Genomes and Genes
Experts and Doctors on transgenic mice in Boston, Massachusetts, United States
Locale: Boston, Massachusetts, United States
Topic: transgenic mice
Publications110 found, 100 shown here
- Stankovic K, Rio C, Xia A, Sugawara M, Adams J, Liberman M, et al. Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear. J Neurosci. 2004;24:8651-61 pubmed
- Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn J, Kaneki M. S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. J Biol Chem. 2005;280:7511-8 pubmed..These data suggest that S-nitrosylation-mediated inactivation may contribute to the pathogenesis of iNOS- and/or oxidative stress-involved insulin resistance. ..
- Bardeesy N, Kim M, Xu J, Kim R, Shen Q, Bosenberg M, et al. Role of epidermal growth factor receptor signaling in RAS-driven melanoma. Mol Cell Biol. 2005;25:4176-88 pubmed..Thus, this inducible tumor model system permits the identification and validation of alternative points of therapeutic intervention without neutralization of the primary genetic lesion. ..
- Ijiri K, Zerbini L, Peng H, Correa R, Lu B, Walsh N, et al. A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem. 2005;280:38544-55 pubmed..These observations indicated that GADD45beta plays an essential role during chondrocyte terminal differentiation. ..
- Durham J, Brand O, Arnold M, Reynolds J, Muthukumar L, Weiler H, et al. Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein. J Biol Chem. 2006;281:6841-9 pubmed..Our findings demonstrate that myospryn functions directly downstream of MEF2A at the costamere in striated muscle potentially playing a role in myofibrillogenesis. ..
- Kubo S, Levantini E, Kobayashi S, Kocher O, Halmos B, Tenen D, et al. Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice. Magn Reson Med. 2006;56:698-703 pubmed..This promising method is noninvasive and has the potential to eventually replace invasive histopathology because it obviates the need to kill groups of animals at multiple time points. ..
- Jin H, He R, Oyoshi M, Geha R. Animal models of atopic dermatitis. J Invest Dermatol. 2009;129:31-40 pubmed publisher..These models have resulted in a better understanding of the pathogenesis of AD. This review discusses these models and emphasizes the role of mechanical skin injury and skin barrier dysfunction in eliciting allergic skin inflammation. ..
- Jeong K, Gill J, Nose V, Parlow A, Carroll R, Kaiser U. Expression of a gonadotropin-releasing hormone receptor-simian virus 40 T-antigen transgene has sex-specific effects on the reproductive axis. Endocrinology. 2009;150:3383-91 pubmed publisher..We conclude that the expression of the TAg transgene driven by the GnRHR gene promoter results in female-specific infertility due to disruption of gonadotropin production and secretion even before tumor development...
- Freitag T, Cham C, Sung H, Beilhack G, Durinovic Bello I, Patel S, et al. Human risk allele HLA-DRB1*0405 predisposes class II transgenic Ab0 NOD mice to autoimmune pancreatitis. Gastroenterology. 2010;139:281-91 pubmed publisher..This humanized mouse model should be useful for studying immunopathogenesis, diagnostic markers, and therapy of human AIP. ..
- Bu D, Tarrio M, Grabie N, Zhang Y, Yamazaki H, Stavrakis G, et al. Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses. J Clin Invest. 2010;120:1961-70 pubmed publisher..We conclude that statins reduce inflammatory functions and pathogenic activity of T cells through KLF2-dependent mechanisms, and this pathway may be a potential therapeutic target for cardiovascular diseases. ..
- Liu K, Lu Y, Lee J, Samara R, Willenberg R, Sears Kraxberger I, et al. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci. 2010;13:1075-81 pubmed publisher..Thus, modulating neuronal intrinsic PTEN/mTOR activity represents a potential therapeutic strategy for promoting axon regeneration and functional repair after adult spinal cord injury. ..
- Kawamoto S, Yalcindag A, Laouini D, Brodeur S, Bryce P, Lu B, et al. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. J Clin Invest. 2004;114:399-407 pubmed..These results suggest that C3a-C3aR interactions inhibit the ability of APCs to drive Th2 cell differentiation in response to epicutaneously introduced antigen and may have important implications for allergic skin diseases. ..
- Yamasaki S, Stoecklin G, Kedersha N, Simarro M, Anderson P. T-cell intracellular antigen-1 (TIA-1)-induced translational silencing promotes the decay of selected mRNAs. J Biol Chem. 2007;282:30070-7 pubmed..These results suggest that TIA-1-induced polysome disassembly is required for enhanced mRNA decay and that TIA-1-induced translational silencing promotes the decay of selected mRNAs. ..
