ..
  10. Ambasudhan R, Wang X, Jablonski M, Thompson D, Lagali P, Wong P, et al. Atrophic macular degeneration mutations in ELOVL4 result in the intracellular misrouting of the protein. Genomics. 2004;83:615-25 pubmed
    ..Our observations suggest that the consequences of defective protein trafficking could underlie the molecular mechanism associated with degeneration of the macula in the patients with adMD/STGD3. ..
  11. Gregory P, Gutmann D, Mitchell A, Park S, Boguski M, Jacks T, et al. Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules. Somat Cell Mol Genet. 1993;19:265-74 pubmed
    ..The unexpected association of neurofibromin with microtubules suggests that neurofibromin is involved in microtubule-mediated intracellular signal transduction pathways...
  12. Clemens J, Ursuliak Z, Clemens K, Price J, Dixon J. A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance. J Biol Chem. 1996;271:17002-5 pubmed
    ..These findings identify potential signal-transducing partners of Dock and propose a role for dPTP61F and the unidentified phosphoproteins in axonal guidance. ..
  13. Chiang S, Hou J, Hwang J, Pessin J, Saltiel A. Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport. J Biol Chem. 2002;277:13067-73 pubmed
    ..Thus, there are two isoforms of this key signaling intermediate, both of which are activated by insulin, but they may play different roles in initiating downstream effectors that influence glucose transport. ..
  14. Hortsch M. The L1 family of neural cell adhesion molecules: old proteins performing new tricks. Neuron. 1996;17:587-93 pubmed
  15. Roh M, Fan S, Liu C, Margolis B. The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. J Cell Sci. 2003;116:2895-906 pubmed
    ..These results provide insight into the function of the mammalian Crumbs complex during TJ formation and epithelial polarization. ..
  16. Makris G, Lomax M. Sequence of the cDNA for the liver/non-muscle isoform of mouse cytochrome-c oxidase subunit VIII. Biochim Biophys Acta. 1996;1308:197-200 pubmed
    ..The most highly conserved regions of this subunit are the N-terminal presequence and the C-terminal domain of the mature protein. ..
  17. Wilkinson J, Richter B, Wilkinson A, Burstein E, Rumble J, Balliu B, et al. VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. J Biol Chem. 2004;279:51091-9 pubmed
    ..Finally, VIAF is a substrate for ubiquitination mediated by Op-IAP. Thus, VIAF is a novel IAP-interacting factor that functions in caspase activation during apoptosis. ..
  18. Chen Y, Kelly V, Stachura S, Garcia G. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. RNA. 2010;16:958-68 pubmed publisher
    ..hQTRTD1 has been implicated as the salvage enzyme that generates free queuine from QMP. Work is ongoing in our laboratory to confirm this activity. ..
  19. Allard J, Brock T. Structural organization of the regulatory domain of human 5-lipoxygenase. Curr Protein Pept Sci. 2005;6:125-31 pubmed
    ..In addition, we point to findings from structural analyses of related proteins to suggest further details relating 5-LO structure to function. ..
  20. McCrea K, Wang M, Xie J, Sandstedt S, Davis G, Lee J, et al. Prevalence of the sodC gene in nontypeable Haemophilus influenzae and Haemophilus haemolyticus by microarray-based hybridization. J Clin Microbiol. 2010;48:714-9 pubmed publisher
    ..haemolyticus, suggesting the possibility of interspecies recombination in these strains. In summary, this study demonstrates that sodC is not completely absent (9.2%) in true NT H. influenzae strains...
  21. Lumeng C, Phelps S, Crawford G, Walden P, Barald K, Chamberlain J. Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. Nat Neurosci. 1999;2:611-7 pubmed
    ..Our data suggest that MAST205 and SAST link the dystrophin/utrophin network with microtubule filaments via the syntrophins. ..
  22. Jin S, Arno N, Cohen A, Shah A, Xu Q, Chen N, et al. In Caenorhabditis elegans, the RNA-binding domains of the cytoplasmic polyadenylation element binding protein FOG-1 are needed to regulate germ cell fates. Genetics. 2001;159:1617-30 pubmed
    ..On the basis of these data, we propose that FOG-1 binds RNA to regulate germ cell fates and that it does so by controlling the translation of its targets. One of these targets might be the fog-1 transcript itself. ..
  23. O Riordan M, Bauler L, Scott F, Duckett C. Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. Dev Cell. 2008;15:497-508 pubmed publisher
    ..Here we describe the shared functional characteristics of several well-characterized IAPs whose defining motifs place them more in the category of multifunctional modular protein interaction domains. ..
  24. Quandt K, Hultquist D. Flavin reductase: sequence of cDNA from bovine liver and tissue distribution. Proc Natl Acad Sci U S A. 1994;91:9322-6 pubmed
    ..RNA blot analysis indicates a single 1-kilobase reductase transcript in human heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle. ..
  25. Biesecker L, Gottschalk L, Emerson S. Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A. 1993;90:7044-8 pubmed
    ..These genes are candidates for receptors or downstream effectors of cytokines that regulate self-renewal and lineage commitment in embryogenesis. ..
  26. Inohara N, Koseki T, Chen S, Benedict M, Nunez G. Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD. J Biol Chem. 1999;274:270-4 pubmed
    ..Thus, CIDE-N represents a new type of domain that is associated with the regulation of the apoptosis/DNA fragmentation pathway. ..
  27. Nasonkin I, Alikasifoglu A, Barrette T, Cheng M, Thomas P, Nikitin A. Cloning, characterization, and embryonic expression analysis of the Drosophila melanogaster gene encoding insulin/relaxin-like peptide. Biochem Biophys Res Commun. 2002;295:312-8 pubmed
    ..Identification of the gene for DIRLP provides a new approach for study of the regulatory pathway of the insulin family of peptides. ..
  28. D Auria J, Chen F, Pichersky E. Characterization of an acyltransferase capable of synthesizing benzylbenzoate and other volatile esters in flowers and damaged leaves of Clarkia breweri. Plant Physiol. 2002;130:466-76 pubmed publisher
  29. Buchner D, Meisler M. TSRC1, a widely expressed gene containing seven thrombospondin type I repeats. Gene. 2003;307:23-30 pubmed
    ..Human TSRC1 is located on chromosome 1q21 within an 11.7 Mb segment of conserved synteny. TSRC1 and the closely linked gene ADAM15 appear to be derived by a chromosomal inversion that interrupted an ancestral ADAMTS gene. ..
  30. Yan Z, Zhao J, Peng P, Chihara R, Li J. BIN2 functions redundantly with other Arabidopsis GSK3-like kinases to regulate brassinosteroid signaling. Plant Physiol. 2009;150:710-21 pubmed publisher
  31. Johnson J, Wimsatt J, Buckel S, Dyer R, Maddipati K. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys. 1995;324:26-34 pubmed
    ..Since the first identification of PGHS, ram seminal vesicles served as a rich source of the enzyme (PGHS-1). Our studies establish the sheep placental cotyledons as a rich natural source of PGHS-2. ..
  32. Qabar A, Lin Z, Wolf F, O Shea K, Lawler J, Dixit V. Thrombospondin 3 is a developmentally regulated heparin binding protein. J Biol Chem. 1994;269:1262-9 pubmed
    ..Finally, a combination of in situ hybridization and immunocytochemistry demonstrated TSP3 to be expressed in a temporal and spatial manner during murine embryogenesis, especially in the gut, cartilage, lung, and central nervous system. ..
  33. Uhler M. Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J Biol Chem. 1993;268:13586-91 pubmed
    ..An expression vector for mouse CGKII was constructed and transfected into COS-1 cells where it directed the expression of a protein kinase which was activated by cGMP with an apparent K alpha of 300 nM cGMP. ..
  34. Vance J, Wilson T. Uncoupling of 3'-phosphatase and 5'-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3'-phosphatase (TPP1). J Biol Chem. 2001;276:15073-81 pubmed
    ..Repair of transformed dephosphorylated plasmids, and 5'-hydroxyl blocking lesions more generally, likely proceeds by a cycle of base removal and resynthesis. ..
  35. Tanabe O, Shen Y, Liu Q, Campbell A, Kuroha T, Yamamoto M, et al. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes Dev. 2007;21:2832-44 pubmed
  36. Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, et al. Molecular cloning of a novel melanocortin receptor. J Biol Chem. 1993;268:8246-50 pubmed
    ..These findings may yield insight into the physiology of peptides derived from pro-opiomelanocortin post-translational processing. ..
  37. Turbay D, Wechsler S, Blanchard K, Izumo S. Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx. Mol Med. 1996;2:86-96 pubmed
    ..Isolation of the hCsx gene will allow further studies of mutations in this gene and their potential associations with some forms of congenital heart disease in humans. ..