- Peng Y, Sun J, Hon S, Nylander A, Xia W, Feng Y, et al. L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease. J Neurosci. 2010;30:8180-9 pubmed publisher..L-NBP shows promising preclinical potential as a multitarget drug for the prevention and/or treatment of Alzheimer's disease. ..
- Ma A, Datta M, Margosian E, Chen J, Horak I. T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. J Exp Med. 1995;182:1567-72 pubmed..IL-2-/-, JH-/- mice do not, however, succumb to anemia. Thus, spontaneous intestinal inflammation in IL-2-/- mice requires mature T cells, not B cells, while anemia is dependent on B cells. ..
- Lu Q, Yuk D, Alberta J, Zhu Z, Pawlitzky I, Chan J, et al. Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron. 2000;25:317-29 pubmed..Gain- and loss-of-function analyses in transgenic mice demonstrate that Shh is both necessary and sufficient for Olg gene expression in vivo. ..
- Belguise K, Sonenshein G. PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor alpha synthesis. J Clin Invest. 2007;117:4009-21 pubmed
- Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez A C, et al. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. J Exp Med. 1996;184:1939-51 pubmed..In contrast to Eotaxin, mRNA for mMCP-5 can be produced by mast cells. From these results, we postulate that mMCP-5 plays a pivotal role during the early stages of allergic lung inflammation. ..
- Karhausen J, Furuta G, Tomaszewski J, Johnson R, Colgan S, Haase V. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest. 2004;114:1098-106 pubmed..Taken together, these studies provide insight into tissue microenvironmental changes during model inflammatory bowel disease and identify HIF-1 as a critical factor for barrier protection during mucosal insult. ..
- Hunter N, Awatramani R, Farley F, Dymecki S. Ligand-activated Flpe for temporally regulated gene modifications. Genesis. 2005;41:99-109 pubmed
- Dhillon H, Zigman J, Ye C, Lee C, McGovern R, Tang V, et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006;49:191-203 pubmed..These results reveal a critical role for leptin action on VMH neurons. ..
- Handschin C, Lin J, Rhee J, Peyer A, Chin S, Wu P, et al. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell. 2005;122:505-15 pubmed..These data show that PGC-1alpha links nutritional status to heme biosynthesis and acute hepatic porphyria. ..
- Kim B, Mao J, Taketo M, Shivdasani R. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology. 2007;133:529-38 pubmed..The canonical Wnt pathway has independent, albeit possibly overlapping, functions in early intestinal villi and adult crypts. These observations advance understanding of Wnt functions in intestinal development and disease. ..
- Rünger T. C-->T transition mutations are not solely UVB-signature mutations, because they are also generated by UVA. J Invest Dermatol. 2008;128:2138-40 pubmed publisher..We hypothesize that weaker anti-mutagenic cellular responses to UVA, as compared to UVB, may result in higher rates of mutation formation for UVA-induced dimers. ..
- Koirala S, Corfas G. Identification of novel glial genes by single-cell transcriptional profiling of Bergmann glial cells from mouse cerebellum. PLoS ONE. 2010;5:e9198 pubmed publisher..Finally, we highlight several genes that in the cerebellum are expressed in Bergmann glia but not astrocytes, and may therefore serve as new, specific markers for Bergmann glia. ..
- Schnitzler A, Mellott T, Lopez Coviella I, Tallini Y, Kotlikoff M, Follettie M, et al. BMP9 (bone morphogenetic protein 9) induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons. J Neurosci. 2010;30:8221-8 pubmed publisher..The data suggest an autocrine/paracrine role for NGF in the development and/or maintenance of BFCN and imply that the stimulation of NGF production and release contributes to the cholinergic-supportive properties of BMP9. ..
- Cai D, Yuan M, Frantz D, Melendez P, Hansen L, Lee J, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005;11:183-90 pubmed..This causes insulin resistance both locally in liver and systemically. ..
- Johnson J, Bagley J, Skaznik Wikiel M, Lee H, Adams G, Niikura Y, et al. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell. 2005;122:303-15 pubmed..These results identify BM as a potential source of germ cells that could sustain oocyte production in adulthood. ..