  38. Zeng Z, Wang W, Yang Y, Chen Y, Yang X, Diehl J, et al. Structural basis of selective ubiquitination of TRF1 by SCFFbx4. Dev Cell. 2010;18:214-25 pubmed publisher
    ..Our results reveal an atypical small GTPase domain within Fbx4 as a substrate-binding motif for SCF(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 in telomere homeostasis control. ..
  39. Holzman L, St John P, Kovari I, Verma R, Holthofer H, Abrahamson D. Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int. 1999;56:1481-91 pubmed
    ..As a putative cell adhesion molecule of the immunoglobulin superfamily, nephrin likely participates in cell-cell interactions between podocyte foot processes and may represent a component of the slit diaphragm. ..
  40. Gong T, Besirli C, Lomax M. MACF1 gene structure: a hybrid of plectin and dystrophin. Mamm Genome. 2001;12:852-61 pubmed
    ..This demonstrates that MACF1 has characteristic features of genes for two classes of cytoskeletal proteins, i.e., plectin and dystrophin. ..
  41. Johnson T, Olsen L. Import of the peroxisomal targeting signal type 2 protein 3-ketoacyl-coenzyme a thiolase into glyoxysomes. Plant Physiol. 2003;133:1991-9 pubmed
    ..Finally, the addition of zinc to PTS2 protein imports increased the level of thiolase bound and imported into the organelles...
  42. Kwak S, Hakes D, Martell K, Dixon J. Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene. J Biol Chem. 1994;269:3596-604 pubmed
    ..The potential significance of a second cdc25 homology domain of CL100 is discussed. ..
  43. Ting C, Burgess D, Chamberlain J, Keith T, Falls K, Meisler M. Phosphoenolpyruvate carboxykinase (GTP): characterization of the human PCK1 gene and localization distal to MODY on chromosome 20. Genomics. 1993;16:698-706 pubmed
    ..PCK1 is part of a conserved linkage group on mouse Chromosome 2 with identical gene order but expanded length in the human genome. ..
  44. Liu P, Thiele D. Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. Mol Biol Cell. 2001;12:3644-57 pubmed
    ..We conclude that Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production. ..
  45. Gang D, Lavid N, Zubieta C, Chen F, Beuerle T, Lewinsohn E, et al. Characterization of phenylpropene O-methyltransferases from sweet basil: facile change of substrate specificity and convergent evolution within a plant O-methyltransferase family. Plant Cell. 2002;14:505-19 pubmed
    ..This prediction was confirmed by site-directed mutagenesis, in which the appropriate mutants of CVOMT1 (F260S) and EOMT1 (S261F) were produced that exhibited the opposite substrate preference relative to the respective native enzyme. ..
  46. Friedman J, Chang B, Kannabiran C, Chakarova C, Singh H, Jalali S, et al. Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration. Am J Hum Genet. 2006;79:1059-70 pubmed
    ..We suggest that the retinopathy-associated RD3 protein is part of subnuclear protein complexes involved in diverse processes, such as transcription and splicing...
  47. Flannagan S, Clewell D, Sedgley C. A "retrocidal" plasmid in Enterococcus faecalis: passage and protection. Plasmid. 2008;59:217-30 pubmed publisher
  48. Chen Y, Dekker E, Somerville R. Functional analysis of E. coli threonine dehydrogenase by means of mutant isolation and characterization. Biochim Biophys Acta. 1995;1253:208-14 pubmed
    ..coli threonine dehydrogenase has considerable similarity with the dimeric horse liver alcohol dehydrogenase. ..
  49. Kalikin L, Sims H, Petty E. Genomic and expression analyses of alternatively spliced transcripts of the MLL septin-like fusion gene (MSF) that map to a 17q25 region of loss in breast and ovarian tumors. Genomics. 2000;63:165-72 pubmed
    ..Nine common exons, three alternatively spliced exons, and six polymorphisms were identified. ..
  50. Lechner M, Levitan I, Dressler G. PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin. Nucleic Acids Res. 2000;28:2741-51 pubmed
    ..Pax2 and PTIP co-localize in the cell nucleus to actively expressed chromatin and the nuclear matrix fraction. For the first time, these results point to a link between Pax transcription factors and active chromatin. ..
  51. Fein A, Meadows L, Chen C, Slat E, Isom L. Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant. BMC Genomics. 2007;8:226 pubmed
    ..These data add to our understanding of structure-function relationships in Na+ channel beta1 subunits and establish zebrafish as an ideal system in which to determine the contribution of scn1ba to electrical excitability in vivo. ..
  52. Wu J, Dunham W, Weiss B. Overproduction and physical characterization of SoxR, a [2Fe-2S] protein that governs an oxidative response regulon in Escherichia coli. J Biol Chem. 1995;270:10323-7 pubmed
    ..The protein is active in its oxidized ([2Fe-2S]2+) state. The presence of a prosthetic group capable of univalent redox reactions may help to explain the activation of the regulon in vivo by compounds that can mediate such reactions...
  53. Abel K, Brody L, Valdes J, Erdos M, McKinley D, Castilla L, et al. Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1. Genomics. 1996;37:161-71 pubmed
    ..The sequence and isolated cDNAs will provide useful reagents for determining the function of EZH1 and the importance of the evolutionarily conserved domains. ..
  54. Lanigan T, Liu A, Huang Y, Mei L, Margolis B, Guan K. Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. FASEB J. 2003;17:2048-60 pubmed
    ..The ability of CNK2 to interact with both Ras effector proteins Raf and Rlf suggests that CNK2 may integrate signals between MAPK and Ral pathways through a complex interplay of components. ..
  55. Park Y, Arvan P. The acetylcholinesterase homology region is essential for normal conformational maturation and secretion of thyroglobulin. J Biol Chem. 2004;279:17085-9 pubmed
    ..Additional studies show that the native structure of the AChE region functions as a "dimerization domain," facilitating intracellular transport of Tg to the site of thyroid hormonogenesis. ..
  56. Ching T, Paal A, Mehta A, Zhong L, Hsu A. drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans. Aging Cell. 2010;9:545-57 pubmed publisher
    ..Together, our findings reveal an important role for eIF4H/drr-2 in the TOR-mediated longevity responses to DR. ..
  57. Sorenson R, Primo Parmo S, Kuo C, Adkins S, Lockridge O, La Du B. Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase. Proc Natl Acad Sci U S A. 1995;92:7187-91 pubmed
    ..Consequently, it is necessary to examine other models for the active-site structure and catalytic mechanism of PON. ..
  58. Mercer J, Livingston J, Hall B, Paynter J, Begy C, Chandrasekharappa S, et al. Isolation of a partial candidate gene for Menkes disease by positional cloning. Nat Genet. 1993;3:20-5 pubmed
    ..Partial sequence of the cDNA shows a unique open reading frame containing putative metal binding motifs which have been found in heavy metal resistance genes in bacteria. This gene is a strong candidate for the Menkes disease gene...
  59. Plummer N, McBurney M, Meisler M. Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells. J Biol Chem. 1997;272:24008-15 pubmed
  60. Lee S, Fan S, Makarova O, Straight S, Margolis B. A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia. Mol Cell Biol. 2002;22:1778-91 pubmed
    ..Our data identify evolutionarily conserved protein-protein interaction domains that link mLin-2/CASK to SAP97 and account for their common phenotype when mutated in mice. ..
  61. Ding X, Peng H, Coon M. Structure-function analysis of CYP2A10 and CYP2A11, P450 cytochromes that differ in only eight amino acids but have strikingly different activities toward testosterone and coumarin. Biochem Biophys Res Commun. 1994;203:373-8 pubmed
    ..In contrast, the identity of the residue at position 372 is important for optimal activity with testosterone but not the regioselectivity at the 17 position and does not influence the activity with coumarin. ..
  62. Mourey R, Vega Q, Campbell J, Wenderoth M, Hauschka S, Krebs E, et al. A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation. J Biol Chem. 1996;271:3795-802 pubmed
    ..rVH6 protein localizes to the cytoplasm and is the first dsPTP to be localized outside the nucleus. This novel subcellular localization may expose rVH6 to potential substrates that differ from nuclear dsPTPs substrates. ..
  63. Fang J, Yin W, Smiley E, Wang S, Bonadio J. Molecular cloning of the mouse activin beta E subunit gene. Biochem Biophys Res Commun. 1996;228:669-74 pubmed
    ..Therefore, activin beta A and beta B are most related to one another, while activin beta C, beta D, and beta E may represent a subset of related sequences. ..
  64. Duan H, Dixit V. RAIDD is a new 'death' adaptor molecule. Nature. 1997;385:86-9 pubmed
    ..Finally, alternations in the sequence of the N-terminal domain that are equivalent to inactivating mutations in the C. elegans ced-3 gene prevent homophilic binding, highlighting the potentially primordial nature of this interaction. ..