- Wang H, Afdhal N, Gendler S, Wang D. Evidence that gallbladder epithelial mucin enhances cholesterol cholelithogenesis in MUC1 transgenic mice. Gastroenterology. 2006;131:210-22 pubmed..Tg and wild-type mice. Increased gallbladder epithelial MUC1 mucin enhances cholelithogenesis by promoting gallbladder cholesterol absorption and impairing gallbladder motility in mice. ..
- Tanwar P, Lee H, Zhang L, Zukerberg L, Taketo M, Rueda B, et al. Constitutive activation of Beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice. Biol Reprod. 2009;81:545-52 pubmed publisher..These results show evidence suggesting that dysregulated, stromal, and myometrial WNT/beta-catenin signaling has pleiotropic effects on uterine function and tumorigenesis. ..
- Levy B, De Sanctis G, Devchand P, Kim E, Ackerman K, Schmidt B, et al. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med. 2002;8:1018-23 pubmed..Moreover, our findings suggest that lipoxin and related pathways offer novel multi-pronged therapeutic approaches for human asthma. ..
- Zhou Y, Lee S, Jin Z, Wright M, Smith S, Anderson M. Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Nat Med. 2009;15:1208-14 pubmed publisher..Thus, LGI1 represents a human gene mutated to promote epilepsy through impaired postnatal development of glutamatergic circuits. ..
- Eichler F, Hornemann T, McCampbell A, Kuljis D, Penno A, Vardeh D, et al. Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1. J Neurosci. 2009;29:14646-51 pubmed publisher..This observation is consistent with the hypothesis that HSAN1 is the result of a gain-of-function mutation in SPTLC1 that leads to accumulation of a toxic metabolite...
- Lin B, Masland R. Populations of wide-field amacrine cells in the mouse retina. J Comp Neurol. 2006;499:797-809 pubmed..These cells are present at every level of the inner plexiform layer, which suggests that they affect most of the mouse retina's final outputs to the brain and, by implication, almost all visual function. ..
- Kolpakova Hart E, Jinnin M, Hou B, Fukai N, Olsen B. Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. Dev Biol. 2007;309:273-84 pubmed..However, the motor appears to be required for the efficient cleavage of the full-length Gli3 transcription factor into a repressor form...
- Valverde P, Zhang J, Fix A, Zhu J, Ma W, Tu Q, et al. Overexpression of bone sialoprotein leads to an uncoupling of bone formation and bone resorption in mice. J Bone Miner Res. 2008;23:1775-88 pubmed publisher..These findings are expected to help the development of therapies to metabolic bone diseases characterized by high serum level of BSP. ..
- Dorenbos R, Contini M, Hirasawa H, Gustincich S, Raviola E. Expression of circadian clock genes in retinal dopaminergic cells. Vis Neurosci. 2007;24:573-80 pubmed..It is therefore likely that DA cells contain a circadian clock that anticipates predictable variations in retinal illumination. ..
- Di Vizio D, Sotgia F, Williams T, Hassan G, Capozza F, Frank P, et al. Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression. Cancer Biol Ther. 2007;6:1263-8 pubmed..In addition, our results provide the first molecular genetic evidence that Cav-1 functions upstream of FASN during prostate cancer progression. ..
- Zhang Y, Klassen H, Tucker B, Perez M, Young M. CNS progenitor cells promote a permissive environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism. J Neurosci. 2007;27:4499-506 pubmed..This suggests a novel therapeutic role for progenitor cells in the treatment of CNS degenerative diseases. ..
- Scadden D. The weight of cell identity. J Clin Invest. 2007;117:3653-5 pubmed..These cells remained true to their roots, indicating how difficult it will be to exploit cell plasticity for therapeutic purposes. ..
- Milstone D, Shaw S, Parker K, Szyf M, Seidman J. An element regulating adrenal-specific steroid 21-hydroxylase expression is located within the slp gene. J Biol Chem. 1992;267:21924-7 pubmed..Analogous genetic arrangements may explain other examples of conserved linkage of disparate genes. ..
- Lane T, Leder P. Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice. Oncogene. 1997;15:2133-44 pubmed..These results suggest that Wnt-10b, or other Wnt genes expressed early in mammary development, play a role in regulating sexual dimorphism and show potent transforming activity when overexpressed. ..
- Fatkin D, Christe M, Aristizabal O, McConnell B, Srinivasan S, Schoen F, et al. Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene. J Clin Invest. 1999;103:147-53 pubmed..We speculate that variable incorporation of mutant and normal MHC into sarcomeres of heterozygotes may account for focal myocyte death in familial hypertrophic cardiomyopathy. ..