  65. Chiang P, Stubbs L, Zhang L, Kurnit D. Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6. Genomics. 1998;47:426-8 pubmed
  66. Hortsch M, Paisley K, Tian M, Qian M, Bouley M, Chandler R. The axonal localization of large Drosophila ankyrin2 protein isoforms is essential for neuronal functionality. Mol Cell Neurosci. 2002;20:43-55 pubmed
    ..We show that once polarization is established, it persists during later stages of Drosophila development. We also present genetic evidence that the absence of axonal Dank2 protein is lethal. ..
  67. Freitag N, Seifert H, Koomey M. Characterization of the pilF-pilD pilus-assembly locus of Neisseria gonorrhoeae. Mol Microbiol. 1995;16:575-86 pubmed
    ..Although expression of orfX and pilD appears to be transcriptionally coupled, mutants containing transposon insertions in orfX expressed pili. Unlike either pilF or pilD mutants, orfX mutants were also competent for DNA transformation. ..
  68. Zhang Z, Wang Y, Dixon J. Dissecting the catalytic mechanism of protein-tyrosine phosphatases. Proc Natl Acad Sci U S A. 1994;91:1624-7 pubmed
    ..This rate enhancement probably occurs via transition-state stabilization. Our results suggest that all PTP-ases use a common mechanism that depends upon formation of a thiol-phosphate intermediate and general acid-general base catalysis...
  69. Gantz I, Shimoto Y, Konda Y, Miwa H, Dickinson C, Yamada T. Molecular cloning, expression, and characterization of a fifth melanocortin receptor. Biochem Biophys Res Commun. 1994;200:1214-20 pubmed
    ..Northern blot analysis demonstrated the expression of mMC5R mRNA in mouse skeletal muscle, lung, spleen, and brain. ..
  70. Gong T, Winnicki R, Kohrman D, Lomax M. A novel mouse kinesin of the UNC-104/KIF1 subfamily encoded by the Kif1b gene. Gene. 1999;239:117-27 pubmed
    ..In addition, alternative splicing of two exons in the conserved region adjacent to the motor domain generates four different isoforms of each kinesin, leading to eight kinesin isoforms derived from the Kif1b gene. ..
  71. Zhao X, Alvarado D, Rainier S, Lemons R, Hedera P, Weber C, et al. Mutations in a newly identified GTPase gene cause autosomal dominant hereditary spastic paraplegia. Nat Genet. 2001;29:326-31 pubmed
    ..Its protein (spastin) is predicted to participate in the assembly or function of nuclear protein complexes. Here we report the identification of mutations in a newly identified GTPase gene, SPG3A, in ADHSP affected individuals. ..
  72. Kim S, Sandusky P, Bowlby N, Aebersold R, Green B, Vlahakis S, et al. Characterization of a spinach psbS cDNA encoding the 22 kDa protein of photosystem II. FEBS Lett. 1992;314:67-71 pubmed
    ..The 22 kDa protein has some sequence similarity to chlorophyll a/b-binding proteins...
  73. Park Y, Sweitzer T, Dixon J, Kent C. Expression, purification, and characterization of CTP:glycerol-3-phosphate cytidylyltransferase from Bacillus subtilis. J Biol Chem. 1993;268:16648-54 pubmed
    ..The availability of large amounts of glycerol-3-phosphate cytidylyltransferase will facilitate enzymological and structural studies on this model cytidylyltransferase. ..
  74. Friis Hansen L, Rourke I, Bundgaard J, Rehfeld J, Samuelson L. Molecular structure and genetic mapping of the mouse gastrin gene. FEBS Lett. 1996;386:128-32 pubmed
    ..The gastrin gene was mapped to the distal region of mouse chromosome 11. ..
  75. Tirasophon W, Welihinda A, Kaufman R. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 1998;12:1812-24 pubmed
    ..These results demonstrate that hIre1p is an essential proximal sensor of the unfolded protein response pathway in mammalian cells. ..
  76. Yamakoshi Y, Hu J, Fukae M, Zhang H, Simmer J. Dentin glycoprotein: the protein in the middle of the dentin sialophosphoprotein chimera. J Biol Chem. 2005;280:17472-9 pubmed
  77. Pearson M, Mobley H. Repression of motility during fimbrial expression: identification of 14 mrpJ gene paralogues in Proteus mirabilis. Mol Microbiol. 2008;69:548-58 pubmed
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