- van Hoek A, Ma T, Yang B, Verkman A, Brown D. Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. Am J Physiol Renal Physiol. 2000;278:F310-6 pubmed..The functional significance of the apparent species-dependent expression of AQP4 in proximal tubules is unknown, but may relate to physiological differences between rats and mice...
- Mogi M, Yang J, Lambert J, Colvin G, Shiojima I, Skurk C, et al. Akt signaling regulates side population cell phenotype via Bcrp1 translocation. J Biol Chem. 2003;278:39068-75 pubmed..These data suggest that Akt signaling modulates the SP cell phenotype by regulating the expression of Bcrp1...
- Gustincich S, Feigenspan A, Sieghart W, Raviola E. Composition of the GABA(A) receptors of retinal dopaminergic neurons. J Neurosci. 1999;19:7812-22 pubmed..Therefore, DA cells possess at least two types of GABA(A) receptors localized in different synapses. Furthermore, they exhibit multiple extrasynaptic GABA(A) receptors. ..
- Lin J, Wu H, Tarr P, Zhang C, Wu Z, Boss O, et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 2002;418:797-801 pubmed..These data indicate that PGC-1 alpha is a principal factor regulating muscle fibre type determination...
- Maison S, Luebke A, Liberman M, Zuo J. Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells. J Neurosci. 2002;22:10838-46 pubmed..These data demonstrate that efferent protection is mediated via the alpha9 nAChR in the outer hair cells and provide direct evidence for a protective role, in vivo, of a member of the nAChR family. ..
- Kershaw E, Morton N, Dhillon H, Ramage L, Seckl J, Flier J. Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity. Diabetes. 2005;54:1023-31 pubmed..These data suggest that reduction of active GCs exclusively in adipose tissue is an important determinant of a favorable metabolic phenotype with respect to energy homeostasis and the metabolic syndrome. ..
- Nishimura W, Bonner Weir S, Sharma A. Expression of MafA in pancreatic progenitors is detrimental for pancreatic development. Dev Biol. 2009;333:108-20 pubmed publisher..These findings imply that MafA should be used to enhance maturation, rather than specification, of beta-cells from stem/progenitor cells. ..
- Paust S, Gill H, Wang B, Flynn M, Moseman E, Senman B, et al. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010;11:1127-35 pubmed publisher..Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell-expressed CXCR6. ..
- Cavanagh L, Bonasio R, Mazo I, Halin C, Cheng G, van der Velden A, et al. Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nat Immunol. 2005;6:1029-37 pubmed..Moreover, using this previously unknown migratory pathway, antigen-pulsed DCs were able to trigger central memory T cell-mediated recall responses in the bone marrow. ..
- Bentires Alj M, Neel B. Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer. Cancer Res. 2007;67:2420-4 pubmed..In contrast, PTP1B deficiency has no effect on MMTV-polyoma middle T tumorigenesis. Our data raise the possibility that PTP1B inhibitors may be chemopreventative for some forms of breast cancer. ..
- Natoli T, Liu J, Eremina V, Hodgens K, Li C, Hamano Y, et al. A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development. J Am Soc Nephrol. 2002;13:2058-67 pubmed..These results suggest that WT1 controls the expression of growth factors that regulate glomerular capillary development and that abnormal capillary development might lead to glomerular disease...
- Hofmann C, Wang X, Sullivan C, Toselli P, Stone P, McLean S, et al. B-Myb represses elastin gene expression in aortic smooth muscle cells. J Biol Chem. 2005;280:7694-701 pubmed..Furthermore, the findings provide additional insight into the mechanism of B-myb-mediated resistance to femoral artery injury. ..
- Lopez J, Lyckman A, Oddo S, LaFerla F, Querfurth H, Shtifman A. Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice. J Neurochem. 2008;105:262-71 pubmed..These results demonstrate that an elevation in resting [Ca2+](i), contributed by aberrant Ca2+entry and release pathways, should be considered a major component of the abnormal Ca2+ homeostasis associated with AD. ..
- Tevosian S, Deconinck A, Tanaka M, Schinke M, Litovsky S, Izumo S, et al. FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell. 2000;101:729-39 pubmed..Our findings provide the molecular inroad into the induction of coronary vasculature by myocardium in the developing heart. ..
- Martemyanov K, Lishko P, Calero N, Keresztes G, Sokolov M, Strissel K, et al. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. J Neurosci. 2003;23:10175-81 pubmed..This presents the possibility that DEP domains might serve to target various DEP-containing proteins to the sites of their intracellular action via interactions with the members of extended SNARE protein family. ..
- Maldonado R, Irvine D, Schreiber R, Glimcher L. A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature. 2004;431:527-32 pubmed..They further suggest a new mechanism of membrane-bound signalling control by the physical disruption of large receptor-rich domains on signalling through a functionally antagonistic receptor. ..
- Jung D, Giallourakis C, Mostoslavsky R, Alt F. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol. 2006;24:541-70 pubmed..In this review, we summarize advances that have been made in understanding how V(D)J recombination at the IgH locus is controlled and discuss important areas for future investigation. ..
- Berland R, Fernandez L, Kari E, Han J, Lomakin I, Akira S, et al. Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity. 2006;25:429-40 pubmed..These results demonstrate that the particular threat of nucleic acid-containing autoantigens lies in their ability to bind both antigen receptor and TLR7. ..
- Balcioglu A, Kim M, Sharma N, Cha J, Breakefield X, Standaert D. Dopamine release is impaired in a mouse model of DYT1 dystonia. J Neurochem. 2007;102:783-8 pubmed..The defect in DA release as observed may contribute to the abnormalities in motor learning as previously documented in this transgenic mouse model, and may contribute to the clinical symptoms of the human disorder...
- Saint Geniez M, Maharaj A, Walshe T, Tucker B, Sekiyama E, Kurihara T, et al. Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors. PLoS ONE. 2008;3:e3554 pubmed publisher..These results indicate an important role for endogenous VEGF in the maintenance and function of adult retina neuronal cells and indicate that anti-VEGF therapies should be administered with caution. ..
- Tong Q, Ye C, Jones J, Elmquist J, Lowell B. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008;11:998-1000 pubmed publisher..These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance. ..
- Song G, Nguyen D, Pietramaggiori G, Scherer S, Chen B, Zhan Q, et al. Use of the parabiotic model in studies of cutaneous wound healing to define the participation of circulating cells. Wound Repair Regen. 2010;18:426-32 pubmed publisher..Application of this approach enables further investigation into the contribution of peripheral blood in normal and abnormal healing responses. ..
- Groves R, Rauschmayr T, Nakamura K, Sarkar S, Williams I, Kupper T. Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes. Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease. J Clin Invest. 1996;98:336-44 pubmed
- Lantz C, Boesiger J, Song C, Mach N, Kobayashi T, Mulligan R, et al. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature. 1998;392:90-3 pubmed..These findings establish a role for IL-3 in immunity to parasites and indicate that one of the functions of IL-3 in host defence against infection is to expand populations of haematopoietic effector cells. ..
- Calvi L, Sims N, Hunzelman J, Knight M, Giovannetti A, Saxton J, et al. Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. J Clin Invest. 2001;107:277-86 pubmed
- de Jesus L, Carvalho S, Ribeiro M, Schneider M, Kim S, Harney J, et al. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest. 2001;108:1379-85 pubmed..Thus, D2 is an essential component in the thyroid-sympathetic synergism required for thermal homeostasis in small mammals. ..
- Goldberg M, Pisani A, Haburcak M, Vortherms T, Kitada T, Costa C, et al. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron. 2005;45:489-96 pubmed..Furthermore, DJ-1(-/-) mice displayed hypoactivity in the open field. Collectively, our findings suggest an essential role for DJ-1 in dopaminergic physiology and D2 receptor-mediated functions...
- McGann J, Pírez N, Gainey M, Muratore C, Elias A, Wachowiak M. Odorant representations are modulated by intra- but not interglomerular presynaptic inhibition of olfactory sensory neurons. Neuron. 2005;48:1039-53 pubmed..This organization allows for control of input sensitivity while maintaining the spatial maps of glomerular activity thought to encode odorant identity. ..
- Cao Y, Espinola J, Fossale E, Massey A, Cuervo A, MacDonald M, et al. Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem. 2006;281:20483-93 pubmed
- Xia W, Zhang J, Ostaszewski B, Kimberly W, Seubert P, Koo E, et al. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 1998;37:16465-71 pubmed..Our results indicate PS1 and APP can interact in the ER and Golgi, where PS1 is required for proper gamma-secretase processing of APP CTFs, and that PS1 mutations augment Abeta42 levels principally in Golgi-like vesicles. ..
- Wong K, Chang S, Weiler S, Ganesan S, Chaudhuri J, Zhu C, et al. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet. 2000;26:85-8 pubmed..Our findings establish a intimate relationship between functionally intact telomeres and the genomic, cellular and organismal response to ionizing radiation. ..
- Rich B, Kupper T. Cytokines: IL-20 - a new effector in skin inflammation. Curr Biol. 2001;11:R531-4 pubmed..The newly discovered cytokine interleukin-20 (IL-20) is structurally related to IL-10, yet it appears to be an autocrine factor for keratinocytes that regulates their participation in inflammation. ..
- Leder A, Lebel M, Zhou F, Fontaine K, Bishop A, Leder P. Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis. Oncogene. 2002;21:6657-68 pubmed..This work demonstrates a genetic interaction between the instability of the multicopy transgene and the Werner Syndrome gene. From this, we conclude that genetic instability remains a key element in this tumor promoter model. ..
- Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, et al. Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. J Neurosci. 2003;23:2769-78 pubmed..Our results show that p25 can substitute for p35/Cdk5 under certain circumstances during development. In addition, they suggest that p25 may have lost some functions of p35. ..
- Yano T, Liu Z, Donovan J, Thomas M, Habener J. Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt. Diabetes. 2007;56:2946-57 pubmed..SDF-1 promotes pancreatic beta-cell survival via activation of Akt, suggesting that SDF-1 agonists may prove beneficial for treatment of diabetes. ..
- Suter B, Nowakowski R, Bhide P, Caviness V. Navigating neocortical neurogenesis and neuronal specification: a positional information system encoded by neurogenetic gradients. J Neurosci. 2007;27:10777-84 pubmed..This mapping system consisting of a combination of signals from two different sources is a novel perspective on the source of positional information for neuronal specification in the developing CNS. ..
- Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell B, Maratos Flier E, et al. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology. 2008;149:5654-61 pubmed publisher..These results suggest that Socs3 in SF1 neurons negatively regulates leptin signaling and plays important roles in mediating leptin sensitivity, glucose homeostasis, and energy expenditure. ..
- Saez E, Rutberg S, Mueller E, Oppenheim H, Smoluk J, Yuspa S, et al. c-fos is required for malignant progression of skin tumors. Cell. 1995;82:721-32 pubmed..These results demonstrate that a member of the AP-1 family of transcription factors is required for the development of a malignant tumor. ..
- Chaillet J, Bader D, Leder P. Regulation of genomic imprinting by gametic and embryonic processes. Genes Dev. 1995;9:1177-87 pubmed..Furthermore, our results suggest that overmethylation is the default status of both parental alleles and that the paternal allele can be marked in trans by polymorphic factors that act in postblastocyst embryos. ..
- Maeda K, Uysal K, Makowski L, Gorgun C, Atsumi G, Parker R, et al. Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes. 2003;52:300-7 pubmed..Hence, our results demonstrate that mal1 modulates adipose tissue function and contributes to systemic glucose metabolism and constitutes a potential therapeutic target in insulin resistance. ..
- Kishi T, Aschkenasi C, Choi B, Lopez M, Lee C, Liu H, et al. Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor. J Comp Neurol. 2005;482:217-43 pubmed..These observations are consistent with the proposed roles of the central NPY/Y1-R system in energy homeostasis. ..
- Farago A, Awatramani R, Dymecki S. Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps. Neuron. 2006;50:205-18 pubmed..Together, these findings provide new platforms for investigating the development and evolution of auditory and cerebellar systems. ..
- Lee J, Ivanova E, Seong I, Cashorali T, Kohane I, Gusella J, et al. Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism. PLoS Genet. 2007;3:e135 pubmed..Elucidation of this HD CAG-dependent pathway would spur efforts to achieve energy-based therapeutics in HD. ..
- Sprengers D, Sillé F, Derkow K, Besra G, Janssen H, Schott E, et al. Critical role for CD1d-restricted invariant NKT cells in stimulating intrahepatic CD8 T-cell responses to liver antigen. Gastroenterology. 2008;134:2132-43 pubmed publisher..Our findings elucidate a previously unknown intervention point for targeted immunotherapy to autoimmune and possibly infectious liver diseases. ..
- Zhang X, Friedman A, Heaney S, Purcell P, Maas R. Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev. 2002;16:2097-107 pubmed..Therefore, despite the striking evolutionary conservation of Pax6 function, Pax6 expression in the vertebrate lens is uniquely regulated. ..
- Ji H, Gupta A, Okamoto S, Blum M, Tan L, Goldring M, et al. T cell-specific expression of the murine CD3delta promoter. J Biol Chem. 2002;277:47898-906 pubmed